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The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
[中文简述(自动翻译):]  由该基因编码的蛋白质,肽酶C1家族中的一员,是可以在MHC II类分子参与抗原蛋白质的降解的肽呈现的溶酶体半胱氨酸蛋白酶。所编码的蛋白质可以作为在广泛的pH范围在肺泡巨噬细胞弹性蛋白酶的作用。已发现该基因编码不同亚型选择性剪接转录变异体。 [由RefSeq的,2010年12月提供]
CTSS基因(以及对应的蛋白质)的细胞分布位置:
CTSS基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Obesity | 0.123724241 | 6 | 0 | BeFree_CTD_human_GAD |
Contact Dermatitis | 0.12 | 1 | 0 | CTD_human |
IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
Neoplasm Invasiveness | 0.12 | 1 | 0 | CTD_human |
Hyperalgesia | 0.080271442 | 2 | 0 | BeFree_RGD |
Intracranial Aneurysm | 0.08 | 1 | 0 | RGD |
Neuralgia | 0.08 | 2 | 0 | RGD |
Multiple Sclerosis | 0.004734064 | 2 | 0 | GAD |
Cardiovascular Diseases | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Pulmonary Emphysema | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Myositis | 0.00272435 | 1 | 0 | LHGDN |
Coronary heart disease | 0.002638474 | 2 | 2 | BeFree_GAD |
Alzheimer's Disease | 0.002367032 | 1 | 0 | GAD |
Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
Atherosclerosis | 0.000814326 | 3 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
Aortic Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Asthma | 0.000271442 | 1 | 0 | BeFree |
Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
Cutis Laxa | 0.000271442 | 1 | 0 | BeFree |
Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Kidney Failure, Chronic | 0.000271442 | 1 | 0 | BeFree |
Liver diseases | 0.000271442 | 1 | 0 | BeFree |
Lung diseases | 0.000271442 | 1 | 0 | BeFree |
Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
Myasthenia Gravis | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Peripheral Neuropathy | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm, Abdominal | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Inflammatory pain | 0.000271442 | 1 | 0 | BeFree |
Stable angina | 0.000271442 | 1 | 0 | BeFree |
Aortic aneurysm without mention of rupture NOS | 0.000271442 | 1 | 0 | BeFree |
Chronic Kidney Insufficiency | 0.000271442 | 1 | 0 | BeFree |
Aortic valve calcification | 0.000271442 | 1 | 0 | BeFree |
Myasthenia Gravis, Autoimmune, Experimental | 0.000271442 | 1 | 0 | BeFree |
Pseudomonas aeruginosa infection | 0.000271442 | 1 | 0 | BeFree |
vascular aneurysm | 0.000271442 | 1 | 0 | BeFree |
Chronic Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
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