更多...
收起
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
[中文简述(自动翻译):]  该基因编码的甘油醛-3-磷酸脱氢酶蛋白家族的一个成员。所编码的蛋白质已被鉴定为是根据它来执行机制上不同功能能力的兼职蛋白。该基因的产物催化碳水化合物代谢的重要产生能量的步骤,在无机磷酸盐和烟酰胺腺嘌呤二核苷酸(NAD)存在下甘油醛-3-磷酸盐的可逆氧化磷酸化。所编码的蛋白质已另外被鉴定为具有在细胞核尿嘧啶DNA糖基化酶活性。此外,此蛋白质包含具有对大肠杆菌,绿脓杆菌,和白色念珠菌的抗微生物活性的肽。已在小鼠的类似蛋白质的研究分配各种附加功能,包括核蛋白质的亚硝基化,mRNA稳定性的调节,并作为巨噬细胞的细胞表面上的运铁蛋白受体。类似于此轨迹许多假存在于人类基因组。选择性剪接结果在多个抄本变形。 [由RefSeq的,2014年11月提供]
GAPDH基因(以及对应的蛋白质)的细胞分布位置:
GAPDH基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Liver carcinoma | 0.122442977 | 11 | 0 | BeFree_CTD_human |
Squamous cell carcinoma | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Anoxia | 0.12 | 1 | 0 | CTD_human |
Esophageal Neoplasms | 0.12 | 1 | 0 | CTD_human |
Mouth Neoplasms | 0.12 | 1 | 0 | CTD_human |
Necrosis | 0.12 | 1 | 0 | CTD_human |
Degenerative polyarthritis | 0.12 | 1 | 0 | CTD_human |
Osteoporosis | 0.12 | 1 | 0 | CTD_human |
Acute Coronary Syndrome | 0.12 | 1 | 0 | CTD_human |
Diabetic Retinopathy | 0.080271442 | 2 | 0 | BeFree_RGD |
Pregnancy in Diabetics | 0.08 | 1 | 0 | RGD |
Alzheimer's Disease | 0.022080057 | 10 | 0 | BeFree_GAD_LHGDN |
Thymoma | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Glioblastoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Huntington Disease | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Schizophrenia | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Cessation of life | 0.00272435 | 1 | 0 | LHGDN |
Multiple Sclerosis | 0.00272435 | 1 | 0 | LHGDN |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Thyroid Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Complications of Diabetes Mellitus | 0.00272435 | 1 | 0 | LHGDN |
Carcinoma of lung | 0.002714419 | 10 | 0 | BeFree |
Malignant neoplasm of lung | 0.002442977 | 9 | 0 | BeFree |
Malignant neoplasm of breast | 0.002171535 | 8 | 0 | BeFree |
Prostate carcinoma | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of prostate | 0.001900093 | 7 | 0 | BeFree |
Breast Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Adenoma | 0.001628651 | 6 | 0 | BeFree |
melanoma | 0.001628651 | 6 | 0 | BeFree |
Neuroblastoma | 0.001357209 | 5 | 0 | BeFree |
Carcinogenesis | 0.001357209 | 5 | 0 | BeFree |
Central neuroblastoma | 0.001357209 | 5 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Malignant tumor of cervix | 0.001085767 | 4 | 0 | BeFree |
Neurodegenerative Disorders | 0.001085767 | 4 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.001085767 | 4 | 0 | BeFree |
Adenocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Asthma | 0.000814326 | 3 | 0 | BeFree |
Diabetes Mellitus | 0.000814326 | 3 | 0 | BeFree |
Down Syndrome | 0.000814326 | 3 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000814326 | 3 | 0 | BeFree |
Liver Cirrhosis | 0.000814326 | 3 | 0 | BeFree |
Lymphoma | 0.000814326 | 3 | 0 | BeFree |
Neoplasm Metastasis | 0.000814326 | 3 | 0 | BeFree |
Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Cervix carcinoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
Mammary Neoplasms | 0.000814326 | 3 | 0 | BeFree |
Cirrhosis | 0.000814326 | 3 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.000542884 | 2 | 0 | BeFree |
Astrocytoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000542884 | 2 | 0 | BeFree |
Carcinoma, Papillary | 0.000542884 | 2 | 0 | BeFree |
Cardiomyopathy, Dilated | 0.000542884 | 2 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
Glioma | 0.000542884 | 2 | 0 | BeFree |
HIV Infections | 0.000542884 | 2 | 0 | BeFree |
Influenza | 0.000542884 | 2 | 0 | BeFree |
Liver diseases | 0.000542884 | 2 | 0 | BeFree |
Lung Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, Follicular | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Multiple Myeloma | 0.000542884 | 2 | 0 | BeFree |
Obesity | 0.000542884 | 2 | 0 | BeFree |
Osteosarcoma | 0.000542884 | 2 | 0 | BeFree |
Pituitary Diseases | 0.000542884 | 2 | 0 | BeFree |
Prolactinoma | 0.000542884 | 2 | 0 | BeFree |
Schistosomiasis | 0.000542884 | 2 | 0 | BeFree |
Turner Syndrome | 0.000542884 | 2 | 0 | BeFree |
Pancreatitis, Chronic | 0.000542884 | 2 | 0 | BeFree |
Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
Follicular adenoma | 0.000542884 | 2 | 0 | BeFree |
Ganglioneuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
Parathyroid Adenoma | 0.000542884 | 2 | 0 | BeFree |
Solid tumour | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma of pancreas | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
Osteosarcoma of bone | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of bladder | 0.000542884 | 2 | 0 | BeFree |
Lung cancer stage I | 0.000542884 | 2 | 0 | BeFree |
ACTH-Secreting Pituitary Adenoma | 0.000542884 | 2 | 0 | BeFree |
Cardiomyopathy, Familial Idiopathic | 0.000542884 | 2 | 0 | BeFree |
Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
Benign Prostatic Hyperplasia | 0.000542884 | 2 | 0 | BeFree |
Alcoholic Intoxication, Chronic | 0.000271442 | 1 | 0 | BeFree |
Anemia, Sickle Cell | 0.000271442 | 1 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Aspergillosis, Allergic Bronchopulmonary | 0.000271442 | 1 | 0 | BeFree |
Azoospermia | 0.000271442 | 1 | 0 | BeFree |
Melanoma, B16 | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Choriocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
Hepatitis D Infection | 0.000271442 | 1 | 0 | BeFree |
Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Eclampsia | 0.000271442 | 1 | 0 | BeFree |
Bacterial Endocarditis | 0.000271442 | 1 | 0 | BeFree |
Ganglioneuroma | 0.000271442 | 1 | 0 | BeFree |
IGA Glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
Hemochromatosis | 0.000271442 | 1 | 1 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Hepatitis, Alcoholic | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Kidney Neoplasm | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Meningioma | 0.000271442 | 1 | 0 | BeFree |
Meningococcal Infections | 0.000271442 | 1 | 0 | BeFree |
Mycoplasma Infections | 0.000271442 | 1 | 0 | BeFree |
Pain | 0.000271442 | 1 | 0 | BeFree |
Parasitic Diseases | 0.000271442 | 1 | 0 | BeFree |
Psoriasis | 0.000271442 | 1 | 0 | BeFree |
Retinal Degeneration | 0.000271442 | 1 | 0 | BeFree |
Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Seminoma | 0.000271442 | 1 | 0 | BeFree |
Septicemia | 0.000271442 | 1 | 0 | BeFree |
Trisomy | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Viral hepatitis | 0.000271442 | 1 | 0 | BeFree |
B-Cell Lymphomas | 0.000271442 | 1 | 0 | BeFree |
High Grade Lymphoma (neoplasm) | 0.000271442 | 1 | 0 | BeFree |
Idiopathic Membranous Glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
Rous Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Cutaneous Melanoma | 0.000271442 | 1 | 0 | BeFree |
HELLP Syndrome | 0.000271442 | 1 | 0 | BeFree |
Undifferentiated carcinoma | 0.000271442 | 1 | 0 | BeFree |
Adrenal Cortical Adenoma | 0.000271442 | 1 | 0 | BeFree |
Gonadal Dysgenesis, 45,X | 0.000271442 | 1 | 0 | BeFree |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Sepsis | 0.000271442 | 1 | 0 | BeFree |
Chronic viral hepatitis | 0.000271442 | 1 | 0 | BeFree |
Non-small cell lung cancer stage I | 0.000271442 | 1 | 0 | BeFree |
Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
Triploidy syndrome | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
Thyroid associated opthalmopathies | 0.000271442 | 1 | 0 | BeFree |
High altitude pulmonary edema | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Isolated aortic stenosis | 0.000271442 | 1 | 0 | BeFree |
Ischemic cardiomyopathy | 0.000271442 | 1 | 0 | BeFree |
Arrhythmogenic Right Ventricular Dysplasia | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Alzheimer Disease, Late Onset | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Microalbuminuria | 0.000271442 | 1 | 0 | BeFree |
Infantile Severe Myoclonic Epilepsy | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathies | 0.000271442 | 1 | 0 | BeFree |
Hurthle Cell Tumor | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
Severe Acute Respiratory Syndrome | 0.000271442 | 1 | 0 | BeFree |
Intraductal papillary-mucinous adenoma | 0.000271442 | 1 | 0 | BeFree |
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Marginal Zone B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Congenital absence of germinal epithelium of testes | 0.000271442 | 1 | 0 | BeFree |
Infective endocarditis | 0.000271442 | 1 | 0 | BeFree |
Non-Malignant Ascites Adverse Event | 0.000271442 | 1 | 0 | BeFree |
Acth-Independent Macronodular Adrenal Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Pyloric Stenosis, Infantile Hypertrophic 1 | 0.000271442 | 1 | 0 | BeFree |
Philadelphia chromosome-positive acute lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。