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This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  此基因是一组基因,其转录水平增加以下压力的生长停滞条件和与DNA损伤剂治疗中的一员。由该基因编码的蛋白质通过介导通过MTK1 / MEKK4激酶的p38 / JNK途径的活化来响应环境压力。该GADD45G在胎盘中高度表达。 [由RefSeq的,2008年7月提供]
GADD45G基因(以及对应的蛋白质)的细胞分布位置:
GADD45G基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Carcinogenesis | 0.003800186 | 14 | 0 | BeFree |
Pituitary Neoplasms | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Liver carcinoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 1 | GAD |
Epithelial ovarian cancer | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of lung | 0.001900093 | 7 | 0 | BeFree |
Carcinoma of lung | 0.001900093 | 7 | 0 | BeFree |
Pituitary Adenoma | 0.000814326 | 3 | 0 | BeFree |
Carcinogenicity | 0.000814326 | 3 | 0 | BeFree |
Adenoma | 0.000542884 | 2 | 0 | BeFree |
Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Esophageal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Lung diseases | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Nephritis | 0.000271442 | 1 | 0 | BeFree |
Pituitary Diseases | 0.000271442 | 1 | 0 | BeFree |
Giant Cell Arteritis | 0.000271442 | 1 | 0 | BeFree |
Teratoma | 0.000271442 | 1 | 0 | BeFree |
Ureteral obstruction | 0.000271442 | 1 | 0 | BeFree |
Esophageal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Chronic glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
Macrocephaly | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Multiple tumors | 0.000271442 | 1 | 0 | BeFree |
Non-Functioning Pituitary Gland Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Gastric Cardia Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
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