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This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
[中文简述(自动翻译):]  该基因编码的多梳组(PCG)家族中的一员。所编码的蛋白质是NuA4组蛋白乙酰转移酶复合物的组分,并且可以同时作为转录激活和阻遏作用。所编码的蛋白质已被链接到细胞凋亡,DNA修复,骨骼肌分化,基因沉默,和成人T细胞白血病/淋巴瘤。选择性剪接结果在多个抄本变形。 [由RefSeq的,2012年12月提供]
EPC1基因(以及对应的蛋白质)的细胞分布位置:
EPC1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Endometrial Stromal Sarcoma | 0.001357209 | 5 | 0 | BeFree |
leukemia | 0.000542884 | 2 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000542884 | 2 | 0 | BeFree |
Echinococcosis | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Neurocysticercosis | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
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