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This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
[中文简述(自动翻译):]  该基??因编码的Kruppel家族锌指蛋白中的一员。所编码的转录因子是由音猬信号转导级联激活,调节造血干细胞的增殖。活性和这种蛋白质的核定位产生负面p53在抑制回路调节。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的,2009年5月提供]
GLI1基因(以及对应的蛋白质)的细胞分布位置:
GLI1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Diffuse Large B-Cell Lymphoma | 0.121085767 | 4 | 0 | BeFree_CTD_human |
Bladder Neoplasm | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Acute Promyelocytic Leukemia | 0.12 | 1 | 0 | CTD_human |
Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
Basal cell carcinoma | 0.010540083 | 4 | 0 | GAD_LHGDN |
Glioma | 0.009248887 | 16 | 0 | BeFree_LHGDN |
Neoplasm Metastasis | 0.006524536 | 15 | 0 | BeFree_LHGDN |
Experimental Organism Basal Cell Carcinoma | 0.006514605 | 24 | 0 | BeFree |
Glioblastoma | 0.006253095 | 14 | 0 | BeFree_LHGDN |
Skin Neoplasms | 0.005905708 | 5 | 0 | BeFree_GAD_LHGDN |
Squamous cell carcinoma | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.005428837 | 20 | 0 | BeFree |
Breast Carcinoma | 0.005428837 | 20 | 0 | BeFree |
Liver carcinoma | 0.005167327 | 10 | 0 | BeFree_LHGDN |
Malignant neoplasm of pancreas | 0.004885954 | 18 | 0 | BeFree |
Pancreatic carcinoma | 0.004614512 | 17 | 0 | BeFree |
Carcinogenesis | 0.00434307 | 16 | 0 | BeFree |
Adenocarcinoma | 0.00408156 | 5 | 0 | BeFree_LHGDN |
Gastrointestinal Stromal Tumors | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Medulloblastoma | 0.003528744 | 13 | 0 | BeFree |
Esophageal Neoplasms | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Pancreatic Neoplasm | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Rhabdomyosarcoma, Embryonal | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Adenoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Colorectal Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Fibroid Tumor | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Carcinoma, Neuroendocrine | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Inflammatory Bowel Diseases | 0.002909916 | 2 | 0 | BeFree_GAD |
leiomyosarcoma | 0.00272435 | 1 | 0 | LHGDN |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of prostate | 0.002714419 | 10 | 0 | BeFree |
Prostate carcinoma | 0.002714419 | 10 | 0 | BeFree |
Ventricular Septal Defects | 0.002638474 | 1 | 0 | BeFree_GAD |
Rhabdomyosarcoma | 0.002442977 | 9 | 0 | BeFree |
Stomach Carcinoma | 0.002442977 | 9 | 0 | BeFree |
Inflammation | 0.002367032 | 1 | 0 | GAD |
Kidney Failure, Chronic | 0.002367032 | 1 | 1 | GAD |
Malignant neoplasm of stomach | 0.002171535 | 8 | 0 | BeFree |
Colon Carcinoma | 0.002171535 | 8 | 1 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.002171535 | 8 | 0 | BeFree |
Neuroblastoma | 0.001628651 | 6 | 0 | BeFree |
Central neuroblastoma | 0.001628651 | 6 | 0 | BeFree |
Sarcoma | 0.001628651 | 6 | 0 | BeFree |
Colorectal Cancer | 0.001628651 | 6 | 0 | BeFree |
Colorectal Carcinoma | 0.001357209 | 5 | 0 | BeFree |
melanoma | 0.001357209 | 5 | 1 | BeFree |
Ovarian Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Basal Cell Nevus Syndrome | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.001085767 | 4 | 0 | BeFree |
Malignant tumor of colon | 0.001085767 | 4 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Chondrosarcoma | 0.001085767 | 4 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.001085767 | 4 | 1 | BeFree |
Secondary malignant neoplasm of lymph node | 0.001085767 | 4 | 0 | BeFree |
Carcinoma of bladder | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of ovary | 0.001085767 | 4 | 0 | BeFree |
Ameloblastoma | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma | 0.000814326 | 3 | 0 | BeFree |
Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma Of Esophagus | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma of pancreas | 0.000814326 | 3 | 0 | BeFree |
Jaw Keratocyst | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma of bone | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
Glioblastoma Multiforme | 0.000814326 | 3 | 0 | BeFree |
Keratocystic Odontogenic Tumor | 0.000814326 | 3 | 0 | BeFree |
Developmental Disabilities | 0.000542884 | 2 | 0 | BeFree |
Esophageal carcinoma | 0.000542884 | 2 | 0 | BeFree |
Hepatoblastoma | 0.000542884 | 2 | 0 | BeFree |
Liposarcoma, Myxoid | 0.000542884 | 2 | 0 | BeFree |
Plexiform Neurofibroma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Cervix carcinoma | 0.000542884 | 2 | 0 | BeFree |
Multiple malignancy | 0.000542884 | 2 | 0 | BeFree |
Trichoepithelioma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000542884 | 2 | 0 | BeFree |
Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
Biliary Tract Cancer | 0.000542884 | 2 | 0 | BeFree |
Stromal Neoplasm | 0.000542884 | 2 | 0 | BeFree |
ovarian neoplasm | 0.000542884 | 2 | 0 | BeFree |
precancerous lesions | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
aggressive cancer | 0.000542884 | 2 | 0 | BeFree |
Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Burkitt Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoid Tumor | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
Celiac Disease | 0.000271442 | 1 | 0 | BeFree |
Cerebellar Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
Chondromatosis, Synovial | 0.000271442 | 1 | 0 | BeFree |
Colitis | 0.000271442 | 1 | 0 | BeFree |
Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
Craniosynostosis | 0.000271442 | 1 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
Failure to Thrive | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Meningioma | 0.000271442 | 1 | 0 | BeFree |
Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Synovial osteochondromatosis | 0.000271442 | 1 | 0 | BeFree |
Pituitary Diseases | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Sarcoidosis | 0.000271442 | 1 | 0 | BeFree |
Cutaneous sarcoidosis | 0.000271442 | 1 | 0 | BeFree |
Dermatologic disorders | 0.000271442 | 1 | 0 | BeFree |
Soft Tissue Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Benign Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Pancreatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Renal fibrosis | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of gallbladder | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Intervertebral Disc Degeneration | 0.000271442 | 1 | 2 | BeFree |
Ki-1+ Anaplastic Large Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Embryonal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Uveal melanoma | 0.000271442 | 1 | 0 | BeFree |
POLYDACTYLY, POSTAXIAL | 0.000271442 | 1 | 0 | BeFree |
Gallbladder Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Anaplastic thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Greig cephalopolysyndactyly syndrome | 0.000271442 | 1 | 0 | BeFree |
Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hyperplastic Polyp | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Malignant mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Atypical Endometrial Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Necrobiosis Lipoidica Diabeticorum | 0.000271442 | 1 | 0 | BeFree |
Trisomy 12 | 0.000271442 | 1 | 0 | BeFree |
Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Ewings sarcoma | 0.000271442 | 1 | 0 | BeFree |
Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
Tumor Initiation | 0.000271442 | 1 | 0 | BeFree |
Malignant Squamous Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Malignant Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Oculo-dento-digital syndrome | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma resectable | 0.000271442 | 1 | 0 | BeFree |
Rhabdoid Tumor of the Kidney | 0.000271442 | 1 | 0 | BeFree |
Undifferentiated (Embryonal) Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Chronic graft-versus-host disease | 0.000271442 | 1 | 0 | BeFree |
Metastatic Prostate Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Invasive Ductal Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Adenoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
Primary Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Desmoplastic | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
Meningioma, benign, no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Intracranial glioma | 0.000271442 | 1 | 0 | BeFree |
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