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This locus represents naturally occurring readthrough transcription between the neighboring MYZAP (myocardial zonula adherens protein) and POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) genes on chromosome 15. Alternative splicing results in multiple readthrough transcript variants. Readthrough variants may encode proteins that share sequence identity with the upstream gene product or with both the upstream and downstream gene products. Some readthrough transcript variants are also expected to be candidates for nonsense-mediated decay (NMD). [provided by RefSeq, Oct 2013]
[中文简述(自动翻译):] 这一位点代表自然发生和POLR2M(聚合酶(RNA)II(DNA导演)多肽M)在15号染色体剪接产生多个通读转录变异体的基因相邻MYZAP(心肌黏着小带蛋白)之间的通读转录。通读变体可编码与上游基因产物或二者的上游和下游的基因产物共享的序列同一性的蛋白质。有些通读转录变异体也有望成为无义介导的衰变(NMD)的候选人。 [由RefSeq的,2013年10月提供]
GCOM1基因(以及对应的蛋白质)的细胞分布位置:
GCOM1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Coronary heart disease | 0.002367032 | 1 | 1 | GAD |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
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