FOSB(FBJ murine osteosarcoma viral oncogene homolog B) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

19q13.3
基因染色体位置图

基因简述

基因简述

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  果寡糖基因家族由4名成员：FOS，FOSB，FOSL1和FOSL2。这些基因编码亮氨酸拉链蛋白可与君家的蛋白质二聚化，由此形成的转录因子复合的AP-1。因此，FOS蛋白质有牵连的细胞增殖，分化和转型的监管。已发现该基因编码不同亚型选择性剪接转录变异体。 [由RefSeq的，2008年7月提供]

OMIM数据库中对FOSB基因的介绍     Wikipedia数据库中对FOSB基因的介绍

基因序列

基因序列

FOSB基因的碱基序列：[NCBI]

基因突变

基因突变

FOSB基因的碱基突变：           显示全部snp
rs708905       rs1049698       rs1049739       rs2238686       rs2238687       rs2276469       rs2276470       rs2276471       rs2276472       rs2282695       rs2282696       rs3170167       rs3745823       rs3831491       rs7254815       rs7259071       rs8105114       rs8105215       rs8106229       rs8106233       rs10409841       rs10418787       rs10422572       rs10424098       rs11351764       rs11667571       rs11669290       rs11879597       rs11883164       rs12373537       rs12373539       rs12976374       rs12981557       rs28381232       rs28381233       rs28381235       rs28381236      
rs28381238       rs28381240       rs28381241       rs28381242       rs28381243       rs28381244       rs28381245       rs28381246       rs28381248       rs28381249       rs28381250       rs28381251       rs28381252       rs28381253       rs28381254       rs28381256       rs28381257       rs28381258       rs35242315       rs61733034       rs71173169       rs75189353       rs75319348       rs75390744       rs76249776       rs79032665       rs80242739       rs111312356       rs111411487       rs112149154       rs112253787       rs112371022       rs112625502       rs112794606       rs113086620       rs113384471       rs113934205       rs114250073       rs114866797       rs115437495       rs117444248       rs138699411       rs138817324       rs139180415       rs139625208       rs139690880       rs140974539       rs141121721       rs141764521       rs141778900       rs141909144       rs142005387       rs142759290       rs143428660       rs143685181       rs143780767       rs144221381       rs145894646       rs146831032       rs147923411       rs148041336       rs148726219       rs149170403       rs149541859       rs150599541       rs151094566       rs151110067       rs180805984       rs181480013       rs181925554       rs182040453       rs182368932       rs183004663       rs183683887       rs183864575       rs184887371       rs185438190       rs185622092       rs186929638       rs186967260       rs187428431       rs188565925       rs188638035       rs189572300       rs189709199       rs190387856       rs191177225       rs191328623       rs191860005       rs193160252       rs199545211       rs199730181       rs199733739       rs200272813       rs200371207       rs200410840       rs200557023       rs200872647       rs201050620       rs201053280       rs201193101       rs201294335       rs201439992       rs201701616       rs201846388       rs367686004       rs368966279       rs369628703       rs369737369       rs370113314       rs370863132       rs371084751       rs371137679       rs371169660       rs371768649       rs373321658       rs373485658       rs373493006       rs373545463       rs374007605       rs374808183       rs375068388       rs375547267       rs375983768       rs376423315       rs376625825       rs376676928       rs377014678       rs377466585       rs377657527       rs386574800       rs397844284       rs527750483       rs527858149       rs528019523       rs528131229       rs529194837       rs529279990       rs529339302       rs529680505       rs530511067       rs531694209       rs531713725       rs531897613       rs532954805       rs533059766       rs533302849       rs534208061       rs534464530       rs534585835       rs534784061       rs534985558       rs535096337       rs535399405       rs535620027       rs535725888       rs536218013       rs536815683       rs536924286       rs537404510       rs537914250       rs538143863       rs538286906       rs538403365       rs538721748       rs538785711       rs539706283       rs539968790       rs540010353       rs540948251       rs540969173       rs540991822       rs541377987       rs541568011       rs541592076       rs542156920       rs542565199       rs542625196       rs542750048       rs543938118       rs544897710       rs545094879       rs545204875       rs545320315       rs545344742       rs546212112       rs546791434       rs547100844       rs547406568       rs547681081       rs547688654       rs547906117       rs547982816       rs548097982       rs548137404       rs548989365       rs549175410       rs549323954       rs549520778       rs550358027       rs550370472       rs550529588       rs550960447       rs551580118       rs552020498       rs552342283       rs553352895       rs553737061       rs553864889       rs554331477       rs554418888       rs554479744       rs556206424       rs556265458       rs556327800       rs556504903       rs557145094       rs557513574       rs558463210       rs558477433       rs558649814       rs558682903       rs558902808       rs559123414       rs561210612       rs561392151       rs561406345       rs561524304       rs561589914       rs561978912       rs562587140       rs562610786       rs562730286       rs563878127       rs564285352       rs565378137       rs565454022       rs565463251       rs565730221       rs566612481       rs566646303       rs566758017       rs567304238       rs567628685       rs568499235       rs569151414       rs569163519       rs569194300       rs569688162       rs569708880       rs569980426       rs570937964       rs571301313       rs572304075       rs572499896       rs572649003       rs573196315       rs573268378       rs573849451       rs574923439       rs575005572       rs575114511       rs575202482       rs575297539       rs575549869       rs576160627       rs576246538       rs576470691       rs576742545       rs577393939       rs577604524       rs745401709       rs745562190       rs745617183       rs745798308       rs745855821       rs745875857       rs745901268       rs745962748       rs746410570       rs746697548       rs746820250       rs747027527       rs747119132       rs747281726       rs747640609       rs747823029       rs748248206       rs748425009       rs748545757       rs748736781       rs749291738       rs749313484       rs749563560       rs749597105       rs749866817       rs750349108       rs750680838       rs750762281       rs750995591       rs751040909       rs751240838       rs751335932       rs751556188       rs751608508       rs751752030       rs752214866       rs752373668       rs752395674       rs753121228       rs753320428       rs753462057       rs753553559       rs753818215       rs754164038       rs754172567       rs754363313       rs754434097       rs754523147       rs754820891       rs754837542       rs755048094       rs755244213       rs755291526       rs755948096       rs756010568       rs756161522       rs756210224       rs756602173       rs756849216       rs757024921       rs757176467       rs757460485       rs757689027       rs757705336       rs758176585       rs758443162       rs758600513       rs758698866       rs759110123       rs759281171       rs759880826       rs760245782       rs760266207       rs760716088       rs761208292       rs761211176       rs761262027       rs761585649       rs761597992       rs761975465       rs761991824       rs762369398       rs762678812       rs762720075       rs762770823       rs763158611       rs763363699       rs763411269       rs763759245       rs763989936       rs764116136       rs764395863       rs764539570       rs764998811       rs765482245       rs765484965       rs765687773       rs765713415       rs765969336       rs766364504       rs766662878       rs767097253       rs767123321       rs767156252       rs767173866       rs767297819       rs767513903       rs767756271       rs768081935       rs768255804       rs768386636       rs768599286       rs769317042       rs769555024       rs769683485       rs770103371       rs770486135       rs770554619       rs770818762       rs770893486       rs771108595       rs771236220       rs771687459       rs771817357       rs772195249       rs772247352       rs772457572       rs772711901       rs772945206       rs773011979       rs773139483       rs773377788       rs773764980       rs773872677       rs773891265       rs774021377       rs774633839       rs774657495       rs775259642       rs775272926       rs775295136       rs775664954       rs775746050       rs776235889       rs776424714       rs776431088       rs776560560       rs776993243       rs777580880       rs777606622       rs777674537       rs778135128       rs778331108       rs778439854       rs778453863       rs778720566       rs778997217       rs779006789       rs779388830       rs780157288       rs780174960       rs780193148       rs780414670       rs780887411       rs780890753       rs781290122       rs781723460       rs781772652      

基因表达

基因表达

FOSB基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GCAGCTAAATGCAGGAACC
60
TCCTCCAACTGATCTGTCTC
59
GCCGAGTCTCAATATCTGTC
58
CAACTGATCTGTCTCCTGG
57
TATCTGTCTTCGGTGGACTC
59
ATGGAAGAGATGAGGGTGG
59
GCAGCTAAATGCAGGAACC
60
TCCTCCAACTGATCTGTCTC
59
CAGCTAAATGCAGGAACCG
59
TCCTCCAACTGATCTGTCTC
59
ATGAGTGGCTACAGCAGTG
60
CGCTTCTCCTCTTCCTCTG
60
ATGAGTGGCTACAGCAGTG
60
AACTGATCTGTCTCCGTCTC
59
GGAGACAGATCAGTTGGAGG
60
AGGACTTGAACTTCCTCCG
59
TCTGCCGAGTCTCAATATCTG
60
CTGATCTGTCTCCTGGGAG
59
AACGTCTGGAGTTTGTGCT
60
AGGACTTGAACTTCCTCCG
59

转录因子

转录因子

转录因子
影响类型
PubMed链接
CXCL8
Activation
20826776
TGFB1
Unknown
10843986
TIMP1
Repression
11337499
TIMP1
Unknown
10051488

基因本体信息

FOSB基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

FOSB基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003677
K7EJ89(UniProtKB)
IEA
GO:0003700
K7EJ89(UniProtKB)
IEA
GO:0005634
K7EJ89(UniProtKB)
IEA
GO:0006357
K7EJ89(UniProtKB)
IEA
GO:0003700
K7EKA0(UniProtKB)
IEA
GO:0005634
K7EKA0(UniProtKB)
IEA
GO:0006357
K7EKA0(UniProtKB)
IEA
GO:0043565
K7EKA0(UniProtKB)
IEA
GO:0003700
K7EKC1(UniProtKB)
IEA
GO:0005634
K7EKC1(UniProtKB)
IEA
GO:0006357
K7EKC1(UniProtKB)
IEA
GO:0043565
K7EKC1(UniProtKB)
IEA
GO:0003700
K7ERZ8(UniProtKB)
IEA
GO:0005634
K7ERZ8(UniProtKB)
IEA
GO:0006357
K7ERZ8(UniProtKB)
IEA
GO:0043565
K7ERZ8(UniProtKB)
IEA
GO:0000122
P53539(UniProtKB)
TAS
GO:0000978
P53539(UniProtKB)
IBA
GO:0000982
P53539(UniProtKB)
IBA
GO:0001077
P53539(UniProtKB)
IEA
GO:0003677
P53539(UniProtKB)
TAS
GO:0005634
P53539(UniProtKB)
IBA
GO:0006366
P53539(UniProtKB)
IEA
GO:0007565
P53539(UniProtKB)
IEA
GO:0008134
P53539(UniProtKB)
TAS
GO:0009612
P53539(UniProtKB)
IEA
GO:0032570
P53539(UniProtKB)
IEA
GO:0032870
P53539(UniProtKB)
IEA
GO:0042493
P53539(UniProtKB)
IEA
GO:0043278
P53539(UniProtKB)
IEA
GO:0045944
P53539(UniProtKB)
IEA
GO:0051412
P53539(UniProtKB)
IEA
GO:0051591
P53539(UniProtKB)
IEA
GO:0071277
P53539(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控FOSB基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Dyskinesia, Drug-Induced 0.12 1 0 CTD_human
Epilepsy 0.12 1 0 CTD_human
Disruptive, Impulse Control, and Conduct Disorders 0.12 1 0 CTD_human
Movement Disorders 0.12 1 0 CTD_human
Cocaine-Related Disorders 0.12 4 0 CTD_human
Juvenile arthritis 0.12 1 0 CTD_human
Carcinogenesis 0.006514605 24 0 BeFree
Malignant neoplasm of breast 0.004071628 15 0 BeFree
Breast Carcinoma 0.003800186 14 0 BeFree
Prostate carcinoma 0.002714419 10 0 BeFree
Malignant neoplasm of prostate 0.002442977 9 0 BeFree
Autistic Disorder 0.002367032 1 0 GAD
Liver carcinoma 0.002171535 8 0 BeFree
Colorectal Cancer 0.001900093 7 0 BeFree
Asthma 0.001628651 6 0 BeFree
Colorectal Carcinoma 0.001628651 6 0 BeFree
Malignant tumor of colon 0.001357209 5 0 BeFree
melanoma 0.001357209 5 0 BeFree
Colon Carcinoma 0.001357209 5 0 BeFree
Stomach Carcinoma 0.001357209 5 0 BeFree
Liver neoplasms 0.001085767 4 0 BeFree
Neoplasm Metastasis 0.001085767 4 0 BeFree
Tumor Promotion 0.001085767 4 0 BeFree
Malignant neoplasm of urinary bladder 0.000814326 3 0 BeFree
Dermatitis, Atopic 0.000814326 3 0 BeFree
Eczema 0.000814326 3 0 BeFree
Glioma 0.000814326 3 0 BeFree
Leukemia, Myelocytic, Acute 0.000814326 3 0 BeFree
Adult T-Cell Lymphoma/Leukemia 0.000814326 3 0 BeFree
Lupus Erythematosus, Systemic 0.000814326 3 0 BeFree
Malignant neoplasm of stomach 0.000814326 3 0 BeFree
Pancreatic carcinoma 0.000814326 3 0 BeFree
Cervix carcinoma 0.000814326 3 0 BeFree
Malignant neoplasm of pancreas 0.000814326 3 0 BeFree
Carcinoma of bladder 0.000814326 3 0 BeFree
Rheumatoid Arthritis 0.000542884 2 0 BeFree
Non-Small Cell Lung Carcinoma 0.000542884 2 0 BeFree
Squamous cell carcinoma 0.000542884 2 0 BeFree
Malignant tumor of cervix 0.000542884 2 0 BeFree
Glioblastoma 0.000542884 2 0 BeFree
HIV Infections 0.000542884 2 0 BeFree
Systemic Scleroderma 0.000542884 2 0 BeFree
Septicemia 0.000542884 2 0 BeFree
Virus Diseases 0.000542884 2 0 BeFree
Tumor Progression 0.000542884 2 0 BeFree
Malignant neoplasm of lung 0.000542884 2 0 BeFree
Sepsis 0.000542884 2 0 BeFree
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 0.000542884 2 0 BeFree
Thyroid carcinoma 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Helicobacter pylori infection 0.000542884 2 0 BeFree
Squamous cell carcinoma of the head and neck 0.000542884 2 0 BeFree
Mammary Neoplasms 0.000542884 2 0 BeFree
Tumor Angiogenesis 0.000542884 2 0 BeFree
Alzheimer's Disease 0.000271442 1 0 BeFree
Anaplasia 0.000271442 1 0 BeFree
Anemia, Sickle Cell 0.000271442 1 0 BeFree
Aortic Aneurysm 0.000271442 1 0 BeFree
Aortic Valve Stenosis 0.000271442 1 0 BeFree
Arthritis 0.000271442 1 0 BeFree
Candidiasis 0.000271442 1 0 BeFree
Carcinoid Tumor 0.000271442 1 0 BeFree
Malignant neoplasm of skin 0.000271442 1 0 BeFree
Malignant neoplasm of thyroid 0.000271442 1 0 BeFree
Cardiovascular Diseases 0.000271442 1 0 BeFree
Cerebral Infarction 0.000271442 1 0 BeFree
Crohn Disease 0.000271442 1 0 BeFree
Cystic Fibrosis 0.000271442 1 0 BeFree
Mental Depression 0.000271442 1 0 BeFree
Depressive disorder 0.000271442 1 0 BeFree
Dermatitis 0.000271442 1 0 BeFree
Drug abuse 0.000271442 1 0 BeFree
Eclampsia 0.000271442 1 0 BeFree
Enteritis 0.000271442 1 0 BeFree
Fibrosarcoma 0.000271442 1 0 BeFree
Gastritis 0.000271442 1 0 BeFree
Glomerulonephritis 0.000271442 1 0 BeFree
IGA Glomerulonephritis 0.000271442 1 0 BeFree
Cardiac Arrest 0.000271442 1 0 BeFree
Hemangioendothelioma 0.000271442 1 0 BeFree
Hyperglycemia 0.000271442 1 0 BeFree
Hypertensive disease 0.000271442 1 0 BeFree
Pulmonary Hypertension 0.000271442 1 0 BeFree
Polycystic Kidney Diseases 0.000271442 1 0 BeFree
Acute lymphocytic leukemia 0.000271442 1 0 BeFree
Myeloid Leukemia 0.000271442 1 0 BeFree
Lung diseases 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Degenerative polyarthritis 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Pneumonia 0.000271442 1 0 BeFree
Psoriasis 0.000271442 1 0 BeFree
Pulmonary Emphysema 0.000271442 1 0 BeFree
Scrub Typhus 0.000271442 1 0 BeFree
Soft Tissue Neoplasms 0.000271442 1 0 BeFree
Thyroid Diseases 0.000271442 1 0 BeFree
Unipolar Depression 0.000271442 1 0 BeFree
Vascular Diseases 0.000271442 1 0 BeFree
Xeroderma Pigmentosum 0.000271442 1 0 BeFree
Polycystic Kidney, Autosomal Dominant 0.000271442 1 0 BeFree
Adenocarcinoma of lung (disorder) 0.000271442 1 0 BeFree
Histiocytoid hemangioma 0.000271442 1 0 BeFree
Sarcoma, Epithelioid 0.000271442 1 0 BeFree
Ki-1+ Anaplastic Large Cell Lymphoma 0.000271442 1 0 BeFree
Follicular thyroid carcinoma 0.000271442 1 0 BeFree
Epithelioid hemangioendothelioma 0.000271442 1 0 BeFree
Medullary carcinoma of thyroid 0.000271442 1 0 BeFree
Erythroblastosis 0.000271442 1 0 BeFree
Cancer of Head and Neck 0.000271442 1 0 BeFree
Vascular Neoplasms 0.000271442 1 0 BeFree
Restenosis 0.000271442 1 0 BeFree
Carcinoid tumor no ICD-O subtype 0.000271442 1 0 BeFree
Epithelioid hemangioendothelioma, malignant 0.000271442 1 0 BeFree
Non-alcoholic Fatty Liver Disease 0.000271442 1 0 BeFree
Idiopathic crescentic glomerulonephritis 0.000271442 1 0 BeFree
Overweight 0.000271442 1 0 BeFree
Epithelial ovarian cancer 0.000271442 1 0 BeFree
Cerebral Ischemia 0.000271442 1 0 BeFree
Malignant neoplasm of ovary 0.000271442 1 0 BeFree
Major Depressive Disorder 0.000271442 1 0 BeFree
Hepatocarcinogenesis 0.000271442 1 0 BeFree
Glucocorticoid Receptor Deficiency 0.000271442 1 0 BeFree
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.000271442 1 0 BeFree
Oropharyngeal Carcinoma 0.000271442 1 0 BeFree
AORTIC VALVE DISEASE 2 0.000271442 1 0 BeFree

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