GCG(glucagon)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

2q36-q37
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白质实际上是被切割成四个不同的成熟肽一个前原。其中之一，胰高血糖素，是胰腺激素，通过刺激糖原分解和糖原异生抵消胰岛素的降血糖作用。胰高血糖素为特定的G蛋白偶联受体，其信号通路控制细胞增殖的配体。其他肽两个来自肠内分泌细胞分泌，并通过不同的机制促进营养吸收。最后，第四肽类似于肠高血糖素，活性enteroglucagon。 [由RefSeq的，2008年7月提供]

OMIM数据库中对GCG基因的介绍     Wikipedia数据库中对GCG基因的介绍

基因序列

基因序列

GCG基因的碱基序列：[NCBI]

基因突变

基因突变

GCG基因的碱基突变：           显示全部snp
rs5645       rs5646       rs5647       rs5648       rs5649       rs5650       rs5651       rs5652       rs5653       rs5654       rs1042405       rs3811539       rs3811540       rs4664447       rs4664448       rs4664449       rs6717263       rs6717609       rs6717659       rs6727317       rs6732914       rs7559086       rs7569992       rs7569999       rs7581952       rs7590067       rs10164435       rs10490424       rs10671204       rs11552330       rs11692314       rs11897425       rs13001107       rs13306376       rs13306377       rs16846320       rs16846334      
rs17762054       rs35205044       rs35328019       rs35920035       rs57137170       rs59607363       rs59884382       rs62636570       rs62636571       rs71009351       rs72176169       rs74412089       rs74432317       rs74507907       rs74595309       rs75316473       rs75507135       rs76107198       rs77498465       rs77608104       rs77708839       rs78099172       rs78543102       rs79305438       rs79802464       rs79820653       rs111991909       rs112307942       rs113344394       rs113811220       rs114598064       rs115158512       rs115169559       rs115354980       rs115679255       rs115882217       rs116510735       rs116524570       rs137862900       rs138170714       rs138197338       rs138583535       rs139451539       rs139562653       rs139861872       rs140134847       rs141096554       rs141239775       rs142104367       rs142111533       rs142383267       rs142968963       rs143177732       rs144980535       rs145123384       rs145343576       rs145461915       rs146302138       rs146344181       rs147511614       rs147561815       rs147789301       rs148278587       rs149043714       rs149201782       rs149306780       rs149831572       rs150023184       rs150179526       rs150655593       rs150700989       rs180922900       rs180923369       rs181104553       rs181811749       rs182137265       rs183088550       rs183105157       rs183138644       rs183433761       rs183860064       rs183896436       rs184086717       rs184782705       rs184951871       rs185076908       rs185099899       rs185541635       rs185729970       rs185983811       rs186381839       rs186928993       rs187183449       rs187626543       rs188033052       rs188121036       rs188127344       rs188439268       rs188463251       rs188487658       rs188639641       rs189546122       rs189608744       rs190021321       rs190153638       rs190160757       rs190782552       rs191322490       rs191594948       rs191700981       rs191806177       rs192487432       rs192917798       rs193050514       rs193237358       rs199563306       rs199990516       rs200220805       rs200358995       rs200956324       rs201109453       rs202010736       rs202213699       rs267598945       rs367812886       rs367829029       rs368051970       rs368316479       rs368807696       rs369253728       rs369682107       rs369963306       rs370287343       rs370833497       rs371084684       rs371234337       rs371413340       rs371985452       rs372618529       rs372666219       rs373576495       rs374121111       rs374750885       rs374935193       rs375023144       rs375356593       rs375447933       rs375603166       rs375610192       rs375700519       rs375991169       rs376313576       rs376498600       rs376928286       rs376961138       rs377278314       rs377455070       rs527299083       rs527429117       rs527646080       rs527890392       rs528681532       rs528821643       rs529437662       rs529511863       rs529879767       rs529881951       rs530411256       rs530741972       rs531564364       rs531752764       rs532547015       rs532551281       rs532797793       rs532985101       rs533094334       rs533290005       rs533349371       rs533505201       rs533584489       rs533713622       rs533941455       rs534068781       rs534309064       rs534351125       rs534634370       rs535215761       rs535828090       rs536229945       rs536427985       rs536593254       rs536593278       rs536991854       rs537074047       rs537229832       rs537669790       rs537711144       rs538029714       rs538480317       rs538587908       rs538812855       rs539473818       rs539474246       rs540759713       rs541221045       rs541413951       rs542043640       rs542301486       rs542626639       rs542657505       rs542661715       rs542696204       rs542866197       rs542866512       rs543447762       rs543719484       rs543859604       rs544023074       rs544676361       rs544694622       rs545213928       rs545620721       rs545677954       rs546180863       rs546253502       rs546871415       rs547244586       rs547285756       rs547562575       rs547679321       rs548162236       rs548475407       rs548912528       rs549001307       rs549016429       rs549977039       rs550192730       rs550229669       rs551225444       rs551354585       rs551409207       rs551515145       rs552141338       rs552197601       rs552484628       rs552936167       rs553036783       rs553448825       rs553711522       rs553713973       rs553986137       rs554655623       rs554874383       rs555189041       rs555452195       rs555967139       rs556649651       rs557976182       rs558163510       rs558295836       rs558625012       rs559299949       rs559868421       rs559905638       rs559909994       rs560012871       rs560191939       rs560342711       rs560398361       rs560568916       rs560915751       rs560950841       rs560985397       rs561085508       rs561430606       rs561647471       rs561671909       rs562407074       rs562543900       rs562983010       rs563134931       rs563515700       rs564205563       rs564348711       rs565178113       rs565210776       rs565328289       rs565393104       rs565979891       rs566490015       rs566624286       rs567071487       rs567281718       rs567400341       rs567680590       rs567813619       rs567847958       rs568629833       rs568835084       rs569462643       rs569505429       rs569589789       rs569979269       rs570146752       rs570210385       rs570306670       rs570983246       rs571051905       rs571508918       rs571834462       rs571980614       rs572040930       rs572277984       rs572287083       rs572315155       rs572433543       rs573251943       rs573587325       rs573624066       rs574228390       rs574975337       rs575016036       rs575721743       rs576058284       rs576194632       rs576321310       rs576321699       rs576358116       rs576861734       rs576868463       rs576906569       rs577537385       rs578090128       rs745467407       rs745474532       rs745577624       rs745902596       rs746153676       rs746207015       rs746329761       rs746732811       rs746752322       rs747188071       rs747661132       rs748036610       rs748434023       rs748734936       rs748824673       rs748879622       rs749317102       rs749529223       rs749633305       rs750166898       rs750292486       rs750421407       rs750990514       rs751131913       rs751489953       rs751499275       rs751546944       rs751801732       rs752002358       rs752560028       rs752628508       rs752849516       rs753022898       rs753698087       rs754012542       rs754280079       rs754815067       rs755048176       rs755356068       rs755974477       rs756588710       rs756602276       rs756760173       rs757046158       rs757245675       rs757350391       rs757576618       rs757689092       rs757967950       rs758342503       rs758708200       rs758831302       rs759093589       rs759750862       rs759990454       rs760205603       rs760243873       rs760390442       rs760534723       rs760794212       rs761017360       rs761321249       rs761533159       rs762144462       rs762268859       rs762355129       rs762656543       rs762834023       rs763101459       rs763229183       rs763266605       rs763315136       rs763747526       rs764019618       rs764200264       rs764511476       rs764566176       rs764756307       rs764884260       rs764971965       rs765303986       rs765350028       rs765632312       rs765748807       rs765979783       rs766091455       rs766216371       rs766273419       rs766312328       rs766623256       rs766676176       rs767533221       rs767986913       rs768111969       rs768277485       rs768619109       rs768746048       rs768897793       rs769237732       rs769871448       rs770254254       rs770590360       rs771066560       rs771192295       rs771470880       rs771499413       rs771651137       rs771838233       rs771982887       rs772255194       rs772518157       rs772618221       rs772740680       rs772779357       rs773010623       rs773586493       rs773636096       rs774143098       rs774304066       rs774778993       rs775037392       rs775161573       rs775217420       rs775573054       rs775888043       rs775901912       rs776131329       rs776183681       rs776220193       rs776344653       rs776694657       rs776747742       rs776879926       rs777002584       rs777264513       rs777387928       rs777630869       rs777959774       rs778032448       rs778526138       rs779177891       rs779553372       rs780067835       rs781016147       rs781139454       rs781381898       rs781476367      

基因表达

基因表达

GCG基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TTCTTATTTGGAAGGCCAAGC
59
TCTTCTGGGAAATCTCGCC
60
GGCTGGATTATTTGTAATGCTG
58
GAGAATGATCTGGATTTCTCCTC
59
AGGAACAGGAATAACATTGCC
59
GAATTCCTTGGCAGCTTGG
60
TTATTTGGAAGGCCAAGCTG
59
ACCTCTTCTGGGAAATCTCG
59
GCTGGATTATTTGTAATGCTGG
58
TGAGAATGATCTGGATTTCTCC
58
AGAGGAACAGGAATAACATTGC
59
GAACTTACATCACTGGTAAAGGTC
60
AAACTGGTTGATTCAGACCA
57
GCTAGCAGGTGATGTTGTG
59
TATTTGGAAGGCCAAGCTG
58
GACCTCTTCTGGGAAATCTC
57
GAGGAACAGGAATAACATTGCC
60
GAACTTACATCACTGGTAAAGGTC
60
TTCTTATTTGGAAGGCCAAGC
59
TCTTCTGGGAAATCTCGCC
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

GCG基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

GCG基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005102
P01275(UniProtKB)
TAS
GO:0005179
P01275(UniProtKB)
IBA
GO:0005515
P01275(UniProtKB)
IPI
GO:0005515
P01275(UniProtKB)
IPI
GO:0005576
P01275(UniProtKB)
TAS
GO:0005576
P01275(UniProtKB)
TAS
GO:0005576
P01275(UniProtKB)
TAS
GO:0005576
P01275(UniProtKB)
TAS
GO:0005576
P01275(UniProtKB)
TAS
GO:0005576
P01275(UniProtKB)
TAS
GO:0005576
P01275(UniProtKB)
TAS
GO:0005576
P01275(UniProtKB)
TAS
GO:0005576
P01275(UniProtKB)
TAS
GO:0005576
P01275(UniProtKB)
TAS
GO:0005576
P01275(UniProtKB)
TAS
GO:0005576
P01275(UniProtKB)
TAS
GO:0005615
P01275(UniProtKB)
IBA
GO:0005788
P01275(UniProtKB)
TAS
GO:0005788
P01275(UniProtKB)
TAS
GO:0005886
P01275(UniProtKB)
TAS
GO:0005886
P01275(UniProtKB)
TAS
GO:0005886
P01275(UniProtKB)
TAS
GO:0005886
P01275(UniProtKB)
TAS
GO:0007165
P01275(UniProtKB)
TAS
GO:0007186
P01275(UniProtKB)
TAS
GO:0007188
P01275(UniProtKB)
IBA
GO:0007631
P01275(UniProtKB)
TAS
GO:0008283
P01275(UniProtKB)
TAS
GO:0010737
P01275(UniProtKB)
IBA
GO:0010800
P01275(UniProtKB)
IEA
GO:0030819
P01275(UniProtKB)
IEA
GO:0031769
P01275(UniProtKB)
IBA
GO:0032092
P01275(UniProtKB)
IEA
GO:0032099
P01275(UniProtKB)
IEA
GO:0033138
P01275(UniProtKB)
IEA
GO:0034774
P01275(UniProtKB)
TAS
GO:0034774
P01275(UniProtKB)
TAS
GO:0035774
P01275(UniProtKB)
IBA
GO:0035948
P01275(UniProtKB)
IEA
GO:0042594
P01275(UniProtKB)
IBA
GO:0042802
P01275(UniProtKB)
IPI
GO:0043066
P01275(UniProtKB)
IBA
GO:0045860
P01275(UniProtKB)
IEA
GO:0050796
P01275(UniProtKB)
TAS
GO:0050796
P01275(UniProtKB)
TAS
GO:0051571
P01275(UniProtKB)
IEA
GO:0070374
P01275(UniProtKB)
IEA
GO:0071377
P01275(UniProtKB)
TAS
GO:0090280
P01275(UniProtKB)
IEA
GO:1900118
P01275(UniProtKB)
IEA
GO:2001243
P01275(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控GCG基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Diabetes Mellitus, Non-Insulin-Dependent 0.154364835 89 2 BeFree_CTD_human_GAD
Obesity 0.129153079 27 1 BeFree_CTD_human_GAD
Hyperglycemia 0.126786047 27 3 BeFree_CTD_human
Hyperinsulinism 0.121628651 7 0 BeFree_CTD_human
Colitis 0.120271442 2 0 BeFree_CTD_human
Hypertensive disease 0.120271442 2 0 BeFree_CTD_human
Catalepsy 0.12 1 0 CTD_human
Colonic Neoplasms 0.12 1 0 CTD_human
Comatose 0.12 1 0 CTD_human
Constipation 0.12 1 0 CTD_human
Heart Diseases 0.12 1 0 CTD_human
Heart failure 0.12 1 0 CTD_human
Hyperlipidemia 0.12 1 0 CTD_human
Hypotension 0.12 2 0 CTD_human
Hypothermia, natural 0.12 1 0 CTD_human
Spasm 0.12 1 0 CTD_human
Stomach Diseases 0.12 1 0 CTD_human
Tachycardia 0.12 1 0 CTD_human
Sinus Tachycardia 0.12 1 0 CTD_human
Vascular Diseases 0.12 1 0 CTD_human
Hyperactive behavior 0.12 1 0 CTD_human
Bradycardia 0.12 5 0 CTD_human
Aberrant Crypt Foci 0.12 1 0 CTD_human
Diabetes Mellitus, Experimental 0.08 1 0 RGD
Diabetes Mellitus 0.015667684 50 2 BeFree_GAD
Diabetes 0.011129117 41 2 BeFree
Impaired glucose tolerance 0.006263026 5 0 BeFree_LHGDN
Hypoglycemia 0.005428837 20 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.003257302 12 0 BeFree
Irritable Bowel Syndrome 0.002995792 2 0 BeFree_LHGDN
Neoplasm Metastasis 0.002995792 2 0 BeFree_LHGDN
Short Bowel Syndrome 0.002995792 2 0 BeFree_LHGDN
Muscular Dystrophy, Oculopharyngeal 0.002985861 11 0 BeFree
Atherosclerosis 0.002909916 3 0 BeFree_GAD
Adenocarcinoma 0.00272435 1 0 LHGDN
Anorexia Nervosa 0.00272435 1 0 LHGDN
Food Allergy 0.00272435 1 0 LHGDN
Myocardial Infarction 0.00272435 1 0 LHGDN
Renal Insufficiency 0.00272435 1 0 LHGDN
Glucagonoma 0.001085767 4 0 BeFree
insulinoma 0.001085767 4 0 BeFree
Malignant neoplasm of breast 0.000814326 3 0 BeFree
Pancreatitis, Chronic 0.000814326 3 0 BeFree
Pancreatic carcinoma 0.000814326 3 0 BeFree
Malignant neoplasm of pancreas 0.000814326 3 0 BeFree
Metabolic Syndrome X 0.000814326 3 0 BeFree
Breast Carcinoma 0.000814326 3 0 BeFree
Arteriosclerosis 0.000542884 2 0 BeFree
Malignant tumor of colon 0.000542884 2 0 BeFree
Cardiovascular Diseases 0.000542884 2 0 BeFree
Pheochromocytoma 0.000542884 2 0 BeFree
Pituitary Diseases 0.000542884 2 0 BeFree
Acute myocardial infarction 0.000542884 2 0 BeFree
Neuroendocrine Tumors 0.000542884 2 0 BeFree
Dyslipidemias 0.000542884 2 0 BeFree
Maturity onset diabetes mellitus in young 0.000542884 2 0 BeFree
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Non-alcoholic Fatty Liver Disease 0.000542884 2 0 BeFree
Oculopharyngodistal Myopathy 0.000542884 2 0 BeFree
Coronary Artery Disease 0.000542884 2 0 BeFree
Azoospermia 0.000271442 1 0 BeFree
Malignant neoplasm of larynx 0.000271442 1 0 BeFree
Cardiomyopathy, Dilated 0.000271442 1 0 BeFree
Coronary Arteriosclerosis 0.000271442 1 0 BeFree
Coronary heart disease 0.000271442 1 0 BeFree
Crohn Disease 0.000271442 1 0 BeFree
Diabetic Nephropathy 0.000271442 1 0 BeFree
Diarrhea 0.000271442 1 0 BeFree
Fibrosarcoma 0.000271442 1 0 BeFree
Von Hippel-Lindau Syndrome 0.000271442 1 0 BeFree
Intestinal Diseases 0.000271442 1 0 BeFree
Intestinal Neoplasms 0.000271442 1 0 BeFree
Liver Cirrhosis 0.000271442 1 0 BeFree
Liver diseases 0.000271442 1 0 BeFree
Multiple Endocrine Neoplasia Type 1 0.000271442 1 0 BeFree
Multiple Endocrine Neoplasia Type 2a 0.000271442 1 0 BeFree
Meningioma 0.000271442 1 0 BeFree
Metabolic Diseases 0.000271442 1 0 BeFree
Spinal Muscular Atrophy 0.000271442 1 0 BeFree
Neuroblastoma 0.000271442 1 0 BeFree
Nodule 0.000271442 1 0 BeFree
polyps 0.000271442 1 0 BeFree
Psoriasis 0.000271442 1 0 BeFree
Subacute Sclerosing Panencephalitis 0.000271442 1 0 BeFree
Substance Dependence 0.000271442 1 0 BeFree
Severe Combined Immunodeficiency 0.000271442 1 0 BeFree
Gestational Diabetes 0.000271442 1 0 BeFree
Malnutrition 0.000271442 1 1 BeFree
Diabetes, Autoimmune 0.000271442 1 0 BeFree
Hepatoblastoma 0.000271442 1 0 BeFree
Gastrointestinal Stromal Tumors 0.000271442 1 0 BeFree
Fasting Hypoglycemia 0.000271442 1 0 BeFree
Reactive hypoglycemia 0.000271442 1 0 BeFree
Benign Meningioma 0.000271442 1 0 BeFree
Chronic ulcer 0.000271442 1 0 BeFree
Corneal dystrophy, Lattice type 3 0.000271442 1 0 BeFree
Diabetes mellitus autosomal dominant type II (disorder) 0.000271442 1 0 BeFree
Diabetes-deafness syndrome maternally transmitted (disorder) 0.000271442 1 0 BeFree
Neurodegenerative Disorders 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Lung Diseases, Obstructive 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Central neuroblastoma 0.000271442 1 0 BeFree
Microalbuminuria 0.000271442 1 0 BeFree
Taste sweet 0.000271442 1 0 BeFree
Intraepithelial Neoplasia 0.000271442 1 0 BeFree
Sarcoma 0.000271442 1 0 BeFree
Liver regeneration disorder 0.000271442 1 0 BeFree
Pancreatic Ductal Adenocarcinoma 0.000271442 1 0 BeFree
Drug Dependence 0.000271442 1 0 BeFree
Cirrhosis 0.000271442 1 0 BeFree
BIETTI CRYSTALLINE CORNEORETINAL DYSTROPHY 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
Nonalcoholic Steatohepatitis 0.000271442 1 0 BeFree
Insulin resistance syndrome 0.000271442 1 0 BeFree

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