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This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码多巴胺受体的D4亚型。 D4的亚型是一个G蛋白偶联受体,其抑制腺苷酸环化酶。这是该治疗精神分裂症和帕金森病药物的靶标。该基因突变与各种行为表现型,包括植物神经系统功能紊乱,注意力缺失/多动症,以及求新求的人格特质有关。该基因包含串联48个核苷酸重复序列的多态性数(2-10份);所示的序列中包含4个重复。 [由RefSeq的,2008年7月提供]
DRD4基因(以及对应的蛋白质)的细胞分布位置:
DRD4基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Attention deficit hyperactivity disorder | 0.329422284 | 179 | 10 | BeFree_CTD_human_GAD_LHGDN_RGD |
Schizophrenia | 0.226108077 | 70 | 8 | BeFree_CTD_human_GAD_LHGDN |
Tic disorder | 0.125276948 | 4 | 0 | BeFree_CTD_human_GAD |
Child Development Disorders, Pervasive | 0.12 | 1 | 0 | CTD_human |
Amphetamine-Related Disorders | 0.12 | 1 | 0 | CTD_human |
Attention Deficit and Disruptive Behavior Disorders | 0.12 | 1 | 0 | CTD_human |
Separation anxiety disorder of childhood | 0.12 | 1 | 0 | CTD_human |
NOVELTY SEEKING PERSONALITY TRAIT | 0.12 | 0 | 0 | CTD_human |
PARKINSON DISEASE, LATE-ONSET | 0.12 | 0 | 0 | CTD_human |
Obesity | 0.090358398 | 14 | 0 | BeFree_GAD_RGD |
Personality Traits | 0.026037352 | 11 | 0 | GAD |
Bipolar Disorder | 0.024646467 | 17 | 0 | BeFree_GAD_LHGDN |
Alcoholic Intoxication, Chronic | 0.022465 | 18 | 0 | BeFree_GAD |
Alcohol abuse | 0.017112108 | 9 | 0 | BeFree_GAD |
Mental Depression | 0.014549579 | 15 | 0 | BeFree_GAD |
Psychotic Disorders | 0.013539756 | 16 | 3 | BeFree_GAD |
Mood Disorders | 0.012811307 | 13 | 0 | BeFree_GAD_LHGDN |
Heroin Dependence | 0.011725539 | 7 | 1 | BeFree_GAD_LHGDN |
Lingual-Facial-Buccal Dyskinesia | 0.010825337 | 6 | 1 | BeFree_GAD |
Migraine Disorders | 0.010096888 | 3 | 0 | BeFree_GAD_LHGDN |
Heroin Abuse | 0.010011012 | 4 | 0 | BeFree_GAD |
Personality Disorders | 0.00973957 | 5 | 0 | BeFree_GAD |
Weight Gain | 0.009468128 | 4 | 0 | GAD |
Weight Gain Adverse Event | 0.009468128 | 4 | 0 | GAD |
Tardive Dyskinesia | 0.008458305 | 6 | 1 | BeFree_GAD |
As If Personality | 0.007101096 | 3 | 0 | GAD |
Parkinson Disease | 0.007101096 | 3 | 0 | GAD |
body mass | 0.007101096 | 3 | 0 | GAD |
Obsessive-Compulsive Disorder | 0.006905599 | 8 | 0 | BeFree_GAD |
Major Depressive Disorder | 0.005276948 | 4 | 0 | BeFree_GAD |
Bedwetting | 0.005091382 | 1 | 0 | GAD_LHGDN |
Malignant neoplasm of lung | 0.005005506 | 2 | 0 | BeFree_GAD |
Methamphetamine abuse | 0.005005506 | 2 | 0 | BeFree_GAD |
Mental disorders | 0.004267125 | 8 | 0 | BeFree_GAD |
NEUROTICISM | 0.004267125 | 7 | 0 | BeFree_GAD |
Anorexia Nervosa | 0.00408156 | 5 | 1 | BeFree_LHGDN |
Gilles de la Tourette syndrome | 0.003724241 | 5 | 0 | BeFree_GAD |
Autistic Disorder | 0.003452799 | 5 | 0 | BeFree_GAD |
Gambling, Pathological | 0.003452799 | 4 | 0 | BeFree_GAD |
Common Migraine | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Drug abuse | 0.003181358 | 4 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.002909916 | 2 | 0 | BeFree_GAD |
Delusional disorder | 0.002909916 | 3 | 0 | BeFree_GAD |
Dyskinetic syndrome | 0.00272435 | 1 | 0 | LHGDN |
Depressive disorder | 0.002714419 | 10 | 0 | BeFree |
Disruptive, Impulse Control, and Conduct Disorders | 0.002638474 | 1 | 0 | BeFree_GAD |
Nicotine Dependence | 0.002638474 | 2 | 0 | BeFree_GAD |
Pain | 0.002638474 | 2 | 0 | BeFree_GAD |
Hyperkinetic conduct disorder of childhood | 0.002638474 | 1 | 0 | BeFree_GAD |
Hyperkinetic conduct disorder | 0.002638474 | 1 | 0 | BeFree_GAD |
Affective Disorders, Psychotic | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Endocrine System Diseases | 0.002367032 | 1 | 0 | GAD |
Headache | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications | 0.002367032 | 1 | 0 | GAD |
Prenatal Exposure Delayed Effects | 0.002367032 | 1 | 0 | GAD |
Psychoses, Substance-Induced | 0.002367032 | 1 | 0 | GAD |
Retinoblastoma | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Malnutrition | 0.002367032 | 1 | 0 | GAD |
Substance-Related Disorders | 0.002367032 | 1 | 0 | GAD |
Atrophic | 0.002367032 | 1 | 0 | GAD |
Sleep Disorders | 0.002367032 | 1 | 0 | GAD |
Systemic arterial pressure | 0.002367032 | 1 | 0 | GAD |
Colorectal Cancer | 0.002367032 | 1 | 0 | GAD |
Finding relating to sexuality and sexual activity | 0.002367032 | 1 | 0 | GAD |
Anxiety Disorders | 0.001900093 | 7 | 1 | BeFree |
Osteochondritis Dissecans | 0.001628651 | 6 | 0 | BeFree |
Inattention | 0.001628651 | 6 | 0 | BeFree |
Marijuana Abuse | 0.001357209 | 5 | 0 | BeFree |
Antisocial behavior | 0.001357209 | 5 | 1 | BeFree |
Alcohol or Other Drugs use | 0.001357209 | 5 | 0 | BeFree |
Nonorganic psychosis | 0.001357209 | 5 | 1 | BeFree |
MAJOR AFFECTIVE DISORDER 2 | 0.001357209 | 5 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 1 | 0.001357209 | 5 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 4 | 0.001357209 | 5 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 5 | 0.001357209 | 5 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 6 | 0.001357209 | 5 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 7 | 0.001357209 | 5 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 8 | 0.001357209 | 5 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 9 | 0.001357209 | 5 | 0 | BeFree |
Oppositional Defiant Disorder | 0.001085767 | 4 | 0 | BeFree |
Seasonal Affective Disorder | 0.001085767 | 4 | 0 | BeFree |
Drug usage | 0.001085767 | 4 | 0 | BeFree |
Delinquent behavior | 0.001085767 | 4 | 0 | BeFree |
heavy drinking | 0.001085767 | 4 | 0 | BeFree |
Bulimia Nervosa | 0.001085767 | 4 | 0 | BeFree |
Bulimia | 0.000814326 | 3 | 2 | BeFree |
Schizoaffective Disorder | 0.000814326 | 3 | 0 | BeFree |
Substance Dependence | 0.000814326 | 3 | 1 | BeFree |
Selenium deficiency | 0.000814326 | 3 | 0 | BeFree |
Opiate Addiction | 0.000814326 | 3 | 1 | BeFree |
Substance abuse problem | 0.000814326 | 3 | 0 | BeFree |
Borderline Personality Disorder | 0.000542884 | 2 | 1 | BeFree |
Down Syndrome | 0.000542884 | 2 | 0 | BeFree |
Atrial Septal Defects | 0.000542884 | 2 | 0 | BeFree |
Hyperphagia | 0.000542884 | 2 | 0 | BeFree |
Panic Disorder | 0.000542884 | 2 | 0 | BeFree |
Substance Use Disorders | 0.000542884 | 2 | 0 | BeFree |
Unipolar Depression | 0.000542884 | 2 | 0 | BeFree |
Depressive Symptoms | 0.000542884 | 2 | 0 | BeFree |
Conduct Disorder | 0.000542884 | 2 | 0 | BeFree |
Dyslexia | 0.000542884 | 2 | 0 | BeFree |
Chronic Daily Headache | 0.000542884 | 2 | 0 | BeFree |
Autism Spectrum Disorders | 0.000542884 | 2 | 0 | BeFree |
PANIC DISORDER 1 | 0.000542884 | 2 | 0 | BeFree |
Bronchopulmonary Dysplasia | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Dependent Personality Disorder | 0.000271442 | 1 | 0 | BeFree |
Eating Disorders | 0.000271442 | 1 | 2 | BeFree |
Eclampsia | 0.000271442 | 1 | 0 | BeFree |
Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
Nicotine withdrawal | 0.000271442 | 1 | 0 | BeFree |
Pituitary Diseases | 0.000271442 | 1 | 0 | BeFree |
Residual schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Sialorrhea | 0.000271442 | 1 | 0 | BeFree |
Specific reading disorder | 0.000271442 | 1 | 0 | BeFree |
Central Nervous System Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Agitation | 0.000271442 | 1 | 0 | BeFree |
Withdrawal Symptoms | 0.000271442 | 1 | 0 | BeFree |
somatization | 0.000271442 | 1 | 0 | BeFree |
Chronic psychosis | 0.000271442 | 1 | 0 | BeFree |
Dysphoric mood | 0.000271442 | 1 | 0 | BeFree |
Expressed Emotion | 0.000271442 | 1 | 0 | BeFree |
Diagnosis, Psychiatric | 0.000271442 | 1 | 0 | BeFree |
Anxiety and fear | 0.000271442 | 1 | 0 | BeFree |
Overweight | 0.000271442 | 1 | 0 | BeFree |
Alcohol problem | 0.000271442 | 1 | 0 | BeFree |
Emotional problems | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Moderate obesity | 0.000271442 | 1 | 0 | BeFree |
Childhood aggression | 0.000271442 | 1 | 0 | BeFree |
Female sexual dysfunction | 0.000271442 | 1 | 0 | BeFree |
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