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This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  本基因编码的免疫球蛋白G的Fc部分的受体,并且它参与从循环中除去抗原 - 抗体复合物,以及其它其它抗体依赖性应答。该基因(FCGR3A)是高度相似位于1号染色体上由该基因编码的受体附近另一基因(FCGR3B)被表示在自然杀伤(NK)细胞作为通过跨膜的肽锚定一个完整的膜糖蛋白,而FCGR3B表示上,其中该受体是通过磷脂酰肌醇(PI)的联动锚中性粒细胞(PMN)。在这个基因的突变已与易感性反复病毒感染,易患系统性红斑狼疮,和免疫性新生儿中性粒细胞减少。另外剪接转录变体编码不同亚型已经发现了这种基因。 [由RefSeq的,2008年7月提供]
FCGR3A基因(以及对应的蛋白质)的细胞分布位置:
FCGR3A基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| IMMUNODEFICIENCY 20 | 0.36 | 1 | 1 | CLINVAR_ORPHANET_UNIPROT |
| Lupus Erythematosus, Systemic | 0.174188819 | 38 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Temporomandibular Joint Dysfunction Syndrome | 0.08 | 1 | 0 | RGD |
| Rheumatoid Arthritis | 0.062385613 | 34 | 2 | BeFree_GAD_LHGDN |
| Lupus Erythematosus | 0.032128625 | 18 | 0 | BeFree_GAD |
| Periodontitis | 0.026851677 | 12 | 0 | BeFree_GAD |
| Colorectal Cancer | 0.017383549 | 10 | 0 | BeFree_GAD |
| Lymphoma | 0.011639663 | 12 | 0 | BeFree_GAD |
| Lymphoma, Non-Hodgkin | 0.009468128 | 4 | 0 | GAD |
| Crohn Disease | 0.009272631 | 9 | 0 | BeFree_GAD |
| Coronary Artery Disease | 0.008987376 | 5 | 0 | BeFree_LHGDN |
| Immune thrombocytopenic purpura | 0.008458305 | 8 | 0 | BeFree_GAD |
| HIV Infections | 0.008414698 | 31 | 1 | BeFree |
| Diffuse Large B-Cell Lymphoma | 0.008186863 | 7 | 0 | BeFree_GAD |
| Celiac Disease | 0.008001298 | 3 | 2 | BeFree_GAD_LHGDN |
| B-Cell Lymphomas | 0.008001298 | 4 | 0 | BeFree_GAD_LHGDN |
| Arthritis | 0.007915422 | 6 | 0 | BeFree_GAD |
| Bullous pemphigoid | 0.007729856 | 2 | 0 | BeFree_GAD_LHGDN |
| Chronic Periodontitis | 0.007372538 | 3 | 1 | BeFree_GAD |
| Lupus Nephritis | 0.006091273 | 6 | 0 | BeFree_GAD |
| Neutropenia | 0.005819831 | 4 | 0 | BeFree_GAD |
| Infection by Cryptococcus neoformans | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
| Hepatitis C, Chronic | 0.005362824 | 2 | 0 | BeFree_GAD_LHGDN |
| Periodontitis, Juvenile | 0.005276948 | 4 | 0 | BeFree_GAD |
| Lymphoma, Follicular | 0.005081451 | 10 | 0 | BeFree_GAD |
| Candidiasis | 0.004734064 | 2 | 0 | GAD |
| Guillain-Barre Syndrome | 0.004734064 | 2 | 0 | GAD |
| Lymphoid leukemia | 0.004734064 | 2 | 0 | GAD |
| Lupus Vulgaris | 0.003724241 | 6 | 0 | BeFree_GAD |
| Lupus Erythematosus, Discoid | 0.003724241 | 6 | 0 | BeFree_GAD |
| Atherosclerosis | 0.003538676 | 4 | 0 | BeFree_LHGDN |
| Coronary Arteriosclerosis | 0.003452799 | 4 | 0 | BeFree_GAD |
| Chronic Lymphocytic Leukemia | 0.003452799 | 4 | 0 | BeFree_GAD |
| Autoimmune Diseases | 0.003257302 | 12 | 1 | BeFree |
| Asthma | 0.003181358 | 3 | 4 | BeFree_GAD |
| IGA Glomerulonephritis | 0.003181358 | 3 | 0 | BeFree_GAD |
| Sepsis | 0.003181358 | 4 | 0 | BeFree_GAD |
| Malignant neoplasm of breast | 0.002909916 | 3 | 0 | BeFree_GAD |
| Cardiovascular Diseases | 0.002909916 | 3 | 0 | BeFree_GAD |
| Neuroblastoma | 0.002909916 | 3 | 0 | BeFree_GAD |
| Pneumonia | 0.002909916 | 3 | 0 | BeFree_GAD |
| Anti-Glomerular Basement Membrane Disease | 0.002909916 | 2 | 0 | BeFree_GAD |
| Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Inflammation | 0.00272435 | 1 | 0 | LHGDN |
| Mammary Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Infection | 0.00272435 | 1 | 0 | LHGDN |
| Arthritis, Psoriatic | 0.002638474 | 2 | 0 | BeFree_GAD |
| Squamous cell carcinoma | 0.002638474 | 2 | 0 | BeFree_GAD |
| Diabetes Mellitus, Insulin-Dependent | 0.002638474 | 2 | 0 | BeFree_GAD |
| Malaria | 0.002638474 | 2 | 0 | BeFree_GAD |
| Mucocutaneous Lymph Node Syndrome | 0.002638474 | 2 | 0 | BeFree_GAD |
| Multiple Myeloma | 0.002638474 | 2 | 0 | BeFree_GAD |
| Multiple Sclerosis | 0.002638474 | 2 | 0 | BeFree_GAD |
| Poliomyelitis | 0.002638474 | 1 | 0 | BeFree_GAD |
| Kaposi Sarcoma | 0.002638474 | 1 | 0 | BeFree_GAD |
| Seizures | 0.002638474 | 2 | 0 | BeFree_GAD |
| Giant Cell Arteritis | 0.002638474 | 1 | 0 | BeFree_GAD |
| Tuberculosis, Pulmonary | 0.002638474 | 1 | 0 | BeFree_GAD |
| Urinary tract infection | 0.002638474 | 1 | 0 | BeFree_GAD |
| Colorectal cancer metastatic | 0.002442977 | 9 | 0 | BeFree |
| Alveolar Bone Loss | 0.002367032 | 1 | 0 | GAD |
| Behcet Syndrome | 0.002367032 | 1 | 0 | GAD |
| Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of stomach | 0.002367032 | 1 | 0 | GAD |
| Meningococcal Infections | 0.002367032 | 1 | 0 | GAD |
| Myasthenia Gravis | 0.002367032 | 1 | 0 | GAD |
| Myositis | 0.002367032 | 1 | 0 | GAD |
| Nephrotic Syndrome | 0.002367032 | 1 | 0 | GAD |
| Periodontal Diseases | 0.002367032 | 1 | 0 | GAD |
| Periodontal Pocket | 0.002367032 | 1 | 0 | GAD |
| Respiratory Tract Infections | 0.002367032 | 1 | 0 | GAD |
| Thrombocytopenia | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Adult-Onset Still Disease | 0.002367032 | 1 | 0 | GAD |
| Juvenile-Onset Still Disease | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of brain | 0.002367032 | 1 | 0 | GAD |
| Periodontal Attachment Loss | 0.002367032 | 1 | 0 | GAD |
| Scleroderma, Limited | 0.002367032 | 1 | 0 | GAD |
| Diffuse Scleroderma | 0.002367032 | 1 | 0 | GAD |
| Granulomatosis with polyangiitis | 0.002367032 | 1 | 0 | GAD |
| Nephritis | 0.001900093 | 7 | 0 | BeFree |
| Colorectal Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Leukopenia | 0.001085767 | 4 | 0 | BeFree |
| Paroxysmal nocturnal hemoglobinuria | 0.001085767 | 4 | 0 | BeFree |
| Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
| Common Variable Immunodeficiency | 0.000814326 | 3 | 0 | BeFree |
| Coronary heart disease | 0.000814326 | 3 | 0 | BeFree |
| Herpes Simplex Infections | 0.000814326 | 3 | 0 | BeFree |
| Hodgkin Disease | 0.000814326 | 3 | 0 | BeFree |
| Septicemia | 0.000814326 | 3 | 0 | BeFree |
| Tuberculosis | 0.000814326 | 3 | 0 | BeFree |
| Leukemia, Large Granular Lymphocytic | 0.000814326 | 3 | 0 | BeFree |
| Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Ulcerative Colitis | 0.000542884 | 2 | 0 | BeFree |
| Epidermodysplasia Verruciformis | 0.000542884 | 2 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000542884 | 2 | 0 | BeFree |
| Kidney Diseases | 0.000542884 | 2 | 0 | BeFree |
| Kidney Failure, Chronic | 0.000542884 | 2 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.000542884 | 2 | 0 | BeFree |
| Lown-Ganong-Levine Syndrome | 0.000542884 | 2 | 0 | BeFree |
| Lymphopenia | 0.000542884 | 2 | 0 | BeFree |
| Lymphoproliferative Disorders | 0.000542884 | 2 | 0 | BeFree |
| Waldenstrom Macroglobulinemia | 0.000542884 | 2 | 0 | BeFree |
| melanoma | 0.000542884 | 2 | 0 | BeFree |
| Myocardial Infarction | 0.000542884 | 2 | 0 | BeFree |
| Obesity | 0.000542884 | 2 | 0 | BeFree |
| Sarcoidosis | 0.000542884 | 2 | 0 | BeFree |
| Virus Diseases | 0.000542884 | 2 | 0 | BeFree |
| Polyneuropathy | 0.000542884 | 2 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Alloimmune neonatal neutropenia | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000542884 | 2 | 0 | BeFree |
| Tumor necrosis | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
| Acquired Immunodeficiency Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Autoimmune hemolytic anemia | 0.000271442 | 1 | 0 | BeFree |
| Biliary Atresia | 0.000271442 | 1 | 0 | BeFree |
| Merkel cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
| Encephalitis | 0.000271442 | 1 | 0 | BeFree |
| Gastritis | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
| Graft-vs-Host Disease | 0.000271442 | 1 | 0 | BeFree |
| Graves Disease | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
| Herpesviridae Infections | 0.000271442 | 1 | 1 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
| Lymphocytosis | 0.000271442 | 1 | 0 | BeFree |
| Meningitis | 0.000271442 | 1 | 0 | BeFree |
| Mitral Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
| Neuromyelitis Optica | 0.000271442 | 1 | 0 | BeFree |
| Periapical Periodontitis | 0.000271442 | 1 | 0 | BeFree |
| Pleural effusion disorder | 0.000271442 | 1 | 0 | BeFree |
| Kidney Failure | 0.000271442 | 1 | 0 | BeFree |
| Rheumatism | 0.000271442 | 1 | 0 | BeFree |
| Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Yellow Fever | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Acute myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
| Liver Failure, Acute | 0.000271442 | 1 | 0 | BeFree |
| X-linked agammaglobulinemia | 0.000271442 | 1 | 0 | BeFree |
| Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Interstitial fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Vesicular Stomatitis | 0.000271442 | 1 | 0 | BeFree |
| Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
| Coinfection | 0.000271442 | 1 | 0 | BeFree |
| Chronic lymphocytic leukaemia refractory | 0.000271442 | 1 | 0 | BeFree |
| Kaposi's sarcoma classical type | 0.000271442 | 1 | 0 | BeFree |
| Anterior myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
| Acute HIV infection | 0.000271442 | 1 | 0 | BeFree |
| Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
| Nasal Type Extranodal NK/T-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Early onset periodontitis | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic crescentic glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
| Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Varicella zoster | 0.000271442 | 1 | 0 | BeFree |
| Immunodeficiency congenital | 0.000271442 | 1 | 0 | BeFree |
| Recurrent Chronic Lymphoid Leukemia | 0.000271442 | 1 | 0 | BeFree |
| pathergy | 0.000271442 | 1 | 0 | BeFree |
| Eczema Herpeticum | 0.000271442 | 1 | 0 | BeFree |
| Acute Coronary Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Alloimmunisation | 0.000271442 | 1 | 0 | BeFree |
| Spondylarthropathies | 0.000271442 | 1 | 0 | BeFree |
| Skin toxicity | 0.000271442 | 1 | 0 | BeFree |
| Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| TNF receptor-associated periodic fever syndrome (TRAPS) | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory disorder | 0.000271442 | 1 | 0 | BeFree |
| Aggressive natural killer-cell leukemia | 0.000271442 | 1 | 0 | BeFree |
| Blastic plasmacytoid dendritic cell neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Immune Reconstitution Inflammatory Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Chronic thromboembolic pulmonary hypertension | 0.000271442 | 1 | 0 | BeFree |
| Allergic rhinitis (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Juvenile arthritis | 0.000271442 | 1 | 0 | BeFree |
| Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
| Pneumonitis | 0.000271442 | 1 | 0 | BeFree |
| Juvenile rheumatoid arthritis | 0.000271442 | 1 | 0 | BeFree |
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