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Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  受体酪氨酸激酶(RTK)发挥其微环境的细胞的通信的关键作用。这些分子参与细胞生长,分化和代谢的调节。在一些情况下由RTK的穿过膜信号转导的生化机制已被证明是配体诱导的受体寡聚和随后的细胞内磷酸化。这个自磷酸化导致的胞质靶的磷酸化以及协会与其他分子,这是参与信号转导的多效性作用。 RTK的与细胞外,跨膜和细胞质地区的三方结构。该基因编码RTK的一种新颖的子类的成员,并包含一个独特的细胞外区包含一个因子VIII样结构域。在5‘端非编码区的结果在多个转录剪接变体编码相同的蛋白质。 [由RefSeq的,2008年7月提供]
DDR2基因(以及对应的蛋白质)的细胞分布位置:
DDR2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| SPONDYLOMETAEPIPHYSEAL DYSPLASIA, SHORT LIMB-HAND TYPE | 0.480271442 | 1 | 4 | BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT |
| Adenocarcinoma of lung (disorder) | 0.12 | 1 | 0 | CTD_human |
| Dwarfism, Levi Type | 0.08 | 0 | 0 | MGD |
| Degenerative polyarthritis | 0.003810118 | 4 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.002442977 | 9 | 0 | BeFree |
| Hypertensive disease | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of ovary | 0.002367032 | 1 | 0 | GAD |
| Squamous cell carcinoma of lung | 0.001900093 | 7 | 1 | BeFree |
| Squamous cell carcinoma | 0.001628651 | 6 | 2 | BeFree |
| Malignant neoplasm of lung | 0.000814326 | 3 | 0 | BeFree |
| Malignant Squamous Cell Neoplasm | 0.000814326 | 3 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 1 | BeFree |
| Osteoporosis | 0.000542884 | 2 | 0 | BeFree |
| Disseminated Malignant Neoplasm | 0.000542884 | 2 | 0 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000542884 | 2 | 0 | BeFree |
| Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Primary biliary cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Cholangitis, Sclerosing | 0.000271442 | 1 | 0 | BeFree |
| Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| liposarcoma | 0.000271442 | 1 | 0 | BeFree |
| Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Primary sclerosing cholangitis | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| CNS metastases | 0.000271442 | 1 | 1 | BeFree |
| Lymphangioleiomyomatosis | 0.000271442 | 1 | 0 | BeFree |
| Rhabdoid Tumor of the Kidney | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
| Invasive Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Liposarcoma, well differentiated | 0.000271442 | 1 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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