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This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因,CYP2A6,编码酶的细胞色素P450超家族的成员。细胞色素P450蛋白是能催化涉及药物代谢和胆固醇,类固醇和其他脂类的合成许多反应单加氧酶。此蛋白质定位于内质网和它的表达是由苯巴比妥诱导。酶是已知的羟基化香豆素,并且还代谢烟碱,黄曲霉毒素B1,亚硝胺,和一些药物。与某些等位基因变体的个体被认为具有差的代谢表型,这意味着它们不能有效地代谢香豆素或尼古丁。该基因是从CYP2A,染色体上19Q CYP2B和CYP2F亚科大型集群的细胞色素P450基因的一部分。该基因以前被称为CYP2A3;然而,它已更名为CYP2A6。 [由RefSeq的,2008年7月提供]
CYP2A6基因(以及对应的蛋白质)的细胞分布位置:
CYP2A6基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Drug-Induced Liver Injury | 0.2 | 2 | 0 | CTD_human_CTD_mouse |
Lung Neoplasms | 0.133178557 | 10 | 0 | BeFree_CTD_human_GAD_LHGDN |
Colorectal Neoplasms | 0.125720142 | 2 | 0 | BeFree_CTD_human_LHGDN |
Tobacco Use Disorder | 0.124734064 | 5 | 0 | CTD_human_GAD |
Adenocarcinoma | 0.123538676 | 4 | 0 | BeFree_CTD_human_LHGDN |
Squamous cell carcinoma of esophagus | 0.120814326 | 3 | 1 | BeFree_CTD_human |
Hepatitis C | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Pulmonary Emphysema | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Carcinoma, Small Cell | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Brain Diseases | 0.12 | 1 | 0 | CTD_human |
Hepatitis B | 0.12 | 1 | 0 | CTD_human |
Liver Diseases, Parasitic | 0.12 | 1 | 0 | CTD_human |
Nasopharyngeal Neoplasms | 0.12 | 1 | 0 | CTD_human |
Opisthorchiasis | 0.12 | 1 | 0 | CTD_human |
Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
Stomach Neoplasms | 0.12 | 2 | 0 | CTD_human |
Carcinoma, Large Cell | 0.12 | 1 | 0 | CTD_human |
Disease Progression | 0.12 | 1 | 0 | CTD_human |
Coumarin Resistance | 0.12 | 0 | 0 | CTD_human |
TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding) | 0.12 | 2 | 0 | CTD_human |
LUNG CANCER, PROTECTION AGAINST | 0.12 | 0 | 0 | CLINVAR |
Liver Neoplasms, Experimental | 0.08 | 1 | 0 | CTD_mouse |
Malignant neoplasm of lung | 0.033366282 | 32 | 4 | BeFree_GAD |
Malignant neoplasm of esophagus | 0.015016517 | 6 | 0 | BeFree_GAD |
HIV Infections | 0.012378044 | 7 | 0 | BeFree_GAD |
Esophageal Neoplasms | 0.010282454 | 6 | 0 | BeFree_GAD |
Colorectal Cancer | 0.008186863 | 7 | 0 | BeFree_GAD |
Mouth Neoplasms | 0.007458414 | 3 | 0 | GAD_LHGDN |
Carcinoma of lung | 0.007328931 | 27 | 4 | BeFree |
Nicotine Dependence | 0.005352893 | 12 | 1 | BeFree_GAD |
Head and Neck Neoplasms | 0.004734064 | 2 | 0 | GAD |
Laryngeal neoplasm | 0.004734064 | 2 | 0 | GAD |
Malignant neoplasm of stomach | 0.004734064 | 2 | 0 | GAD |
Pharyngeal Neoplasms | 0.004734064 | 2 | 0 | GAD |
Tobacco Dependence | 0.003995683 | 6 | 0 | BeFree_GAD |
Squamous cell carcinoma | 0.003181358 | 4 | 0 | BeFree_GAD |
Liver carcinoma | 0.003181358 | 3 | 0 | BeFree_GAD |
Malignant neoplasm of pancreas | 0.002909916 | 3 | 1 | BeFree_GAD |
Hepatitis | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of urinary bladder | 0.002638474 | 1 | 0 | BeFree_GAD |
Neoplasm Metastasis | 0.002638474 | 1 | 0 | BeFree_GAD |
Malignant neoplasm of mouth | 0.002638474 | 1 | 0 | BeFree_GAD |
Cancer of Head and Neck | 0.002638474 | 1 | 0 | BeFree_GAD |
As If Personality | 0.002367032 | 1 | 0 | GAD |
Drug toxicity | 0.002367032 | 1 | 0 | GAD |
Pathological accumulation of air in tissues | 0.002367032 | 1 | 0 | GAD |
Epilepsy | 0.002367032 | 1 | 0 | GAD |
Fetal Growth Retardation | 0.002367032 | 1 | 0 | GAD |
Growth Disorders | 0.002367032 | 1 | 0 | GAD |
Mesothelioma | 0.002367032 | 1 | 0 | GAD |
Pleural Neoplasms | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications | 0.002367032 | 1 | 0 | GAD |
Cancer of Nasopharynx | 0.002367032 | 1 | 0 | GAD |
Genomic Instability | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of ovary | 0.002367032 | 1 | 0 | GAD |
Attention deficit hyperactivity disorder | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.000814326 | 3 | 0 | BeFree |
Esophageal carcinoma | 0.000814326 | 3 | 0 | BeFree |
Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
Adenoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Liver diseases | 0.000542884 | 2 | 0 | BeFree |
Pancreatic carcinoma | 0.000542884 | 2 | 1 | BeFree |
Malignant neoplasm of stomach stage IV | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Alcoholic Intoxication, Chronic | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Mental Depression | 0.000271442 | 1 | 0 | BeFree |
Depressive disorder | 0.000271442 | 1 | 0 | BeFree |
Hypertensive disease | 0.000271442 | 1 | 0 | BeFree |
Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Lymphedema | 0.000271442 | 1 | 0 | BeFree |
Myotonic Dystrophy | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Withdrawal Symptoms | 0.000271442 | 1 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Gastric Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Chronic liver disease | 0.000271442 | 1 | 0 | BeFree |
Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
Congenital Myotonic Dystrophy | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
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