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The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  果寡糖基因家族由4名成员:FOS,FOSB,FOSL1和FOSL2。这些基因编码亮氨酸拉链蛋白可与君家的蛋白质二聚化,由此形成的转录因子复合的AP-1。因此,FOS蛋白质有牵连的细胞增殖,分化和转型的监管。在一些情况下,FOS基因的表达也与细胞凋亡相关联。 [由RefSeq的,2008年7月提供]
FOS基因(以及对应的蛋白质)的细胞分布位置:
FOS基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Hypertensive disease | 0.200271442 | 3 | 0 | BeFree_CTD_human_RGD |
| Reperfusion Injury | 0.2 | 2 | 0 | CTD_human_RGD |
| Liver carcinoma | 0.126253095 | 14 | 0 | BeFree_CTD_human_LHGDN |
| Mammary Neoplasms | 0.123538676 | 5 | 0 | BeFree_CTD_human_LHGDN |
| Endometriosis | 0.122995792 | 3 | 0 | BeFree_CTD_human_LHGDN |
| Anxiety Disorders | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Lipoatrophic Diabetes Mellitus | 0.12 | 0 | 0 | ORPHANET |
| Epilepsy | 0.12 | 1 | 0 | CTD_human |
| Osteitis Fibrosa Disseminata | 0.12 | 1 | 0 | CTD_human |
| Heat Stroke | 0.12 | 1 | 0 | CTD_human |
| Hemorrhage | 0.12 | 1 | 0 | CTD_human |
| Lung Neoplasms | 0.12 | 1 | 0 | CTD_human |
| nervous system disorder | 0.12 | 1 | 0 | CTD_human |
| Seizures | 0.12 | 4 | 0 | CTD_human |
| Status Epilepticus | 0.12 | 4 | 0 | CTD_human |
| Substance Withdrawal Syndrome | 0.12 | 3 | 0 | CTD_human |
| Neurotoxicity Syndromes | 0.12 | 1 | 0 | CTD_human |
| Amphetamine-Related Disorders | 0.12 | 1 | 0 | CTD_human |
| Cocaine-Related Disorders | 0.12 | 3 | 0 | CTD_human |
| Hyperactive behavior | 0.12 | 1 | 0 | CTD_human |
| Infarction, Middle Cerebral Artery | 0.12 | 1 | 0 | CTD_human |
| AMYOTROPHIC LATERAL SCLEROSIS 1 | 0.12 | 1 | 0 | CTD_human |
| Juvenile arthritis | 0.12 | 1 | 0 | CTD_human |
| Glomerulonephritis | 0.080271442 | 2 | 0 | BeFree_RGD |
| Heart failure | 0.08 | 1 | 0 | RGD |
| Hematuria | 0.08 | 1 | 0 | RGD |
| Hyperalgesia | 0.08 | 1 | 0 | RGD |
| Tongue Neoplasms | 0.08 | 1 | 0 | RGD |
| Carcinogenesis | 0.007057489 | 26 | 0 | BeFree |
| Malignant neoplasm of breast | 0.005971721 | 22 | 0 | BeFree |
| Anoxia | 0.0054487 | 2 | 0 | LHGDN |
| Breast Carcinoma | 0.005428837 | 20 | 0 | BeFree |
| Rheumatoid Arthritis | 0.004624443 | 7 | 0 | BeFree_LHGDN |
| Liver neoplasms | 0.004353001 | 7 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.004353001 | 7 | 0 | BeFree_LHGDN |
| Asthma | 0.003995683 | 7 | 0 | BeFree_GAD |
| Glioma | 0.003810118 | 5 | 0 | BeFree_LHGDN |
| Lymphoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Malignant neoplasm of urinary bladder | 0.003181358 | 4 | 0 | BeFree_GAD |
| Malignant neoplasm of lung | 0.003181358 | 4 | 0 | BeFree_GAD |
| Polycystic Kidney, Autosomal Dominant | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| HIV Infections | 0.002985861 | 11 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.002909916 | 3 | 0 | BeFree_GAD |
| Adenocarcinoma | 0.00272435 | 1 | 0 | LHGDN |
| Ameloblastoma | 0.00272435 | 1 | 0 | LHGDN |
| Endometrial Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Pulmonary Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
| Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Sudden infant death syndrome | 0.00272435 | 1 | 0 | LHGDN |
| Thyroid Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Infection | 0.00272435 | 1 | 0 | LHGDN |
| Prostate carcinoma | 0.002714419 | 10 | 0 | BeFree |
| melanoma | 0.002442977 | 9 | 0 | BeFree |
| Stomach Carcinoma | 0.002442977 | 9 | 0 | BeFree |
| Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
| Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
| Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of prostate | 0.002171535 | 8 | 0 | BeFree |
| Colorectal Cancer | 0.002171535 | 8 | 0 | BeFree |
| Colorectal Carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.001900093 | 7 | 0 | BeFree |
| Colon Carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Malignant tumor of colon | 0.001628651 | 6 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.001628651 | 6 | 0 | BeFree |
| Squamous cell carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Neuroblastoma | 0.001357209 | 5 | 0 | BeFree |
| Ovarian Carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Central neuroblastoma | 0.001357209 | 5 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.001085767 | 4 | 0 | BeFree |
| Osteosarcoma | 0.001085767 | 4 | 0 | BeFree |
| Tumor Progression | 0.001085767 | 4 | 0 | BeFree |
| Cervix carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Epithelial ovarian cancer | 0.001085767 | 4 | 0 | BeFree |
| Tumor Promotion | 0.001085767 | 4 | 0 | BeFree |
| Arthritis | 0.000814326 | 3 | 0 | BeFree |
| Malignant tumor of cervix | 0.000814326 | 3 | 0 | BeFree |
| Dermatitis, Atopic | 0.000814326 | 3 | 0 | BeFree |
| Eczema | 0.000814326 | 3 | 0 | BeFree |
| Glioblastoma | 0.000814326 | 3 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.000814326 | 3 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.000814326 | 3 | 0 | BeFree |
| Meningioma | 0.000814326 | 3 | 0 | BeFree |
| Pancreatic carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000814326 | 3 | 0 | BeFree |
| Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000814326 | 3 | 0 | BeFree |
| Thyroid carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Osteosarcoma of bone | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of bladder | 0.000814326 | 3 | 0 | BeFree |
| Helicobacter pylori infection | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of endometrium | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of thyroid | 0.000542884 | 2 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Cardiovascular Diseases | 0.000542884 | 2 | 0 | BeFree |
| Ulcerative Colitis | 0.000542884 | 2 | 1 | BeFree |
| Crohn Disease | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus, Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
| Obesity | 0.000542884 | 2 | 0 | BeFree |
| Degenerative polyarthritis | 0.000542884 | 2 | 0 | BeFree |
| Systemic Scleroderma | 0.000542884 | 2 | 0 | BeFree |
| Septicemia | 0.000542884 | 2 | 0 | BeFree |
| Unipolar Depression | 0.000542884 | 2 | 0 | BeFree |
| Virus Diseases | 0.000542884 | 2 | 0 | BeFree |
| Lymphoma, T-Cell, Cutaneous | 0.000542884 | 2 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000542884 | 2 | 0 | BeFree |
| Sepsis | 0.000542884 | 2 | 0 | BeFree |
| Endometrial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
| Sarcoma | 0.000542884 | 2 | 0 | BeFree |
| Major Depressive Disorder | 0.000542884 | 2 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Tumor Angiogenesis | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Large Granular Lymphocytic | 0.000542884 | 2 | 0 | BeFree |
| Meningioma, benign, no ICD-O subtype | 0.000542884 | 2 | 0 | BeFree |
| Uterine Corpus Cancer | 0.000542884 | 2 | 0 | BeFree |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
| Anemia, Sickle Cell | 0.000271442 | 1 | 0 | BeFree |
| Epithelioid hemangioma of skin | 0.000271442 | 1 | 0 | BeFree |
| Aortic Aneurysm | 0.000271442 | 1 | 0 | BeFree |
| Aortic Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
| Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Candidiasis | 0.000271442 | 1 | 0 | BeFree |
| Carcinoid Tumor | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
| Cerebral Infarction | 0.000271442 | 1 | 0 | BeFree |
| Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
| Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Dermatitis | 0.000271442 | 1 | 0 | BeFree |
| Eclampsia | 0.000271442 | 1 | 0 | BeFree |
| Enteritis | 0.000271442 | 1 | 0 | BeFree |
| Fibrosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Gastritis | 0.000271442 | 1 | 0 | BeFree |
| Gastroesophageal reflux disease | 0.000271442 | 1 | 0 | BeFree |
| Giant Cell Tumors | 0.000271442 | 1 | 0 | BeFree |
| IGA Glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
| Cardiac Arrest | 0.000271442 | 1 | 0 | BeFree |
| Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Hypertension | 0.000271442 | 1 | 0 | BeFree |
| Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| Polycystic Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| Fibroid Tumor | 0.000271442 | 1 | 0 | BeFree |
| leukemia | 0.000271442 | 1 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Lung diseases | 0.000271442 | 1 | 0 | BeFree |
| Malaria | 0.000271442 | 1 | 0 | BeFree |
| Neurilemmoma | 0.000271442 | 1 | 0 | BeFree |
| Nevus | 0.000271442 | 1 | 0 | BeFree |
| Melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Diseases | 0.000271442 | 1 | 0 | BeFree |
| Pneumonia | 0.000271442 | 1 | 0 | BeFree |
| Polycystic Ovary Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Adenomatous Polyposis Coli | 0.000271442 | 1 | 0 | BeFree |
| Precancerous Conditions | 0.000271442 | 1 | 0 | BeFree |
| Preleukemia | 0.000271442 | 1 | 0 | BeFree |
| Progeria | 0.000271442 | 1 | 0 | BeFree |
| Prolactinoma | 0.000271442 | 1 | 0 | BeFree |
| Psoriasis | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Emphysema | 0.000271442 | 1 | 0 | BeFree |
| Sarcoidosis | 0.000271442 | 1 | 0 | BeFree |
| Scrub Typhus | 0.000271442 | 1 | 0 | BeFree |
| Skin Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
| Thyroid Diseases | 0.000271442 | 1 | 0 | BeFree |
| Uterine Fibroids | 0.000271442 | 1 | 0 | BeFree |
| Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
| Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Spina Bifida | 0.000271442 | 1 | 1 | BeFree |
| Neurofibrillary degeneration (morphologic abnormality) | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Histiocytoid hemangioma | 0.000271442 | 1 | 0 | BeFree |
| Hyperandrogenism | 0.000271442 | 1 | 0 | BeFree |
| Ki-1+ Anaplastic Large Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Sarcoma, Clear Cell | 0.000271442 | 1 | 0 | BeFree |
| Familial generalized lipodystrophy | 0.000271442 | 1 | 0 | BeFree |
| Basophilic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Medullary carcinoma of thyroid | 0.000271442 | 1 | 0 | BeFree |
| Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Severe myopia | 0.000271442 | 1 | 0 | BeFree |
| Erythroblastosis | 0.000271442 | 1 | 0 | BeFree |
| Familial Alzheimer Disease (FAD) | 0.000271442 | 1 | 0 | BeFree |
| Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
| Restenosis | 0.000271442 | 1 | 0 | BeFree |
| Carcinoid tumor no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
| Cycloid psychosis | 0.000271442 | 1 | 0 | BeFree |
| Nonorganic psychosis | 0.000271442 | 1 | 0 | BeFree |
| Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic crescentic glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
| Benign bone neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Cerebral Ischemia | 0.000271442 | 1 | 0 | BeFree |
| Arthritis, Collagen-Induced | 0.000271442 | 1 | 0 | BeFree |
| Benign melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
| Malignant Conversion | 0.000271442 | 1 | 0 | BeFree |
| Familial medullary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Glucocorticoid Receptor Deficiency | 0.000271442 | 1 | 0 | BeFree |
| Coronary Artery Disease | 0.000271442 | 1 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Oropharyngeal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Promyelocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Nonalcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
| MYELODYSPLASTIC SYNDROME | 0.000271442 | 1 | 0 | BeFree |
| AORTIC VALVE DISEASE 2 | 0.000271442 | 1 | 0 | BeFree |
| Melanocytic nevus of skin | 0.000271442 | 1 | 0 | BeFree |
| Intellectual Disability | 0.000271442 | 1 | 0 | BeFree |
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