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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的酶的细胞色素P450超家族的成员。细胞色素P450蛋白是能催化涉及药物代谢和胆固醇,类固醇和其他脂类的合成许多反应单加氧酶。此蛋白质定位于内质网。酶启动灭活和降解白三烯B4,炎症的强效介体的过程。这个基因的细胞色素P450基因的染色体19上的这个家族的另一位成员,CYP4F11集群的一部分,约16 kb的路程。 [由RefSeq的,2008年7月提供]
CYP4F2基因(以及对应的蛋白质)的细胞分布位置:
CYP4F2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hypertensive disease | 0.019455395 | 11 | 1 | BeFree_GAD_LHGDN |
Cerebrovascular accident | 0.011182656 | 7 | 1 | BeFree_GAD_LHGDN |
Myocardial Infarction | 0.01036833 | 3 | 0 | BeFree_GAD_LHGDN |
Cerebral Infarction | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Brain Ischemia | 0.004734064 | 2 | 1 | GAD |
Atrial Fibrillation | 0.002367032 | 1 | 0 | GAD |
Venous Thrombosis | 0.002367032 | 1 | 0 | GAD |
Venous Thromboembolism | 0.002367032 | 1 | 0 | GAD |
Ischemic stroke | 0.001357209 | 5 | 1 | BeFree |
Ischemic Cerebrovascular Accident | 0.001357209 | 5 | 1 | BeFree |
Essential Hypertension | 0.000542884 | 2 | 0 | BeFree |
WARFARIN SENSITIVITY (disorder) | 0.000542884 | 2 | 0 | BeFree |
Celiac Disease | 0.000271442 | 1 | 0 | BeFree |
Hypercholesterolemia | 0.000271442 | 1 | 0 | BeFree |
Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Fibrillation | 0.000271442 | 1 | 0 | BeFree |
Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
Metabolic Syndrome X | 0.000271442 | 1 | 1 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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