FOXA2(forkhead box A2)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

20p11
基因染色体位置图

基因简述

基因简述

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

[中文简述(自动翻译):]  该基因编码的叉头类DNA结合蛋白中的一员。这些肝细胞核因子是肝特异性基因如白蛋白和转甲状腺素转录激活，它们也与染色质相互作用。在小鼠中类似的家庭成员在代谢的调节，并在胰腺和肝的分化作用。该基因已被链接到年轻的成年发病型糖尿病的散发病例。编码不同亚型的变种成绩单已经确定了这个基因。 [由RefSeq的，2008年10月提供]

OMIM数据库中对FOXA2基因的介绍     Wikipedia数据库中对FOXA2基因的介绍

基因序列

基因序列

FOXA2基因的碱基序列：[NCBI]

基因突变

基因突变

FOXA2基因的碱基突变：           显示全部snp
rs1974       rs1055080       rs1203908       rs1203909       rs1203910       rs1203911       rs1203912       rs1209523       rs1212275       rs1337918       rs1800847       rs2277764       rs3833331       rs6048206       rs6113724       rs7351141       rs58717509       rs66483039       rs72470548       rs72470549       rs72470550       rs72470551       rs72470552       rs72470553       rs72470554       rs72470555       rs72470556       rs72470557       rs72470558       rs72470559       rs72470560       rs72470561       rs74388871       rs76255908       rs76417740       rs79530716       rs111405491      
rs112357559       rs112780671       rs113453999       rs113880581       rs113980200       rs114117965       rs116351363       rs116754279       rs137956508       rs138675916       rs139011032       rs139031966       rs139156578       rs140377203       rs140650149       rs140746447       rs141031822       rs141207172       rs141305468       rs142879151       rs144279222       rs144565456       rs144613529       rs145128227       rs145951708       rs146538183       rs147214296       rs147303608       rs147876848       rs148876337       rs148944490       rs149455805       rs149723917       rs149977159       rs150761586       rs150786045       rs151082119       rs151323690       rs183397804       rs183473625       rs183487574       rs184802720       rs186146393       rs186945948       rs186961015       rs187289759       rs188098326       rs189528498       rs189843959       rs190376369       rs190862458       rs192713078       rs199654135       rs199678088       rs199796119       rs200013287       rs200064227       rs200122483       rs200211848       rs200275849       rs200305574       rs200457711       rs200459003       rs200785320       rs200818750       rs200852135       rs200967462       rs200970860       rs201077294       rs201279073       rs201350646       rs201700439       rs201834142       rs201902165       rs201904776       rs202105409       rs202108779       rs367765231       rs369254349       rs369460581       rs370372046       rs370472927       rs370688536       rs370745578       rs370902087       rs371100879       rs371309076       rs372510372       rs372655549       rs372706266       rs372773557       rs373349797       rs373835404       rs374444990       rs374581893       rs374693904       rs374765423       rs375272681       rs375662176       rs375732034       rs375739739       rs376057692       rs376209663       rs376256662       rs377010140       rs377224269       rs527454054       rs527996235       rs528733192       rs529080992       rs529563054       rs529738395       rs530403490       rs530463577       rs531983388       rs532048447       rs532824108       rs533193071       rs533268768       rs534093428       rs534233854       rs534432180       rs534577829       rs534816386       rs535137409       rs535747395       rs536752861       rs537617611       rs537681032       rs537901259       rs538209864       rs538273157       rs538410692       rs538965220       rs539405235       rs539469065       rs540114241       rs541700224       rs542016336       rs542253305       rs542462923       rs542480721       rs542677507       rs542768573       rs542911250       rs543093659       rs543368695       rs543700200       rs543763169       rs545907201       rs546245594       rs546281811       rs546374465       rs546892140       rs547223520       rs547290652       rs547427388       rs547785059       rs548377429       rs548947704       rs549242685       rs549659594       rs549782130       rs550144677       rs550869341       rs551961134       rs552151528       rs552885152       rs553430638       rs553735261       rs553952300       rs554089078       rs554282736       rs554541466       rs555014032       rs555416014       rs556149376       rs556204459       rs556267281       rs556684561       rs557266912       rs557625028       rs557999207       rs558338567       rs558508968       rs559246060       rs559555474       rs559620996       rs559960427       rs560224517       rs560551728       rs561404961       rs562210295       rs562230926       rs562261138       rs562309598       rs563307220       rs563368757       rs563473069       rs564808735       rs564870112       rs565350443       rs565657865       rs565865865       rs566278415       rs566947189       rs568239960       rs568354595       rs568698697       rs569532601       rs569643068       rs569658000       rs569704676       rs570393099       rs570531300       rs570815274       rs571330298       rs572936417       rs573040510       rs573681680       rs574332953       rs574940917       rs575003775       rs575184474       rs575696318       rs576158499       rs576219104       rs576415462       rs576811306       rs577864868       rs577928747       rs577997601       rs745424789       rs745498650       rs745674979       rs745684613       rs745785942       rs745915278       rs746203062       rs746278450       rs746347217       rs746486260       rs746533493       rs746537555       rs746665789       rs746804024       rs747169418       rs747174796       rs747616574       rs747671628       rs747926313       rs748047644       rs748052515       rs748219243       rs748287662       rs748482202       rs748535239       rs748700386       rs749146776       rs749322241       rs749328515       rs749671701       rs749880587       rs750224836       rs750349218       rs750595455       rs750648594       rs750714622       rs750729464       rs751374316       rs751442261       rs751531721       rs751743415       rs751798478       rs752200690       rs752266641       rs752325199       rs752425171       rs752547674       rs753174581       rs753223729       rs753457285       rs753634683       rs753849283       rs754143212       rs754267975       rs754322875       rs754565884       rs754831973       rs754852639       rs755036513       rs755340142       rs755715343       rs756072603       rs756333092       rs756389581       rs756462005       rs756505230       rs756558691       rs756818226       rs756979765       rs757177085       rs757447343       rs757492186       rs757587272       rs757617228       rs758030793       rs758059957       rs758106702       rs758223832       rs758275197       rs758430055       rs758482850       rs758986166       rs759347671       rs759593310       rs759791855       rs759947849       rs759975608       rs760318416       rs760393465       rs760742754       rs760812511       rs760939505       rs761326049       rs761452163       rs761515313       rs761794530       rs761992311       rs762402710       rs762454139       rs762472615       rs762504396       rs763153872       rs763183408       rs763214832       rs763384130       rs763407064       rs763459424       rs763486846       rs763538618       rs763824541       rs763973385       rs764471884       rs764618950       rs764677040       rs764708032       rs765012987       rs765065964       rs765327451       rs765460718       rs765489023       rs765611813       rs765684208       rs765778841       rs765955954       rs766193461       rs766284272       rs766301853       rs766433993       rs766470566       rs766523990       rs766824188       rs767212576       rs767367100       rs767446616       rs767588191       rs767606002       rs767670886       rs767701070       rs768134616       rs768194412       rs768259668       rs768704026       rs768920290       rs769039037       rs769189984       rs769250523       rs769397287       rs769555276       rs769791749       rs769823311       rs769846491       rs770347016       rs770425793       rs770545932       rs770661422       rs771348577       rs771400505       rs771404959       rs771549316       rs771672049       rs772066333       rs772248551       rs772278013       rs772587345       rs772638884       rs772749987       rs772938809       rs773082912       rs773099906       rs773232660       rs773339023       rs773365412       rs773719307       rs773886523       rs773892259       rs773948952       rs774135723       rs774809716       rs774841083       rs774892375       rs775025069       rs775128451       rs775317324       rs775402453       rs775592057       rs775662539       rs775715069       rs775862541       rs776215689       rs776381227       rs776556211       rs776611261       rs776729449       rs776794043       rs777187102       rs777253855       rs777271879       rs777307731       rs777695135       rs777713858       rs777960503       rs778171681       rs778382712       rs778436499       rs778622651       rs778660365       rs778852896       rs778855332       rs778913511       rs779405437       rs779707130       rs780074827       rs780089828       rs780546461       rs780746036       rs781041744       rs781117288       rs781511903       rs781573020       rs781573160       rs781582856       rs781618461       rs781660247      

基因表达

基因表达

FOXA2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CGAGTTAAAGTATGCTGGGAG
59
GTTCATGTTGCTCACGGAG
59
GAGTTAAAGTATGCTGGGAGC
59
GTTCATGTTGCTCACGGAG
59
AGCAGCTACTATGCAGAGC
60
GTGTTCATGCCGTTCATCC
60
CTACTATGCAGAGCCCGAG
60
GTGTTCATGCCGTTCATCC
60
GCGAGTTAAAGTATGCTGGG
59
GTTCATGTTGCTCACGGAG
59
CTACTATGCAGAGCCCGAG
60
CATGTACGTGTTCATGCCG
60

转录因子

转录因子

转录因子
影响类型
PubMed链接
ABCA1
Repression
24807696
AGR2
Unknown
16222343
APOA1
Unknown
7961760
CDH1
Activation
20160041
CFTR
Repression
24440874
COL18A1
Unknown
11093745
GCG
Unknown
15828872
GFER
Unknown
20382118
MMP7
Activation
22268124
NKX2-1
Unknown
23358112

基因本体信息

FOXA2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

FOXA2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000432
Q9Y261(UniProtKB)
ISS
GO:0000433
Q9Y261(UniProtKB)
ISS
GO:0000978
Q9Y261(UniProtKB)
IDA
GO:0000981
Q9Y261(UniProtKB)
IBA
GO:0001708
Q9Y261(UniProtKB)
ISS
GO:0003677
Q9Y261(UniProtKB)
IDA
GO:0003700
Q9Y261(UniProtKB)
IDA
GO:0003700
Q9Y261(UniProtKB)
IDA
GO:0003700
Q9Y261(UniProtKB)
IDA
GO:0005634
Q9Y261(UniProtKB)
IDA
GO:0005634
Q9Y261(UniProtKB)
IDA
GO:0005634
Q9Y261(UniProtKB)
IDA
GO:0005654
Q9Y261(UniProtKB)
IDA
GO:0005737
Q9Y261(UniProtKB)
IEA
GO:0006351
Q9Y261(UniProtKB)
IEA
GO:0006357
Q9Y261(UniProtKB)
IDA
GO:0008134
Q9Y261(UniProtKB)
IEA
GO:0008344
Q9Y261(UniProtKB)
ISS
GO:0010719
Q9Y261(UniProtKB)
IMP
GO:0016568
Q9Y261(UniProtKB)
IEA
GO:0019904
Q9Y261(UniProtKB)
IEA
GO:0030054
Q9Y261(UniProtKB)
IDA
GO:0030193
Q9Y261(UniProtKB)
IDA
GO:0031018
Q9Y261(UniProtKB)
IDA
GO:0033132
Q9Y261(UniProtKB)
ISS
GO:0040019
Q9Y261(UniProtKB)
ISS
GO:0043433
Q9Y261(UniProtKB)
IMP
GO:0044212
Q9Y261(UniProtKB)
IMP
GO:0045893
Q9Y261(UniProtKB)
ISS
GO:0045893
Q9Y261(UniProtKB)
IDA
GO:0045944
Q9Y261(UniProtKB)
IDA
GO:0045944
Q9Y261(UniProtKB)
IDA
GO:0045944
Q9Y261(UniProtKB)
TAS
GO:0061178
Q9Y261(UniProtKB)
ISS
GO:0070741
Q9Y261(UniProtKB)
TAS
GO:0071542
Q9Y261(UniProtKB)
ISS
GO:0071542
Q9Y261(UniProtKB)
IGI
GO:0071542
Q9Y261(UniProtKB)
TAS
GO:0090009
Q9Y261(UniProtKB)
ISS
GO:2000049
Q9Y261(UniProtKB)
IC
GO:2000543
Q9Y261(UniProtKB)
ISS
GO:2000971
Q9Y261(UniProtKB)
ISS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控FOXA2基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Lung diseases 0.120542884 3 0 BeFree_CTD_human
Diaphragmatic Hernia 0.12 1 0 CTD_human
Diabetes Mellitus, Experimental 0.08 1 0 RGD
Diabetes Mellitus, Non-Insulin-Dependent 0.008186863 6 1 BeFree_GAD
Liver carcinoma 0.007077352 7 1 BeFree_LHGDN
Neoplasm Metastasis 0.003810118 5 0 BeFree_LHGDN
Prostatic Neoplasms 0.002995792 2 0 BeFree_LHGDN
Lung Neoplasms 0.00272435 1 0 LHGDN
Thyroid Neoplasm 0.00272435 1 0 LHGDN
Malignant neoplasm of lung 0.001357209 5 0 BeFree
Carcinoma of lung 0.001357209 5 0 BeFree
Diabetes Mellitus 0.001085767 4 0 BeFree
Diabetes 0.000814326 3 0 BeFree
Liver neoplasms 0.000814326 3 0 BeFree
Non-Small Cell Lung Carcinoma 0.000542884 2 0 BeFree
Papillary thyroid carcinoma 0.000542884 2 0 BeFree
Maturity onset diabetes mellitus in young 0.000542884 2 0 BeFree
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Secondary malignant neoplasm of liver 0.000542884 2 0 BeFree
Carcinogenesis 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Adenovirus Infections 0.000271442 1 0 BeFree
Biliary Atresia 0.000271442 1 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Cholestasis 0.000271442 1 0 BeFree
Hepatitis C 0.000271442 1 0 BeFree
Hypoglycemia 0.000271442 1 0 BeFree
Liver diseases 0.000271442 1 0 BeFree
Malignant neoplasm of stomach 0.000271442 1 0 BeFree
Respiratory Distress Syndrome, Newborn 0.000271442 1 0 BeFree
Respiratory Distress Syndrome, Adult 0.000271442 1 0 BeFree
Supernumerary structure 0.000271442 1 0 BeFree
Holoprosencephaly 0.000271442 1 0 BeFree
Adenocarcinoma of lung (disorder) 0.000271442 1 0 BeFree
Carcinoma, Neuroendocrine 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Parkinsonian Disorders 0.000271442 1 0 BeFree
Carcinoma, Small Cell 0.000271442 1 0 BeFree
Psoriasis vulgaris 0.000271442 1 0 BeFree
Non-small cell lung cancer stage I 0.000271442 1 0 BeFree
Malignant neoplasm of pancreas 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Stomach Carcinoma 0.000271442 1 0 BeFree
AICARDI-GOUTIERES SYNDROME 1 0.000271442 1 0 BeFree
Pancreatic Ductal Adenocarcinoma 0.000271442 1 0 BeFree
Idiopathic Pulmonary Fibrosis 0.000271442 1 0 BeFree
Tumor thrombus 0.000271442 1 0 BeFree

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