FUT3(fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group))

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

19p13.3
基因染色体位置图

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  刘易斯组织相容血型系统包括一组由外分泌腺上皮细胞合成和体液循环岩藻糖化鞘糖脂。的鞘糖脂在胚胎发生,组织分化,肿瘤转移,炎症,与细菌粘附的作用。它们被二次吸收到血红细胞引起他们的刘易斯表型。此基因是岩藻糖转移家族,其催化在加入岩藻糖的前体多糖在路易斯抗原生物合成的最后步骤中的一员。它编码具有α(1,3)-fucosyltransferase和α(1,4)-fucosyltransferase活动的酶。在这个基因的突变是负责多数路易斯抗原阴性表型。多个可变剪接变体,编码相同的蛋白质,已发现这种基因。 [由RefSeq的,2008年7月提供]

FUT3基因的碱基序列:[NCBI]
FUT3基因的碱基突变:           显示全部snp
rs407645       rs410044       rs417341       rs422073       rs440578       rs441610       rs778985       rs778986       rs778987       rs809646       rs812936       rs874232       rs1135729       rs2306969       rs2339237       rs2561796       rs2608892       rs2608893       rs2608894       rs2637193       rs2637194       rs2637195       rs3745635       rs3887968       rs3894326       rs4807052       rs4807816       rs4807817       rs4807818       rs4807819       rs10405209       rs10406157       rs10418972       rs11666252       rs11668191       rs11671428       rs11671528      
rs11673407       rs11882055       rs28362435       rs28362436       rs28362437       rs28362438       rs28362439       rs28362440       rs28362441       rs28362442       rs28362443       rs28362444       rs28362445       rs28362446       rs28362447       rs28362448       rs28362449       rs28362450       rs28362451       rs28362452       rs28362453       rs28362454       rs28362456       rs28362457       rs28362458       rs28362459       rs28362460       rs28362461       rs28362462       rs28362463       rs28362465       rs28381969       rs28381970       rs28381971       rs28742581       rs28742582       rs28742583       rs28742584       rs28742585       rs28742586       rs28742587       rs28742588       rs28742589       rs28742591       rs28742592       rs28742594       rs28742595       rs34304528       rs34552692       rs35082514       rs56224344       rs57861181       rs58614528       rs58634952       rs59796499       rs61385436       rs61737303       rs61737304       rs73920070       rs74663821       rs75313902       rs77360006       rs77559081       rs78686542       rs80213446       rs111987035       rs112846161       rs112930579       rs113277409       rs113732176       rs113782178       rs114114554       rs116074878       rs117080615       rs117095068       rs117643491       rs137909900       rs138120018       rs138410688       rs138500064       rs138529655       rs138592161       rs139001067       rs139116734       rs139326855       rs139430609       rs139654247       rs139688649       rs139862748       rs140438495       rs140806726       rs140865012       rs141112110       rs141188376       rs141537657       rs142212576       rs142305462       rs143012663       rs143154253       rs143255844       rs143289507       rs144073737       rs144104123       rs144130818       rs144219026       rs144354196       rs144569478       rs144953440       rs145321439       rs145362171       rs145475599       rs145513606       rs146199130       rs146514727       rs146519599       rs147046153       rs147095597       rs147885615       rs147904934       rs148170391       rs148313339       rs148418325       rs148635874       rs148881389       rs149020247       rs149611774       rs149661823       rs149713601       rs150092813       rs150146742       rs150418165       rs150534851       rs150624204       rs150816205       rs151012703       rs151206901       rs151218854       rs180814111       rs181302967       rs181653079       rs181692658       rs181737022       rs182279703       rs182633284       rs182880041       rs183072593       rs183245125       rs183487403       rs183580284       rs184371724       rs184450156       rs185056509       rs185187258       rs185319634       rs185878829       rs185911190       rs185989186       rs186010177       rs186449285       rs186481748       rs186838123       rs187397780       rs187758293       rs187852319       rs187995217       rs187998492       rs188231337       rs188487168       rs188541227       rs188764160       rs188914622       rs189244736       rs189718091       rs189824061       rs190151545       rs190615512       rs190665553       rs191271876       rs191362623       rs192043927       rs192187311       rs192331707       rs192405528       rs192462779       rs192515129       rs192526926       rs192731738       rs199931170       rs200003995       rs200131213       rs200140355       rs200332425       rs200392116       rs200441527       rs200448479       rs200453866       rs200524827       rs201104904       rs201172488       rs201385068       rs201508055       rs201556334       rs201675766       rs201685274       rs201844619       rs201928449       rs202012829       rs202018501       rs202119101       rs202176153       rs367700481       rs368383393       rs368546139       rs368830205       rs368907541       rs369189958       rs369338387       rs369547707       rs370008347       rs370374203       rs370593833       rs370651465       rs371316236       rs371816472       rs371856464       rs371952402       rs372597863       rs372800604       rs372972419       rs373337765       rs373456531       rs373885739       rs373974295       rs374701684       rs375070581       rs375251063       rs375252568       rs375570571       rs375655846       rs376085211       rs376131737       rs376471696       rs376544237       rs376700470       rs376786294       rs377154201       rs377243210       rs377716323       rs398033782       rs527262765       rs527288264       rs528380391       rs528866037       rs529121136       rs529204500       rs529463516       rs529595171       rs529778174       rs529820183       rs529856223       rs529982544       rs530058849       rs530083622       rs530675727       rs530765417       rs531162973       rs531284270       rs531702869       rs532027314       rs532065049       rs532085233       rs532524066       rs533516085       rs533606011       rs533643686       rs533957663       rs534092744       rs534175656       rs534444539       rs534640031       rs535095921       rs535218976       rs535367747       rs535873198       rs535914406       rs535972484       rs536299094       rs536335960       rs537000575       rs537011167       rs537043642       rs537073622       rs537160971       rs537282844       rs537403750       rs537500553       rs537658586       rs537757549       rs538080275       rs538198034       rs538932346       rs538960504       rs539362725       rs539364298       rs539953033       rs540052597       rs540077824       rs540091536       rs540302875       rs540457302       rs540490654       rs540544810       rs540621530       rs540658930       rs541016485       rs541045957       rs541150965       rs541545966       rs541747605       rs542162171       rs542971906       rs543434743       rs543476439       rs543564207       rs543567876       rs543591597       rs543765709       rs544096954       rs544108718       rs544133116       rs544310710       rs544394979       rs545325609       rs545586237       rs545623060       rs546293650       rs546588597       rs546760995       rs547329863       rs547987781       rs548074725       rs548979898       rs549018779       rs549218801       rs549223272       rs549308833       rs549468366       rs549506285       rs549625477       rs549813554       rs550391567       rs550463997       rs550591667       rs550747748       rs551390406       rs551587581       rs551619908       rs551668830       rs551737241       rs551817525       rs551821294       rs552462381       rs552495056       rs552662405       rs552909940       rs553568947       rs553603709       rs553930170       rs554097420       rs554274438       rs554280759       rs554814633       rs555246118       rs555462313       rs555477035       rs555552199       rs555785491       rs555885379       rs556048003       rs556581625       rs556665084       rs557066884       rs557418953       rs557842786       rs557878673       rs557927383       rs557941684       rs558707540       rs559449607       rs559710047       rs559948923       rs560041767       rs560550668       rs561133035       rs561149844       rs561203886       rs561395638       rs561521392       rs561532592       rs561545505       rs561580438       rs562289544       rs562397688       rs562478109       rs563251241       rs563841612       rs563944118       rs563967148       rs563982796       rs564009306       rs564329676       rs564815811       rs564842703       rs564997651       rs565081309       rs565225343       rs565286645       rs565590532       rs565957678       rs566032568       rs566033544       rs566210167       rs567152363       rs567277010       rs567283366       rs567346200       rs567372133       rs568405811       rs568536856       rs568643388       rs568688591       rs569641642       rs569650698       rs570040584       rs570413190       rs570445856       rs570991913       rs571276342       rs571329046       rs571478505       rs571489624       rs571604913       rs571754360       rs572042278       rs572167428       rs572225172       rs572409843       rs572629855       rs573070694       rs573076427       rs573251243       rs573546881       rs573725509       rs573769909       rs574193718       rs574231422       rs574660146       rs575445119       rs575587703       rs575798689       rs575833713       rs575929303       rs576467994       rs576548673       rs576584223       rs576600595       rs577264874       rs577300658       rs577652853       rs577724229       rs577982064       rs578246614       rs745362005       rs745362812       rs745450723       rs745470541       rs746238116       rs746879407       rs746923319       rs747036561       rs747211875       rs747326818       rs747465235       rs747958928       rs748132604       rs748154120       rs748297235       rs748364396       rs748559458       rs748642163       rs748803445       rs749062021       rs749098737       rs749102650       rs749651333       rs749920542       rs750177892       rs750231414       rs750246535       rs750540541       rs751007314       rs751016273       rs751688026       rs751880525       rs752152680       rs753252962       rs753412386       rs753562916       rs753673182       rs753760174       rs754099940       rs754222866       rs754562149       rs754612077       rs754652493       rs754892591       rs754985444       rs755158014       rs755169655       rs755755587       rs755905566       rs756051359       rs756103678       rs756147991       rs756705991       rs757125324       rs757251768       rs757530473       rs757770735       rs757862405       rs757978763       rs758044736       rs758068307       rs758462525       rs758469169       rs758845569       rs758856535       rs759224287       rs759659003       rs759784403       rs759979161       rs760033082       rs760071150       rs760317122       rs760467123       rs760873914       rs760995140       rs760997070       rs761087037       rs761121538       rs761374915       rs761465127       rs761505779       rs762213265       rs762434807       rs762649552       rs762791120       rs762824050       rs763030588       rs763457483       rs763843530       rs763917491       rs764102782       rs764291945       rs764402725       rs764961125       rs764992248       rs765162500       rs765181195       rs765224654       rs765480346       rs765556305       rs765817255       rs766082976       rs766314331       rs766521223       rs766779359       rs766890392       rs766998559       rs767305253       rs767664739       rs768016305       rs768056277       rs768440398       rs768861673       rs769035649       rs770028110       rs770311088       rs770350611       rs770505430       rs771264786       rs771268621       rs771464694       rs771523036       rs771608539       rs771994600       rs772153226       rs772179376       rs772708866       rs772791626       rs772986346       rs773176680       rs773652751       rs773737378       rs773846821       rs773934140       rs773938439       rs774569168       rs774762978       rs774765334       rs774889998       rs774923197       rs775556079       rs775829517       rs776321271       rs776427705       rs776472141       rs776672187       rs776720291       rs776789988       rs776912583       rs777176573       rs777657292       rs777657616       rs777772809       rs777927400       rs777949245       rs778220743       rs778404400       rs778507665       rs778522520       rs778597276       rs778720792       rs779363554       rs779480504       rs779570257       rs779654904       rs779746950       rs779913543       rs780009544       rs780104855       rs780708266       rs781072245       rs781244714       rs781250343       rs781453608       rs781517394      

FUT3基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GCCTCTCCAGATACTCTGAC
59
CAGCTGAAATAGCAGTGCG
60
CCTCTCCAGATACTCTGACC
58
AGCAGCTGAAATAGCAGTG
58
CATTTAAGATACTCTGACCCATGG
59
AGCAGCTGAAATAGCAGTG
58
GGTCCAACAGAGAAAGCAG
59
CATGGGTCAGAGTATCTTAAATGG
59
CAAACAGGCTTTGTATCTTCAG
58
AAGCTAAGCCATCATATCCC
57
CTTAGACCAGTTCGGTCCA
59
CATGGGTCAGAGTATCTTAAATGG
59
CATTTAAGATACTCTGACCCATGG
59
CAGCAGCTGAAATAGCAGTG
60
CAAACAGGCTTTGTATCTTCAG
58
CCAAGCTAAGCCATCATATCC
59
GTCCAACAGAGAAAGCAGG
59
CATGGGTCAGAGTATCTTAAATGG
59
CAAACAGGCTTTGTATCTTCAG
58
CAAGCTAAGCCATCATATCCC
59
      尚未收录相关数据

FUT3基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

FUT3基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0006486
K7ENT3(UniProtKB)
IEA
GO:0008417
K7ENT3(UniProtKB)
IEA
GO:0016021
K7ENT3(UniProtKB)
IEA
GO:0036065
K7ENT3(UniProtKB)
IEA
GO:0006486
K7EQ20(UniProtKB)
IEA
GO:0008417
K7EQ20(UniProtKB)
IEA
GO:0016021
K7EQ20(UniProtKB)
IEA
GO:0036065
K7EQ20(UniProtKB)
IEA
GO:0006486
K7ES24(UniProtKB)
IEA
GO:0008417
K7ES24(UniProtKB)
IEA
GO:0016021
K7ES24(UniProtKB)
IEA
GO:0036065
K7ES24(UniProtKB)
IEA
GO:0000139
P21217(UniProtKB)
TAS
GO:0006486
P21217(UniProtKB)
IEA
GO:0008417
P21217(UniProtKB)
IDA
GO:0009312
P21217(UniProtKB)
IDA
GO:0009988
P21217(UniProtKB)
IC
GO:0016020
P21217(UniProtKB)
IDA
GO:0016021
P21217(UniProtKB)
IEA
GO:0017060
P21217(UniProtKB)
TAS
GO:0032580
P21217(UniProtKB)
IEA
GO:0036065
P21217(UniProtKB)
IEA
GO:0036065
P21217(UniProtKB)
IEA
GO:0036065
P21217(UniProtKB)
IEA
GO:0043413
P21217(UniProtKB)
IDA
GO:0043413
P21217(UniProtKB)
IDA
GO:0046920
P21217(UniProtKB)
IDA
GO:0070062
P21217(UniProtKB)
IDA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控FUT3基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Helicobacter pylori infection 0.007372538 4 0 BeFree_GAD
Carotid Atherosclerosis 0.004734064 2 0 GAD
Neoplasm Metastasis 0.00272435 1 0 LHGDN
Infection 0.00272435 1 0 LHGDN
Malignant neoplasm of stomach 0.002638474 2 0 BeFree_GAD
Asthma 0.002367032 1 0 GAD
Malignant neoplasm of breast 0.002367032 1 0 GAD
Cardiovascular Diseases 0.002367032 1 0 GAD
Cystic Fibrosis 0.002367032 1 0 GAD
Obesity 0.002367032 1 0 GAD
Pseudomonas Infections 0.002367032 1 0 GAD
Enteritis due to Norovirus 0.002367032 1 0 GAD
Colon Carcinoma 0.000542884 2 0 BeFree
Colorectal Carcinoma 0.000271442 1 0 BeFree
Crohn Disease 0.000271442 1 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
leukemia 0.000271442 1 0 BeFree
Lung diseases 0.000271442 1 0 BeFree
melanoma 0.000271442 1 0 BeFree
Pancreatic Neoplasm 0.000271442 1 0 BeFree
Respiration Disorders 0.000271442 1 0 BeFree
Respiratory Tract Diseases 0.000271442 1 0 BeFree
Cholangiocarcinoma 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Malignant neoplasm of pancreas 0.000271442 1 0 BeFree
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 0.000271442 1 0 BeFree
Primary sclerosing cholangitis 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Stomach Carcinoma 0.000271442 1 0 BeFree
Colorectal cancer metastatic 0.000271442 1 0 BeFree
Colorectal Cancer 0.000271442 1 0 BeFree
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