更多...
收起
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  脱氧胞苷激酶(DCK)所需的几个脱氧核糖核苷和它们的核苷类似物的磷酸化。 DCK的缺乏与抗病毒和抗癌化疗药物耐药有关。相反,增加的脱氧胞苷激酶活性与这些化合物的活化增加相关细胞毒性核苷三磷酸衍生物。 DCK是由于其耐药性与灵敏度关系临床上重要的。 [由RefSeq的,2008年7月提供]
DCK基因(以及对应的蛋白质)的细胞分布位置:
DCK基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
Leukemia, Myelocytic, Acute | 0.005981653 | 12 | 0 | BeFree_LHGDN |
leukemia | 0.004538567 | 9 | 0 | BeFree_GAD |
Malignant neoplasm of pancreas | 0.004538567 | 9 | 0 | BeFree_GAD |
Lymphoma | 0.00272435 | 1 | 0 | LHGDN |
Neoplasm, Residual | 0.002638474 | 1 | 0 | BeFree_GAD |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.002638474 | 2 | 0 | BeFree_GAD |
Pancreatic Neoplasm | 0.002367032 | 1 | 0 | GAD |
Thrombocytopenia | 0.002367032 | 1 | 0 | GAD |
Inflammatory disease of mucous membrane | 0.002367032 | 1 | 0 | GAD |
Pancreatic carcinoma | 0.002171535 | 8 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Leukemia, Lymphocytic, Acute, L1 | 0.000814326 | 3 | 0 | BeFree |
Solid tumour | 0.000814326 | 3 | 0 | BeFree |
Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Down Syndrome | 0.000542884 | 2 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, Follicular | 0.000542884 | 2 | 0 | BeFree |
Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Refractory cancer | 0.000542884 | 2 | 0 | BeFree |
Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 0 | BeFree |
Esophageal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
HIV Infections | 0.000271442 | 1 | 0 | BeFree |
Reticulosarcoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of gallbladder | 0.000271442 | 1 | 0 | BeFree |
gliosarcoma | 0.000271442 | 1 | 0 | BeFree |
Medullary carcinoma of thyroid | 0.000271442 | 1 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
Histiocytic sarcoma | 0.000271442 | 1 | 0 | BeFree |
Uterine Corpus Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Malignant mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Hematopoietic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Hematologic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Rash and Dermatitis Adverse Event Associated with Chemoradiation | 0.000271442 | 1 | 0 | BeFree |
tumor vasculature | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。