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The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  果寡糖基因家族由4名成员:FOS,FOSB,FOSL1和FOSL2。这些基因编码亮氨酸拉链蛋白可与君家的蛋白质二聚化,由此形成的转录因子复合的AP-1。因此,FOS蛋白质有牵连的细胞增殖,分化和转型的监管。在一些情况下,FOS基因的表达也与细胞凋亡相关联。 [由RefSeq的,2008年7月提供]
FOS基因(以及对应的蛋白质)的细胞分布位置:
FOS基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hypertensive disease | 0.200271442 | 3 | 0 | BeFree_CTD_human_RGD |
Reperfusion Injury | 0.2 | 2 | 0 | CTD_human_RGD |
Liver carcinoma | 0.126253095 | 14 | 0 | BeFree_CTD_human_LHGDN |
Mammary Neoplasms | 0.123538676 | 5 | 0 | BeFree_CTD_human_LHGDN |
Endometriosis | 0.122995792 | 3 | 0 | BeFree_CTD_human_LHGDN |
Anxiety Disorders | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Lipoatrophic Diabetes Mellitus | 0.12 | 0 | 0 | ORPHANET |
Epilepsy | 0.12 | 1 | 0 | CTD_human |
Osteitis Fibrosa Disseminata | 0.12 | 1 | 0 | CTD_human |
Heat Stroke | 0.12 | 1 | 0 | CTD_human |
Hemorrhage | 0.12 | 1 | 0 | CTD_human |
Lung Neoplasms | 0.12 | 1 | 0 | CTD_human |
nervous system disorder | 0.12 | 1 | 0 | CTD_human |
Seizures | 0.12 | 4 | 0 | CTD_human |
Status Epilepticus | 0.12 | 4 | 0 | CTD_human |
Substance Withdrawal Syndrome | 0.12 | 3 | 0 | CTD_human |
Neurotoxicity Syndromes | 0.12 | 1 | 0 | CTD_human |
Amphetamine-Related Disorders | 0.12 | 1 | 0 | CTD_human |
Cocaine-Related Disorders | 0.12 | 3 | 0 | CTD_human |
Hyperactive behavior | 0.12 | 1 | 0 | CTD_human |
Infarction, Middle Cerebral Artery | 0.12 | 1 | 0 | CTD_human |
AMYOTROPHIC LATERAL SCLEROSIS 1 | 0.12 | 1 | 0 | CTD_human |
Juvenile arthritis | 0.12 | 1 | 0 | CTD_human |
Glomerulonephritis | 0.080271442 | 2 | 0 | BeFree_RGD |
Heart failure | 0.08 | 1 | 0 | RGD |
Hematuria | 0.08 | 1 | 0 | RGD |
Hyperalgesia | 0.08 | 1 | 0 | RGD |
Tongue Neoplasms | 0.08 | 1 | 0 | RGD |
Carcinogenesis | 0.007057489 | 26 | 0 | BeFree |
Malignant neoplasm of breast | 0.005971721 | 22 | 0 | BeFree |
Anoxia | 0.0054487 | 2 | 0 | LHGDN |
Breast Carcinoma | 0.005428837 | 20 | 0 | BeFree |
Rheumatoid Arthritis | 0.004624443 | 7 | 0 | BeFree_LHGDN |
Liver neoplasms | 0.004353001 | 7 | 0 | BeFree_LHGDN |
Neoplasm Metastasis | 0.004353001 | 7 | 0 | BeFree_LHGDN |
Asthma | 0.003995683 | 7 | 0 | BeFree_GAD |
Glioma | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Lymphoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Malignant neoplasm of urinary bladder | 0.003181358 | 4 | 0 | BeFree_GAD |
Malignant neoplasm of lung | 0.003181358 | 4 | 0 | BeFree_GAD |
Polycystic Kidney, Autosomal Dominant | 0.002995792 | 2 | 0 | BeFree_LHGDN |
HIV Infections | 0.002985861 | 11 | 0 | BeFree |
Malignant neoplasm of ovary | 0.002909916 | 3 | 0 | BeFree_GAD |
Adenocarcinoma | 0.00272435 | 1 | 0 | LHGDN |
Ameloblastoma | 0.00272435 | 1 | 0 | LHGDN |
Endometrial Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Pulmonary Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Sudden infant death syndrome | 0.00272435 | 1 | 0 | LHGDN |
Thyroid Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Prostate carcinoma | 0.002714419 | 10 | 0 | BeFree |
melanoma | 0.002442977 | 9 | 0 | BeFree |
Stomach Carcinoma | 0.002442977 | 9 | 0 | BeFree |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of prostate | 0.002171535 | 8 | 0 | BeFree |
Colorectal Cancer | 0.002171535 | 8 | 0 | BeFree |
Colorectal Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Malignant neoplasm of stomach | 0.001900093 | 7 | 0 | BeFree |
Colon Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Malignant tumor of colon | 0.001628651 | 6 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.001628651 | 6 | 0 | BeFree |
Squamous cell carcinoma | 0.001357209 | 5 | 0 | BeFree |
Neuroblastoma | 0.001357209 | 5 | 0 | BeFree |
Ovarian Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Central neuroblastoma | 0.001357209 | 5 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.001085767 | 4 | 0 | BeFree |
Osteosarcoma | 0.001085767 | 4 | 0 | BeFree |
Tumor Progression | 0.001085767 | 4 | 0 | BeFree |
Cervix carcinoma | 0.001085767 | 4 | 0 | BeFree |
Epithelial ovarian cancer | 0.001085767 | 4 | 0 | BeFree |
Tumor Promotion | 0.001085767 | 4 | 0 | BeFree |
Arthritis | 0.000814326 | 3 | 0 | BeFree |
Malignant tumor of cervix | 0.000814326 | 3 | 0 | BeFree |
Dermatitis, Atopic | 0.000814326 | 3 | 0 | BeFree |
Eczema | 0.000814326 | 3 | 0 | BeFree |
Glioblastoma | 0.000814326 | 3 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000814326 | 3 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000814326 | 3 | 0 | BeFree |
Meningioma | 0.000814326 | 3 | 0 | BeFree |
Pancreatic carcinoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000814326 | 3 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000814326 | 3 | 0 | BeFree |
Thyroid carcinoma | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma of bone | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of bladder | 0.000814326 | 3 | 0 | BeFree |
Helicobacter pylori infection | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000542884 | 2 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cardiovascular Diseases | 0.000542884 | 2 | 0 | BeFree |
Ulcerative Colitis | 0.000542884 | 2 | 1 | BeFree |
Crohn Disease | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
Obesity | 0.000542884 | 2 | 0 | BeFree |
Degenerative polyarthritis | 0.000542884 | 2 | 0 | BeFree |
Systemic Scleroderma | 0.000542884 | 2 | 0 | BeFree |
Septicemia | 0.000542884 | 2 | 0 | BeFree |
Unipolar Depression | 0.000542884 | 2 | 0 | BeFree |
Virus Diseases | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, T-Cell, Cutaneous | 0.000542884 | 2 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000542884 | 2 | 0 | BeFree |
Sepsis | 0.000542884 | 2 | 0 | BeFree |
Endometrial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
Sarcoma | 0.000542884 | 2 | 0 | BeFree |
Major Depressive Disorder | 0.000542884 | 2 | 0 | BeFree |
Hepatocarcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Tumor Angiogenesis | 0.000542884 | 2 | 0 | BeFree |
Leukemia, Large Granular Lymphocytic | 0.000542884 | 2 | 0 | BeFree |
Meningioma, benign, no ICD-O subtype | 0.000542884 | 2 | 0 | BeFree |
Uterine Corpus Cancer | 0.000542884 | 2 | 0 | BeFree |
Adenoma | 0.000271442 | 1 | 0 | BeFree |
Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
Anemia, Sickle Cell | 0.000271442 | 1 | 0 | BeFree |
Epithelioid hemangioma of skin | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Aortic Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
Candidiasis | 0.000271442 | 1 | 0 | BeFree |
Carcinoid Tumor | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
Cerebral Infarction | 0.000271442 | 1 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Dermatitis | 0.000271442 | 1 | 0 | BeFree |
Eclampsia | 0.000271442 | 1 | 0 | BeFree |
Enteritis | 0.000271442 | 1 | 0 | BeFree |
Fibrosarcoma | 0.000271442 | 1 | 0 | BeFree |
Gastritis | 0.000271442 | 1 | 0 | BeFree |
Gastroesophageal reflux disease | 0.000271442 | 1 | 0 | BeFree |
Giant Cell Tumors | 0.000271442 | 1 | 0 | BeFree |
IGA Glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
Cardiac Arrest | 0.000271442 | 1 | 0 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Hypertension | 0.000271442 | 1 | 0 | BeFree |
Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Polycystic Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Fibroid Tumor | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Lung diseases | 0.000271442 | 1 | 0 | BeFree |
Malaria | 0.000271442 | 1 | 0 | BeFree |
Neurilemmoma | 0.000271442 | 1 | 0 | BeFree |
Nevus | 0.000271442 | 1 | 0 | BeFree |
Melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
Ovarian Diseases | 0.000271442 | 1 | 0 | BeFree |
Pneumonia | 0.000271442 | 1 | 0 | BeFree |
Polycystic Ovary Syndrome | 0.000271442 | 1 | 0 | BeFree |
Adenomatous Polyposis Coli | 0.000271442 | 1 | 0 | BeFree |
Precancerous Conditions | 0.000271442 | 1 | 0 | BeFree |
Preleukemia | 0.000271442 | 1 | 0 | BeFree |
Progeria | 0.000271442 | 1 | 0 | BeFree |
Prolactinoma | 0.000271442 | 1 | 0 | BeFree |
Psoriasis | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Emphysema | 0.000271442 | 1 | 0 | BeFree |
Sarcoidosis | 0.000271442 | 1 | 0 | BeFree |
Scrub Typhus | 0.000271442 | 1 | 0 | BeFree |
Skin Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
Thyroid Diseases | 0.000271442 | 1 | 0 | BeFree |
Uterine Fibroids | 0.000271442 | 1 | 0 | BeFree |
Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Spina Bifida | 0.000271442 | 1 | 1 | BeFree |
Neurofibrillary degeneration (morphologic abnormality) | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Histiocytoid hemangioma | 0.000271442 | 1 | 0 | BeFree |
Hyperandrogenism | 0.000271442 | 1 | 0 | BeFree |
Ki-1+ Anaplastic Large Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Sarcoma, Clear Cell | 0.000271442 | 1 | 0 | BeFree |
Familial generalized lipodystrophy | 0.000271442 | 1 | 0 | BeFree |
Basophilic leukemia | 0.000271442 | 1 | 0 | BeFree |
Medullary carcinoma of thyroid | 0.000271442 | 1 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Severe myopia | 0.000271442 | 1 | 0 | BeFree |
Erythroblastosis | 0.000271442 | 1 | 0 | BeFree |
Familial Alzheimer Disease (FAD) | 0.000271442 | 1 | 0 | BeFree |
Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
Restenosis | 0.000271442 | 1 | 0 | BeFree |
Carcinoid tumor no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
Cycloid psychosis | 0.000271442 | 1 | 0 | BeFree |
Nonorganic psychosis | 0.000271442 | 1 | 0 | BeFree |
Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
Idiopathic crescentic glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
Benign bone neoplasm | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Cerebral Ischemia | 0.000271442 | 1 | 0 | BeFree |
Arthritis, Collagen-Induced | 0.000271442 | 1 | 0 | BeFree |
Benign melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
Malignant Conversion | 0.000271442 | 1 | 0 | BeFree |
Familial medullary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Glucocorticoid Receptor Deficiency | 0.000271442 | 1 | 0 | BeFree |
Coronary Artery Disease | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Oropharyngeal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Promyelocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Nonalcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
MYELODYSPLASTIC SYNDROME | 0.000271442 | 1 | 0 | BeFree |
AORTIC VALVE DISEASE 2 | 0.000271442 | 1 | 0 | BeFree |
Melanocytic nevus of skin | 0.000271442 | 1 | 0 | BeFree |
Intellectual Disability | 0.000271442 | 1 | 0 | BeFree |
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