GATA1(GATA binding protein 1 (globin transcription factor 1))

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

Xp11.23
基因染色体位置图

基因简述

基因简述

This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  这个基因编码属于转录因子GATA家族的转录因子的蛋白质。蛋白质起着由胎儿血红蛋白的开关调节到成人血红蛋白中红细胞发展中起重要作用。在这种基因突变与X连锁红细胞生成异常性贫血和血小板减少症有关。 [由RefSeq的，2008年7月提供]

OMIM数据库中对GATA1基因的介绍     Wikipedia数据库中对GATA1基因的介绍

基因序列

基因序列

GATA1基因的碱基序列：[NCBI]

基因突变

基因突变

GATA1基因的碱基突变：           显示全部snp
rs782819200       rs782810903       rs782809675       rs782808635       rs782804166       rs782794515       rs782803793       rs782788437       rs782790256       rs782785151       rs782770234       rs782774506       rs782750237       rs782756445       rs782756928       rs782749568       rs782748775       rs782747696       rs782744605       rs782741534       rs782744233       rs782740230       rs782717582       rs782736258       rs782711761       rs782705135       rs782701142       rs782701437       rs782697197       rs782698349       rs782690876       rs782691816       rs782695653       rs782686857       rs782688895       rs782685566       rs782678694      
rs782668006       rs782664671       rs782664582       rs782656507       rs782651118       rs782652721       rs782650748       rs782641552       rs782649435       rs782628386       rs782632688       rs782637887       rs782626863       rs782623356       rs782622755       rs782617771       rs782618060       rs782611560       rs782607748       rs782599587       rs782601348       rs782591058       rs782599487       rs782588112       rs782589518       rs782584812       rs782583794       rs782576780       rs782569926       rs782557449       rs782555228       rs782548842       rs782546475       rs782547892       rs782543504       rs782544805       rs782528630       rs782534643       rs782536159       rs782527464       rs782524610       rs782507228       rs782505834       rs782497793       rs782494873       rs782495426       rs782476971       rs782482888       rs782473995       rs782474159       rs782473821       rs782470513       rs782469019       rs782467893       rs782452748       rs782448947       rs782444069       rs782443272       rs782443458       rs782439030       rs782442206       rs782437592       rs782435808       rs782435835       rs782432208       rs782427793       rs782431585       rs782414582       rs782418881       rs782408441       rs782411113       rs782411199       rs782403511       rs782397894       rs782391440       rs782396819       rs782385740       rs782384907       rs782377129       rs782384053       rs782376844       rs782374576       rs782366452       rs782371904       rs782360499       rs782358790       rs782357429       rs782356409       rs782347891       rs782352992       rs782337409       rs782341488       rs782347403       rs782328620       rs782326935       rs782322842       rs782323921       rs782313325       rs782306488       rs782304729       rs782302196       rs782300796       rs782294292       rs782299679       rs782283920       rs782282009       rs782271840       rs782273718       rs782270931       rs782265153       rs782270363       rs782263736       rs782258887       rs782261590       rs782249320       rs782239362       rs782231308       rs782231862       rs782236381       rs782214998       rs782213465       rs782205532       rs782208453       rs782205103       rs782193818       rs782198015       rs782188059       rs782187787       rs782185527       rs782180657       rs782179331       rs782167312       rs782177448       rs782160624       rs782165033       rs782165657       rs782155672       rs782150782       rs782153111       rs782150554       rs782147990       rs782146708       rs782145814       rs782142651       rs782129707       rs782127979       rs782127900       rs782127453       rs782126313       rs782126554       rs782123071       rs782124121       rs782120820       rs782120073       rs782109292       rs782116095       rs782094568       rs782106118       rs782085777       rs782091239       rs782068997       rs782069619       rs782080386       rs782064537       rs782052617       rs782046941       rs782045903       rs782039463       rs782038466       rs782038543       rs782009481       rs782012546       rs782037276       rs782008052       rs782005360       rs782006063       rs781987026       rs781984293       rs781979595       rs781979718       rs781977639       rs781967611       rs781967992       rs781963384       rs781964937       rs781958271       rs781957095       rs781950794       rs781950543       rs781948952       rs781935644       rs781942870       rs781933933       rs781928506       rs781930891       rs781933047       rs781924453       rs781920985       rs781921917       rs781912832       rs781914019       rs781904528       rs781902307       rs781903508       rs781895544       rs781896705       rs781895369       rs781890805       rs781887823       rs781880992       rs781878071       rs781876280       rs781871070       rs781874359       rs781868496       rs781868016       rs781863187       rs781862939       rs781860722       rs781856701       rs781858722       rs781859069       rs781856531       rs781852329       rs781852903       rs781853054       rs781849995       rs781847807       rs781847300       rs781845766       rs781841789       rs781832650       rs781822537       rs781823379       rs781816862       rs781811859       rs377293299       rs781786443       rs377196815       rs377057415       rs377114719       rs376546932       rs376582617       rs375789273       rs374457234       rs374811368       rs375110503       rs374272075       rs374300356       rs372777182       rs372131208       rs371005242       rs371752832       rs370706809       rs370821248       rs370522986       rs369832793       rs369844571       rs368635356       rs369454016       rs368193049       rs368477415       rs368003194       rs367937634       rs202091014       rs201489369       rs201336096       rs200599207       rs201176390       rs200509606       rs200263656       rs199710067       rs199888647       rs192952143       rs192871898       rs192402435       rs192395206       rs191717663       rs190859193       rs190844303       rs189368080       rs189275911       rs188525830       rs187978973       rs187535255       rs186975246       rs186872605       rs186393065       rs186026956       rs184915683       rs184815507       rs184692721       rs184537593       rs183506623       rs183159954       rs182863789       rs182622317       rs182328680       rs182015204       rs181821403       rs181607342       rs181451440       rs181400617       rs181230880       rs150572851       rs150473615       rs150167139       rs149753411       rs149856254       rs149177751       rs148929866       rs148773292       rs147681544       rs148357840       rs147375255       rs147320486       rs146587548       rs146196033       rs145355350       rs144282688       rs144017862       rs142614402       rs143332634       rs141512330       rs141479621       rs140561920       rs140860091       rs140328998       rs139959114       rs139614533       rs139472040       rs138483498       rs139200954       rs138042906       rs113966884       rs112880333       rs113190478       rs78735836       rs112226999       rs76007270       rs78523230       rs73491506       rs66717003       rs62600348       rs61753429       rs61735969       rs12841023       rs59609788       rs5906709       rs2293950       rs1126581      

基因表达

基因表达

GATA1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
ACTACCTATGCAACGCCTG
59
TTACTGACAATCAGGCGCT
59
ACTACCTATGCAACGCCTG
59
CGTTTACTGACAATCAGGCG
59
TACACCAGCACTACTGTGG
59
ACAAGAGGAGAAGGACACC
59
ACTACCTATGCAACGCCTG
60
TTACTGACAATCAGGCGCT
59
TACACCAGCACTACTGTGG
59
CAAGAGGAGAAGGACACCA
59
TACACCAGCACTACTGTGG
59
AAGAGGAGAAGGACACCAC
59
CACTACCTATGCAACGCCT
60
TTACTGACAATCAGGCGCT
59
CACTACCTATGCAACGCCT
59
TTACTGACAATCAGGCGCT
59
ACTACCTATGCAACGCCTG
60
CGTTTACTGACAATCAGGCG
60

转录因子

转录因子

转录因子
影响类型
PubMed链接
AGGF1
Activation
19556247
ALAS2
Unknown
23935018
BACE1
Unknown
12815710
BACH1
Activation
16492768
BDKRB1
Unknown
10842322
BST2
Activation
16249385
CBFB
Repression
19825991
CCR3
Unknown
22217447
CDA
Activation
14744791
CDC6
Activation
22871742

基因本体信息

GATA1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

GATA1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003700
B7WNQ9(UniProtKB)
IEA
GO:0005634
B7WNQ9(UniProtKB)
IEA
GO:0006355
B7WNQ9(UniProtKB)
IEA
GO:0008270
B7WNQ9(UniProtKB)
IEA
GO:0030219
B7WNQ9(UniProtKB)
IEA
GO:0030221
B7WNQ9(UniProtKB)
IEA
GO:0030222
B7WNQ9(UniProtKB)
IEA
GO:0043565
B7WNQ9(UniProtKB)
IEA
GO:0048821
B7WNQ9(UniProtKB)
IEA
GO:0000122
P15976(UniProtKB)
IDA
GO:0000976
P15976(UniProtKB)
IMP
GO:0000977
P15976(UniProtKB)
IDA
GO:0000978
P15976(UniProtKB)
IEA
GO:0000979
P15976(UniProtKB)
IMP
GO:0001047
P15976(UniProtKB)
IDA
GO:0001077
P15976(UniProtKB)
IEA
GO:0001078
P15976(UniProtKB)
IDA
GO:0001085
P15976(UniProtKB)
IPI
GO:0001085
P15976(UniProtKB)
IPI
GO:0001158
P15976(UniProtKB)
IEA
GO:0001228
P15976(UniProtKB)
IBA
GO:0001701
P15976(UniProtKB)
IEA
GO:0002039
P15976(UniProtKB)
IEA
GO:0003677
P15976(UniProtKB)
IDA
GO:0003677
P15976(UniProtKB)
IDA
GO:0003677
P15976(UniProtKB)
IDA
GO:0003700
P15976(UniProtKB)
IDA
GO:0005515
P15976(UniProtKB)
IPI
GO:0005515
P15976(UniProtKB)
IPI
GO:0005515
P15976(UniProtKB)
IPI
GO:0005515
P15976(UniProtKB)
IPI
GO:0005515
P15976(UniProtKB)
IPI
GO:0005515
P15976(UniProtKB)
IPI
GO:0005515
P15976(UniProtKB)
IPI
GO:0005515
P15976(UniProtKB)
IPI
GO:0005515
P15976(UniProtKB)
IPI
GO:0005515
P15976(UniProtKB)
IPI
GO:0005515
P15976(UniProtKB)
IPI
GO:0005515
P15976(UniProtKB)
IPI
GO:0005515
P15976(UniProtKB)
IPI
GO:0005634
P15976(UniProtKB)
IDA
GO:0005634
P15976(UniProtKB)
IDA
GO:0005634
P15976(UniProtKB)
IDA
GO:0005654
P15976(UniProtKB)
TAS
GO:0005667
P15976(UniProtKB)
IDA
GO:0006366
P15976(UniProtKB)
IDA
GO:0007267
P15976(UniProtKB)
IEA
GO:0007507
P15976(UniProtKB)
IBA
GO:0007596
P15976(UniProtKB)
TAS
GO:0008270
P15976(UniProtKB)
IEA
GO:0008285
P15976(UniProtKB)
IEA
GO:0008301
P15976(UniProtKB)
IEA
GO:0008584
P15976(UniProtKB)
IMP
GO:0009887
P15976(UniProtKB)
IBA
GO:0009888
P15976(UniProtKB)
IBA
GO:0010559
P15976(UniProtKB)
IMP
GO:0010724
P15976(UniProtKB)
IDA
GO:0010724
P15976(UniProtKB)
IDA
GO:0010725
P15976(UniProtKB)
IEA
GO:0017053
P15976(UniProtKB)
IDA
GO:0030218
P15976(UniProtKB)
IEP
GO:0030219
P15976(UniProtKB)
IMP
GO:0030220
P15976(UniProtKB)
IMP
GO:0030220
P15976(UniProtKB)
IMP
GO:0030220
P15976(UniProtKB)
IMP
GO:0030221
P15976(UniProtKB)
IEP
GO:0030222
P15976(UniProtKB)
IEP
GO:0030502
P15976(UniProtKB)
IEA
GO:0031490
P15976(UniProtKB)
IDA
GO:0033690
P15976(UniProtKB)
IEA
GO:0035162
P15976(UniProtKB)
IEA
GO:0035854
P15976(UniProtKB)
IDA
GO:0043066
P15976(UniProtKB)
IMP
GO:0043565
P15976(UniProtKB)
IMP
GO:0045648
P15976(UniProtKB)
IMP
GO:0045893
P15976(UniProtKB)
IDA
GO:0045944
P15976(UniProtKB)
IDA
GO:0045944
P15976(UniProtKB)
IMP
GO:0048565
P15976(UniProtKB)
IBA
GO:0048821
P15976(UniProtKB)
IMP
GO:0048873
P15976(UniProtKB)
IEA
GO:0050731
P15976(UniProtKB)
IMP
GO:0070527
P15976(UniProtKB)
IMP
GO:0070742
P15976(UniProtKB)
IPI
GO:0071733
P15976(UniProtKB)
ISS
GO:0097028
P15976(UniProtKB)
IEA
GO:0097067
P15976(UniProtKB)
IDA
GO:2000678
P15976(UniProtKB)
IDA
GO:2001240
P15976(UniProtKB)
IMP

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控GATA1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Thrombocytopenia, Platelet Dysfunction, Hemolysis, and Imbalanced Globin Synthesis 0.48 1 2 CLINVAR_CTD_human_ORPHANET_UNIPROT
THROMBOCYTOPENIA, X-LINKED, WITH OR WITHOUT DYSERYTHROPOIETIC ANEMIA 0.36 4 0 CTD_human_ORPHANET_UNIPROT
Down Syndrome 0.17486456 84 0 BeFree_CTD_human_GAD_LHGDN
Acute Megakaryocytic Leukemias 0.154271197 56 1 BeFree_CLINVAR_LHGDN
MYELOPROLIFERATIVE SYNDROME, TRANSIENT 0.133496149 42 0 BeFree_GAD_ORPHANET
Thrombocytopenia 0.128173051 4 0 CTD_human_LHGDN
Anemia, Diamond-Blackfan 0.121900093 7 0 BeFree_ORPHANET
Porphyria, Erythropoietic 0.121085767 4 1 BeFree_ORPHANET
Dyserythropoietic Anemia with Thrombocytopenia 0.120814326 3 10 BeFree_CLINVAR
Acute Basophilic Leukemia 0.120271442 1 0 BeFree_ORPHANET
Transient Myeloproliferative Disorder of Down Syndrome 0.120271442 2 0 BeFree_CTD_human
Leukemia, Megakaryoblastic, of Down Syndrome 0.12 0 1 CLINVAR
Anemia, X-Linked, without Thrombocytopenia 0.12 0 0 CLINVAR
ANEMIA, X-LINKED, WITH OR WITHOUT NEUTROPENIA AND/OR PLATELET ABNORMALITIES 0.12 0 0 ORPHANET
THROMBOCYTOPENIA 1 (disorder) 0.081628651 6 0 BeFree_MGD
Myelofibrosis 0.080814326 3 0 BeFree_MGD
Myeloproliferative disease 0.011983168 8 0 BeFree_LHGDN
leukemia 0.009781839 26 0 BeFree_LHGDN
Leukemia, Myelocytic, Acute 0.00842463 22 0 BeFree_LHGDN
Myeloid Leukemia 0.007077352 8 0 BeFree_LHGDN
Thalassemia 0.005720142 2 0 BeFree_LHGDN
Temporomandibular Joint Dysfunction Syndrome 0.005700279 21 0 BeFree
TIBIAL MUSCULAR DYSTROPHY, TARDIVE 0.005700279 21 0 BeFree
Leukemogenesis 0.004885954 18 1 BeFree
Primary Myelofibrosis 0.003538676 3 0 BeFree_LHGDN
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.003267234 3 0 BeFree_LHGDN
Congenital dyserythropoietic anemia 0.002995792 2 0 BeFree_LHGDN
Blast Phase 0.002995792 2 0 BeFree_LHGDN
MYELODYSPLASTIC SYNDROME 0.002995792 2 0 BeFree_LHGDN
Alzheimer's Disease 0.002367032 1 0 GAD
Lymphoproliferative Disorders 0.002367032 1 0 GAD
Pancreatic Neoplasm 0.002367032 1 0 GAD
Acute Erythroblastic Leukemia 0.002171535 8 0 BeFree
Acute leukemia 0.002171535 8 0 BeFree
Anemia 0.001900093 7 1 BeFree
Preleukemia 0.001085767 4 0 BeFree
Hematological Disease 0.000814326 3 0 BeFree
Myeloid Leukemia, Chronic 0.000814326 3 0 BeFree
Nephroblastoma 0.000814326 3 0 BeFree
Neoplasm, Residual 0.000814326 3 0 BeFree
Breast Carcinoma 0.000814326 3 0 BeFree
Chronic myeloproliferative disorder 0.000814326 3 0 BeFree
Asthma 0.000542884 2 0 BeFree
beta Thalassemia 0.000542884 2 4 BeFree
Blood Platelet Disorders 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Acute lymphocytic leukemia 0.000542884 2 0 BeFree
Polycythemia Vera 0.000542884 2 0 BeFree
Thrombocythemia, Essential 0.000542884 2 0 BeFree
Trisomy 0.000542884 2 0 BeFree
childhood acute megakaryocytic leukemia (M7) 0.000542884 2 0 BeFree
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Leukemia in children 0.000542884 2 0 BeFree
Cooley's anemia 0.000271442 1 0 BeFree
Blood Coagulation Disorders 0.000271442 1 1 BeFree
Eosinophilia 0.000271442 1 0 BeFree
Hemoglobin F Disease 0.000271442 1 0 BeFree
HIV Infections 0.000271442 1 0 BeFree
Leukemia, Lymphocytic, Acute, L1 0.000271442 1 0 BeFree
Osteosarcoma 0.000271442 1 0 BeFree
Plague 0.000271442 1 0 BeFree
Disorders of Porphyrin Metabolism 0.000271442 1 0 BeFree
Precancerous Conditions 0.000271442 1 0 BeFree
Protein Deficiency 0.000271442 1 0 BeFree
pediatric acute myeloblastic leukemia 0.000271442 1 0 BeFree
Neonatal leukaemia 0.000271442 1 0 BeFree
Iron deficiency 0.000271442 1 0 BeFree
Solid tumour 0.000271442 1 0 BeFree
Acute Undifferentiated Leukemia 0.000271442 1 0 BeFree
Anemia due to decreased red cell production 0.000271442 1 0 BeFree
Beta thalassemia intermedia 0.000271442 1 0 BeFree
Osteosarcoma of bone 0.000271442 1 0 BeFree
Dyserythropoietic anemia 0.000271442 1 4 BeFree
Partial Trisomy 0.000271442 1 0 BeFree
Eosinophilic disorder 0.000271442 1 0 BeFree
Undifferentiated leukemia 0.000271442 1 0 BeFree
Disorder characterized by eosinophilia 0.000271442 1 0 BeFree
MULTICYSTIC RENAL DYSPLASIA, BILATERAL 0.000271442 1 0 BeFree
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 0.000271442 1 0 BeFree
Hyperdiploid B Acute Lymphoblastic Leukemia 0.000271442 1 0 BeFree
Myeloid neoplasm 0.000271442 1 0 BeFree

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