GPT基因详情-基因数据库-基因云馆

GPT(glutamic-pyruvate transaminase (alanine aminotransferase)) 转至新版数据库

基因简称(symbol)

GPT [HGNC] [GeneCards] [NCBI]

基因种类(locus group)

protein-coding gene

同源简称(alias symbol)

ALT1|GPT1

基因家族代码(gene_family_id)

[HGNC] [GenScript]

omim代码

138200

entrez码

2875 [Vega]

vega基因码

OTTHUMG00000165176

ensembl基因码

ENSG00000167701 [Ensembl]

基因家族(gene family)

refseq数据库代号

NM_005309

更多...

基因种类(locus_type)

gene with protein product

基因名称状态(status)

Approved

location_sortable

08q24.3

同源基因名称(alias name)

基因名称批准使用时间(date_approved_reserved)

2001-06-22T00:00:00Z

基因简称更名时间(date_symbol_changed)

基因名称更名时间(date_name_changed)

更新时间(date_modified)

2014-11-19T00:00:00Z

ucsc码

uc003zdh.4

ena

ccds数据码

CCDS6430

uniprot数据码

P24298

pubmed代码

mgd码

MGI:95802

rgd码

RGD:621720

生命科学数据库(lsdb)

更新时间(date modified)

2014-11-19T00:00:00Z

cosmic

GPT

mirbase

基因曾用简称(prev symbol)

基因曾用名称(prev name)

homeodb

cosmic

GPT

snornabase

bioparadigms slc

orphanet

假基因信息(pseudogeneorg)

horde id

merops

imgt

iuphar

kznf基因类别

mamit-trnadb

cd

LncRNA数据库

酶代码

2.6.1.2

中间纤维数据库

收起

8q24.3

This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]

[中文简述(自动翻译):] 该基因编码细胞内丙氨酸aminotransaminase 1（ALT1）;也称为谷氨酸 - 丙酮酸转氨酶1.这种酶催化丙氨酸和2-酮戊二酸，生成丙酮酸和谷氨酸，因此，起着的葡萄糖和氨基酸的中间代谢关键作用之间的可逆氨基转移。这种酶的血清活性水平被常规用作肝损伤引起的药物毒性，感染，酒精和脂肪变性的生物标志物。 16号染色体上的一??个相关基因编码一个假定的线粒体丙氨酸aminotransaminase [由RefSeq的，2009年11月提供]

OMIM数据库中对GPT基因的介绍 Wikipedia数据库中对GPT基因的介绍

GPT基因的碱基序列：[NCBI]

GPT基因的碱基突变：显示全部snp

rs1044618 rs1063739 rs1871542 rs2101039 rs2721197 rs2721198 rs3891233 rs3891235 rs4378003 rs4559279 rs4581096 rs6988333 rs12542399 rs13254911 rs34491386 rs45492895 rs45592435 rs56010190 rs59798065 rs61740411 rs71520577 rs79355846 rs80017057 rs80198511 rs111681499 rs111938043 rs112574791 rs112827945 rs113004086 rs113183656 rs113518434 rs114840278 rs115678773 rs115700265 rs116684584 rs138238489 rs138353402

rs138531202 rs138709427 rs139040022 rs139107415 rs139247503 rs139339388 rs139849083 rs140001090 rs140441371 rs140517764 rs140630174 rs140704858 rs140901015 rs141187317 rs141381983 rs141505249 rs141554257 rs141571140 rs141693746 rs142450169 rs142640247 rs142958733 rs143080454 rs143408057 rs143462595 rs143572581 rs143578380 rs143641515 rs143779924 rs143942722 rs144054398 rs144520970 rs144588980 rs144666868 rs144799905 rs145155876 rs145331563 rs145365806 rs145551173 rs145950433 rs146152870 rs146211713 rs146639111 rs146709136 rs146795720 rs146813308 rs147672961 rs147998249 rs148163358 rs148452229 rs148513946 rs148683067 rs148879135 rs148927692 rs149399224 rs149452487 rs149505691 rs150134930 rs150447348 rs150549846 rs150748518 rs150902628 rs151004055 rs181246062 rs181450148 rs182226976 rs183284546 rs184018376 rs184507175 rs186077722 rs186086380 rs186831096 rs187561199 rs188616818 rs189110209 rs189393585 rs190931650 rs191354445 rs191933161 rs192904904 rs199614717 rs199690645 rs199705423 rs199842045 rs199966200 rs200028932 rs200051514 rs200081242 rs200088103 rs200095776 rs200128241 rs200263358 rs200304696 rs200363587 rs200388860 rs200465186 rs200479839 rs200508853 rs200550202 rs200594000 rs200690809 rs200716831 rs200726053 rs200835664 rs200853809 rs200913027 rs201065145 rs201081960 rs201082887 rs201113193 rs201282843 rs201355232 rs201355879 rs201375969 rs201383085 rs201413052 rs201426715 rs201458953 rs201590136 rs201688778 rs201783570 rs201792209 rs201815297 rs201844010 rs201994913 rs202006693 rs202022536 rs202096061 rs202140398 rs202142537 rs202199621 rs367801266 rs367895411 rs368002605 rs368458474 rs368470587 rs368474149 rs368857055 rs369003484 rs369149626 rs369157167 rs369193887 rs369274659 rs369294221 rs369447294 rs369547937 rs369730724 rs370011145 rs370056728 rs370098669 rs370128580 rs370247961 rs370352430 rs370395815 rs370530302 rs370730581 rs370893871 rs371048594 rs371146513 rs371202011 rs371204142 rs371263663 rs371303972 rs371318945 rs371451014 rs371565005 rs371616471 rs371985904 rs372141763 rs372169605 rs372247642 rs372255059 rs372280992 rs372301239 rs372387867 rs372608637 rs372684551 rs372754838 rs372762824 rs372818661 rs372822089 rs372839620 rs372867794 rs372885450 rs373034425 rs373097107 rs373341171 rs373397761 rs373520194 rs373632268 rs373855599 rs374035225 rs374057837 rs374307577 rs374357547 rs374426053 rs374457286 rs374566192 rs374721145 rs374889154 rs375095062 rs375120964 rs375214280 rs375274571 rs375329874 rs375371163 rs375436494 rs375466978 rs375588825 rs375690215 rs375770081 rs375809661 rs375840377 rs376008663 rs376189057 rs376198243 rs376363949 rs376386494 rs376437557 rs376594173 rs376611071 rs376857303 rs376968770 rs377001173 rs377045644 rs377104389 rs377311669 rs377414458 rs377443927 rs377705965 rs527686200 rs528081075 rs528169048 rs528506871 rs528675744 rs528760570 rs528996027 rs529260032 rs529332227 rs529361468 rs529543079 rs529679428 rs529923184 rs530290663 rs530331385 rs530433732 rs530505425 rs530982165 rs531134486 rs531504907 rs531547039 rs531841125 rs532313058 rs532637254 rs533144476 rs533370457 rs534748295 rs534857727 rs534968284 rs535541009 rs535844929 rs536282328 rs536288971 rs536530053 rs536732113 rs536931964 rs537094982 rs538093303 rs538599984 rs538669846 rs538807552 rs539260252 rs539291212 rs539737069 rs539897181 rs540187394 rs540198249 rs540431167 rs540894994 rs541457382 rs541584130 rs541667740 rs542473121 rs542613881 rs542669955 rs543057022 rs543570003 rs544115127 rs544184414 rs544229245 rs544343805 rs544522423 rs545061802 rs545103039 rs545510201 rs545709062 rs545775484 rs546107651 rs546399607 rs546586317 rs546698741 rs546710368 rs546969111 rs547075873 rs547236150 rs547296072 rs547406291 rs547692332 rs547778127 rs547966842 rs548004987 rs548200227 rs548206071 rs548793104 rs548832084 rs548905016 rs549195237 rs549993849 rs550030859 rs550665172 rs550764711 rs551745532 rs551989240 rs552732658 rs552905302 rs553201287 rs553522650 rs553528646 rs553559563 rs553841622 rs554139775 rs554179390 rs554263341 rs554454561 rs554853278 rs554981350 rs555267402 rs555269423 rs555308127 rs555640614 rs557002999 rs557930410 rs558195542 rs558794924 rs558968614 rs559264971 rs559267252 rs559557046 rs559645042 rs560271096 rs561078996 rs561106229 rs561319762 rs561409231 rs561474610 rs561704160 rs561721324 rs561998224 rs562085930 rs562529660 rs562794201 rs562959816 rs563283311 rs563852753 rs563911518 rs563920735 rs564073131 rs564095309 rs564377711 rs564582068 rs564673709 rs564918488 rs565556920 rs565685352 rs565790019 rs566366974 rs566405666 rs566678188 rs567604388 rs568104481 rs568243820 rs568487484 rs568801245 rs568969925 rs569059245 rs569438469 rs569440310 rs570171561 rs570410548 rs570776341 rs571083994 rs572474138 rs572639218 rs572727344 rs573085814 rs573389434 rs573680496 rs573754411 rs574293673 rs574630534 rs574866707 rs575118703 rs575189875 rs576608308 rs576646311 rs577262676 rs577299311 rs577835978 rs577951664 rs578183347 rs745306268 rs745364481 rs745388111 rs745478940 rs745556641 rs745562918 rs745617545 rs745631565 rs745652946 rs745741227 rs745778805 rs745822646 rs745891303 rs745908236 rs745919002 rs745932486 rs745937587 rs746049991 rs746152978 rs746166602 rs746189243 rs746325471 rs746344306 rs746419405 rs746444835 rs746477697 rs746504111 rs746749454 rs746798773 rs746826518 rs746932155 rs746957997 rs746958634 rs746987943 rs747080189 rs747098200 rs747338893 rs747358499 rs747432300 rs747447603 rs747498921 rs747616812 rs747620337 rs747681228 rs747697160 rs747704575 rs747718326 rs747777499 rs747826842 rs747843263 rs748008493 rs748082273 rs748119689 rs748130026 rs748143101 rs748144013 rs748258162 rs748280562 rs748372331 rs748399690 rs748409747 rs748417596 rs748457700 rs748460442 rs748499226 rs748547625 rs748583557 rs748669302 rs748706977 rs748817984 rs748820435 rs748933417 rs749054711 rs749139745 rs749218452 rs749227363 rs749252338 rs749288207 rs749313882 rs749492017 rs749566823 rs749577737 rs749597350 rs749635812 rs749649028 rs749729638 rs749836766 rs749868522 rs749906793 rs749959135 rs750038133 rs750130376 rs750148469 rs750175698 rs750306278 rs750323005 rs750391734 rs750427788 rs750442911 rs750626811 rs750638175 rs750673373 rs750675244 rs750681011 rs750747453 rs750748002 rs750763247 rs750967411 rs750983778 rs751016517 rs751253095 rs751317477 rs751336078 rs751337590 rs751356057 rs751510590 rs751558115 rs751595181 rs751608206 rs751685146 rs751737148 rs751740696 rs751761064 rs751767383 rs751825101 rs751827193 rs751843593 rs751907921 rs752068526 rs752080977 rs752113101 rs752130961 rs752135706 rs752165596 rs752377348 rs752379530 rs752383291 rs752397971 rs752435533 rs752457447 rs752568557 rs752596725 rs752668706 rs752686497 rs752775906 rs752805176 rs753030623 rs753047103 rs753107681 rs753155789 rs753197453 rs753219034 rs753222214 rs753281271 rs753283113 rs753411777 rs753449017 rs753567992 rs753670951 rs753705080 rs753719809 rs753819541 rs753824118 rs753857754 rs753986303 rs754006020 rs754011368 rs754091629 rs754179437 rs754184671 rs754197478 rs754271637 rs754312657 rs754484141 rs754484320 rs754527405 rs754557567 rs754705926 rs754719078 rs754789116 rs754809596 rs754822821 rs754863097 rs754868571 rs754982986 rs755003534 rs755039914 rs755094385 rs755111201 rs755279250 rs755326106 rs755373318 rs755451701 rs755524000 rs755532016 rs755615509 rs755615955 rs755633945 rs755684251 rs755842813 rs755881328 rs755883296 rs755951924 rs755956337 rs756004927 rs756037936 rs756087551 rs756130692 rs756132776 rs756151404 rs756169975 rs756304033 rs756341516 rs756403978 rs756518024 rs756607887 rs756626466 rs756660977 rs756690796 rs756731766 rs756756813 rs756777368 rs756909307 rs756991495 rs757062979 rs757090626 rs757128853 rs757182382 rs757301530 rs757320127 rs757432715 rs757464652 rs757536171 rs757590525 rs757592608 rs757626184 rs757715535 rs757853029 rs757878396 rs757892583 rs757926914 rs758051064 rs758071361 rs758153683 rs758243896 rs758324329 rs758328894 rs758341140 rs758376636 rs758443116 rs758536748 rs758578129 rs758745322 rs758784417 rs758787114 rs758832808 rs758875108 rs758902613 rs758962078 rs759048715 rs759106808 rs759126477 rs759156616 rs759223375 rs759240795 rs759308893 rs759335196 rs759335306 rs759416969 rs759462401 rs759585525 rs759613792 rs759651323 rs759695712 rs759784022 rs759784704 rs759838284 rs759928158 rs759947263 rs759979846 rs760002275 rs760013246 rs760134834 rs760158522 rs760176502 rs760205268 rs760247280 rs760293071 rs760320204 rs760337307 rs760385283 rs760399550 rs760411762 rs760427070 rs760475837 rs760512990 rs760707897 rs760741326 rs760804575 rs760808298 rs760842726 rs760848217 rs760930815 rs760932712 rs761091390 rs761121667 rs761155245 rs761224351 rs761331940 rs761395130 rs761438660 rs761540978 rs761546067 rs761664060 rs761860329 rs761903768 rs761914169 rs761951983 rs761979276 rs761989809 rs762001859 rs762168599 rs762170689 rs762260669 rs762290090 rs762326628 rs762355091 rs762385509 rs762452001 rs762567550 rs762649719 rs762649725 rs762764568 rs762766505 rs762814084 rs762848175 rs762924568 rs762997607 rs763054355 rs763055722 rs763068488 rs763130402 rs763154411 rs763226263 rs763232780 rs763324132 rs763330190 rs763375784 rs763398079 rs763406811 rs763407503 rs763514165 rs763542493 rs763553812 rs763600216 rs763633394 rs763678112 rs763689807 rs763777444 rs763916421 rs763930347 rs763932469 rs763952459 rs764043208 rs764048138 rs764071887 rs764126314 rs764204491 rs764233826 rs764305959 rs764369102 rs764375709 rs764395897 rs764402392 rs764431793 rs764435489 rs764467729 rs764483815 rs764484724 rs764498697 rs764620727 rs764663540 rs764780268 rs764852964 rs764916788 rs765057110 rs765080403 rs765105086 rs765144654 rs765186663 rs765214755 rs765235280 rs765331413 rs765379936 rs765483408 rs765501508 rs765501647 rs765512229 rs765542863 rs765553302 rs765593035 rs765645168 rs765657098 rs765669439 rs765787079 rs765923514 rs765957833 rs765957840 rs765958896 rs766188121 rs766199978 rs766238311 rs766288130 rs766301911 rs766308413 rs766420184 rs766571164 rs766585665 rs766632606 rs766694721 rs766707602 rs766711055 rs766724293 rs766797443 rs766815870 rs766902019 rs766945069 rs767067083 rs767099328 rs767221297 rs767271817 rs767300625 rs767361154 rs767361705 rs767361778 rs767379783 rs767457007 rs767478951 rs767534994 rs767715606 rs767736622 rs767747471 rs767769469 rs767790104 rs767835983 rs767839047 rs767874822 rs767936601 rs768044950 rs768050634 rs768119857 rs768257668 rs768259380 rs768259950 rs768299034 rs768393831 rs768397194 rs768412132 rs768576455 rs768663099 rs768692147 rs768714771 rs768731992 rs768748757 rs768873942 rs768891704 rs769036858 rs769049027 rs769057783 rs769178699 rs769246482 rs769306414 rs769394527 rs769443988 rs769471662 rs769546068 rs769552512 rs769713014 rs769714692 rs769734771 rs769804293 rs769804699 rs769846176 rs769950392 rs769967846 rs769986664 rs770070762 rs770110037 rs770221705 rs770229545 rs770249976 rs770272781 rs770313213 rs770500560 rs770527938 rs770534529 rs770554695 rs770588636 rs770627758 rs770644138 rs770751233 rs770779620 rs770892937 rs770930250 rs771013930 rs771039469 rs771044777 rs771105855 rs771266915 rs771282203 rs771390796 rs771407331 rs771407906 rs771426072 rs771508375 rs771514065 rs771665689 rs771687797 rs771707681 rs771785463 rs771805043 rs771873400 rs771950529 rs772070124 rs772157593 rs772159817 rs772161437 rs772213729 rs772234384 rs772253546 rs772319250 rs772483757 rs772490826 rs772502508 rs772512733 rs772561179 rs772581592 rs772711549 rs772794949 rs772800304 rs772884954 rs772918270 rs772924716 rs773012570 rs773126140 rs773214190 rs773394933 rs773420066 rs773436396 rs773478792 rs773480719 rs773492340 rs773547243 rs773568283 rs773828325 rs773843554 rs773863932 rs773894148 rs773933970 rs773949932 rs773993974 rs774117125 rs774129797 rs774156720 rs774169083 rs774189700 rs774265869 rs774335721 rs774342984 rs774615837 rs774618377 rs774627632 rs774645693 rs774659581 rs774668188 rs774705682 rs774820971 rs774899840 rs774925715 rs775002591 rs775101850 rs775104723 rs775109565 rs775127714 rs775213760 rs775350170 rs775371734 rs775470130 rs775507923 rs775560041 rs775597747 rs775597998 rs775628935 rs775646493 rs775659216 rs775677970 rs775719240 rs775813325 rs775854766 rs776056956 rs776083232 rs776136592 rs776147070 rs776157825 rs776165677 rs776169645 rs776251118 rs776332104 rs776337762 rs776459877 rs776527086 rs776606424 rs776612392 rs776696325 rs776710655 rs776744432 rs776809181 rs776818156 rs776937028 rs776968576 rs776969044 rs777058322 rs777094565 rs777095348 rs777096925 rs777200112 rs777220340 rs777224992 rs777241995 rs777251291 rs777329738 rs777370445 rs777448606 rs777459970 rs777485072 rs777698260 rs777764097 rs777786200 rs777851951 rs777852066 rs777862170 rs777867324 rs777931588 rs777966841 rs777983501 rs778159097 rs778244305 rs778310245 rs778325246 rs778435733 rs778524553 rs778598396 rs778615051 rs778801162 rs778829952 rs778857077 rs778930915 rs778945760 rs778949454 rs779029770 rs779099164 rs779115769 rs779122855 rs779299756 rs779327694 rs779419372 rs779423053 rs779496876 rs779578484 rs779666591 rs779685262 rs779754569 rs779790078 rs779825822 rs779851829 rs779879908 rs779971365 rs780046164 rs780080239 rs780081552 rs780112950 rs780128101 rs780170301 rs780253648 rs780294492 rs780313550 rs780355280 rs780445187 rs780515249 rs780539557 rs780616345 rs780622928 rs780704292 rs780720685 rs780726435 rs780820403 rs780826085 rs780838921 rs780980656 rs781045098 rs781168811 rs781170913 rs781196445 rs781279489 rs781492889 rs781519972 rs781567379 rs781650289 rs781665876 rs781699796

GPT基因在不同组织中的表达： [UniProt]

正向引物序列

正向引物Tm值

反向引物序列

反向引物Tm值

rank

GAGAGTGGAGTACGCAGTG

60

GGTGAAAGGCTTCTTCACAC

60

GTAGAGTCATGGCCTCGAG

59

AAAGGCTTCTTCACACCCT

59

GAGAGTGGAGTACGCAGTG

60

GTGAAAGGCTTCTTCACACC

60

GAGAGTGGAGTACGCAGTG

60

GGTGAAAGGCTTCTTCACAC

60

GAGAGTGGAGTACGCAGTG

60

GGTGAAAGGCTTCTTCACAC

60

GAGAGTGGAGTACGCAGTG

60

AAAGGCTTCTTCACACCCT

59

CCTACCACTTCCGGATGAC

60

GAACTTGGCATGGAACCTG

59

GAGAGTGGAGTACGCAGTG

60

GTGAAAGGCTTCTTCACACC

60

CTACCACTTCCGGATGACC

60

GAACTTGGCATGGAACCTG

59

GAGAGTGGAGTACGCAGTG

60

TGAAAGGCTTCTTCACACC

58

尚未收录相关数据

GPT基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

溶酶体
内涵体
细胞核
细胞质
液泡
细胞膜
细胞外基质
内质网
线粒体
高尔基体
细胞骨架

GPT基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0004021

P24298(UniProtKB)

EXP

GO:0004021

P24298(UniProtKB)

NAS

GO:0005615

P24298(UniProtKB)

IEA

GO:0005829

P24298(UniProtKB)

TAS

GO:0005829

P24298(UniProtKB)

TAS

GO:0008652

P24298(UniProtKB)

TAS

GO:0030170

P24298(UniProtKB)

IEA

GO:0042853

P24298(UniProtKB)

IEA

GO:0070062

P24298(UniProtKB)

IDA

序号	作用方式	资源库来源/分值	基因名称	基因名称

可能调控GPT基因的相关microRNA：

通路基因列表

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Fatty Liver	0.130897401	5	0	CTD_human_LHGDN
Liver diseases	0.128173051	4	0	CTD_human_LHGDN
Liver Cirrhosis, Experimental	0.12	1	0	CTD_human
Reperfusion Injury	0.12	1	0	CTD_human
Drug-Induced Liver Injury	0.12	2	0	CTD_human
Liver carcinoma	0.003538676	4	0	BeFree_LHGDN
Hepatitis C	0.002995792	2	0	BeFree_LHGDN
Ischemia	0.00272435	1	0	LHGDN
Impaired glucose tolerance	0.00272435	1	0	LHGDN
Sleep Apnea, Obstructive	0.00272435	1	0	LHGDN
Severe Acute Respiratory Syndrome	0.00272435	1	0	LHGDN
Liver neoplasms	0.000814326	3	0	BeFree
leukemia	0.000542884	2	0	BeFree
Cerebral atrophy	0.000542884	2	0	BeFree
Dehydration	0.000271442	1	0	BeFree
Fatigue	0.000271442	1	0	BeFree
Filariasis	0.000271442	1	0	BeFree
Neoplasm Metastasis	0.000271442	1	0	BeFree
Rhabdomyosarcoma	0.000271442	1	0	BeFree
Malignant neoplasm of testis	0.000271442	1	0	BeFree
childhood rhabdomyosarcoma	0.000271442	1	0	BeFree
Anemia, severe	0.000271442	1	0	BeFree
Vitelliform Macular Dystrophy	0.000271442	1	0	BeFree