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This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010]
[中文简述(自动翻译):]  该基因编码一个高度保守的神经营养因子。该蛋白的重组形式示出,以促进在培养的存活和多巴胺能神经元的分化,并能防止由切断导致运动神经元的凋亡。所编码的蛋白质被处理以存在作为同二聚体成熟分泌形式。该蛋白质的成熟形式是对于RET原癌基因(转染期间重排)的产物的配体。已发现该基因编码不同亚型的多个抄本变形。在这个基因的突变可以与先天性巨结肠症相关联。 [由RefSeq的,2010年6月提供]
GDNF基因(以及对应的蛋白质)的细胞分布位置:
GDNF基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hirschsprung Disease | 0.258250076 | 22 | 1 | BeFree_CTD_human_GAD_LHGDN_ORPHANET |
Congenital central hypoventilation | 0.24 | 1 | 0 | CTD_human_ORPHANET |
Parkinsonian Disorders | 0.200542884 | 6 | 0 | BeFree_CTD_human_RGD |
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 3 | 0.2 | 2 | 0 | MGD_UNIPROT |
Neurodegenerative Disorders | 0.12408156 | 6 | 0 | BeFree_CTD_human_LHGDN |
Huntington Disease | 0.122995792 | 3 | 0 | BeFree_CTD_human_LHGDN |
Retinal Degeneration | 0.122995792 | 2 | 0 | BeFree_CTD_human_LHGDN |
Glioma | 0.121900093 | 7 | 0 | BeFree_CTD_human |
Parkinson Disease | 0.121357209 | 7 | 0 | BeFree_CTD_human |
Glioblastoma | 0.121085767 | 4 | 0 | BeFree_CTD_human |
Pheochromocytoma | 0.121085767 | 4 | 0 | BeFree_CTD_human |
Ependymoma | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Dyskinesia, Drug-Induced | 0.12 | 1 | 0 | CTD_human |
Hyperalgesia | 0.12 | 1 | 0 | CTD_human |
Neurologic Manifestations | 0.12 | 1 | 0 | CTD_human |
oligodendroglioma | 0.12 | 1 | 0 | CTD_human |
Secondary Parkinson Disease | 0.12 | 1 | 0 | CTD_human |
Status Epilepticus | 0.12 | 2 | 0 | CTD_human |
Amphetamine-Related Disorders | 0.12 | 1 | 0 | CTD_human |
Cocaine-Related Disorders | 0.12 | 2 | 0 | CTD_human |
CCHS WITH HIRSCHSPRUNG DISEASE | 0.12 | 0 | 1 | CLINVAR |
Hirschsprung disease type 3 | 0.12 | 0 | 4 | CLINVAR |
Sciatic Neuropathy | 0.08 | 1 | 0 | RGD |
Schizophrenia | 0.011182656 | 5 | 0 | BeFree_GAD_LHGDN |
melanoma | 0.008338753 | 22 | 0 | BeFree_GAD |
Pancreatic Neoplasm | 0.008173051 | 3 | 0 | LHGDN |
Sarcoma, Clear Cell | 0.006243163 | 23 | 0 | BeFree |
Attention deficit hyperactivity disorder | 0.005005506 | 2 | 0 | BeFree_GAD |
Hirschsprung disease 1 | 0.004885954 | 18 | 1 | BeFree |
Amyotrophic Lateral Sclerosis | 0.00434307 | 16 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Pancreatic carcinoma | 0.003257302 | 12 | 1 | BeFree |
Malignant neoplasm of pancreas | 0.003257302 | 12 | 1 | BeFree |
Diabetic Retinopathy | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Neuroblastoma | 0.002985861 | 11 | 0 | BeFree |
Central neuroblastoma | 0.002985861 | 11 | 0 | BeFree |
Skin Neoplasms | 0.002909916 | 3 | 0 | BeFree_GAD |
Major Depressive Disorder | 0.002909916 | 3 | 1 | BeFree_GAD |
Neurofibromatosis 1 | 0.00272435 | 1 | 0 | LHGDN |
Sleep Apnea, Obstructive | 0.002638474 | 1 | 0 | BeFree_GAD |
Carcinogenesis | 0.002442977 | 9 | 0 | BeFree |
Histiocytoma, Angiomatoid Fibrous | 0.002442977 | 9 | 0 | BeFree |
Hydronephrosis | 0.002367032 | 1 | 0 | GAD |
Narcolepsy | 0.002367032 | 1 | 0 | GAD |
Neoplasm Invasiveness | 0.002367032 | 1 | 0 | GAD |
Gilles de la Tourette syndrome | 0.002367032 | 1 | 0 | GAD |
Vesico-Ureteral Reflux | 0.002367032 | 1 | 0 | GAD |
Multiple Endocrine Neoplasia Type 2a | 0.002171535 | 8 | 0 | BeFree |
Cerebrovascular accident | 0.001900093 | 7 | 0 | BeFree |
Breast Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Malignant neoplasm of breast | 0.001628651 | 6 | 0 | BeFree |
Neoplasm Metastasis | 0.001628651 | 6 | 0 | BeFree |
Motor Neuron Disease | 0.001357209 | 5 | 0 | BeFree |
Mental Depression | 0.001085767 | 4 | 8 | BeFree |
Depressive disorder | 0.001085767 | 4 | 8 | BeFree |
Ischemia | 0.001085767 | 4 | 0 | BeFree |
Myxoid cyst | 0.001085767 | 4 | 0 | BeFree |
Cerebral Infarction | 0.000814326 | 3 | 0 | BeFree |
Multiple Endocrine Neoplasia | 0.000814326 | 3 | 1 | BeFree |
Synovial Cyst | 0.000814326 | 3 | 0 | BeFree |
Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of lung | 0.000814326 | 3 | 0 | BeFree |
Metastatic melanoma | 0.000814326 | 3 | 0 | BeFree |
Ewings sarcoma | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
Middle Cerebral Artery Occlusion | 0.000814326 | 3 | 0 | BeFree |
Sarcoma | 0.000814326 | 3 | 0 | BeFree |
Alzheimer's Disease | 0.000542884 | 2 | 0 | BeFree |
Behavior Disorders | 0.000542884 | 2 | 0 | BeFree |
Bipolar Disorder | 0.000542884 | 2 | 0 | BeFree |
Cyst | 0.000542884 | 2 | 0 | BeFree |
Medullary sponge kidney | 0.000542884 | 2 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000542884 | 2 | 0 | BeFree |
Multiple Endocrine Neoplasia Type 2b | 0.000542884 | 2 | 0 | BeFree |
Myoepithelioma | 0.000542884 | 2 | 0 | BeFree |
Pituitary Diseases | 0.000542884 | 2 | 0 | BeFree |
Substance Dependence | 0.000542884 | 2 | 0 | BeFree |
Tetanus | 0.000542884 | 2 | 0 | BeFree |
Unipolar Depression | 0.000542884 | 2 | 0 | BeFree |
Cutaneous Melanoma | 0.000542884 | 2 | 1 | BeFree |
Liposarcoma, Myxoid | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma, Clear Cell | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Neuropathy | 0.000542884 | 2 | 0 | BeFree |
Clear cell odontogenic tumor | 0.000542884 | 2 | 0 | BeFree |
Congenital absence of kidney | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Mammary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Drug Dependence | 0.000542884 | 2 | 0 | BeFree |
Congenital absence of kidneys syndrome | 0.000542884 | 2 | 0 | BeFree |
Familial medullary thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
Low grade glioma | 0.000542884 | 2 | 0 | BeFree |
Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
Acromegaly | 0.000271442 | 1 | 0 | BeFree |
Adenovirus Infections | 0.000271442 | 1 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Brain Diseases | 0.000271442 | 1 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Drug abuse | 0.000271442 | 1 | 0 | BeFree |
Gastroesophageal reflux disease | 0.000271442 | 1 | 0 | BeFree |
Globus Hystericus | 0.000271442 | 1 | 0 | BeFree |
Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Lymphocytic, Acute, L1 | 0.000271442 | 1 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
liposarcoma | 0.000271442 | 1 | 0 | BeFree |
Lymphatic Metastasis | 0.000271442 | 1 | 0 | BeFree |
Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Muscular Atrophy | 0.000271442 | 1 | 0 | BeFree |
Muscular Dystrophy | 0.000271442 | 1 | 0 | BeFree |
Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
Acoustic Neuroma | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Peripheral Neuropathy | 0.000271442 | 1 | 0 | BeFree |
Seizures | 0.000271442 | 1 | 0 | BeFree |
Seminoma | 0.000271442 | 1 | 0 | BeFree |
Shy-Drager Syndrome | 0.000271442 | 1 | 0 | BeFree |
synovial sarcoma | 0.000271442 | 1 | 0 | BeFree |
Teratoma | 0.000271442 | 1 | 0 | BeFree |
Testicular Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Urogenital Abnormalities | 0.000271442 | 1 | 0 | BeFree |
Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
Ichthyosis, X-Linked | 0.000271442 | 1 | 0 | BeFree |
Essential Hypertension | 0.000271442 | 1 | 1 | BeFree |
Akinesia | 0.000271442 | 1 | 0 | BeFree |
Germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
Embryonal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Neuroendocrine Tumors | 0.000271442 | 1 | 0 | BeFree |
Neonatal encephalopathy | 0.000271442 | 1 | 0 | BeFree |
Erosive esophagitis | 0.000271442 | 1 | 0 | BeFree |
Stage IV Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
stage, gastric cancer | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Hematopoietic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Multiple System Atrophy | 0.000271442 | 1 | 0 | BeFree |
Motor symptoms | 0.000271442 | 1 | 0 | BeFree |
Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cerebellar lesion NOS | 0.000271442 | 1 | 0 | BeFree |
Respiratory Distress Syndrome | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
Chronic esophagitis | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathy, Familial Idiopathic | 0.000271442 | 1 | 0 | BeFree |
Desmoplastic | 0.000271442 | 1 | 0 | BeFree |
Tumor Expansion | 0.000271442 | 1 | 0 | BeFree |
Tumor Promotion | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Bulbo-Spinal Atrophy, X-Linked | 0.000271442 | 1 | 0 | BeFree |
AMYOTROPHIC LATERAL SCLEROSIS 1 | 0.000271442 | 1 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
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