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Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
[中文简述(自动翻译):]  Fractalkine的是一种跨膜蛋白,趋化因子参与粘附和白细胞的迁移。由该基因编码的蛋白质是用于fractalkine的受体。所编码的蛋白质也是HIV-1的一个辅助受体,并且在该基因引线一些变型中,以增加的易感性的HIV-1感染和迅速发展为艾滋病。已发现该基因编码的两种不同亚型四个抄本变形。 [由RefSeq的,2010年1月提供]
CX3CR1基因(以及对应的蛋白质)的细胞分布位置:
CX3CR1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
MACULAR DEGENERATION, AGE-RELATED, 12 | 0.2 | 0 | 2 | CLINVAR_MGD |
HIV Infections | 0.15984855 | 27 | 3 | BeFree_CTD_human_GAD |
Coronary heart disease | 0.122171535 | 8 | 2 | BeFree_CTD_human |
Chloracne | 0.12 | 1 | 0 | CTD_human |
Macular Degeneration, Age-Related, 1 | 0.12 | 0 | 0 | CTD_human |
Experimental Autoimmune Encephalomyelitis | 0.080542884 | 4 | 0 | BeFree_RGD |
Heart failure | 0.080271442 | 2 | 0 | BeFree_RGD |
Borna Disease | 0.08 | 1 | 0 | RGD |
Transient Ischemic Attack | 0.08 | 1 | 0 | RGD |
Cystitis | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
Glomerulonephritis | 0.08 | 2 | 0 | RGD |
Hyperalgesia | 0.08 | 4 | 0 | RGD |
Hypertension, Portal | 0.08 | 1 | 0 | RGD |
Pulmonary Hypertension | 0.08 | 1 | 0 | RGD |
Inflammation | 0.08 | 1 | 0 | RGD |
Intervertebral Disk Displacement | 0.08 | 1 | 0 | RGD |
Memory Disorders | 0.08 | 1 | 0 | RGD |
Nephrosis | 0.08 | 1 | 0 | RGD |
Neuritis, Autoimmune, Experimental | 0.08 | 1 | 0 | RGD |
Pain | 0.08 | 1 | 0 | RGD |
Pulmonary Embolism | 0.08 | 1 | 0 | RGD |
Status Epilepticus | 0.08 | 1 | 0 | RGD |
Uveitis | 0.08 | 1 | 0 | RGD |
Sciatic Neuropathy | 0.08 | 2 | 0 | RGD |
Prion Diseases | 0.08 | 1 | 0 | RGD |
Parkinsonian Disorders | 0.08 | 1 | 0 | RGD |
Anti-Glomerular Basement Membrane Disease | 0.08 | 1 | 0 | RGD |
Hepatopulmonary Syndrome | 0.08 | 1 | 0 | RGD |
Arthritis, Experimental | 0.08 | 2 | 0 | RGD |
Coronary Artery Disease | 0.018717015 | 14 | 2 | BeFree_GAD_LHGDN |
Atherosclerosis | 0.01743575 | 20 | 2 | BeFree_GAD_LHGDN |
Age related macular degeneration | 0.012344368 | 19 | 2 | BeFree_GAD_LHGDN |
Asthma | 0.00827274 | 4 | 2 | BeFree_GAD_LHGDN |
Acute Coronary Syndrome | 0.00827274 | 4 | 2 | BeFree_GAD_LHGDN |
Coronary Arteriosclerosis | 0.007177041 | 11 | 2 | BeFree_GAD |
Rheumatoid Arthritis | 0.006534468 | 6 | 0 | BeFree_LHGDN |
Crohn Disease | 0.005905708 | 3 | 2 | BeFree_GAD_LHGDN |
Fibrosis | 0.0054487 | 2 | 0 | LHGDN |
Prostatic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Infection | 0.0054487 | 2 | 0 | LHGDN |
Lymphoma | 0.005362824 | 2 | 0 | BeFree_GAD_LHGDN |
Hepatitis C, Chronic | 0.005362824 | 1 | 1 | BeFree_GAD_LHGDN |
Obesity | 0.005276948 | 4 | 0 | BeFree_GAD |
Liver Cirrhosis | 0.005091382 | 1 | 1 | GAD_LHGDN |
Acquired Immunodeficiency Syndrome | 0.005005506 | 3 | 2 | BeFree_GAD |
Arteriosclerosis | 0.004614512 | 17 | 2 | BeFree |
Multiple Sclerosis | 0.003538676 | 4 | 2 | BeFree_LHGDN |
Myocardial Infarction | 0.003452799 | 4 | 0 | BeFree_GAD |
Dermatitis, Atopic | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Cerebrovascular accident | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Cardiovascular Diseases | 0.003181358 | 4 | 0 | BeFree_GAD |
Glioblastoma | 0.003181358 | 3 | 0 | BeFree_GAD |
Kidney Diseases | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Adult T-Cell Lymphoma/Leukemia | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Retinal Vasculitis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Kidney Failure, Chronic | 0.002909916 | 3 | 2 | BeFree_GAD |
Malignant neoplasm of lung | 0.002909916 | 3 | 0 | BeFree_GAD |
Adenocarcinoma | 0.00272435 | 1 | 0 | LHGDN |
Anoxia | 0.00272435 | 1 | 0 | LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Cytomegalovirus Infections | 0.00272435 | 1 | 0 | LHGDN |
Hypertensive disease | 0.00272435 | 1 | 0 | LHGDN |
Rhinitis | 0.00272435 | 1 | 0 | LHGDN |
Peripheral Vascular Diseases | 0.00272435 | 1 | 0 | LHGDN |
Aortic Aneurysm, Abdominal | 0.00272435 | 1 | 0 | LHGDN |
Headache | 0.002638474 | 1 | 0 | BeFree_GAD |
Psoriasis | 0.002638474 | 1 | 0 | BeFree_GAD |
Vascular Diseases | 0.002638474 | 2 | 0 | BeFree_GAD |
Diffuse Large B-Cell Lymphoma | 0.002638474 | 2 | 0 | BeFree_GAD |
Migraine Disorders | 0.002638474 | 1 | 0 | BeFree_GAD |
Restenosis | 0.002638474 | 1 | 1 | BeFree_GAD |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Carotid Stenosis | 0.002367032 | 1 | 0 | GAD |
Cerebrovascular Disorders | 0.002367032 | 1 | 0 | GAD |
Intestinal Obstruction | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
Mucocutaneous Lymph Node Syndrome | 0.002367032 | 1 | 0 | GAD |
Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
Retinal vascular occlusion | 0.002367032 | 1 | 0 | GAD |
Low Vision | 0.002367032 | 1 | 0 | GAD |
Renal transplant rejection | 0.002367032 | 1 | 0 | GAD |
Metabolic Syndrome X | 0.002367032 | 1 | 0 | GAD |
Neurogenic Inflammation | 0.002367032 | 1 | 0 | GAD |
Retinal Degeneration | 0.001085767 | 4 | 0 | BeFree |
Macular degeneration | 0.000814326 | 3 | 1 | BeFree |
Carotid Atherosclerosis | 0.000814326 | 3 | 0 | BeFree |
Endothelial dysfunction | 0.000814326 | 3 | 2 | BeFree |
Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
Eczema | 0.000542884 | 2 | 0 | BeFree |
Glioma | 0.000542884 | 2 | 0 | BeFree |
Congestive heart failure | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Neuralgia | 0.000542884 | 2 | 0 | BeFree |
Kidney Failure | 0.000542884 | 2 | 0 | BeFree |
Systemic candidiasis | 0.000542884 | 2 | 0 | BeFree |
Acute myocardial infarction | 0.000542884 | 2 | 0 | BeFree |
Fibrosis, Liver | 0.000542884 | 2 | 0 | BeFree |
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 1 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Tauopathies | 0.000542884 | 2 | 0 | BeFree |
CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 5 | 0.000542884 | 2 | 2 | BeFree |
Photoreceptor degeneration | 0.000542884 | 2 | 0 | BeFree |
Chronic kidney disease stage 5 | 0.000542884 | 2 | 2 | BeFree |
Albinism | 0.000271442 | 1 | 0 | BeFree |
Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
Amnesia | 0.000271442 | 1 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Angina, Unstable | 0.000271442 | 1 | 0 | BeFree |
Arthritis, Adjuvant-Induced | 0.000271442 | 1 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Biliary Atresia | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Bronchiolitis | 0.000271442 | 1 | 0 | BeFree |
Candidiasis | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Primary biliary cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Dermatitis | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Encephalitis | 0.000271442 | 1 | 0 | BeFree |
IGA Glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
Hip Dislocation, Congenital | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Lymphadenitis | 0.000271442 | 1 | 0 | BeFree |
Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
Neuritis | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Peritonitis | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Emphysema | 0.000271442 | 1 | 0 | BeFree |
Respiratory Syncytial Virus Infections | 0.000271442 | 1 | 0 | BeFree |
Retinal Drusen | 0.000271442 | 1 | 0 | BeFree |
Sarcoidosis | 0.000271442 | 1 | 0 | BeFree |
Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Vasculitis | 0.000271442 | 1 | 0 | BeFree |
Pancreatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
Vasculitis, Leukocytoclastic, Cutaneous | 0.000271442 | 1 | 0 | BeFree |
Atrophic condition of skin | 0.000271442 | 1 | 0 | BeFree |
Idiopathic pulmonary hypertension | 0.000271442 | 1 | 0 | BeFree |
Lesion of brain | 0.000271442 | 1 | 0 | BeFree |
Memory impairment | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Headache recurrent | 0.000271442 | 1 | 0 | BeFree |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular Abnormalities | 0.000271442 | 1 | 2 | BeFree |
Exudative age-related macular degeneration | 0.000271442 | 1 | 0 | BeFree |
Acute otitis media | 0.000271442 | 1 | 1 | BeFree |
Herpes encephalitis | 0.000271442 | 1 | 0 | BeFree |
Infection by Candida albicans | 0.000271442 | 1 | 0 | BeFree |
Stage IV Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
Stable angina | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Lung Diseases, Obstructive | 0.000271442 | 1 | 0 | BeFree |
Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
invasive cancer | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Disorder of macula of retina | 0.000271442 | 1 | 0 | BeFree |
Memory Loss | 0.000271442 | 1 | 0 | BeFree |
Carotid Artery Plaque | 0.000271442 | 1 | 0 | BeFree |
Brain Infarction | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis, Relapsing-Remitting | 0.000271442 | 1 | 0 | BeFree |
Metastases to adrenals | 0.000271442 | 1 | 0 | BeFree |
Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Pancreatic intraepithelial neoplasia | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Non-Malignant Ascites Adverse Event | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
Leukocytoclastic vasculitis | 0.000271442 | 1 | 0 | BeFree |
Pulmonary arterial hypertension | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
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