GPBAR1(G protein-coupled bile acid receptor 1) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

2q35
基因染色体位置图

基因简述

基因简述

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  该基因编码的G蛋白偶合受体（GPCR）超家族的成员。这种酶的功能，作为胆汁酸的细胞表面受体。表达该GPCR与胆汁酸的细胞治疗诱导产生细胞内cAMP，一个MAP激酶信号传导途径的活化，和该受体的内化。该受体在由胆汁酸的抑制巨噬细胞功能和能量稳态调节牵连。在多个转录剪接的结果变体编码相同的蛋白质。 [由RefSeq的，2008年7月提供]

OMIM数据库中对GPBAR1基因的介绍     Wikipedia数据库中对GPBAR1基因的介绍

基因序列

基因序列

GPBAR1基因的碱基序列：[NCBI]

基因突变

基因突变

GPBAR1基因的碱基突变：           显示全部snp
rs1051165       rs1051182       rs1051183       rs2292549       rs2382816       rs77115694       rs138049376       rs143767549       rs150424889       rs151289529       rs186850591       rs199838633       rs199986029       rs200024655       rs200266946       rs200372685       rs201236854       rs201591872       rs201965997       rs202200326       rs368536887       rs372633150       rs528188094       rs536926054       rs541705846       rs546582155       rs546747931       rs548872721       rs558735504       rs561654974       rs563257178       rs563982975       rs570643457       rs574519337       rs577278735       rs749450128       rs752302294      
rs753787452       rs754774621       rs761945899       rs763290281       rs764225683       rs764513481       rs764994899       rs769009500       rs770146033       rs771474789       rs774573264       rs776612541       rs780596142       rs1567869       rs3731859       rs3795981       rs4674276       rs4674277       rs4674278       rs5838688       rs6743642       rs6746791       rs6758848       rs7369292       rs10190292       rs10203642       rs11554825       rs13003334       rs28665899       rs56154150       rs56192869       rs57621524       rs59274449       rs60510402       rs71064421       rs71064422       rs71064423       rs76800165       rs78291641       rs78909564       rs111447924       rs111925653       rs112666439       rs113167548       rs113609589       rs113846772       rs114064331       rs114774275       rs115448647       rs115741813       rs116083266       rs116219220       rs117130820       rs138332451       rs138439621       rs139097847       rs139175127       rs139824756       rs141336434       rs144467445       rs144572495       rs145681740       rs145836224       rs145881577       rs146024152       rs146271918       rs147203485       rs148977822       rs149245876       rs149904657       rs150118963       rs150801320       rs151246606       rs181016231       rs181236250       rs181909662       rs182793911       rs183278605       rs183703858       rs183803595       rs184400761       rs185670905       rs185939623       rs186702546       rs187578695       rs189083175       rs189117027       rs190420788       rs190689957       rs192064257       rs192584832       rs192792948       rs199514423       rs199517286       rs199550995       rs199556363       rs199613196       rs199637113       rs199646972       rs199688937       rs199759333       rs199822804       rs199941566       rs200010375       rs200077654       rs200096596       rs200126718       rs200183179       rs200257647       rs200340218       rs200360810       rs200372604       rs200468807       rs200516871       rs200558126       rs200583524       rs200662014       rs200717262       rs200722201       rs200729959       rs200786480       rs200824783       rs200857397       rs200890305       rs200909291       rs200915643       rs201017530       rs201063611       rs201091893       rs201129128       rs201145373       rs201264973       rs201272591       rs201285530       rs201459930       rs201530699       rs201565188       rs201573186       rs201586913       rs201635895       rs201747442       rs201761361       rs201796154       rs201861035       rs201873554       rs201881617       rs201897222       rs201963856       rs202032682       rs202132344       rs202136704       rs202154681       rs202193441       rs202233050       rs368061335       rs369876318       rs370152013       rs370878053       rs371444837       rs373065865       rs373073683       rs374082644       rs374268179       rs374298865       rs375107430       rs375209442       rs376686452       rs376966143       rs377520941       rs397695422       rs528248238       rs528393543       rs528849195       rs528989806       rs529402767       rs531707356       rs532575824       rs532990960       rs533956476       rs534073216       rs534624465       rs534857145       rs535548740       rs535684736       rs535922699       rs536606884       rs537280453       rs537996260       rs538132921       rs538468695       rs539472874       rs540200868       rs540427906       rs540902818       rs540933933       rs541779447       rs541841103       rs542263858       rs543539272       rs544309109       rs544553361       rs545274390       rs545729723       rs547700545       rs549545529       rs550063224       rs550074029       rs550605222       rs550634779       rs550649048       rs550743818       rs550773601       rs551613641       rs551817757       rs554140596       rs554143069       rs554280056       rs554480858       rs555170124       rs555671698       rs556383309       rs556925511       rs557058384       rs557688105       rs557723066       rs558257242       rs559026699       rs559183065       rs561380828       rs562006645       rs562447337       rs562858270       rs563121301       rs564137260       rs564424495       rs565116677       rs565722792       rs565915956       rs565939450       rs566843061       rs567569690       rs568171660       rs568290510       rs569850227       rs570334700       rs571401288       rs571470670       rs572058811       rs573909340       rs575279126       rs575599180       rs576236393       rs576741564       rs576819656       rs577820953       rs577957104       rs578194069       rs745643950       rs746126359       rs746731355       rs747009245       rs747205893       rs747236635       rs747708687       rs747879212       rs748847632       rs749106499       rs749343268       rs749374588       rs749522380       rs749647848       rs749795150       rs750062930       rs750106315       rs750336003       rs750336246       rs751403305       rs751882593       rs751885784       rs752840888       rs753677730       rs753986195       rs754159946       rs754234858       rs755147795       rs755488291       rs755577468       rs755950734       rs756055296       rs756161981       rs756760558       rs757886549       rs757932369       rs758184409       rs758377744       rs758607963       rs758760146       rs758852293       rs759114030       rs759328571       rs759826576       rs759881264       rs760264610       rs760312764       rs760796376       rs761046924       rs761133945       rs761588028       rs761785978       rs762365546       rs762928432       rs763093470       rs763662195       rs763742631       rs764317783       rs764793684       rs764881762       rs764902875       rs765510924       rs765699564       rs766437738       rs766576897       rs766683052       rs766773102       rs767252891       rs767660471       rs767819043       rs767914077       rs767999122       rs768424371       rs768592890       rs769115943       rs769777368       rs769928118       rs770486496       rs771194923       rs771464145       rs771639228       rs771789619       rs772368080       rs772430608       rs772578409       rs772733931       rs773111690       rs773374681       rs773769534       rs773938746       rs774237339       rs774695406       rs775590022       rs775640251       rs775667051       rs776392548       rs776487827       rs776924820       rs777085891       rs777199090       rs777570977       rs778422127       rs778529941       rs778821198       rs779099264       rs779355516       rs779541312       rs779552638       rs779676791       rs779917409       rs779995184       rs781068296       rs781279355       rs781386241      

基因表达

基因表达

GPBAR1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank

转录因子

转录因子

      尚未收录相关数据

基因本体信息

GPBAR1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

GPBAR1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005737
Q8TDU6(UniProtKB)
IDA
GO:0005886
Q8TDU6(UniProtKB)
IDA
GO:0005886
Q8TDU6(UniProtKB)
IDA
GO:0005886
Q8TDU6(UniProtKB)
TAS
GO:0005886
Q8TDU6(UniProtKB)
TAS
GO:0005886
Q8TDU6(UniProtKB)
TAS
GO:0005886
Q8TDU6(UniProtKB)
TAS
GO:0007186
Q8TDU6(UniProtKB)
IEA
GO:0016021
Q8TDU6(UniProtKB)
IEA
GO:0038181
Q8TDU6(UniProtKB)
IDA
GO:0038181
Q8TDU6(UniProtKB)
IDA
GO:0038181
Q8TDU6(UniProtKB)
IDA
GO:0038181
Q8TDU6(UniProtKB)
IDA
GO:0038182
Q8TDU6(UniProtKB)
NAS
GO:0038184
Q8TDU6(UniProtKB)
IC
GO:2000810
Q8TDU6(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控GPBAR1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Constipation 0.12 1 0 CTD_human
Crohn Disease 0.12 1 0 CTD_human
Squamous cell carcinoma 0.003267234 3 0 BeFree_LHGDN
Cholangitis, Sclerosing 0.003181358 3 0 BeFree_GAD
Ulcerative Colitis 0.002909916 3 2 BeFree_GAD
Chronic ulcerative colitis 0.002367032 1 0 GAD
Obesity 0.001357209 5 0 BeFree
HIV Infections 0.001085767 4 0 BeFree
Tumor Progression 0.001085767 4 0 BeFree
Primary sclerosing cholangitis 0.001085767 4 0 BeFree
Asthma 0.000814326 3 0 BeFree
Diabetes 0.000814326 3 0 BeFree
Diabetes Mellitus 0.000814326 3 0 BeFree
Heart failure 0.000814326 3 0 BeFree
Congestive heart failure 0.000814326 3 0 BeFree
Carcinogenesis 0.000814326 3 0 BeFree
Tumor Angiogenesis 0.000814326 3 0 BeFree
Bile Duct Diseases 0.000542884 2 0 BeFree
melanoma 0.000542884 2 0 BeFree
Metabolic Diseases 0.000542884 2 0 BeFree
Pruritus 0.000542884 2 0 BeFree
Taste bitter 0.000542884 2 0 BeFree
Neurodegenerative Disorders 0.000542884 2 0 BeFree
Hepatitis B, Chronic 0.000542884 2 0 BeFree
Conn Syndrome 0.000542884 2 0 BeFree
Albinism 0.000271442 1 0 BeFree
Mental disorders 0.000271442 1 0 BeFree
Blood Coagulation Disorders 0.000271442 1 0 BeFree
Cholestasis 0.000271442 1 0 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000271442 1 0 BeFree
Experimental Autoimmune Encephalomyelitis 0.000271442 1 0 BeFree
Gastroesophageal reflux disease 0.000271442 1 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
Huntington Disease 0.000271442 1 0 BeFree
Intestinal Diseases 0.000271442 1 0 BeFree
Irritable Bowel Syndrome 0.000271442 1 0 BeFree
Ischemia 0.000271442 1 0 BeFree
Multiple Sclerosis 0.000271442 1 0 BeFree
Degenerative polyarthritis 0.000271442 1 0 BeFree
Liver Failure 0.000271442 1 0 BeFree
Neuroendocrine Tumors 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Cholestasis of pregnancy 0.000271442 1 0 BeFree
Adenocarcinoma Of Esophagus 0.000271442 1 0 BeFree
Ichthyosis Bullosa of Siemens 0.000271442 1 0 BeFree
Functional Gastrointestinal Disorders 0.000271442 1 0 BeFree
Inflammatory disorder 0.000271442 1 0 BeFree
Cancer Cell Growth 0.000271442 1 0 BeFree
Acth-Independent Macronodular Adrenal Hyperplasia 0.000271442 1 0 BeFree
Bowel dysfunction 0.000271442 1 0 BeFree

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