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Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene encodes the largest protein in the enamel matrix of developing teeth. The protein is involved in the mineralization and structural organization of enamel. Defects in this gene result in amelogenesis imperfect type 1C.[provided by RefSeq, Oct 2009]
[中文简述(自动翻译):]  牙釉质形成牙齿的外盖,并在脊椎动物中发现的最坚硬的物质。该基因编码的最大蛋白在显影齿的釉质基质。该蛋白质是参与矿化和釉质的结构组织。缺陷这个基因导致amelogenesis不完善类型1C。[由RefSeq的,2009年10月提供]
ENAM基因(以及对应的蛋白质)的细胞分布位置:
ENAM基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Amelogenesis Imperfecta, Type IB | 0.440271442 | 2 | 3 | BeFree_CLINVAR_CTD_human_MGD_UNIPROT |
| Amelogenesis Imperfecta, Type Ic | 0.36 | 1 | 1 | CLINVAR_CTD_human_UNIPROT |
| Amelogenesis Imperfecta | 0.132777631 | 28 | 0 | BeFree_CTD_human_LHGDN |
| Dental caries | 0.003452799 | 5 | 0 | BeFree_GAD |
| Caries (morphologic abnormality) | 0.000814326 | 3 | 0 | BeFree |
| Amelogenesis imperfecta local hypoplastic form | 0.000814326 | 3 | 0 | BeFree |
| Malocclusion | 0.000542884 | 2 | 0 | BeFree |
| Hepatitis, Autoimmune | 0.000542884 | 2 | 0 | BeFree |
| Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Dental Enamel Hypoplasia | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
| Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Odontogenic Tumors | 0.000271442 | 1 | 0 | BeFree |
| Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Early childhood caries | 0.000271442 | 1 | 5 | BeFree |
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