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This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]
[中文简述(自动翻译):]  该基因编码的CCAAT /增强子结合蛋白(C / EBP)家族的转录因子的成员。该蛋白质的功能如通过形成与其他C / EBP部件,如C / EBP和LAP(肝激活蛋白)异二聚体,并防止它们的DNA结合活性的显性负抑制剂。该蛋白质在脂肪生成和红细胞生成牵连,是通过内质网应激活化,促进细胞凋亡。这种基因和FUS对由易位染色体诱导染色体22 16或EWSR1融合生成黏液样脂肪肉瘤或尤文肉瘤嵌合蛋白。多个可变剪接转录物变体编码两种同种型具有不同的长度已被确定。 [由RefSeq的,2010年8月提供]
DDIT3基因(以及对应的蛋白质)的细胞分布位置:
DDIT3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Liposarcoma, Myxoid | 0.253843535 | 51 | 0 | BeFree_CTD_human_ORPHANET |
Nephrosis | 0.2 | 1 | 0 | CTD_human_RGD |
Ocular Hypertension | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Mammary Neoplasms | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Asbestosis | 0.12 | 1 | 0 | CTD_human |
Contact Dermatitis | 0.12 | 1 | 0 | CTD_human |
Diabetes Mellitus, Insulin-Dependent | 0.12 | 1 | 0 | CTD_human |
Intestinal Diseases | 0.12 | 1 | 0 | CTD_human |
Myocardial Infarction | 0.12 | 1 | 0 | CTD_human |
Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
Ulcer | 0.12 | 1 | 0 | CTD_human |
Juvenile arthritis | 0.12 | 1 | 0 | CTD_human |
Acute-Phase Reaction | 0.08 | 1 | 0 | RGD |
Brain Ischemia | 0.08 | 1 | 0 | RGD |
Galactosemias | 0.08 | 1 | 0 | RGD |
Acute kidney injury | 0.08 | 1 | 0 | RGD |
Diffuse Large B-Cell Lymphoma | 0.014114977 | 52 | 1 | BeFree |
liposarcoma | 0.013853467 | 41 | 0 | BeFree_LHGDN |
Sarcoma | 0.005710211 | 11 | 0 | BeFree_LHGDN |
Colonic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Neuroblastoma | 0.004353001 | 7 | 0 | BeFree_LHGDN |
Lymphoma | 0.00434307 | 16 | 5 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.003995683 | 6 | 0 | BeFree_GAD |
Diabetes Mellitus | 0.003810118 | 5 | 0 | BeFree_LHGDN |
melanoma | 0.003810118 | 5 | 0 | BeFree_LHGDN |
leukemia | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Cystic Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
Cessation of life | 0.00272435 | 1 | 0 | LHGDN |
Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Breast Carcinoma | 0.002714419 | 10 | 0 | BeFree |
Liver carcinoma | 0.002714419 | 10 | 0 | BeFree |
Malignant neoplasm of breast | 0.002442977 | 9 | 0 | BeFree |
Myxoid/Round Cell Liposarcoma | 0.002171535 | 8 | 0 | BeFree |
Malignant tumor of colon | 0.001900093 | 7 | 0 | BeFree |
Liver neoplasms | 0.001900093 | 7 | 0 | BeFree |
Colon Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Lymphoma, Follicular | 0.001628651 | 6 | 0 | BeFree |
Central neuroblastoma | 0.001628651 | 6 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.001357209 | 5 | 0 | BeFree |
Round cell liposarcoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of stomach | 0.001085767 | 4 | 0 | BeFree |
Neoplasm Metastasis | 0.001085767 | 4 | 0 | BeFree |
B-Cell Lymphomas | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of prostate | 0.001085767 | 4 | 0 | BeFree |
Prostate carcinoma | 0.001085767 | 4 | 0 | BeFree |
Carcinoma of lung | 0.001085767 | 4 | 0 | BeFree |
Stomach Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000814326 | 3 | 0 | BeFree |
Ischemia | 0.000814326 | 3 | 0 | BeFree |
Multiple Myeloma | 0.000814326 | 3 | 0 | BeFree |
Uterine Fibroids | 0.000814326 | 3 | 0 | BeFree |
Malignant Fibrous Histiocytoma | 0.000814326 | 3 | 0 | BeFree |
Thyroid carcinoma | 0.000814326 | 3 | 0 | BeFree |
Ewings sarcoma | 0.000814326 | 3 | 0 | BeFree |
Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000814326 | 3 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of cervix | 0.000542884 | 2 | 0 | BeFree |
Diabetes | 0.000542884 | 2 | 0 | BeFree |
Epilepsy | 0.000542884 | 2 | 0 | BeFree |
Fibrosarcoma | 0.000542884 | 2 | 0 | BeFree |
Glioblastoma | 0.000542884 | 2 | 0 | BeFree |
Glioma | 0.000542884 | 2 | 0 | BeFree |
Hepatitis B | 0.000542884 | 2 | 0 | BeFree |
Leukopenia | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, Non-Hodgkin | 0.000542884 | 2 | 0 | BeFree |
Mixed Salivary Gland Tumor | 0.000542884 | 2 | 0 | BeFree |
Neutropenia | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, Large-Cell, Follicular | 0.000542884 | 2 | 0 | BeFree |
Peripheral T-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Pelizaeus-Merzbacher Disease | 0.000542884 | 2 | 0 | BeFree |
Liposarcoma, Pleomorphic | 0.000542884 | 2 | 0 | BeFree |
Solid tumour | 0.000542884 | 2 | 0 | BeFree |
Cervix carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000542884 | 2 | 0 | BeFree |
Primary Effusion Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Borderline Personality Disorder | 0.000271442 | 1 | 0 | BeFree |
Bronchopulmonary Dysplasia | 0.000271442 | 1 | 0 | BeFree |
Burkitt Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
Chest Pain | 0.000271442 | 1 | 0 | BeFree |
Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Diarrhea | 0.000271442 | 1 | 1 | BeFree |
Gastroenteritis | 0.000271442 | 1 | 0 | BeFree |
Head and Neck Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Atrial Septal Defects | 0.000271442 | 1 | 1 | BeFree |
Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
Hepatosplenomegaly | 0.000271442 | 1 | 0 | BeFree |
Hyperinsulinism | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
Fibroid Tumor | 0.000271442 | 1 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Lymphoid leukemia | 0.000271442 | 1 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
Liver diseases | 0.000271442 | 1 | 0 | BeFree |
Alcoholic Liver Diseases | 0.000271442 | 1 | 0 | BeFree |
Lung diseases | 0.000271442 | 1 | 0 | BeFree |
Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
Lupus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Discoid | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Papillon-Lefevre Disease | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Edema | 0.000271442 | 1 | 0 | BeFree |
Respiratory Distress Syndrome, Adult | 0.000271442 | 1 | 0 | BeFree |
Retinal Degeneration | 0.000271442 | 1 | 1 | BeFree |
Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
Seizures | 0.000271442 | 1 | 0 | BeFree |
Status Epilepticus | 0.000271442 | 1 | 0 | BeFree |
Unipolar Depression | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, AIDS-Related | 0.000271442 | 1 | 0 | BeFree |
Gestational Diabetes | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
Intervertebral Disc Degeneration | 0.000271442 | 1 | 0 | BeFree |
Liver Failure, Acute | 0.000271442 | 1 | 0 | BeFree |
Pleomorphic Lipoma | 0.000271442 | 1 | 0 | BeFree |
Pneumonia, Interstitial | 0.000271442 | 1 | 0 | BeFree |
Lipomatous neoplasm | 0.000271442 | 1 | 0 | BeFree |
Angiomyolipoma | 0.000271442 | 1 | 0 | BeFree |
Sarcoma, Clear Cell | 0.000271442 | 1 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Clear cell sarcoma, of tendons and aponeuroses | 0.000271442 | 1 | 0 | BeFree |
Angioendotheliomatosis | 0.000271442 | 1 | 0 | BeFree |
Autosomal dominant retinitis pigmentosa | 0.000271442 | 1 | 0 | BeFree |
Chronic liver disease | 0.000271442 | 1 | 0 | BeFree |
Viral gastroenteritis due to Rotavirus | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Malignant Lipomatous Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus | 0.000271442 | 1 | 0 | BeFree |
Follicular neoplasm | 0.000271442 | 1 | 0 | BeFree |
Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
Inclusion Body Myopathy, Sporadic | 0.000271442 | 1 | 0 | BeFree |
Radiculomyelopathy | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Mammary Carcinoma, Human | 0.000271442 | 1 | 0 | BeFree |
Histiocytoma, Angiomatoid Fibrous | 0.000271442 | 1 | 0 | BeFree |
Atypical Lipoma | 0.000271442 | 1 | 0 | BeFree |
Major Depressive Disorder | 0.000271442 | 1 | 0 | BeFree |
Degenerative disorder | 0.000271442 | 1 | 0 | BeFree |
Single tumor | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Well Differentiated Pancreatic Endocrine Tumor | 0.000271442 | 1 | 0 | BeFree |
Liposarcoma, well differentiated | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Pneumocystis jiroveci pneumonia | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
Idiopathic Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Coronary Artery Disease | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Leukemia, B-Cell | 0.000271442 | 1 | 0 | BeFree |
Urothelial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Clinically isolated syndrome | 0.000271442 | 1 | 0 | BeFree |
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