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This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因属于亚科叉头框(FOX)转录因子家族的P上。叉头框转录因子在组织 - 和细胞类型特异性基因转录的发展和成年期的调节中起重要作用。叉头框P1蛋白含有两个DNA的binding-和蛋白质 - 蛋白质结合域。因为它是在一些肿瘤类型和地图输给(3p14.1)报道含有肿瘤抑制基因(多个)的染色体区域该基因可作为肿瘤抑制作用。在多个转录剪接变异体导致编码不同亚型。 [由RefSeq的,2008年7月提供]
FOXP1基因(以及对应的蛋白质)的细胞分布位置:
FOXP1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES | 0.24 | 0 | 0 | CTD_human_ORPHANET |
Vitiligo | 0.122367032 | 1 | 0 | CTD_human_GAD |
Child Development Disorders, Pervasive | 0.12 | 1 | 0 | CTD_human |
Lymphatic Metastasis | 0.12 | 1 | 0 | CTD_human |
Neoplasm Invasiveness | 0.12 | 1 | 0 | CTD_human |
Pancreatic Neoplasm | 0.12 | 1 | 0 | CTD_human |
Adenocarcinoma Of Esophagus | 0.12 | 1 | 0 | CTD_human |
MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND AUTISTIC FEATURES | 0.12 | 0 | 8 | CLINVAR |
Juvenile arthritis | 0.12 | 1 | 0 | CTD_human |
LEUKEMIA, ACUTE LYMPHOBLASTIC, SUSCEPTIBILITY TO, 3 | 0.12 | 0 | 0 | ORPHANET |
B-Cell Lymphomas | 0.015250402 | 10 | 0 | BeFree_LHGDN |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.008977445 | 13 | 0 | BeFree_LHGDN |
Lymphoma | 0.007891677 | 10 | 0 | BeFree_LHGDN |
Mammary Neoplasms | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Diffuse Large B-Cell Lymphoma | 0.005700279 | 21 | 0 | BeFree |
Anoxia | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of breast | 0.002442977 | 9 | 0 | BeFree |
Breast Carcinoma | 0.002442977 | 9 | 0 | BeFree |
Apraxias | 0.002367032 | 1 | 0 | GAD |
Behcet Syndrome | 0.002367032 | 1 | 8 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Attention deficit hyperactivity disorder | 0.002367032 | 1 | 1 | GAD |
Trisomy | 0.001628651 | 6 | 0 | BeFree |
Neoplasm Metastasis | 0.001357209 | 5 | 0 | BeFree |
Autistic Disorder | 0.001085767 | 4 | 0 | BeFree |
Carcinogenesis | 0.001085767 | 4 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000814326 | 3 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
Leukemogenesis | 0.000814326 | 3 | 0 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Sarcoma | 0.000814326 | 3 | 0 | BeFree |
Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
Cognition Disorders | 0.000542884 | 2 | 0 | BeFree |
Speech and language disorder | 0.000542884 | 2 | 0 | BeFree |
Language Disorders | 0.000542884 | 2 | 0 | BeFree |
Mental Retardation | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Soft Tissue Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Speech Disorders | 0.000542884 | 2 | 0 | BeFree |
Speech Delay | 0.000542884 | 2 | 0 | BeFree |
Malignant Bone Neoplasm | 0.000542884 | 2 | 0 | BeFree |
Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Primary Cutaneous Follicle Center Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Gastric Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Autism Spectrum Disorders | 0.000542884 | 2 | 0 | BeFree |
Diaphyseal medullary stenosis with malignant fibrous histiocytoma | 0.000542884 | 2 | 0 | BeFree |
Intellectual Disability | 0.000542884 | 2 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Congenital Heart Defects | 0.000271442 | 1 | 0 | BeFree |
Atrial Septal Defects | 0.000271442 | 1 | 0 | BeFree |
Hodgkin Disease | 0.000271442 | 1 | 0 | BeFree |
Huntington Disease | 0.000271442 | 1 | 0 | BeFree |
Immune System Diseases | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
liposarcoma | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Non-Hodgkin | 0.000271442 | 1 | 0 | BeFree |
Myeloproliferative disease | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Stomach Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Thromboangiitis Obliterans | 0.000271442 | 1 | 0 | BeFree |
Peripheral T-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Hypoplastic Left Heart Syndrome | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
adult soft tissue sarcoma | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Conventional (Clear Cell) Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
secondary acute myeloid leukemia | 0.000271442 | 1 | 0 | BeFree |
Primary central nervous system lymphoma | 0.000271442 | 1 | 0 | BeFree |
Insulin-dependent diabetes mellitus secretory diarrhea syndrome | 0.000271442 | 1 | 0 | BeFree |
Atrioventricular septal defect and common atrioventricular junction | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Obsessive compulsive behavior | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Apraxia, Developmental Verbal | 0.000271442 | 1 | 0 | BeFree |
Familial Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
ovarian neoplasm | 0.000271442 | 1 | 0 | BeFree |
Chronic myeloproliferative disorder | 0.000271442 | 1 | 0 | BeFree |
Generalized vitiligo | 0.000271442 | 1 | 0 | BeFree |
Hereditary Nonpolyposis Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Marginal Zone B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Liposarcoma, well differentiated | 0.000271442 | 1 | 0 | BeFree |
ATRIOVENTRICULAR CANAL DEFECT | 0.000271442 | 1 | 0 | BeFree |
Atrioventricular Septal Defect | 0.000271442 | 1 | 0 | BeFree |
Neurodevelopmental Disorders | 0.000271442 | 1 | 0 | BeFree |
Bone Sarcoma | 0.000271442 | 1 | 0 | BeFree |
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