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This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
[中文简述(自动翻译):]  该基因属于蛋白 - 酪氨酸激酶家族的肝配蛋白受体亚家族。 EPH和EPH相关受体已经牵涉于介导发育事件,特别是在神经系统。在弗亚科受体通常具有单一的激酶结构域和含有富含Cys结构域和2型纤连蛋白III重复的胞外区。的肝配蛋白受体分为基于它们的胞外结构域序列和它们的结合肝配蛋白-A和肝配蛋白-B的配体亲和性的相似2组。该基因的表达增加与癌的多种形式相关联。选择性剪接结果在多个抄本变形。 [由RefSeq的,2013年12月提供]
EPHA7基因(以及对应的蛋白质)的细胞分布位置:
EPHA7基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Small cell carcinoma of lung | 0.12 | 1 | 0 | CTD_human |
| Glioblastoma | 0.00272435 | 1 | 0 | LHGDN |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Lymphoma | 0.001085767 | 4 | 0 | BeFree |
| Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Hodgkin Disease | 0.000271442 | 1 | 0 | BeFree |
| Hydronephrosis | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
| Ureterocele | 0.000271442 | 1 | 0 | BeFree |
| B-Cell Lymphomas | 0.000271442 | 1 | 0 | BeFree |
| Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Dilatation of ureter | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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