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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
[中文简述(自动翻译):]  该基??因编码在F-box蛋白家族,其特征是一个约40个氨基酸基序,在F-盒的成员。在F-box蛋白组成四个亚基被叫泛素蛋白连接酶复合SCFS(SKP1-滞-F-箱)中的其中一个功能的磷酸化依赖泛素化。在F-box蛋白被分为3类:Fbws含WD-40结构域,含有Fbls富含亮氨酸的重复序列,以及含有任一不同的蛋白质 - 蛋白质相互作用的模块或没有可识别的图案Fbxs。由该基因编码的蛋白质属于Fbxs类。它也是NFB42(神经F箱42 kDa)的家族,类似于F盒只蛋白2和F-盒只蛋白6.若干可变剪接转录物变体编码两种不同的同种型已发现此基因的一个成员。 [由RefSeq的,2015年2月提供]
FBXO44基因(以及对应的蛋白质)的细胞分布位置:
FBXO44基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Polycystic Ovary Syndrome | 0.12 | 1 | 0 | CTD_human |
Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
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