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This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  这个基因编码氨酰tRNA合成酶,与它们的同源氨基酸充电的t??RNA的氨酰基tRNA合成酶之一。所编码的酶是(阿尔法)2二聚体属于II类家族tRNA合成酶。它已被证明是在人类自身免疫性疾病,多肌炎或皮肌炎自身抗体的靶标。 [由RefSeq的,2008年7月提供]
GARS基因(以及对应的蛋白质)的细胞分布位置:
GARS基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Charcot-Marie-Tooth disease, Type 2D | 0.561628651 | 7 | 6 | BeFree_CLINVAR_CTD_human_MGD_ORPHANET_UNIPROT |
NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE V | 0.363257302 | 12 | 5 | BeFree_CLINVAR_CTD_human_UNIPROT |
Charcot-Marie-Tooth Disease | 0.009434452 | 17 | 0 | BeFree_GAD_LHGDN |
Spinal Muscular Atrophy | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Nerve Degeneration | 0.00272435 | 1 | 0 | LHGDN |
Neuropathy | 0.001900093 | 7 | 0 | BeFree |
Diabetic Nephropathy | 0.001085767 | 4 | 0 | BeFree |
granulosa cell tumor | 0.001085767 | 4 | 0 | BeFree |
Hereditary Motor and Sensory-Neuropathy Type II | 0.001085767 | 4 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Muscular Atrophy | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma | 0.000814326 | 3 | 0 | BeFree |
Stiff-Person Syndrome | 0.000814326 | 3 | 0 | BeFree |
Hyperexplexia | 0.000814326 | 3 | 0 | BeFree |
Distal Spinal Muscular Atrophy | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma of bone | 0.000814326 | 3 | 0 | BeFree |
Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Fibrodysplasia Ossificans Progressiva | 0.000542884 | 2 | 1 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Hereditary Motor and Sensory Neuropathies | 0.000542884 | 2 | 0 | BeFree |
Peripheral Neuropathy | 0.000542884 | 2 | 0 | BeFree |
Familial generalized lipodystrophy | 0.000542884 | 2 | 0 | BeFree |
Axonal neuropathy | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Inherited neuropathies | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Spastic paraplegia 17 | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
Dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Muscle Spasticity | 0.000271442 | 1 | 0 | BeFree |
Myositis | 0.000271442 | 1 | 0 | BeFree |
Neurofibromatosis 1 | 0.000271442 | 1 | 0 | BeFree |
Osteoblastoma | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Renal fibrosis | 0.000271442 | 1 | 0 | BeFree |
Congenital heart disease | 0.000271442 | 1 | 0 | BeFree |
Adult type dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
Tumor necrosis | 0.000271442 | 1 | 0 | BeFree |
Congenital keratoglobus | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Ovarian failure | 0.000271442 | 1 | 0 | BeFree |
Spondylarthropathies | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
Inherited Peripheral Neuropathy | 0.000271442 | 1 | 0 | BeFree |
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