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Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  细胞色素b由轻链(阿尔法)和重链(测试版)。该基因编码已被提议作为吞噬细胞的杀微生物氧化酶系统的主分量的光,α亚基。在这种基因突变与常染色体隐性慢性肉芽肿病(CGD),其特征是激活的吞噬细胞未能产生超氧化物,它是这些细胞的杀微生物活性是重要的关联。 [由RefSeq的,2008年7月提供]
CYBA基因(以及对应的蛋白质)的细胞分布位置:
CYBA基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative | 0.36 | 5 | 12 | CLINVAR_CTD_human_UNIPROT |
Hypertensive disease | 0.24827923 | 28 | 1 | BeFree_CTD_human_GAD_LHGDN_RGD |
Chronic granulomatous disease | 0.247338862 | 18 | 0 | BeFree_CTD_human_LHGDN_ORPHANET |
Kidney Failure, Chronic | 0.208001298 | 4 | 0 | BeFree_CTD_human_GAD_LHGDN_RGD |
Diabetes Mellitus, Experimental | 0.2 | 3 | 0 | CTD_human_RGD |
Atherosclerosis | 0.145089661 | 17 | 1 | BeFree_CTD_human_GAD_LHGDN |
Diabetes Mellitus, Non-Insulin-Dependent | 0.134549579 | 15 | 1 | BeFree_CTD_human_GAD |
Heart Diseases | 0.122367032 | 2 | 0 | CTD_human_GAD |
Myocardial Infarction | 0.08554839 | 6 | 1 | BeFree_GAD_RGD |
Metabolic Syndrome X | 0.080271442 | 2 | 1 | BeFree_RGD |
Diabetic Retinopathy | 0.08 | 1 | 0 | RGD |
Pulmonary Hypertension | 0.08 | 1 | 0 | RGD |
Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Coronary Artery Disease | 0.031418701 | 34 | 7 | BeFree_GAD_LHGDN |
Coronary Arteriosclerosis | 0.028360776 | 33 | 3 | BeFree_GAD |
Coronary heart disease | 0.026708381 | 31 | 6 | BeFree_GAD_LHGDN |
Asthma | 0.01518827 | 4 | 0 | BeFree_GAD_LHGDN |
Cerebrovascular accident | 0.013178557 | 3 | 0 | BeFree_GAD_LHGDN |
Diabetic Nephropathy | 0.009172942 | 6 | 2 | BeFree_GAD_LHGDN |
Cardiovascular Diseases | 0.007719925 | 13 | 6 | BeFree_GAD |
Lymphoma, Non-Hodgkin | 0.00764398 | 4 | 0 | BeFree_GAD |
Hypercholesterolemia | 0.00617715 | 4 | 3 | BeFree_GAD_LHGDN |
Diabetes Mellitus, Insulin-Dependent | 0.00554839 | 3 | 1 | BeFree_GAD |
Insulin Resistance | 0.004734064 | 2 | 0 | GAD |
Oxidative Stress | 0.004734064 | 2 | 0 | GAD |
Sleep Apnea, Obstructive | 0.003181358 | 3 | 2 | BeFree_GAD |
Degenerative polyarthritis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Tetralogy of Fallot | 0.002995792 | 1 | 1 | BeFree_LHGDN |
Obesity | 0.002909916 | 2 | 0 | BeFree_GAD |
Infarction | 0.00272435 | 1 | 0 | LHGDN |
leukemia | 0.00272435 | 1 | 0 | LHGDN |
Coronary Stenosis | 0.00272435 | 1 | 0 | LHGDN |
Arteriosclerosis | 0.002714419 | 10 | 1 | BeFree |
Coronary Artery Vasospasm | 0.002638474 | 1 | 0 | BeFree_GAD |
Kidney Failure, Acute | 0.002638474 | 1 | 0 | BeFree_GAD |
Lupus Erythematosus, Systemic | 0.002638474 | 1 | 0 | BeFree_GAD |
Periodontitis, Juvenile | 0.002638474 | 2 | 0 | BeFree_GAD |
Brain Infarction | 0.002638474 | 2 | 0 | BeFree_GAD |
Agranulocytosis | 0.002367032 | 1 | 0 | GAD |
Albuminuria | 0.002367032 | 1 | 0 | GAD |
Angina Pectoris | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Candidiasis | 0.002367032 | 1 | 0 | GAD |
Carotid Artery Diseases | 0.002367032 | 1 | 0 | GAD |
Intracranial Arteriosclerosis | 0.002367032 | 1 | 0 | GAD |
Cerebral Infarction | 0.002367032 | 1 | 0 | GAD |
Brain Ischemia | 0.002367032 | 1 | 0 | GAD |
Cerebrovascular Disorders | 0.002367032 | 1 | 0 | GAD |
DNA Damage | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Peptic Ulcer | 0.002367032 | 1 | 0 | GAD |
Periodontitis | 0.002367032 | 1 | 0 | GAD |
Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
Helicobacter Infections | 0.002367032 | 1 | 0 | GAD |
Complications of Diabetes Mellitus | 0.002367032 | 1 | 0 | GAD |
Neuropathy | 0.002367032 | 1 | 0 | GAD |
Carcinoma in situ of uterine cervix | 0.002367032 | 1 | 0 | GAD |
Acute Coronary Syndrome | 0.002367032 | 1 | 0 | GAD |
Diabetes Mellitus | 0.001085767 | 4 | 0 | BeFree |
Kidney Diseases | 0.001085767 | 4 | 0 | BeFree |
Diabetes | 0.000814326 | 3 | 0 | BeFree |
Essential Hypertension | 0.000814326 | 3 | 1 | BeFree |
Hyperuricemia | 0.000814326 | 3 | 3 | BeFree |
Ischemic stroke | 0.000814326 | 3 | 0 | BeFree |
Autosomal Recessive Chronic Granulomatous Disease | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of breast | 0.000542884 | 2 | 6 | BeFree |
Ulcerative Colitis | 0.000542884 | 2 | 0 | BeFree |
Kidney Failure | 0.000542884 | 2 | 0 | BeFree |
High altitude pulmonary edema | 0.000542884 | 2 | 0 | BeFree |
Carotid Atherosclerosis | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 6 | BeFree |
Ischemic Cerebrovascular Accident | 0.000542884 | 2 | 0 | BeFree |
Intracranial Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Transient Ischemic Attack | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 2 | BeFree |
Lymphoma, Large-Cell, Follicular | 0.000271442 | 1 | 0 | BeFree |
T-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Left Ventricular Hypertrophy | 0.000271442 | 1 | 0 | BeFree |
Myocardial Ischemia | 0.000271442 | 1 | 0 | BeFree |
Disease of capillaries | 0.000271442 | 1 | 0 | BeFree |
Familial eosinophilia | 0.000271442 | 1 | 0 | BeFree |
Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
Restenosis | 0.000271442 | 1 | 0 | BeFree |
Primary immune deficiency disorder | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cerebral Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Infiltrating Cervical Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Peripheral Arterial Diseases | 0.000271442 | 1 | 3 | BeFree |
Chronic kidney disease stage 5 | 0.000271442 | 1 | 0 | BeFree |
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