DUSP2基因详情-基因数据库-基因云馆

DUSP2(dual specificity phosphatase 2) 转至新版数据库

基因简称(symbol)

DUSP2 [HGNC] [GeneCards] [NCBI]

基因种类(locus group)

protein-coding gene

同源简称(alias symbol)

PAC-1

基因家族代码(gene_family_id)

895 [HGNC] [GenScript]

omim代码

603068

entrez码

1844 [Vega]

vega基因码

OTTHUMG00000130456

ensembl基因码

ENSG00000158050 [Ensembl]

基因家族(gene family)

MAP kinase phosphatases

refseq数据库代号

NM_004418

更多...

基因种类(locus_type)

gene with protein product

基因名称状态(status)

Approved

location_sortable

02q11

同源基因名称(alias name)

基因名称批准使用时间(date_approved_reserved)

1994-12-14T00:00:00Z

基因简称更名时间(date_symbol_changed)

基因名称更名时间(date_name_changed)

更新时间(date_modified)

2014-11-19T00:00:00Z

ucsc码

uc002svk.4

ena

L11329

ccds数据码

CCDS2016

uniprot数据码

Q05923

pubmed代码

7806236|7590752|12673251

mgd码

MGI:101911

rgd码

RGD:1305804

生命科学数据库(lsdb)

更新时间(date modified)

2014-11-19T00:00:00Z

cosmic

DUSP2

mirbase

基因曾用简称(prev symbol)

基因曾用名称(prev name)

homeodb

cosmic

DUSP2

snornabase

bioparadigms slc

orphanet

假基因信息(pseudogeneorg)

horde id

merops

imgt

iuphar

kznf基因类别

mamit-trnadb

cd

LncRNA数据库

酶代码

中间纤维数据库

收起

2q11

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):] 由该基因编码的蛋白是双重特异性蛋白磷酸酶亚家族的一个成员。这些通过磷酸酶脱磷酸化两个磷酸丝氨酸/苏氨酸和磷酸化酪氨酸残基的灭活他们的目标激酶。它们负调节有丝分裂原活化蛋白（MAP）激酶家族（MAPK / ERK，SAPK / JNK，p38的），其与细胞增殖和分化相关的成员。家庭双重特异性磷酸酶的不同成员显示各种MAP激酶，不同的组织分布和亚细胞定位，并通过细胞外刺激其表达诱导的不同模式不同的底物特异性。该基因产物灭活的ERK1和ERK2，在造血组织中表达，并在细胞核中被定位。 [由RefSeq的，2008年7月提供]

OMIM数据库中对DUSP2基因的介绍 Wikipedia数据库中对DUSP2基因的介绍

DUSP2基因的碱基序列：[NCBI]

DUSP2基因的碱基突变：显示全部snp

rs1042361 rs1724120 rs1724121 rs57072789 rs60626294 rs74720410 rs75059788 rs111226214 rs111938402 rs112286236 rs114113616 rs115523494 rs115786506 rs116699863 rs117548456 rs117976212 rs137991595 rs138796808 rs139318314 rs140138990 rs141261455 rs141345431 rs143038411 rs143940850 rs144192490 rs144243944 rs144927730 rs145177272 rs146609611 rs147952657 rs148997852 rs150034773 rs151080230 rs180817110 rs182119570 rs182916062 rs184429608

rs185121318 rs187607778 rs188363703 rs190041400 rs190055407 rs190717625 rs192294242 rs199527601 rs199945308 rs200368289 rs200712914 rs200846467 rs201028960 rs201093774 rs201412020 rs201468327 rs201829031 rs201899099 rs202128160 rs202170773 rs368049350 rs369320464 rs369325506 rs369390154 rs369633913 rs369831290 rs370042908 rs370602049 rs370789460 rs372344461 rs372357109 rs372766743 rs373082796 rs373647887 rs373944250 rs374064287 rs374262102 rs375737797 rs376516669 rs377434804 rs528627160 rs529330086 rs529392486 rs529726368 rs531488809 rs532272614 rs533153952 rs534259868 rs534601595 rs535465705 rs535515060 rs535580341 rs537374232 rs537645061 rs539894350 rs539952138 rs540921692 rs541334714 rs542151051 rs542663886 rs543384464 rs543598429 rs545476318 rs545914740 rs546304508 rs547654715 rs548942138 rs549079274 rs549966683 rs551138731 rs551527506 rs552069757 rs552405899 rs554313825 rs555380866 rs556235439 rs558374852 rs559291993 rs559414512 rs559690961 rs559823081 rs562529374 rs563170454 rs564414409 rs566028992 rs569902661 rs570047731 rs570661321 rs570855741 rs572028879 rs572092788 rs576187055 rs576247409 rs576641475 rs577846736 rs577899253 rs745381899 rs745737498 rs745791600 rs745878412 rs746076346 rs746339897 rs746625044 rs747120101 rs747298849 rs747609840 rs747722629 rs747889631 rs748240347 rs748272134 rs748669725 rs749013732 rs749202296 rs749292287 rs749389431 rs749713427 rs750087780 rs750223026 rs750307086 rs750624388 rs751263132 rs751919546 rs752250965 rs752730372 rs752824511 rs752968740 rs753010881 rs753164081 rs753494105 rs753630020 rs754112547 rs754959106 rs755188894 rs755424676 rs755773859 rs755844352 rs755931212 rs756203530 rs756683491 rs756891334 rs757400657 rs757557678 rs757838312 rs758347817 rs758546875 rs758609462 rs758707947 rs758793748 rs759149005 rs759397760 rs759596126 rs760353350 rs760580274 rs760676017 rs760865185 rs760880863 rs760953286 rs761126265 rs761159833 rs761720858 rs762195420 rs762354515 rs762552745 rs762677764 rs762740788 rs763429869 rs763478415 rs764502826 rs764902433 rs765869354 rs766312401 rs766531469 rs766621091 rs767097357 rs767273870 rs767365912 rs767499624 rs767865278 rs767892413 rs768107972 rs768679007 rs768849806 rs769578355 rs769813572 rs770238290 rs770469798 rs770858997 rs771621313 rs771694150 rs771854789 rs771931357 rs772378100 rs773533210 rs773604439 rs773621641 rs774392717 rs774790294 rs774950837 rs775141232 rs775166409 rs775439306 rs775535169 rs775901984 rs776220088 rs776464088 rs776496987 rs776753272 rs777122405 rs777343774 rs777430150 rs777693501 rs777787330 rs778377674 rs778571583 rs779039146 rs779404624 rs779589878 rs780185750 rs780282847 rs780547246 rs780640891 rs780828125 rs781733980 rs781738664 rs2969489 rs3813659 rs3813660 rs72825846 rs72937811 rs74544203 rs76641569 rs113231765 rs113282542 rs113884704 rs114771089 rs115683193 rs138159530 rs139634598 rs142756095 rs144681132 rs146954147 rs148497457 rs149316780 rs182101239 rs183836217 rs186875590 rs187940411 rs191481254 rs192408294 rs371243689 rs527466433 rs529650914 rs530329347 rs530549800 rs530815927 rs531202204 rs534446919 rs534500363 rs536115663 rs536178959 rs536655396 rs537320690 rs538377053 rs540879544 rs540943067 rs544613883 rs544879494 rs545367330 rs546616665 rs548646302 rs550147523 rs551107136 rs551318349 rs552779134 rs556589090 rs557719539 rs558761826 rs558794590 rs560203906 rs560501269 rs560629373 rs560706362 rs561293519 rs561554354 rs564818054 rs565171293 rs565763652 rs566941739 rs567203743 rs567814907 rs571168541 rs573458167 rs575170288 rs577504558 rs747677932 rs749032414 rs750926717 rs751698426 rs751786084 rs753015027 rs756547339 rs757359036 rs760492286 rs760586152 rs761246392 rs762018561 rs763073385 rs764240732 rs764301796 rs767680724 rs768197657 rs768211327 rs768266724 rs773176077 rs773725611 rs776286763 rs778569752 rs780265250 rs781771035

DUSP2基因在不同组织中的表达： [UniProt]

正向引物序列

正向引物Tm值

反向引物序列

反向引物Tm值

rank

GAGTATCCCTGTGGAGGAC

58

TTCACCCAGTCAATGAAGC

58

GAGTATCCCTGTGGAGGAC

58

CTTCACCCAGTCAATGAAGC

59

AGAGTATCCCTGTGGAGGA

58

TTCACCCAGTCAATGAAGC

58

尚未收录相关数据

DUSP2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

溶酶体
内涵体
细胞核
细胞质
液泡
细胞膜
细胞外基质
内质网
线粒体
高尔基体
细胞骨架

DUSP2基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000188

Q05923(UniProtKB)

TAS

GO:0001706

Q05923(UniProtKB)

IBA

GO:0004725

Q05923(UniProtKB)

IEA

GO:0005515

Q05923(UniProtKB)

IPI

GO:0005634

Q05923(UniProtKB)

IEA

GO:0006470

Q05923(UniProtKB)

TAS

GO:0008330

Q05923(UniProtKB)

TAS

GO:0017017

Q05923(UniProtKB)

IEA

GO:0035335

Q05923(UniProtKB)

IEA

GO:0051019

Q05923(UniProtKB)

IEA

序号	作用方式	资源库来源/分值	基因名称	基因名称

可能调控DUSP2基因的相关microRNA：

hsa-miR-124 hsa-let-7a hsa-let-7b hsa-let-7b* hsa-let-7c hsa-let-7c* hsa-let-7d hsa-let-7d* hsa-let-7e hsa-let-7e* hsa-let-7f hsa-let-7g hsa-let-7g* hsa-let-7i hsa-let-7i* hsa-miR-122 hsa-miR-122* hsa-miR-26a hsa-miR-26b hsa-miR-26b* hsa-miR-27b hsa-miR-27b* hsa-miR-29a hsa-miR-29a* hsa-miR-29c hsa-miR-29c* hsa-miR-29b

通路基因列表

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Juvenile arthritis	0.12	1	0	CTD_human
leukemia	0.00272435	1	0	LHGDN
Inflammation	0.002367032	1	0	GAD
Lymphoma, Non-Hodgkin	0.002367032	1	0	GAD
Pituitary Diseases	0.001357209	5	0	BeFree
Multiple Myeloma	0.000814326	3	0	BeFree
Malignant neoplasm of lung	0.000814326	3	0	BeFree
Malignant neoplasm of prostate	0.000814326	3	0	BeFree
Prostate carcinoma	0.000814326	3	0	BeFree
Carcinoma of lung	0.000814326	3	0	BeFree
Malignant neoplasm of breast	0.000542884	2	0	BeFree
Malignant tumor of colon	0.000542884	2	4	BeFree
Neuroblastoma	0.000542884	2	0	BeFree
Retinoblastoma	0.000542884	2	0	BeFree
Schizophrenia	0.000542884	2	0	BeFree
Migraine Disorders	0.000542884	2	0	BeFree
Breast Carcinoma	0.000542884	2	0	BeFree
Colon Carcinoma	0.000542884	2	4	BeFree
Central neuroblastoma	0.000542884	2	0	BeFree
Mammary Neoplasms	0.000542884	2	0	BeFree
Congenital Abnormality	0.000271442	1	0	BeFree
Mental disorders	0.000271442	1	0	BeFree
Bipolar Disorder	0.000271442	1	0	BeFree
Adenocarcinoma of prostate	0.000271442	1	0	BeFree
Rectal Carcinoma	0.000271442	1	4	BeFree
Endometriosis	0.000271442	1	0	BeFree
Glioma	0.000271442	1	0	BeFree
Hydrocephalus	0.000271442	1	0	BeFree
Congenital Hydrocephalus	0.000271442	1	0	BeFree
Chronic Lymphocytic Leukemia	0.000271442	1	0	BeFree
oligodendroglioma	0.000271442	1	0	BeFree
Ovarian Carcinoma	0.000271442	1	0	BeFree
Post-Traumatic Stress Disorder	0.000271442	1	0	BeFree
Stress, Psychological	0.000271442	1	0	BeFree
Acute leukemia	0.000271442	1	0	BeFree
Neuroendocrine Tumors	0.000271442	1	0	BeFree
Epithelial ovarian cancer	0.000271442	1	0	BeFree
Well Differentiated Oligodendroglioma	0.000271442	1	0	BeFree
Pancreatic Ductal Adenocarcinoma	0.000271442	1	0	BeFree
Benign Prostatic Hyperplasia	0.000271442	1	0	BeFree
Bisphosphonate-associated osteonecrosis	0.000271442	1	0	BeFree