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The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  这个基因的产物属于ficolin蛋白家族。该家族的特征在于前导肽,短N-末端片段,随后是胶原样区的存在,以及一个C端的纤维蛋白原样结构域。该基因是在肝脏中表达,并已被证明具有碳水化合物结合和调理活性。编码不同同种型的可变剪接转录物变体也已确定。 [由RefSeq的,2008年7月提供]
FCN2基因(以及对应的蛋白质)的细胞分布位置:
FCN2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Respiratory Tract Infections | 0.005819831 | 4 | 0 | BeFree_GAD |
Leprosy | 0.002909916 | 2 | 0 | BeFree_GAD |
Bacterial Infections | 0.002638474 | 2 | 0 | BeFree_GAD |
Behcet Syndrome | 0.002638474 | 1 | 0 | BeFree_GAD |
Rheumatic Fever | 0.002638474 | 1 | 0 | BeFree_GAD |
Rheumatic Heart Disease | 0.002638474 | 1 | 0 | BeFree_GAD |
Streptococcal Infections | 0.002638474 | 1 | 0 | BeFree_GAD |
Rheumatoid Arthritis | 0.002367032 | 1 | 0 | GAD |
Postoperative Complications | 0.002367032 | 1 | 0 | GAD |
Neurodegenerative Disorders | 0.001085767 | 4 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
Hepatitis B | 0.000542884 | 2 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000542884 | 2 | 0 | BeFree |
Lyme Disease | 0.000542884 | 2 | 0 | BeFree |
Malaria | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Schistosomiasis | 0.000542884 | 2 | 0 | BeFree |
Virus Diseases | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Mannose-Binding Protein Deficiency | 0.000542884 | 2 | 0 | BeFree |
Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
Asthma | 0.000271442 | 1 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Brain Diseases | 0.000271442 | 1 | 0 | BeFree |
Bronchiectasis | 0.000271442 | 1 | 0 | BeFree |
Common Variable Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
Cytomegalovirus Infections | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
Leishmaniasis | 0.000271442 | 1 | 0 | BeFree |
Leishmaniasis, Cutaneous | 0.000271442 | 1 | 0 | BeFree |
Leishmaniasis, Visceral | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Spinal Muscular Atrophy | 0.000271442 | 1 | 0 | BeFree |
nervous system disorder | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Paratuberculosis | 0.000271442 | 1 | 0 | BeFree |
Peritonitis | 0.000271442 | 1 | 0 | BeFree |
Pneumococcal Infections | 0.000271442 | 1 | 0 | BeFree |
Respiration Disorders | 0.000271442 | 1 | 0 | BeFree |
Respiratory Tract Diseases | 0.000271442 | 1 | 0 | BeFree |
Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Sexually Transmitted Diseases | 0.000271442 | 1 | 0 | BeFree |
Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis, Pulmonary | 0.000271442 | 1 | 0 | BeFree |
Tuberous Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Infections specific to perinatal period | 0.000271442 | 1 | 0 | BeFree |
Chronic rheumatic heart disease | 0.000271442 | 1 | 0 | BeFree |
Niemann-Pick Disease, Type C | 0.000271442 | 1 | 0 | BeFree |
Memory impairment | 0.000271442 | 1 | 0 | BeFree |
Acute type B viral hepatitis | 0.000271442 | 1 | 0 | BeFree |
Restenosis | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Recurrent respiratory tract infections | 0.000271442 | 1 | 0 | BeFree |
ovarian neoplasm | 0.000271442 | 1 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Leprosy, Paucibacillary | 0.000271442 | 1 | 0 | BeFree |
Urinary Schistosomiasis | 0.000271442 | 1 | 0 | BeFree |
Recurrent infections (sinusitis and bacterial pneumonia and meningitis) | 0.000271442 | 1 | 0 | BeFree |
X-Linked Lissencephaly | 0.000271442 | 1 | 0 | BeFree |
Allergic rhinitis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Unspecified visual loss | 0.000271442 | 1 | 0 | BeFree |
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