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The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
[中文简述(自动翻译):]  由该基因编码的蛋白质是控制生产,分化,和巨噬细胞功能的细胞因子。该蛋白质的活性形式在细胞外发现了作为二硫键连接的同型二聚体,和被认为是由膜结合的前体的蛋白水解切割产生。所编码的蛋白质可能参与了胎盘的发展。选择性剪接结果在多个抄本变形。 [由RefSeq的,2011年9月提供]
CSF1基因(以及对应的蛋白质)的细胞分布位置:
CSF1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Osteitis Deformans | 0.122367032 | 1 | 0 | CTD_human_GAD |
Mammary Neoplasms | 0.121900093 | 8 | 0 | BeFree_CTD_human |
Osteopetrosis | 0.084895885 | 10 | 0 | BeFree_LHGDN_RGD |
Glioma | 0.080542884 | 3 | 0 | BeFree_RGD |
Systemic Scleroderma | 0.080271442 | 1 | 0 | BeFree_RGD |
Albuminuria | 0.08 | 1 | 0 | RGD |
Hypercholesterolemia | 0.08 | 1 | 0 | RGD |
Anti-Glomerular Basement Membrane Disease | 0.08 | 1 | 0 | RGD |
Squamous cell carcinoma | 0.008173051 | 3 | 0 | LHGDN |
Pre-Eclampsia | 0.007815732 | 3 | 0 | GAD_LHGDN |
Rheumatoid Arthritis | 0.006534468 | 6 | 0 | BeFree_LHGDN |
Neoplasm Metastasis | 0.006524536 | 15 | 0 | BeFree_LHGDN |
Malignant neoplasm of ovary | 0.006167218 | 15 | 0 | BeFree_GAD |
Malignant neoplasm of breast | 0.005700279 | 21 | 0 | BeFree |
Breast Carcinoma | 0.005700279 | 21 | 0 | BeFree |
Atherosclerosis | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
Periodontitis | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
Ovarian Carcinoma | 0.00434307 | 16 | 0 | BeFree |
Giant Cell Tumors | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Bone Diseases | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Hematological Disease | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Cardiovascular Diseases | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Pulmonary Fibrosis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Leukemia, Myelocytic, Acute | 0.002985861 | 11 | 0 | BeFree |
Leukemia, Myelomonocytic, Chronic | 0.002909916 | 3 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.00272435 | 1 | 0 | LHGDN |
Anoxia | 0.00272435 | 1 | 0 | LHGDN |
Arteriosclerosis Obliterans | 0.00272435 | 1 | 0 | LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Histiocytosis, Langerhans-Cell | 0.00272435 | 1 | 0 | LHGDN |
Inflammation | 0.00272435 | 1 | 0 | LHGDN |
Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Thromboangiitis Obliterans | 0.00272435 | 1 | 0 | LHGDN |
Ureteral obstruction | 0.00272435 | 1 | 0 | LHGDN |
Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
Premature Birth | 0.002367032 | 1 | 0 | GAD |
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
Tumor Progression | 0.001628651 | 6 | 0 | BeFree |
Pigmented villonodular synovitis | 0.001357209 | 5 | 0 | BeFree |
Epithelial ovarian cancer | 0.001357209 | 5 | 0 | BeFree |
HIV Infections | 0.001085767 | 4 | 0 | BeFree |
Carcinoma of lung | 0.001085767 | 4 | 0 | BeFree |
Adenocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Choriocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Endometriosis | 0.000814326 | 3 | 0 | BeFree |
Solid tumour | 0.000814326 | 3 | 0 | BeFree |
Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
Sarcoma | 0.000814326 | 3 | 0 | BeFree |
Fibrous histiocytoma of tendon sheath | 0.000814326 | 3 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Hyperglycemia | 0.000542884 | 2 | 0 | BeFree |
Osteoporosis | 0.000542884 | 2 | 0 | BeFree |
Synovitis | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of bone | 0.000542884 | 2 | 0 | BeFree |
Endometrial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000542884 | 2 | 0 | BeFree |
ovarian neoplasm | 0.000542884 | 2 | 0 | BeFree |
Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
ALZHEIMER DISEASE 10 | 0.000542884 | 2 | 0 | BeFree |
Hereditary Diffuse Leukoencephalopathy with Spheroids | 0.000542884 | 2 | 0 | BeFree |
Ameloblastoma | 0.000271442 | 1 | 0 | BeFree |
Refractory anemias | 0.000271442 | 1 | 0 | BeFree |
Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Arthritis | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cyst | 0.000271442 | 1 | 0 | BeFree |
Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
Heart failure | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Kidney Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
Acute myelomonocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lupus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Discoid | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
Lupus Nephritis | 0.000271442 | 1 | 0 | BeFree |
Lymphoma | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Myasthenia Gravis | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Alveolar Proteinosis | 0.000271442 | 1 | 0 | BeFree |
Ankylosing spondylitis | 0.000271442 | 1 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Neuroectodermal Tumor, Primitive | 0.000271442 | 1 | 0 | BeFree |
Memory impairment | 0.000271442 | 1 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
bone destruction | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Chronic Periodontitis | 0.000271442 | 1 | 0 | BeFree |
Stage IV Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Extraosseous Ewings sarcoma-primitive neuroepithelial tumor | 0.000271442 | 1 | 0 | BeFree |
Superficial ulcer | 0.000271442 | 1 | 0 | BeFree |
Malignant mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Monocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
invasive cancer | 0.000271442 | 1 | 0 | BeFree |
Ewings sarcoma-primitive neuroectodermal tumor (PNET) | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
Stromal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Endometrial adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms, Human | 0.000271442 | 1 | 0 | BeFree |
Inflammatory disorder | 0.000271442 | 1 | 0 | BeFree |
Partial Trisomy | 0.000271442 | 1 | 0 | BeFree |
M5b Acute differentiated monocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Invasive Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Well Differentiated Pancreatic Endocrine Tumor | 0.000271442 | 1 | 0 | BeFree |
Adamantinoma | 0.000271442 | 1 | 0 | BeFree |
Epithelioma | 0.000271442 | 1 | 0 | BeFree |
Mammary Tumorigenesis | 0.000271442 | 1 | 0 | BeFree |
Non-Malignant Ascites Adverse Event | 0.000271442 | 1 | 0 | BeFree |
Osteofibrous Dysplasia | 0.000271442 | 1 | 0 | BeFree |
Chromosome 5, trisomy 5q | 0.000271442 | 1 | 0 | BeFree |
Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Refractory anemia, without ringed sideroblasts, without excess blasts | 0.000271442 | 1 | 0 | BeFree |
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
dowling-degos disease | 0.000271442 | 1 | 0 | BeFree |
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