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The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
[中文简述(自动翻译):]  由该基因编码的蛋白质是G蛋白偶联受体家族的一个成员。这种蛋白质是白细胞介素8(IL8)的受体。其结合以高亲和力IL8,并转导通过G-蛋白激活第二信使系统的信号。该受体还结合的趋化因子(C-X-C基序)配体1(CXCL1 / MGSA),已被证明是血清依赖性黑色素瘤细胞生长所需的主要成分的黑色素瘤生长刺激活性的蛋白质,和。该受体介导嗜中性粒细胞迁移至炎症部位。被发现的IL8在肠微血管内皮细胞的血管生成作用通过该受体介导的。在小鼠中敲除研究表明,这种受体控制少突胶质前体在逮捕他们的移民脊髓发育的定位。这个基因,IL8RA,编码另一个高亲和力的IL8受体,以及IL8RBP,IL8RB的假基因,形成在定位于染色体2q33-Q36的区域的基因簇。可变剪接变体,编码相同的蛋白质,也已确定。 [由RefSeq的,2009年11月提供]
CXCR2基因(以及对应的蛋白质)的细胞分布位置:
CXCR2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Ulcerative Colitis | 0.122638474 | 2 | 1 | BeFree_CTD_human_GAD |
Mastitis | 0.12 | 1 | 0 | CTD_human |
Sepsis | 0.12 | 1 | 0 | CTD_human |
Inflammation | 0.082367032 | 2 | 0 | GAD_RGD |
Colitis | 0.080271442 | 2 | 0 | BeFree_RGD |
Nephritis | 0.080271442 | 1 | 0 | BeFree_RGD |
Demyelinating Diseases | 0.08 | 1 | 0 | RGD |
Hyperalgesia | 0.08 | 1 | 0 | RGD |
Periapical Periodontitis | 0.08 | 1 | 0 | RGD |
Lung Injury | 0.08 | 1 | 0 | RGD |
Asthma | 0.007915422 | 6 | 0 | BeFree_GAD |
Neoplasm Metastasis | 0.007338862 | 17 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.006091273 | 5 | 0 | BeFree_GAD |
melanoma | 0.005991584 | 4 | 0 | BeFree_LHGDN |
Malignant neoplasm of stomach | 0.00554839 | 5 | 0 | BeFree_GAD |
HIV Infections | 0.005276948 | 4 | 0 | BeFree_GAD |
Premature Birth | 0.004734064 | 2 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.003181358 | 4 | 0 | BeFree_GAD |
Multiple Sclerosis | 0.003181358 | 3 | 0 | BeFree_GAD |
Primary Myelofibrosis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Alzheimer's Disease | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Arthritis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Polycystic Kidney, Autosomal Dominant | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Atherosclerosis | 0.002909916 | 3 | 0 | BeFree_GAD |
Malignant neoplasm of prostate | 0.002909916 | 2 | 0 | BeFree_GAD |
Malignant neoplasm of esophagus | 0.002909916 | 3 | 0 | BeFree_GAD |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Cyst | 0.00272435 | 1 | 0 | LHGDN |
Endometriosis | 0.00272435 | 1 | 0 | LHGDN |
Peptic Esophagitis | 0.00272435 | 1 | 0 | LHGDN |
Disease Progression | 0.00272435 | 1 | 0 | LHGDN |
Behcet Syndrome | 0.002638474 | 2 | 0 | BeFree_GAD |
Periodontitis | 0.002638474 | 1 | 0 | BeFree_GAD |
Respiratory Syncytial Virus Infections | 0.002638474 | 2 | 0 | BeFree_GAD |
Malignant neoplasm of ovary | 0.002638474 | 2 | 0 | BeFree_GAD |
Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
Bacteriuria | 0.002367032 | 1 | 0 | GAD |
Biliary Tract Neoplasm | 0.002367032 | 1 | 0 | GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
Hepatitis C | 0.002367032 | 1 | 0 | GAD |
Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
Leishmaniasis, Cutaneous | 0.002367032 | 1 | 0 | GAD |
Mucocutaneous Lymph Node Syndrome | 0.002367032 | 1 | 0 | GAD |
Multiple Myeloma | 0.002367032 | 1 | 0 | GAD |
Periodontal Diseases | 0.002367032 | 1 | 0 | GAD |
Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
Tuberculosis | 0.002367032 | 1 | 0 | GAD |
Diffuse Large B-Cell Lymphoma | 0.002367032 | 1 | 0 | GAD |
Maduromycosis | 0.002367032 | 1 | 0 | GAD |
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
Malignant tumor of colon | 0.001900093 | 7 | 0 | BeFree |
Colon Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Pancreatic carcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.001357209 | 5 | 0 | BeFree |
Carcinogenesis | 0.001357209 | 5 | 0 | BeFree |
Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Stomach Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Rheumatoid Arthritis | 0.000814326 | 3 | 0 | BeFree |
Colorectal Carcinoma | 0.000814326 | 3 | 1 | BeFree |
Inflammatory Bowel Diseases | 0.000814326 | 3 | 0 | BeFree |
Pneumonia | 0.000814326 | 3 | 0 | BeFree |
Psoriasis | 0.000814326 | 3 | 0 | BeFree |
Systemic Scleroderma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of lung | 0.000814326 | 3 | 0 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000814326 | 3 | 0 | BeFree |
Colorectal Cancer | 0.000814326 | 3 | 1 | BeFree |
Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Esophageal Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Ischemia | 0.000542884 | 2 | 0 | BeFree |
Lung diseases | 0.000542884 | 2 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000542884 | 2 | 0 | BeFree |
Obesity | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000542884 | 2 | 0 | BeFree |
Esophageal carcinoma | 0.000542884 | 2 | 0 | BeFree |
Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000542884 | 2 | 0 | BeFree |
Tumor necrosis | 0.000542884 | 2 | 0 | BeFree |
Endometrial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of liver | 0.000542884 | 2 | 0 | BeFree |
Sarcoma | 0.000542884 | 2 | 0 | BeFree |
Cold Ischemia | 0.000542884 | 2 | 0 | BeFree |
Alveolar Bone Loss | 0.000271442 | 1 | 0 | BeFree |
Anemia, Sickle Cell | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Aortic Rupture | 0.000271442 | 1 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
Biliary Atresia | 0.000271442 | 1 | 0 | BeFree |
Bronchiolitis | 0.000271442 | 1 | 0 | BeFree |
Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carotid Stenosis | 0.000271442 | 1 | 0 | BeFree |
Cholestasis | 0.000271442 | 1 | 0 | BeFree |
Crohn Disease | 0.000271442 | 1 | 1 | BeFree |
Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Dental caries | 0.000271442 | 1 | 0 | BeFree |
Dermatitis | 0.000271442 | 1 | 0 | BeFree |
Dermatitis, Atopic | 0.000271442 | 1 | 0 | BeFree |
Eczema | 0.000271442 | 1 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Hepatitis, Alcoholic | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Hypertension | 0.000271442 | 1 | 0 | BeFree |
Intestinal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Keratitis | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Measles | 0.000271442 | 1 | 0 | BeFree |
Myelofibrosis | 0.000271442 | 1 | 0 | BeFree |
Myeloid Metaplasia | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Signs and Symptoms, Respiratory | 0.000271442 | 1 | 0 | BeFree |
Thrombocythemia, Essential | 0.000271442 | 1 | 0 | BeFree |
Pyoderma Gangrenosum | 0.000271442 | 1 | 0 | BeFree |
Hamman-Rich syndrome | 0.000271442 | 1 | 0 | BeFree |
Epstein-Barr Virus Infections | 0.000271442 | 1 | 0 | BeFree |
Deep Vein Thrombosis | 0.000271442 | 1 | 0 | BeFree |
Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Hepatic necrosis | 0.000271442 | 1 | 0 | BeFree |
Systemic candidiasis | 0.000271442 | 1 | 0 | BeFree |
Hereditary pancreatitis | 0.000271442 | 1 | 0 | BeFree |
acute aortic dissection | 0.000271442 | 1 | 0 | BeFree |
Proliferative vitreoretinopathy | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Lewis Lung | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Small Cell | 0.000271442 | 1 | 0 | BeFree |
Miller Dieker syndrome | 0.000271442 | 1 | 0 | BeFree |
Rhinovirus infection | 0.000271442 | 1 | 0 | BeFree |
Gastric Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Caries (morphologic abnormality) | 0.000271442 | 1 | 0 | BeFree |
Deep vein thrombosis of lower limb | 0.000271442 | 1 | 0 | BeFree |
Congenital neutropenia | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B, Chronic | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
airway disease | 0.000271442 | 1 | 0 | BeFree |
Corneal infection | 0.000271442 | 1 | 0 | BeFree |
Bile duct carcinoma | 0.000271442 | 1 | 3 | BeFree |
Thrombocytosis | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori infection | 0.000271442 | 1 | 0 | BeFree |
asthma with copd | 0.000271442 | 1 | 0 | BeFree |
Stromal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Colorectal cancer metastatic | 0.000271442 | 1 | 0 | BeFree |
Endometrial adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Intestinal Polyposis | 0.000271442 | 1 | 0 | BeFree |
Adenoviral keratitis | 0.000271442 | 1 | 0 | BeFree |
Chronic inflammatory disorder | 0.000271442 | 1 | 0 | BeFree |
Chronic myeloproliferative disorder | 0.000271442 | 1 | 0 | BeFree |
Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome | 0.000271442 | 1 | 0 | BeFree |
Gastric Cardia Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
tumor vasculature | 0.000271442 | 1 | 0 | BeFree |
Idiopathic Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA | 0.000271442 | 1 | 0 | BeFree |
Severe congenital neutropenia | 0.000271442 | 1 | 0 | BeFree |
Allergic rhinitis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Neutrophilia (disorder) | 0.000271442 | 1 | 0 | BeFree |
Chronic idiopathic pulmonary fibrosis | 0.000271442 | 1 | 0 | BeFree |
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