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The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是exocyst复合物的组分,用于靶向胞吐泡在质膜特定对接位点的多蛋白复合物是至关重要的。虽然在酵母最好其特征在于,组分的蛋白质和exocyst复杂的功能已被证明在高等真核生物是高度保守的。至少八个所述exocyst复杂的部件,包括该蛋白质,被发现与肌动蛋白细胞骨架重构,囊泡运输机械相互作用。复数也是上皮细胞表面极性的生物合成是必不可少的。备用转录剪接变体,编码不同同种型,已经表征。 [由RefSeq的,2008年7月提供]
EXOC4基因(以及对应的蛋白质)的细胞分布位置:
EXOC4基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Alzheimer's Disease | 0.12 | 1 | 1 | GWASCAT |
Rheumatoid Arthritis | 0.002638474 | 1 | 0 | BeFree_GAD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.002638474 | 1 | 0 | BeFree_GAD |
Amyotrophic Lateral Sclerosis | 0.002367032 | 1 | 0 | GAD |
Blood pressure finding | 0.002367032 | 1 | 2 | GAD |
Systemic arterial pressure | 0.002367032 | 1 | 2 | GAD |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Polycystic Kidney, Autosomal Dominant | 0.000271442 | 1 | 0 | BeFree |
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