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The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  刘易斯组织相容血型系统包括一组由外分泌腺上皮细胞合成和体液循环岩藻糖化鞘糖脂。的鞘糖脂在胚胎发生,组织分化,肿瘤转移,炎症,与细菌粘附的作用。它们被二次吸收到血红细胞引起他们的刘易斯表型。此基因是岩藻糖转移家族,其催化在加入岩藻糖的前体多糖在路易斯抗原生物合成的最后步骤中的一员。它编码具有α(1,3)-fucosyltransferase和α(1,4)-fucosyltransferase活动的酶。在这个基因的突变是负责多数路易斯抗原阴性表型。多个可变剪接变体,编码相同的蛋白质,已发现这种基因。 [由RefSeq的,2008年7月提供]
FUT3基因(以及对应的蛋白质)的细胞分布位置:
FUT3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Helicobacter pylori infection | 0.007372538 | 4 | 0 | BeFree_GAD |
Carotid Atherosclerosis | 0.004734064 | 2 | 0 | GAD |
Neoplasm Metastasis | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of stomach | 0.002638474 | 2 | 0 | BeFree_GAD |
Asthma | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of breast | 0.002367032 | 1 | 0 | GAD |
Cardiovascular Diseases | 0.002367032 | 1 | 0 | GAD |
Cystic Fibrosis | 0.002367032 | 1 | 0 | GAD |
Obesity | 0.002367032 | 1 | 0 | GAD |
Pseudomonas Infections | 0.002367032 | 1 | 0 | GAD |
Enteritis due to Norovirus | 0.002367032 | 1 | 0 | GAD |
Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Lung diseases | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Respiration Disorders | 0.000271442 | 1 | 0 | BeFree |
Respiratory Tract Diseases | 0.000271442 | 1 | 0 | BeFree |
Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Primary sclerosing cholangitis | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colorectal cancer metastatic | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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