E2F4(E2F transcription factor 4, p107/p130-binding) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

16q22.1
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白质是E2F家族转录因子的成员。的E2F家族在肿瘤抑制蛋白的细胞周期和动作的控制的关键作用，也是小的DNA肿瘤病毒转化的蛋白质的靶。该E2F蛋白含有在家族的大部分成员发现了一些进化上保守结构域。这些域包括一个DNA结合结构域，其中确定与该分化调节转录因子的蛋白质（DP），在酸性氨基酸富集的一个激活结构域相互作用二聚化结构域，并且其中已经被嵌入所述激活域内的肿瘤抑制蛋白相关结构域。此蛋白结合所有三种肿瘤抑制蛋白的pRB，P107和P130，但具有到最后两个更高的亲和力。它在细胞增殖相关基因的抑制中起重要作用，并且其基因突变和增加的表达可以与人类癌症有关。 [由RefSeq的，2008年7月提供]

OMIM数据库中对E2F4基因的介绍     Wikipedia数据库中对E2F4基因的介绍

基因序列

基因序列

E2F4基因的碱基序列：[NCBI]

基因突变

基因突变

E2F4基因的碱基突变：           显示全部snp
rs11700       rs1053308       rs1801013       rs3729639       rs3730388       rs3730389       rs3730390       rs3730391       rs3730392       rs3730393       rs3730394       rs3730395       rs3730396       rs3730397       rs3730398       rs3730399       rs3730400       rs3730401       rs3730402       rs3730403       rs3730404       rs3730405       rs3730406       rs3730407       rs3730408       rs3730409       rs3730410       rs3730411       rs3730412       rs3730413       rs3809629       rs9932087       rs12923138       rs61735430       rs75193761       rs75396868       rs76429782      
rs78635507       rs78899755       rs79137113       rs112388145       rs112393563       rs112951318       rs113365817       rs113851064       rs114086140       rs114750874       rs116116940       rs117299478       rs138138612       rs139092130       rs139460622       rs139824421       rs139952669       rs140931625       rs141245085       rs141264556       rs141549734       rs142389152       rs142486052       rs142920724       rs143184493       rs143427926       rs143539916       rs143573854       rs143700278       rs143853278       rs144205517       rs144382460       rs145601096       rs145622192       rs145860239       rs145869946       rs145929720       rs146072162       rs146208428       rs146349780       rs146809771       rs147127862       rs147383610       rs147869928       rs148234724       rs148595862       rs148778336       rs149100099       rs149807830       rs150071922       rs150173967       rs150698601       rs150782599       rs151096716       rs180736764       rs181059319       rs181192294       rs182316876       rs182740246       rs183077283       rs184513001       rs184580695       rs184957442       rs185270550       rs186265317       rs186377111       rs187530788       rs188113549       rs189257170       rs189291049       rs189616961       rs189971383       rs190860015       rs191645835       rs192462551       rs192621438       rs199527162       rs199566877       rs199882527       rs199975562       rs200123345       rs200220235       rs200259730       rs200268370       rs200422281       rs200439672       rs200611774       rs200871588       rs200920591       rs201259106       rs201338753       rs201480060       rs201493100       rs201693553       rs201730127       rs201849494       rs202020885       rs202137368       rs202169613       rs367662113       rs367663947       rs367732752       rs367771994       rs367781358       rs367905434       rs367922852       rs367936946       rs368074030       rs368101540       rs368405674       rs368560421       rs368638005       rs368666591       rs368708398       rs369048953       rs369060687       rs369066135       rs369209616       rs369525978       rs370022423       rs370191195       rs370559345       rs370857092       rs371191935       rs371430202       rs371524763       rs371574170       rs371607109       rs371767620       rs371788671       rs372204012       rs372301833       rs372337777       rs372772302       rs372924076       rs372944523       rs372968208       rs373220412       rs373235577       rs373436200       rs373813394       rs373869677       rs373980503       rs374001217       rs374051976       rs374152056       rs374173510       rs374181513       rs374358555       rs374700548       rs374709097       rs374809081       rs374860691       rs375039814       rs375187299       rs375650807       rs375663141       rs375666198       rs375719412       rs376024571       rs376202405       rs376285216       rs376362007       rs376555283       rs376579427       rs376860346       rs376886990       rs376942340       rs377030974       rs377389907       rs377455512       rs377657577       rs527625811       rs527684199       rs527975962       rs528050686       rs528594727       rs528879412       rs529873809       rs529986034       rs530262974       rs530323350       rs530894420       rs531197784       rs531493831       rs531712252       rs532112190       rs532173731       rs532624773       rs532826537       rs533361806       rs533638864       rs533731588       rs533758628       rs534067052       rs534346229       rs535424893       rs535487785       rs535864891       rs536394279       rs536606769       rs536669063       rs537645516       rs537804498       rs538347624       rs538781474       rs539915339       rs540039717       rs540284145       rs540819469       rs541536417       rs541969393       rs542030769       rs542274290       rs543054204       rs543952492       rs544016563       rs544234574       rs544281104       rs544344464       rs544893537       rs544907030       rs545469619       rs546284842       rs546305954       rs546643231       rs546771691       rs546820422       rs547429805       rs547662352       rs548086077       rs548304709       rs548449378       rs548509775       rs548591583       rs548881935       rs548916393       rs549700210       rs550026534       rs550471473       rs550729946       rs551156315       rs551227451       rs551383517       rs551688798       rs552245719       rs552823502       rs553043365       rs553588481       rs554270585       rs554930868       rs555009300       rs555171020       rs556137987       rs556293784       rs557254925       rs557487713       rs557626686       rs558126505       rs560561068       rs560639758       rs561319887       rs561954938       rs562378144       rs562457731       rs562651827       rs562794280       rs563846092       rs563909699       rs563989936       rs564712141       rs564713537       rs564776904       rs564824509       rs565176275       rs565262883       rs565338324       rs565591674       rs566500354       rs566531811       rs566904805       rs566908262       rs567440574       rs568092187       rs568158921       rs568544718       rs568831542       rs568957417       rs569051274       rs569052745       rs569786532       rs570425810       rs570973717       rs571037086       rs571269056       rs571466790       rs572519790       rs573063442       rs573115524       rs573143069       rs573162700       rs573677300       rs574717740       rs575614504       rs576101163       rs576162692       rs576357448       rs576749735       rs576812038       rs577207109       rs577346547       rs577365720       rs577742150       rs578206454       rs745359508       rs745390568       rs745551133       rs745697932       rs745768190       rs746040011       rs746229580       rs746269056       rs746423797       rs746428098       rs746546328       rs746739278       rs746988034       rs746994269       rs747009933       rs747021704       rs747069312       rs747222235       rs747276875       rs747401766       rs747655429       rs747682568       rs747843182       rs747849285       rs747900680       rs748136602       rs748157791       rs748185219       rs748249574       rs748557232       rs748729451       rs748743089       rs748836117       rs749016852       rs749039906       rs749094733       rs749331339       rs749411097       rs749597514       rs749861665       rs749919476       rs749922307       rs750153343       rs750201715       rs750280060       rs750289655       rs750464005       rs750515162       rs750658582       rs750707005       rs750812581       rs750890716       rs751046899       rs751120955       rs751177826       rs751386542       rs751409710       rs751416067       rs751503222       rs751587728       rs751631573       rs751649990       rs751878038       rs752020560       rs752022423       rs752220865       rs752244507       rs752626507       rs752782625       rs752813070       rs753070646       rs753333027       rs753504527       rs753672194       rs753836202       rs754060853       rs754082976       rs754170562       rs754279869       rs754637980       rs754889490       rs755035084       rs755298790       rs755307028       rs755331134       rs755406160       rs755418911       rs755790677       rs755798896       rs755807245       rs756033028       rs756058018       rs756142607       rs756154667       rs756259717       rs756373164       rs756414640       rs756507860       rs756676087       rs756743172       rs756909955       rs756947077       rs756949405       rs757043561       rs757139019       rs757233250       rs757259236       rs757260912       rs757390658       rs757531041       rs757559240       rs757660011       rs758019818       rs758048925       rs758107981       rs758109303       rs758224346       rs758404795       rs758419181       rs758469086       rs758630000       rs758640226       rs758892318       rs759099769       rs759272055       rs759277058       rs759305308       rs759473562       rs759531736       rs759539575       rs759634194       rs759689997       rs759749178       rs759845624       rs759908704       rs760143133       rs760451719       rs760472888       rs760543611       rs760587607       rs760602299       rs760695048       rs760828806       rs761080564       rs761251681       rs761287669       rs761328592       rs761350193       rs761414731       rs761451704       rs761626001       rs761692438       rs761697299       rs761733949       rs761983341       rs762197679       rs762346686       rs762373268       rs762395988       rs762462600       rs762696530       rs762715981       rs762792916       rs763111395       rs763256769       rs763431771       rs763519840       rs763688036       rs763749631       rs764030598       rs764086212       rs764117710       rs764202464       rs764512687       rs764590918       rs764935854       rs765168266       rs765190305       rs765355963       rs765556755       rs765671607       rs765699823       rs765749645       rs765767893       rs766050920       rs766136949       rs766137399       rs766245224       rs766332943       rs766371360       rs766415217       rs766451948       rs766647604       rs766653093       rs766795929       rs766804851       rs766815494       rs767025605       rs767265222       rs767282443       rs767466593       rs767487314       rs767577798       rs767675378       rs767801931       rs767999787       rs768162623       rs768262664       rs768293921       rs768368882       rs768378136       rs768398358       rs768458457       rs768469611       rs768489916       rs768571421       rs768652858       rs768765641       rs768918727       rs768949780       rs768951112       rs768961024       rs769005366       rs769177982       rs769237234       rs769306816       rs769330028       rs769502993       rs769594181       rs769947373       rs769980836       rs770197957       rs770355121       rs770391730       rs770714875       rs770986442       rs771157075       rs771168933       rs771307420       rs771564955       rs771581639       rs771684145       rs771864789       rs771881783       rs771917627       rs772133152       rs772188950       rs772201604       rs772273245       rs772337091       rs772380144       rs772618612       rs772635193       rs772816433       rs772818699       rs773050398       rs773136774       rs773175133       rs773353905       rs773546731       rs773704692       rs773790833       rs773970251       rs774063697       rs774083122       rs774366439       rs774396136       rs774468646       rs774504912       rs774520533       rs774590768       rs774676096       rs774753887       rs774755930       rs774879472       rs774940740       rs775026507       rs775328540       rs775460095       rs775536838       rs775619297       rs775779581       rs775804840       rs775816608       rs775931538       rs775983343       rs775985947       rs776110554       rs776262453       rs776310384       rs776344088       rs776376704       rs776464961       rs776471131       rs776754432       rs776775240       rs776817198       rs776833894       rs776911851       rs776931675       rs777237962       rs777479854       rs777503156       rs777523089       rs777613387       rs777866947       rs777872195       rs777908322       rs777989753       rs778062342       rs778173464       rs778326506       rs778468713       rs778560573       rs778658200       rs778828164       rs778833176       rs778835702       rs778952840       rs779113642       rs779261201       rs779302894       rs779420375       rs779580429       rs779653903       rs779695042       rs780065163       rs780098860       rs780454630       rs780543618       rs780649262       rs780733882       rs780946213       rs781048916       rs781213749       rs781296185       rs781307077       rs781332736       rs781424602       rs781770589      

基因表达

基因表达

E2F4基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank

转录因子

转录因子

转录因子
影响类型
PubMed链接
AR
Unknown
22508987
AURKB
Unknown
15033491
BIRC5
Unknown
18504435
BRCA1
Activation
20818429
BRCA1
Repression
17106239     20133863     21701264     23108140    
BRCA1
Unknown
17001309
CCNB1
Unknown
22508987
CCND1
Unknown
9584162
CDK2
Unknown
22447046
CUX1
Unknown
18347061

基因本体信息

E2F4基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

E2F4基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000278
H3BMP3(UniProtKB)
IEA
GO:0003677
H3BMP3(UniProtKB)
IEA
GO:0003700
H3BMP3(UniProtKB)
IEA
GO:0005634
H3BMP3(UniProtKB)
IEA
GO:0005667
H3BMP3(UniProtKB)
IEA
GO:0006351
H3BMP3(UniProtKB)
IEA
GO:0006355
H3BMP3(UniProtKB)
IEA
GO:0000278
H3BTM3(UniProtKB)
IEA
GO:0003677
H3BTM3(UniProtKB)
IEA
GO:0003700
H3BTM3(UniProtKB)
IEA
GO:0005634
H3BTM3(UniProtKB)
IEA
GO:0005667
H3BTM3(UniProtKB)
IEA
GO:0006351
H3BTM3(UniProtKB)
IEA
GO:0006355
H3BTM3(UniProtKB)
IEA
GO:0000278
H3BVE4(UniProtKB)
IEA
GO:0003677
H3BVE4(UniProtKB)
IEA
GO:0003700
H3BVE4(UniProtKB)
IEA
GO:0005634
H3BVE4(UniProtKB)
IEA
GO:0005667
H3BVE4(UniProtKB)
IEA
GO:0006351
H3BVE4(UniProtKB)
IEA
GO:0006355
H3BVE4(UniProtKB)
IEA
GO:0000278
I3L1B6(UniProtKB)
IEA
GO:0003700
I3L1B6(UniProtKB)
IEA
GO:0006355
I3L1B6(UniProtKB)
IEA
GO:0000083
Q16254(UniProtKB)
IEA
GO:0000790
Q16254(UniProtKB)
IDA
GO:0000978
Q16254(UniProtKB)
IDA
GO:0001077
Q16254(UniProtKB)
IC
GO:0002064
Q16254(UniProtKB)
IEA
GO:0003677
Q16254(UniProtKB)
IMP
GO:0003700
Q16254(UniProtKB)
IDA
GO:0005515
Q16254(UniProtKB)
IPI
GO:0005515
Q16254(UniProtKB)
IPI
GO:0005515
Q16254(UniProtKB)
IPI
GO:0005515
Q16254(UniProtKB)
IPI
GO:0005515
Q16254(UniProtKB)
IPI
GO:0005515
Q16254(UniProtKB)
IPI
GO:0005654
Q16254(UniProtKB)
IDA
GO:0005654
Q16254(UniProtKB)
TAS
GO:0005654
Q16254(UniProtKB)
TAS
GO:0005654
Q16254(UniProtKB)
TAS
GO:0005654
Q16254(UniProtKB)
TAS
GO:0005654
Q16254(UniProtKB)
TAS
GO:0005654
Q16254(UniProtKB)
TAS
GO:0005654
Q16254(UniProtKB)
TAS
GO:0005654
Q16254(UniProtKB)
TAS
GO:0005654
Q16254(UniProtKB)
TAS
GO:0005667
Q16254(UniProtKB)
IEA
GO:0006366
Q16254(UniProtKB)
IEA
GO:0006884
Q16254(UniProtKB)
IEA
GO:0006977
Q16254(UniProtKB)
TAS
GO:0008015
Q16254(UniProtKB)
IEA
GO:0008134
Q16254(UniProtKB)
IPI
GO:0008134
Q16254(UniProtKB)
IPI
GO:0009887
Q16254(UniProtKB)
IEA
GO:0019904
Q16254(UniProtKB)
IPI
GO:0042127
Q16254(UniProtKB)
IEA
GO:0044458
Q16254(UniProtKB)
ISS
GO:0045944
Q16254(UniProtKB)
ISS
GO:0045944
Q16254(UniProtKB)
IDA
GO:0045944
Q16254(UniProtKB)
TAS
GO:0098534
Q16254(UniProtKB)
ISS
GO:1903251
Q16254(UniProtKB)
ISS
GO:1990841
Q16254(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控E2F4基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
OTITIS MEDIA, SUSCEPTIBILITY TO (finding) 0.08 0 0 MGD
Macrocytosis, Familial 0.08 0 0 MGD
Colorectal Neoplasms 0.003538676 4 0 BeFree_LHGDN
Malignant neoplasm of ovary 0.002638474 2 0 BeFree_GAD
Coronary heart disease 0.002367032 1 1 GAD
Breast Carcinoma 0.001900093 7 0 BeFree
Malignant neoplasm of breast 0.001628651 6 0 BeFree
Carcinogenesis 0.001628651 6 0 BeFree
Colorectal Cancer 0.001628651 6 0 BeFree
Colorectal Carcinoma 0.001085767 4 0 BeFree
Malignant tumor of colon 0.000814326 3 0 BeFree
Tumor Progression 0.000814326 3 0 BeFree
Prostate carcinoma 0.000814326 3 0 BeFree
Colon Carcinoma 0.000814326 3 0 BeFree
Stomach Carcinoma 0.000542884 2 0 BeFree
Liver carcinoma 0.000542884 2 0 BeFree
Burkitt Lymphoma 0.000271442 1 0 BeFree
Malignant neoplasm of thyroid 0.000271442 1 0 BeFree
Ulcerative Colitis 0.000271442 1 0 BeFree
Colonic Neoplasms 0.000271442 1 0 BeFree
Gastrointestinal Neoplasms 0.000271442 1 0 BeFree
Leukemia, Lymphocytic, Acute, L1 0.000271442 1 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Leukemia, T-Cell 0.000271442 1 0 BeFree
Adult T-Cell Lymphoma/Leukemia 0.000271442 1 0 BeFree
Lung Neoplasms 0.000271442 1 0 BeFree
Malignant neoplasm of stomach 0.000271442 1 0 BeFree
Microphthalmos 0.000271442 1 0 BeFree
Myocardial Infarction 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Stomach Neoplasms 0.000271442 1 0 BeFree
Turcot syndrome (disorder) 0.000271442 1 0 BeFree
Disorder of lymph node 0.000271442 1 0 BeFree
Multiple polyps 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Hematologic Neoplasms 0.000271442 1 0 BeFree
Thyroid carcinoma 0.000271442 1 0 BeFree
Ewings sarcoma 0.000271442 1 0 BeFree
Tumor Initiation 0.000271442 1 0 BeFree
Adenoma of large intestine 0.000271442 1 0 BeFree
Sporadic Burkitt's lymphoma 0.000271442 1 0 BeFree
Oropharyngeal Carcinoma 0.000271442 1 0 BeFree

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