DFFA(DNA fragmentation factor, 45kDa, alpha polypeptide) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

1p36.3-p36.2
基因染色体位置图

基因简述

基因简述

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  细胞凋亡是细胞死亡的过程，哺乳动物发育过程中删除的毒性和/或无用的细胞。细胞凋亡过程伴随着细胞和细胞核和染色体DNA成核小体单位的降解的收??缩和碎片。 DNA片段化因子（DFF）为40-KD（DFFB）和45 kD的（DFFA）亚基的异源二聚体蛋白质。 DFFA为胱天蛋白酶3在基片和凋亡过程中触发DNA片段。当DFFA由caspase-3的裂解DFF被激活。 DFFA的切割片段从DFFB，DFF的活性成分分解。 DFFB已经发现细胞凋亡过程中，同时触发DNA片段化和染色质浓缩。已经发现了这个基因编码两种不同亚型选择性剪接转录变异体。 [由RefSeq的，2008年7月提供]

OMIM数据库中对DFFA基因的介绍     Wikipedia数据库中对DFFA基因的介绍

基因序列

基因序列

DFFA基因的碱基序列：[NCBI]

基因突变

基因突变

DFFA基因的碱基突变：           显示全部snp
rs672606       rs1057026       rs1135131       rs1188529       rs1188530       rs1203122       rs2027087       rs2274986       rs2483687       rs2781233       rs3215947       rs3829642       rs4611017       rs6667629       rs7520077       rs7527223       rs7529609       rs7532322       rs7534136       rs7552283       rs7552932       rs9661820       rs10864457       rs11121573       rs11578995       rs11588506       rs11588734       rs11799743       rs12027804       rs12065251       rs12093208       rs12567380       rs12567730       rs12729844       rs17856222       rs34132699       rs34172830      
rs34389737       rs34862260       rs35502618       rs35783598       rs41301975       rs57035535       rs58464882       rs59658414       rs61657764       rs61776017       rs61776019       rs61776020       rs61776039       rs61776040       rs61776041       rs61776042       rs61776043       rs71583873       rs71583874       rs71643093       rs71643094       rs72869115       rs72869119       rs74552084       rs74703019       rs74709532       rs74834298       rs75387702       rs75521795       rs75956311       rs76676818       rs76689119       rs76858503       rs77891640       rs78046004       rs78256349       rs80100562       rs80153219       rs80336932       rs111443910       rs111495326       rs112127951       rs112134101       rs112771607       rs113202985       rs113649170       rs115279820       rs115589789       rs115734208       rs115846607       rs116316162       rs137950953       rs138357125       rs138579895       rs138622972       rs138729395       rs138842024       rs139117158       rs139851340       rs139956763       rs140221027       rs140269107       rs140650992       rs140912423       rs141276310       rs142126689       rs142286331       rs142286842       rs142383097       rs142419140       rs142954972       rs143082645       rs143293907       rs143472367       rs144037035       rs144212799       rs144357578       rs144450578       rs145327902       rs145346082       rs145405906       rs145486605       rs145531128       rs145882179       rs145910223       rs146112251       rs146116701       rs146450686       rs146607674       rs147033969       rs147203929       rs147563718       rs147639577       rs148038511       rs148199800       rs148645727       rs148766616       rs148818182       rs148875202       rs149229825       rs149347929       rs149393491       rs149589861       rs149697144       rs149855440       rs150098472       rs150212842       rs150617947       rs150903132       rs151168647       rs180710967       rs180822750       rs181137931       rs181220021       rs181284576       rs181285077       rs181774839       rs181824449       rs182037207       rs182146268       rs182165288       rs182381372       rs182775126       rs183230038       rs183400141       rs183569195       rs183679605       rs184020083       rs184079351       rs184233094       rs184593722       rs184768054       rs184879957       rs184928611       rs185283766       rs185345967       rs185680862       rs185683422       rs185694804       rs185810720       rs185887345       rs186083478       rs186095987       rs186706069       rs186823833       rs186868469       rs186933436       rs187266295       rs187314256       rs187341281       rs187754130       rs187766062       rs187998539       rs188176909       rs188569916       rs188602952       rs188907825       rs189080634       rs189327971       rs189423719       rs189424960       rs189657298       rs189659134       rs189908581       rs190154580       rs190332090       rs190551472       rs191174190       rs191717615       rs191732443       rs191819924       rs191992394       rs192248643       rs192370949       rs192644542       rs192694187       rs192788301       rs193021516       rs199582986       rs199935123       rs200082967       rs200149870       rs200190552       rs200410427       rs200565656       rs200725571       rs201049220       rs201135693       rs201194418       rs201283888       rs201448489       rs201503304       rs201613622       rs201753478       rs201799892       rs201801359       rs201880040       rs201908330       rs201991921       rs202059186       rs202121774       rs367785591       rs368842683       rs369167862       rs369581230       rs370194873       rs370207143       rs370273583       rs370681036       rs371120168       rs371326793       rs371766475       rs372075601       rs372395272       rs372477690       rs372495734       rs372939210       rs373341798       rs373346497       rs373650508       rs374537999       rs374995148       rs375541032       rs375616513       rs375651747       rs375656224       rs375676032       rs375755872       rs376299380       rs376466803       rs376547736       rs376777029       rs377456322       rs397979188       rs527319629       rs527522931       rs527547174       rs527849399       rs528255063       rs528305317       rs528535323       rs528598769       rs528834154       rs529164805       rs529412377       rs529815256       rs530011637       rs530065791       rs530138238       rs530224684       rs530456889       rs530685906       rs531244397       rs531303673       rs531364540       rs531601067       rs532019660       rs532107068       rs532240141       rs532332156       rs532556614       rs532724564       rs532954990       rs533015884       rs533118271       rs533569552       rs534013552       rs534214224       rs534425353       rs534552652       rs534846066       rs534904397       rs534909681       rs534918945       rs535066860       rs535354570       rs535676247       rs535690485       rs535730927       rs535744967       rs536004867       rs536011452       rs537276443       rs537324243       rs538196571       rs538262381       rs538502450       rs538676013       rs540056471       rs540059103       rs540121751       rs540182423       rs540343466       rs540424038       rs540761652       rs541102579       rs541306663       rs541607891       rs541831105       rs541870849       rs542100432       rs542202642       rs542430379       rs543339445       rs543450804       rs543617571       rs543687119       rs543785119       rs544680802       rs544736125       rs544755907       rs544821048       rs545088578       rs545568858       rs545806125       rs546172125       rs546233623       rs546298800       rs546411314       rs546614077       rs546709707       rs546825777       rs546844774       rs547095340       rs547391145       rs547771110       rs548367826       rs548426899       rs548576385       rs548633459       rs548689373       rs548713735       rs548911605       rs549036663       rs549098669       rs549820235       rs550102674       rs550157790       rs550185781       rs550495520       rs550825684       rs550967746       rs551300586       rs551629851       rs552005134       rs552743861       rs552867050       rs553145478       rs553336842       rs553548471       rs553592799       rs553820785       rs554465673       rs554526760       rs555075697       rs555472091       rs555788275       rs556089553       rs556284665       rs556806757       rs556947666       rs557239129       rs557276131       rs557328590       rs557400059       rs557459668       rs557533901       rs557534118       rs557597043       rs557856562       rs558515911       rs558576053       rs558715683       rs558716774       rs558916417       rs559448250       rs559520686       rs559533743       rs559580302       rs559681988       rs559814245       rs559972393       rs559976386       rs560039987       rs560142365       rs560502409       rs560639002       rs560907776       rs561196799       rs561525379       rs562064353       rs562124006       rs562455943       rs562696115       rs562871705       rs563645743       rs563729328       rs563791280       rs563852888       rs564258156       rs564501986       rs564531194       rs564592781       rs564655542       rs564849257       rs564925600       rs564987888       rs565129960       rs565190828       rs565251958       rs565328054       rs565721662       rs565784702       rs566113039       rs566172770       rs566179968       rs566449644       rs566913213       rs567056631       rs567115253       rs567115256       rs567179671       rs567266683       rs567533910       rs568027816       rs568247132       rs568551565       rs568592153       rs568614889       rs569013535       rs569074978       rs569451729       rs569518366       rs569581617       rs569788970       rs570151818       rs570771677       rs570816974       rs570993490       rs571516497       rs571534065       rs571887926       rs571929572       rs572246646       rs572254689       rs572615751       rs572907002       rs572910619       rs573245011       rs573253898       rs573414959       rs573805126       rs574017325       rs574051619       rs574390728       rs574469691       rs574481279       rs574523820       rs574668576       rs574794412       rs574971976       rs575084270       rs575172818       rs575300833       rs575564887       rs575683638       rs575741425       rs575744502       rs575793601       rs575897900       rs575913088       rs576136707       rs576228613       rs576287906       rs576883073       rs576946812       rs576996791       rs577391533       rs577727238       rs578039455       rs745408700       rs745520878       rs745707454       rs745904147       rs745906249       rs745995307       rs746384142       rs746433569       rs746562781       rs746903840       rs747075066       rs747110407       rs747165023       rs747181944       rs747270629       rs747293530       rs747335419       rs747353594       rs747907798       rs748300602       rs748514381       rs748687022       rs748708630       rs749025715       rs749301775       rs749779847       rs749789482       rs749892835       rs749896782       rs749984566       rs750029863       rs750105966       rs750382901       rs750549888       rs750637697       rs750685225       rs750823360       rs750866837       rs751053547       rs751292529       rs751789370       rs752249326       rs752420810       rs752647573       rs752665264       rs753320199       rs753338589       rs753601785       rs753605135       rs753798140       rs753885748       rs754147021       rs754280896       rs754486178       rs754544065       rs754634163       rs755063988       rs755323383       rs755383781       rs755542987       rs755641615       rs755703182       rs755822908       rs756032927       rs756187569       rs756206412       rs756243629       rs756412772       rs756698486       rs757159787       rs757172761       rs757447705       rs757499835       rs757575044       rs757754174       rs757811839       rs757982041       rs758026773       rs758525464       rs758582569       rs758808475       rs758940114       rs759001817       rs759033363       rs759302335       rs759394129       rs759520106       rs759565708       rs759820339       rs759848494       rs760010253       rs760217209       rs760305037       rs760334483       rs760393244       rs760395202       rs760634852       rs760695942       rs761102520       rs761384807       rs761386584       rs761521224       rs761623041       rs761637000       rs762198729       rs762414872       rs762516592       rs762713375       rs762873683       rs763189247       rs763254987       rs763280107       rs763328530       rs763523699       rs763760139       rs764905737       rs765042204       rs765089819       rs765132228       rs765233935       rs765334322       rs765569556       rs765571310       rs765663327       rs765986425       rs766024087       rs766280142       rs766477853       rs766637969       rs766642706       rs766807668       rs766935315       rs767131713       rs767288918       rs767603460       rs767676381       rs767766199       rs768119414       rs768154363       rs768240715       rs768605343       rs768932062       rs769074689       rs769149703       rs769341883       rs769678616       rs769771336       rs769832519       rs770218414       rs770306498       rs770308299       rs770458538       rs770637273       rs770887537       rs771284750       rs771453332       rs771645842       rs771850413       rs772455668       rs772882002       rs772980696       rs772982346       rs773067527       rs773068427       rs773262047       rs773934021       rs774165346       rs774251160       rs774307153       rs774603856       rs774955448       rs775465307       rs775859944       rs775862837       rs775942783       rs775953860       rs776604487       rs776779999       rs776863082       rs777251360       rs777274602       rs777546137       rs777639485       rs777830922       rs777920700       rs778007707       rs778099664       rs778172871       rs778328997       rs778373960       rs778583526       rs779341675       rs779515834       rs780008876       rs780122410       rs780211685       rs780492494       rs780603438       rs780774277       rs780941852       rs781137474       rs781227271       rs781251872       rs781432914       rs781629030      

基因表达

基因表达

DFFA基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
ACAATTCAGATGGAGGTACAG
58
ATTCTTCCACTTCAACCCTG
58
AAGTGGAAGAATGTGGCCA
60
CTTTGGACTCTGGAGGTCC
59
ACAATTCAGATGGAGGTACAG
58
TTCTTCCACTTCAACCCTG
57
AAGTGGAAGAATGTGGCCA
60
AACAAGCATCTGGAGGTCC
60
AGTCAGGATTTGGAGTTGGT
59
CTCCGTCTTCTTTATGTCCCA
60
AACAATTCAGATGGAGGTACAG
58
TTCTTCCACTTCAACCCTG
57
GAAGTGGAAGAATGTGGCC
59
CTTTGGACTCTGGAGGTCC
59
GAAGTGGAAGAATGTGGCC
59
CAACAAGCATCTGGAGGTC
59
TTGAAGTGGAAGAATGTGGC
59
CTTTGGACTCTGGAGGTCC
59
CTAGTCAGGATTTGGAGTTGG
58
CCGTCTTCTTTATGTCCCAG
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

DFFA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

DFFA基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005622
K7ERT1(UniProtKB)
IEA
GO:0006915
K7ERT1(UniProtKB)
IEA
GO:0007165
K7ERT1(UniProtKB)
IEA
GO:0000790
O00273(UniProtKB)
IDA
GO:0005515
O00273(UniProtKB)
IPI
GO:0005515
O00273(UniProtKB)
IPI
GO:0005634
O00273(UniProtKB)
IDA
GO:0005634
O00273(UniProtKB)
IDA
GO:0005654
O00273(UniProtKB)
TAS
GO:0005654
O00273(UniProtKB)
TAS
GO:0005654
O00273(UniProtKB)
TAS
GO:0005654
O00273(UniProtKB)
TAS
GO:0005737
O00273(UniProtKB)
IDA
GO:0005829
O00273(UniProtKB)
IDA
GO:0005829
O00273(UniProtKB)
TAS
GO:0005829
O00273(UniProtKB)
TAS
GO:0005829
O00273(UniProtKB)
TAS
GO:0006309
O00273(UniProtKB)
TAS
GO:0043065
O00273(UniProtKB)
IEA
GO:0070242
O00273(UniProtKB)
IEA
GO:1900118
O00273(UniProtKB)
IDA
GO:1902511
O00273(UniProtKB)
IDA
GO:0005811
O00273(UniProtKB)
IBA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控DFFA基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Neuroblastoma 0.003538676 3 0 BeFree_LHGDN
Hepatitis C 0.00272435 1 0 LHGDN
Central neuroblastoma 0.000814326 3 0 BeFree
Renal Cell Carcinoma 0.000542884 2 0 BeFree
Keloid 0.000271442 1 0 BeFree
Esophageal carcinoma 0.000271442 1 0 BeFree
Germ cell tumor 0.000271442 1 0 BeFree
Squamous cell carcinoma of esophagus 0.000271442 1 0 BeFree
stage, neuroblastoma 0.000271442 1 0 BeFree

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