FCN3基因详情-基因数据库-基因云馆

FCN3(ficolin (collagen/fibrinogen domain containing) 3) 转至新版数据库

基因简称(symbol)

FCN3 [HGNC] [GeneCards] [NCBI]

基因种类(locus group)

protein-coding gene

同源简称(alias symbol)

FCNH|HAKA1

基因家族代码(gene_family_id)

554 [HGNC] [GenScript]

omim代码

604973

entrez码

8547 [Vega]

vega基因码

OTTHUMG00000005722

ensembl基因码

ENSG00000142748 [Ensembl]

基因家族(gene family)

Fibrinogen C domain containing

refseq数据库代号

NM_003665

更多...

基因种类(locus_type)

gene with protein product

基因名称状态(status)

Approved

location_sortable

01p36.11

同源基因名称(alias name)

Hakata antigen

基因名称批准使用时间(date_approved_reserved)

1999-12-10T00:00:00Z

基因简称更名时间(date_symbol_changed)

基因名称更名时间(date_name_changed)

2013-09-12T00:00:00Z

更新时间(date_modified)

2015-04-22T00:00:00Z

ucsc码

uc001boa.3

ena

D88587

ccds数据码

CCDS300|CCDS301

uniprot数据码

O75636

pubmed代码

9694814|10330454

mgd码

rgd码

生命科学数据库(lsdb)

LRG_171|http://www.lrg-sequence.org/LRG/LRG_171

更新时间(date modified)

2015-04-22T00:00:00Z

cosmic

FCN3

mirbase

基因曾用简称(prev symbol)

基因曾用名称(prev name)

ficolin (collagen/fibrinogen domain-containing) 3 (Hakata antigen)

homeodb

cosmic

FCN3

snornabase

bioparadigms slc

orphanet

332191

假基因信息(pseudogeneorg)

horde id

merops

imgt

iuphar

kznf基因类别

mamit-trnadb

cd

LncRNA数据库

酶代码

中间纤维数据库

收起

1p36.11

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):] Ficolins是一个基团，其包括胶原蛋白样结构域和纤维蛋白原样结构域的蛋白质。在人血清中，有两种类型的ficolins的，这两者有凝集素的活性。由该基因编码的蛋白质是一个不耐热在所有人类血清中发现β-2- macroglycoprotein并且是ficolin /调理素p35的凝集素家族的一个成员。的蛋白，其最初被鉴定基于其与患者系统性红斑狼疮的血清的反应性，已被证明为具有钙无关的凝集素的活性。该蛋白质可以激活与MASPS和SMAP协会补体途径，从而在宿主防御通过凝集素途径的激活辅助。选择性剪接发生在该位点和两个变体，各自编码一个不同的同种型，也已确定。 [由RefSeq的，2008年7月提供]

OMIM数据库中对FCN3基因的介绍 Wikipedia数据库中对FCN3基因的介绍

FCN3基因的碱基序列：[NCBI]

FCN3基因的碱基突变：显示全部snp

rs15544 rs3813800 rs4134410 rs4494157 rs4545358 rs4582825 rs6699625 rs10218730 rs10794501 rs11247642 rs11432761 rs12750457 rs28362807 rs28385647 rs28385648 rs28385649 rs28385650 rs28385651 rs28385652 rs28385717 rs28385718 rs28385719 rs28385720 rs28385721 rs28385722 rs28385723 rs28385724 rs28385725 rs28385726 rs28385727 rs28385728 rs28741387 rs29001532 rs34295487 rs34661034 rs41291100 rs41291102

rs41465749 rs55831836 rs55863154 rs56174383 rs56405086 rs56407240 rs60078240 rs61787062 rs71010351 rs71584882 rs72882747 rs72882750 rs76041454 rs76995864 rs77741467 rs78387600 rs112062854 rs112471839 rs112502361 rs113797761 rs114358705 rs115988736 rs116138824 rs116683284 rs138304758 rs138831719 rs138884484 rs138940198 rs140272684 rs140590744 rs140868118 rs141102037 rs141300199 rs141468956 rs141949779 rs142070699 rs142397200 rs142828984 rs143220107 rs143244488 rs144340265 rs145351493 rs145577947 rs145628515 rs146328942 rs146535239 rs147142056 rs147554263 rs147597344 rs147795062 rs148066145 rs148234540 rs148415449 rs148888919 rs149306559 rs149617808 rs149734712 rs149892753 rs149936787 rs150694369 rs150808590 rs151012494 rs181116349 rs181500308 rs182181753 rs182742646 rs183148024 rs183429987 rs183598115 rs183728053 rs185126170 rs187336683 rs187404749 rs188566659 rs188685893 rs189227069 rs189381929 rs190211710 rs190301256 rs191146698 rs191476566 rs191743297 rs191952030 rs192441014 rs199525271 rs199689497 rs199734850 rs199907175 rs200179996 rs200546088 rs200720652 rs201110787 rs201375985 rs201580290 rs201654480 rs201665812 rs201979374 rs202230664 rs369159057 rs369275569 rs369387822 rs369424243 rs369494256 rs369579099 rs369799164 rs369807612 rs369987756 rs370467588 rs370673118 rs370680683 rs370867466 rs371444212 rs371511517 rs372098705 rs372118978 rs372282794 rs372596836 rs372696678 rs372707264 rs373234547 rs373443059 rs373558253 rs373914427 rs373935238 rs374013809 rs374018072 rs374223436 rs374251896 rs375113680 rs375334546 rs375520373 rs375904051 rs376119183 rs376347485 rs376437282 rs377040918 rs377314529 rs377389893 rs397706245 rs527574109 rs527792811 rs528706809 rs528796484 rs528985312 rs529945854 rs530033295 rs530317780 rs530456422 rs530465234 rs530753410 rs531049152 rs531495371 rs531766844 rs532369374 rs532405060 rs532571995 rs532662348 rs532781899 rs533602324 rs535063834 rs536111224 rs536294836 rs536301576 rs536365021 rs536505012 rs536505067 rs536565971 rs537358744 rs537438892 rs537498859 rs537557156 rs538327484 rs538677703 rs538766794 rs538886953 rs539122788 rs540239032 rs540472686 rs541420186 rs542628876 rs542879731 rs543088456 rs543381876 rs543940787 rs544380945 rs544521222 rs545855777 rs546449247 rs546584321 rs546596843 rs546909955 rs547124670 rs548047815 rs548629523 rs549607106 rs550157999 rs550506404 rs550566965 rs550786745 rs550830875 rs551134397 rs552328656 rs552355109 rs552522244 rs552604649 rs553026191 rs553340869 rs554140953 rs554700972 rs555167662 rs556126955 rs556473648 rs556844557 rs557017819 rs557316808 rs557793026 rs557856627 rs558135237 rs558269367 rs559771616 rs560127485 rs560301004 rs560401089 rs560441234 rs560448881 rs561233853 rs561341714 rs561633816 rs561696106 rs562025241 rs562213827 rs562502843 rs562755770 rs562846661 rs562854825 rs563039672 rs563233731 rs563883216 rs564221224 rs564357451 rs564549414 rs564630068 rs565481410 rs565729737 rs566620432 rs566891028 rs566932873 rs567295964 rs567431384 rs567440921 rs567563666 rs567670563 rs568552259 rs569318898 rs569714355 rs569773662 rs570125085 rs571877387 rs572014686 rs572432602 rs573644095 rs573781857 rs574793284 rs574988104 rs575296520 rs575831214 rs577863445 rs577866578 rs578034956 rs745422827 rs745480553 rs745573259 rs745599639 rs745735735 rs745814286 rs745832502 rs745897276 rs746006129 rs746216217 rs746300270 rs746464677 rs746624418 rs746674895 rs746876244 rs747169032 rs747603082 rs747603248 rs747725294 rs747833801 rs748003132 rs748239361 rs748278677 rs748808644 rs748889216 rs749146507 rs749252935 rs749554269 rs749956317 rs750094364 rs750122426 rs750964366 rs751117858 rs751241684 rs751330142 rs751454717 rs751525696 rs751750968 rs751993679 rs752059640 rs752089709 rs752456913 rs752536196 rs752587067 rs752933842 rs753039803 rs753381366 rs753552705 rs753618382 rs753804930 rs753855015 rs754670027 rs754688017 rs754811652 rs754831565 rs755062496 rs755497136 rs755516832 rs755762104 rs755977604 rs756039497 rs756190859 rs756449470 rs756463435 rs756684452 rs756753982 rs756772261 rs756916302 rs757228209 rs757779855 rs757913198 rs758229685 rs758251606 rs758425956 rs758684318 rs758930710 rs758972568 rs759374713 rs759497509 rs759572431 rs759733826 rs759763365 rs760012512 rs760178059 rs760302616 rs760316888 rs760452725 rs760619018 rs760626552 rs760660955 rs760700797 rs760751792 rs761471363 rs761615129 rs761868698 rs761923448 rs761954369 rs761988444 rs762224811 rs762384554 rs762407802 rs762931208 rs763335663 rs763379781 rs763657253 rs763783597 rs763786651 rs764013410 rs764192346 rs764269218 rs764351943 rs764882744 rs765030063 rs765477901 rs765503451 rs765768419 rs765841309 rs765898727 rs766167339 rs766170878 rs766453890 rs766968789 rs767380723 rs767496784 rs767553923 rs767569533 rs767619703 rs767786831 rs767839461 rs768187268 rs768309002 rs768468538 rs768526825 rs768631036 rs768658968 rs768795527 rs768920855 rs769028499 rs769451051 rs769505639 rs769577079 rs770479599 rs770650851 rs770897072 rs770980672 rs771321875 rs771358061 rs771519454 rs771796495 rs771807923 rs771917345 rs772437631 rs772470237 rs772977741 rs773203671 rs773222505 rs773327605 rs773360166 rs773443432 rs773781318 rs773813058 rs774015485 rs774112351 rs774481237 rs774568591 rs774739195 rs774852608 rs774927752 rs775014167 rs775267301 rs775288128 rs775389755 rs775545378 rs775653789 rs775655432 rs775706497 rs775813048 rs775989626 rs776317862 rs776423358 rs776442952 rs776477057 rs776483001 rs776618595 rs776709383 rs777109588 rs777315106 rs777398635 rs777639664 rs777714663 rs778005506 rs778101387 rs778528208 rs778768902 rs778978580 rs779116197 rs779349192 rs779366769 rs779399381 rs779528863 rs779973101 rs780104177 rs780342236 rs780833091 rs780943252 rs780994513 rs781053078 rs781103320 rs781140630 rs781329306 rs781596074

FCN3基因在不同组织中的表达： [UniProt]

正向引物序列

正向引物Tm值

反向引物序列

反向引物Tm值

rank

CTTACTCTCCAGGGTAACTGG

59

TAGTGGTCTACCTCACCGA

59

CTTACTCTCCAGGGTAACTGG

59

TAGTGGTCTACCTCACCGA

59

GAAGCCAGCAAAGTTGTCC

60

GGTTCACTGGATCTCCTGG

60

TTACTCTCCAGGGTAACTGG

58

TAGTGGTCTACCTCACCGA

59

TTACTCTCCAGGGTAACTGG

58

GTAGTGGTCTACCTCACCG

58

CTTACTCTCCAGGGTAACTGG

59

TAGTGGTCTACCTCACCGA

59

TTACTCTCCAGGGTAACTGG

58

TAGTGGTCTACCTCACCGA

59

TTACTCTCCAGGGTAACTGG

58

TAGTGGTCTACCTCACCGA

59

CAGCAAAGTTGTCCTCCTG

59

GGTTCACTGGATCTCCTGG

60

CAGCAAAGTTGTCCTCCTG

59

AGGTTCACTGGATCTCCTG

58

尚未收录相关数据

FCN3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

溶酶体
内涵体
细胞核
细胞质
液泡
细胞膜
细胞外基质
内质网
线粒体
高尔基体
细胞骨架

FCN3基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0001867

O75636(UniProtKB)

IDA

GO:0001867

O75636(UniProtKB)

TAS

GO:0001867

O75636(UniProtKB)

TAS

GO:0003823

O75636(UniProtKB)

IDA

GO:0004252

O75636(UniProtKB)

TAS

GO:0004252

O75636(UniProtKB)

TAS

GO:0005515

O75636(UniProtKB)

IPI

GO:0005515

O75636(UniProtKB)

IPI

GO:0005576

O75636(UniProtKB)

NAS

GO:0005576

O75636(UniProtKB)

TAS

GO:0005576

O75636(UniProtKB)

TAS

GO:0005576

O75636(UniProtKB)

TAS

GO:0005576

O75636(UniProtKB)

TAS

GO:0005581

O75636(UniProtKB)

IEA

GO:0006508

O75636(UniProtKB)

IEA

GO:0006956

O75636(UniProtKB)

IDA

GO:0006956

O75636(UniProtKB)

TAS

GO:0030246

O75636(UniProtKB)

IEA

GO:0043654

O75636(UniProtKB)

IDA

GO:0046597

O75636(UniProtKB)

IMP

GO:0046872

O75636(UniProtKB)

IEA

GO:0051607

O75636(UniProtKB)

IDA

GO:0072562

O75636(UniProtKB)

IDA

GO:1902679

O75636(UniProtKB)

IDA

序号	作用方式	资源库来源/分值	基因名称	基因名称

可能调控FCN3基因的相关microRNA：

通路基因列表

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
IMMUNODEFICIENCY DUE TO FICOLIN 3 DEFICIENCY	0.240271442	1	1	BeFree_CLINVAR_ORPHANET
Immunologic Deficiency Syndromes	0.12	1	0	CTD_human
Crohn Disease	0.00272435	1	0	LHGDN
Respiratory Tract Infections	0.002638474	1	0	BeFree_GAD
Rheumatoid Arthritis	0.002367032	1	0	GAD
Ventricular Septal Defects	0.000271442	1	0	BeFree
Ovarian Carcinoma	0.000271442	1	0	BeFree
Infections specific to perinatal period	0.000271442	1	0	BeFree
Recurrent respiratory tract infections	0.000271442	1	0	BeFree
ovarian neoplasm	0.000271442	1	0	BeFree
Malignant neoplasm of ovary	0.000271442	1	0	BeFree
Recurrent infections (sinusitis and bacterial pneumonia and meningitis)	0.000271442	1	0	BeFree
Liver carcinoma	0.000271442	1	0	BeFree