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The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白是一种溶酶体半胱氨酸蛋白酶和成员的肽酶C1家族的。它显示出两个羧基monopeptidase和羧基二肽酶的活动。所编码的蛋白质也被称为组织蛋白酶X和组织蛋白酶P.该基因在癌细胞系和原发性肿瘤广泛表达,并且,象该家族的其他成员,可能参与肿瘤发生。 [由RefSeq的,2008年10月提供]
CTSZ基因(以及对应的蛋白质)的细胞分布位置:
CTSZ基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Leukemia, Myelocytic, Acute | 0.12 | 1 | 0 | CTD_human |
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) | 0.12 | 0 | 0 | CTD_human |
Neuralgia | 0.08 | 1 | 0 | RGD |
Tuberculosis, Pulmonary | 0.002638474 | 2 | 2 | BeFree_GAD |
Tuberculosis | 0.000814326 | 3 | 0 | BeFree |
Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Helicobacter pylori infection | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Adenoma | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Gastroesophageal reflux disease | 0.000271442 | 1 | 0 | BeFree |
Lymphatic Metastasis | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Giant Cell Tumor of Bone | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Prostatic Intraepithelial Neoplasias | 0.000271442 | 1 | 0 | BeFree |
Senile Plaques | 0.000271442 | 1 | 0 | BeFree |
Helicobacter-associated gastritis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
gastritis h pylori | 0.000271442 | 1 | 0 | BeFree |
High Grade Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
ABLEPHARON-MACROSTOMIA SYNDROME | 0.000271442 | 1 | 0 | BeFree |
Plaque, Amyloid | 0.000271442 | 1 | 0 | BeFree |
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