GP5(glycoprotein V (platelet))

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

3q29
基因染色体位置图

基因简述

基因简述

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]

[中文简述(自动翻译):]  人类血小板糖蛋白V（GP5）是构成用于冯维勒布兰德因子的受体表面糖蛋白的的Ib-V-IX系统的一部分（vWF; MIM 613160），并介导对在受伤的血管表面的血小板的粘附动脉循环，在止血中的关键起始事件。该受体的主要部分是一个的2条多肽链，α-链组成的异二聚体（GP1BA; MIM 606672）和一个β链（GP1BB; MIM 138720），由二硫键连接。完整的受体复合物包括α和β亚基与血小板膜糖蛋白IX的非共价结合（GP9; MIM 173515）和GP5。在GP1BA，GP1BB和GP9突变已显示导致巨大血小板综合征（MIM 231200），出血性疾病（审查Lopez等人，1998 [搜索PubMed 9616133]）。[由OMIM，2010年11月供给]

OMIM数据库中对GP5基因的介绍     Wikipedia数据库中对GP5基因的介绍

基因序列

基因序列

GP5基因的碱基序列：[NCBI]

基因突变

基因突变

GP5基因的碱基突变：           显示全部snp
rs3047       rs1223989       rs1466733       rs1538863       rs1572840       rs1965980       rs2071638       rs2185479       rs3732466       rs3834184       rs7631261       rs10638925       rs12493288       rs12493310       rs12493363       rs34799505       rs56116201       rs56144534       rs57496231       rs58379059       rs59617643       rs60085137       rs60913085       rs61655400       rs61656396       rs62286670       rs71316299       rs73069165       rs73069169       rs73069171       rs73889854       rs73889855       rs73889856       rs73889857       rs74867693       rs75122941       rs77113987      
rs78188562       rs78332923       rs78668394       rs79064082       rs79407664       rs79591432       rs79660950       rs111229267       rs111343836       rs111709221       rs112261724       rs112399795       rs112452101       rs113052158       rs113392344       rs113415706       rs113701236       rs113857904       rs114732844       rs115240841       rs115431348       rs115992957       rs116214556       rs116798624       rs116980619       rs138140981       rs138331692       rs138752666       rs138983803       rs139517746       rs140404736       rs140461228       rs140642486       rs140792753       rs140994443       rs141381785       rs142240804       rs142373745       rs142440028       rs142512027       rs143004931       rs143237677       rs144423499       rs144720350       rs144911830       rs145101432       rs145481862       rs145597337       rs145810471       rs145958971       rs146380015       rs146696146       rs147093306       rs147473508       rs147680603       rs147841437       rs147851876       rs147926792       rs148000202       rs148261848       rs148391579       rs148635904       rs148737453       rs148797033       rs149056532       rs149317860       rs149552896       rs150190099       rs181060278       rs181078134       rs181927698       rs182603524       rs183048070       rs183161352       rs183335220       rs183855669       rs184969685       rs185139360       rs185732072       rs186344507       rs186560527       rs187150308       rs187890753       rs188392120       rs189097872       rs189898188       rs189901403       rs190002419       rs190587026       rs191208101       rs191243865       rs191549351       rs199511845       rs199581779       rs199615949       rs199936836       rs200212020       rs200310605       rs200544767       rs200675342       rs200962215       rs201082933       rs201416119       rs201748538       rs201946987       rs202032002       rs202163032       rs267599745       rs367835468       rs368297435       rs369093144       rs369490163       rs370504832       rs370787336       rs370921872       rs371602520       rs371735992       rs372044750       rs372304170       rs372324195       rs372962545       rs372994408       rs373097680       rs373377330       rs374056502       rs375045535       rs375063501       rs376133816       rs376570848       rs377055798       rs377335397       rs528687510       rs529104158       rs529238019       rs529433682       rs530254349       rs530380169       rs530995059       rs531464548       rs532030333       rs532116069       rs532735135       rs532798966       rs533167022       rs533393058       rs534047293       rs534415245       rs535303021       rs536083958       rs536435403       rs536642860       rs536712827       rs537245848       rs537688049       rs537887908       rs538235455       rs538685853       rs539453568       rs540539749       rs540625597       rs540732026       rs541888716       rs542059499       rs542871017       rs544389967       rs544876274       rs544985059       rs545551127       rs546059539       rs547261216       rs547298050       rs548322581       rs549187925       rs549398995       rs549784939       rs550342914       rs551005925       rs551799399       rs552136303       rs552634774       rs552673554       rs553723694       rs555037923       rs555073533       rs555297751       rs555776304       rs557091233       rs557557809       rs558020104       rs559082728       rs559295767       rs560286404       rs561401378       rs562312596       rs562871344       rs563535564       rs564091697       rs564652213       rs564790004       rs566646759       rs566684750       rs566858396       rs567781354       rs568045079       rs568890266       rs569003232       rs570695165       rs571050331       rs571748512       rs572086210       rs573212391       rs573487988       rs573524725       rs574883928       rs575009498       rs575358111       rs575497571       rs576131379       rs577395101       rs745325700       rs745390651       rs745587507       rs745851802       rs746160624       rs746203777       rs746246856       rs746530464       rs746725604       rs747021716       rs747024152       rs747049345       rs747330061       rs747382859       rs747810611       rs747897878       rs747949677       rs748131440       rs748195787       rs748249277       rs748727646       rs749035045       rs749087395       rs749179860       rs749331862       rs749575320       rs749631647       rs749818356       rs749857036       rs749862386       rs750092905       rs750136044       rs750181282       rs750927392       rs751033170       rs751580409       rs751662816       rs751728758       rs752054881       rs752108067       rs752147061       rs752449361       rs752627528       rs752627621       rs752780195       rs752814508       rs753016329       rs753107434       rs753182459       rs753195251       rs753524407       rs753538809       rs753596185       rs753623237       rs753707405       rs754094776       rs754105338       rs754422098       rs754547536       rs754760971       rs754850636       rs755100270       rs755113793       rs755190216       rs755334543       rs755553340       rs755849586       rs755888264       rs755943185       rs756248593       rs756336300       rs756480098       rs756533140       rs756816416       rs756902646       rs756906495       rs756984676       rs757110853       rs757314771       rs757339732       rs757582911       rs757961631       rs757962685       rs758214797       rs758295793       rs758590525       rs758840525       rs759297738       rs759376535       rs759633768       rs759683798       rs759813736       rs759843994       rs760127909       rs760150766       rs760366839       rs760537446       rs760595151       rs760822849       rs761098935       rs761153641       rs761333814       rs761651431       rs761880420       rs762140183       rs762239469       rs762241412       rs762597397       rs762818342       rs762994127       rs763048450       rs763049064       rs763148728       rs763248310       rs763647906       rs763979524       rs764055488       rs764336697       rs764463615       rs764613759       rs764667824       rs764705809       rs764761485       rs764998085       rs765186322       rs765293779       rs765569501       rs765628539       rs765840057       rs765977841       rs766334066       rs766423838       rs766501150       rs767071239       rs767073211       rs767163149       rs767540996       rs767870641       rs767971070       rs768103652       rs768301550       rs768416144       rs768484317       rs768608448       rs768824700       rs768901298       rs769233893       rs769240414       rs769615979       rs769709278       rs770033096       rs770204579       rs770248104       rs770371388       rs770577099       rs770606358       rs770908656       rs771091355       rs771093225       rs771413204       rs771665773       rs771718752       rs771742761       rs771813293       rs772042244       rs772128081       rs772189930       rs772466637       rs772732114       rs773058933       rs773089110       rs773186091       rs773407579       rs773566428       rs773579447       rs773697033       rs773860297       rs773882653       rs773979922       rs774229812       rs774236332       rs774532809       rs774586236       rs774711561       rs774925410       rs775083744       rs775105351       rs775156169       rs775175208       rs775805104       rs775848940       rs776105867       rs776175659       rs776219236       rs776477645       rs776621159       rs776782452       rs776902005       rs777081348       rs777537024       rs777590156       rs777613253       rs777692043       rs777768347       rs777974837       rs778058382       rs778320454       rs778402630       rs778635870       rs778672527       rs778725674       rs778829280       rs778974879       rs778980398       rs779182714       rs779446549       rs779830095       rs779938514       rs780066557       rs780165992       rs780468551       rs780556426       rs780872965       rs780895842       rs781350355       rs781530104       rs781585201       rs781760228      

基因表达

基因表达

GP5基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CAGAATCAGCTCGATTTCCT
58
ACAACTTCAGGTTCTCCAG
57
GATTTCCTTCCTGCCAGTC
58
CCGATAAATCCAACAACTTCAG
58
ATCAGCTCGATTTCCTTCC
57
TCCAACAACTTCAGGTTCTC
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

GP5基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

GP5基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005515
P40197(UniProtKB)
IPI
GO:0005886
P40197(UniProtKB)
TAS
GO:0005886
P40197(UniProtKB)
TAS
GO:0005886
P40197(UniProtKB)
TAS
GO:0005886
P40197(UniProtKB)
TAS
GO:0005886
P40197(UniProtKB)
TAS
GO:0005886
P40197(UniProtKB)
TAS
GO:0005886
P40197(UniProtKB)
TAS
GO:0005886
P40197(UniProtKB)
TAS
GO:0005886
P40197(UniProtKB)
TAS
GO:0005886
P40197(UniProtKB)
TAS
GO:0005886
P40197(UniProtKB)
TAS
GO:0005887
P40197(UniProtKB)
TAS
GO:0007155
P40197(UniProtKB)
IEA
GO:0007409
P40197(UniProtKB)
IBA
GO:0007596
P40197(UniProtKB)
TAS
GO:0007597
P40197(UniProtKB)
TAS
GO:0030168
P40197(UniProtKB)
TAS
GO:0070062
P40197(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控GP5基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Thrombocytopenia 0.002367032 1 0 GAD
Tobacco Use Disorder 0.002367032 1 0 GAD
Bernard-Soulier Syndrome 0.001085767 4 0 BeFree
Brooke-Spiegler syndrome 0.000814326 3 0 BeFree
Blood Platelet Disorders 0.000271442 1 0 BeFree
Coronary Thrombosis 0.000271442 1 0 BeFree
Varicella zoster 0.000271442 1 0 BeFree
Persistent infection 0.000271442 1 0 BeFree

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