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This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因是免疫球蛋白超家族的成员,并编码一种发送抑制性信号到T细胞的蛋白质。该蛋白质包含V结构域,跨膜结构域和胞质尾。备用转录剪接变体,编码不同同种型,已经表征。膜结合同种型用作通过二硫键相互连接的同型二聚体,而可溶性同种型用作单体。在这种基因突变已与胰岛素依赖型糖尿病,格雷夫斯病,桥本甲状腺炎,腹腔疾病,系统性红斑狼疮,甲状腺相关眼病,以及其他自身免疫性疾病相关联。 [由RefSeq的,2008年7月提供]
CTLA4基因(以及对应的蛋白质)的细胞分布位置:
CTLA4基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Rheumatoid Arthritis | 0.345272224 | 82 | 9 | BeFree_CTD_human_GAD_GWASCAT_LHGDN |
Diabetes Mellitus, Insulin-Dependent | 0.247813496 | 157 | 6 | BeFree_GAD_GWASCAT_LHGDN |
AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE V | 0.24 | 1 | 0 | ORPHANET_UNIPROT |
Graves Disease | 0.228259749 | 85 | 5 | BeFree_CTD_human_GAD_LHGDN |
Celiac Disease | 0.174546137 | 34 | 0 | BeFree_CTD_human_GAD_LHGDN |
Hashimoto Disease | 0.149181152 | 11 | 2 | BeFree_CTD_human_GAD_LHGDN |
melanoma | 0.136892866 | 19 | 0 | BeFree_CTD_human_GAD_LHGDN |
Graft-vs-Host Disease | 0.130553895 | 9 | 0 | BeFree_CTD_human_GAD |
Juvenile arthritis | 0.12554839 | 5 | 0 | BeFree_CTD_human_GAD |
Oral Submucous Fibrosis | 0.122638474 | 2 | 0 | BeFree_CTD_human_GAD |
Alopecia Areata | 0.122367032 | 1 | 0 | CTD_human_GAD |
Lymphoma, T-Cell, Cutaneous | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Peripheral Neuropathy | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Adult T-Cell Lymphoma/Leukemia | 0.12 | 1 | 0 | CTD_human |
DIABETES MELLITUS, INSULIN-DEPENDENT, 12 | 0.12 | 0 | 0 | CTD_human |
CELIAC DISEASE, SUSCEPTIBILITY TO, 3 (finding) | 0.12 | 0 | 1 | CLINVAR |
Myocarditis | 0.082995792 | 2 | 0 | BeFree_LHGDN_RGD |
Arthritis, Experimental | 0.080271442 | 1 | 0 | BeFree_RGD |
Lupus Erythematosus, Systemic | 0.067790707 | 59 | 4 | BeFree_GAD_LHGDN |
Autoimmune Diseases | 0.063853648 | 143 | 7 | BeFree_GAD_LHGDN |
Multiple Sclerosis | 0.063633202 | 43 | 0 | BeFree_GAD_LHGDN |
Asthma | 0.038196154 | 25 | 9 | BeFree_GAD_LHGDN |
Ulcerative Colitis | 0.031204679 | 16 | 1 | BeFree_GAD_LHGDN |
Myasthenia Gravis | 0.028542461 | 17 | 0 | BeFree_GAD_LHGDN |
Systemic Scleroderma | 0.024989972 | 8 | 3 | BeFree_GAD_LHGDN |
Lupus Erythematosus | 0.023474823 | 16 | 0 | BeFree_GAD |
Thyroid associated opthalmopathies | 0.022007993 | 13 | 1 | BeFree_GAD_LHGDN |
Diabetes Mellitus, Non-Insulin-Dependent | 0.020836349 | 12 | 0 | BeFree_GAD |
Thyroid Diseases | 0.020255908 | 13 | 0 | BeFree_GAD_LHGDN |
Biliary cirrhosis | 0.019293574 | 7 | 0 | GAD_LHGDN |
Behcet Syndrome | 0.019012201 | 11 | 1 | BeFree_GAD |
HIV Infections | 0.018316089 | 42 | 0 | BeFree_GAD_LHGDN |
Autoimmune thyroiditis | 0.017197984 | 7 | 0 | BeFree_GAD_LHGDN |
Inflammation | 0.016569224 | 7 | 0 | GAD |
Autoimmune thyroid disease | 0.01633012 | 34 | 5 | BeFree_GAD |
Vitiligo | 0.015373836 | 6 | 0 | BeFree_GAD_LHGDN |
Crohn Disease | 0.014635455 | 12 | 1 | BeFree_GAD_LHGDN |
Infection | 0.012907115 | 5 | 0 | GAD_LHGDN |
Hepatitis C | 0.012649486 | 7 | 0 | BeFree_GAD |
Granulomatosis with polyangiitis | 0.012192478 | 4 | 0 | GAD_LHGDN |
Hepatitis, Autoimmune | 0.011911105 | 11 | 0 | BeFree_GAD |
Hypothyroidism | 0.010725648 | 5 | 1 | BeFree_GAD_LHGDN |
Psoriasis | 0.010639772 | 4 | 0 | BeFree_GAD_LHGDN |
Lymphoma | 0.010358398 | 14 | 0 | BeFree_GAD |
Cervix carcinoma | 0.010358398 | 12 | 1 | BeFree_GAD |
Hemophilia A | 0.010011012 | 5 | 0 | BeFree_GAD |
Hepatitis B | 0.009815515 | 13 | 0 | BeFree_GAD |
Malignant neoplasm of breast | 0.009001189 | 7 | 1 | BeFree_GAD |
Inflammatory Bowel Diseases | 0.009001189 | 7 | 1 | BeFree_GAD |
Neoplasm Metastasis | 0.008815624 | 8 | 0 | BeFree_GAD_LHGDN |
Colorectal Cancer | 0.008729747 | 7 | 0 | BeFree_GAD |
Hepatitis B, Chronic | 0.008458305 | 6 | 0 | BeFree_GAD |
Diabetes Mellitus | 0.008338753 | 22 | 0 | BeFree_GAD |
Squamous cell carcinoma | 0.008001298 | 4 | 0 | BeFree_GAD_LHGDN |
Lymphoma, Non-Hodgkin | 0.008001298 | 4 | 0 | BeFree_GAD_LHGDN |
Liver Cirrhosis, Alcoholic | 0.007458414 | 2 | 0 | GAD_LHGDN |
Multiple Myeloma | 0.007448483 | 11 | 0 | BeFree_GAD |
Addison Disease | 0.007101096 | 3 | 0 | GAD |
Pancreatitis, Chronic | 0.007101096 | 3 | 0 | GAD |
Chronic ulcerative colitis | 0.007101096 | 3 | 0 | GAD |
Lupus Erythematosus, Discoid | 0.006905599 | 10 | 0 | BeFree_GAD |
Dermatitis, Atopic | 0.006720033 | 7 | 0 | BeFree_GAD_LHGDN |
Lupus Vulgaris | 0.006634157 | 9 | 0 | BeFree_GAD |
Hypothyroidism, Autoimmune | 0.006362715 | 7 | 0 | BeFree_GAD |
Common Variable Immunodeficiency | 0.006167218 | 14 | 0 | BeFree_GAD |
Hepatitis C, Chronic | 0.005905708 | 4 | 0 | BeFree_GAD_LHGDN |
Schizophrenia | 0.005819831 | 4 | 0 | BeFree_GAD |
Ankylosing spondylitis | 0.005819831 | 4 | 0 | BeFree_GAD |
Autoimmune hemolytic anemia | 0.005720142 | 2 | 0 | BeFree_LHGDN |
Arthritis | 0.00554839 | 5 | 0 | BeFree_GAD |
Uveomeningoencephalitic Syndrome | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Mammary Neoplasms | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
Bronchial Hyperreactivity | 0.005276948 | 3 | 1 | BeFree_GAD |
Malignant neoplasm of lung | 0.005276948 | 3 | 0 | BeFree_GAD |
Colonic Neoplasms | 0.005091382 | 1 | 0 | GAD_LHGDN |
Alcoholic Liver Diseases | 0.005091382 | 2 | 0 | GAD_LHGDN |
Renal Cell Carcinoma | 0.005005506 | 2 | 0 | BeFree_GAD |
Pemphigus | 0.005005506 | 3 | 0 | BeFree_GAD |
Immune thrombocytopenic purpura | 0.005005506 | 2 | 0 | BeFree_GAD |
Liver carcinoma | 0.005005506 | 3 | 0 | BeFree_GAD |
Primary biliary cirrhosis | 0.004885954 | 18 | 0 | BeFree |
Diabetes | 0.004885954 | 18 | 0 | BeFree |
Uterine Cervical Neoplasm | 0.004734064 | 2 | 0 | GAD |
Hay fever | 0.004734064 | 2 | 0 | GAD |
Immediate hypersensitivity | 0.004734064 | 2 | 0 | GAD |
Kidney Neoplasm | 0.004734064 | 2 | 0 | GAD |
Liver diseases | 0.004734064 | 2 | 0 | GAD |
Liver neoplasms | 0.004734064 | 2 | 0 | GAD |
Pre-Eclampsia | 0.004734064 | 2 | 0 | GAD |
Sarcoidosis | 0.004734064 | 2 | 0 | GAD |
Premature Birth | 0.004734064 | 2 | 0 | GAD |
Sjogren's Syndrome | 0.004734064 | 2 | 0 | GAD |
Thymoma | 0.004624443 | 7 | 3 | BeFree_LHGDN |
Chronic Lymphocytic Leukemia | 0.003995683 | 6 | 0 | BeFree_GAD |
Periodontitis | 0.003810118 | 4 | 0 | BeFree_LHGDN |
Endocrine System Diseases | 0.003452799 | 4 | 0 | BeFree_GAD |
Chronic Obstructive Airway Disease | 0.003452799 | 5 | 0 | BeFree_GAD |
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | 0.003452799 | 4 | 0 | BeFree_GAD |
Bipolar Disorder | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Mycosis Fungoides | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Malignant tumor of cervix | 0.003257302 | 12 | 1 | BeFree |
Malignant neoplasm of stomach | 0.003181358 | 3 | 0 | BeFree_GAD |
Vasculitis | 0.003181358 | 4 | 0 | BeFree_GAD |
Adenocarcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Glomerulonephritis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Thyroiditis | 0.002985861 | 11 | 1 | BeFree |
Metastatic melanoma | 0.002985861 | 11 | 0 | BeFree |
Lymphoproliferative Disorders | 0.002909916 | 3 | 0 | BeFree_GAD |
Myocardial Infarction | 0.002909916 | 3 | 0 | BeFree_GAD |
Henoch-Schoenlein Purpura | 0.002909916 | 2 | 0 | BeFree_GAD |
Tuberculosis, Pulmonary | 0.002909916 | 2 | 0 | BeFree_GAD |
Postpartum Thyroiditis | 0.002909916 | 2 | 0 | BeFree_GAD |
Cervical Squamous Cell Carcinoma | 0.002909916 | 2 | 0 | BeFree_GAD |
Spondylarthropathies | 0.002909916 | 3 | 0 | BeFree_GAD |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.002909916 | 3 | 0 | BeFree_GAD |
Bronchiolitis | 0.00272435 | 1 | 0 | LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
pathologic fistula | 0.00272435 | 1 | 0 | LHGDN |
Iridocyclitis | 0.00272435 | 1 | 0 | LHGDN |
Lymphoid leukemia | 0.00272435 | 1 | 0 | LHGDN |
Pancreatitis | 0.00272435 | 1 | 0 | LHGDN |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Purpura | 0.00272435 | 1 | 0 | LHGDN |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.00272435 | 1 | 0 | LHGDN |
Multiple Sclerosis, Chronic Progressive | 0.00272435 | 1 | 0 | LHGDN |
Thrombocytopenic purpura | 0.00272435 | 1 | 0 | LHGDN |
Anemia | 0.002638474 | 2 | 0 | BeFree_GAD |
Malignant neoplasm of urinary bladder | 0.002638474 | 2 | 0 | BeFree_GAD |
Cardiomyopathy, Dilated | 0.002638474 | 1 | 0 | BeFree_GAD |
Chlamydia Infections | 0.002638474 | 2 | 0 | BeFree_GAD |
Cholangitis, Sclerosing | 0.002638474 | 2 | 0 | BeFree_GAD |
Bronchitis, Chronic | 0.002638474 | 1 | 0 | BeFree_GAD |
Dengue Fever | 0.002638474 | 2 | 0 | BeFree_GAD |
Erythema Nodosum | 0.002638474 | 2 | 0 | BeFree_GAD |
Severe Dengue | 0.002638474 | 1 | 0 | BeFree_GAD |
Lymphohistiocytosis, Hemophagocytic | 0.002638474 | 1 | 0 | BeFree_GAD |
Pretibial myxedema | 0.002638474 | 1 | 0 | BeFree_GAD |
Dermatologic disorders | 0.002638474 | 2 | 0 | BeFree_GAD |
Cerebrovascular accident | 0.002638474 | 2 | 0 | BeFree_GAD |
Chagas Disease | 0.002638474 | 2 | 0 | BeFree_GAD |
Uveitis, Intermediate | 0.002638474 | 1 | 0 | BeFree_GAD |
Immunoglobulin A deficiency (disorder) | 0.002638474 | 1 | 0 | BeFree_GAD |
Prediabetes syndrome | 0.002638474 | 2 | 0 | BeFree_GAD |
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating | 0.002638474 | 2 | 0 | BeFree_GAD |
Coronary Artery Disease | 0.002638474 | 2 | 0 | BeFree_GAD |
Non-Small Cell Lung Carcinoma | 0.002442977 | 9 | 0 | BeFree |
Virus Diseases | 0.002442977 | 9 | 0 | BeFree |
Spontaneous abortion | 0.002367032 | 1 | 0 | GAD |
Abruptio Placentae | 0.002367032 | 1 | 0 | GAD |
Arthritis, Psoriatic | 0.002367032 | 1 | 0 | GAD |
Autoimmune Response | 0.002367032 | 1 | 0 | GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Calcinosis | 0.002367032 | 1 | 0 | GAD |
Basal cell carcinoma | 0.002367032 | 1 | 0 | GAD |
Brain Ischemia | 0.002367032 | 1 | 0 | GAD |
Choriocarcinoma | 0.002367032 | 1 | 0 | GAD |
Connective Tissue Diseases | 0.002367032 | 1 | 0 | GAD |
Eosinophilia | 0.002367032 | 1 | 0 | GAD |
Fatty Liver | 0.002367032 | 1 | 0 | GAD |
Fetal Diseases | 0.002367032 | 1 | 0 | GAD |
Heart Diseases | 0.002367032 | 1 | 0 | GAD |
Hepatitis, Chronic | 0.002367032 | 1 | 0 | GAD |
Hydatidiform Mole | 0.002367032 | 1 | 0 | GAD |
Hypoparathyroidism | 0.002367032 | 1 | 0 | GAD |
Leishmaniasis, Cutaneous | 0.002367032 | 1 | 0 | GAD |
Myeloid Leukemia | 0.002367032 | 1 | 0 | GAD |
Lymphocytosis | 0.002367032 | 1 | 0 | GAD |
Animal Mammary Neoplasms | 0.002367032 | 1 | 0 | GAD |
Meniere Disease | 0.002367032 | 1 | 0 | GAD |
Musculoskeletal Diseases | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications, Hematologic | 0.002367032 | 1 | 0 | GAD |
Proteinuria | 0.002367032 | 1 | 0 | GAD |
Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
Rhinitis | 0.002367032 | 1 | 0 | GAD |
Rhinitis, Allergic, Perennial | 0.002367032 | 1 | 0 | GAD |
Skin Neoplasms | 0.002367032 | 1 | 0 | GAD |
Aphthous Stomatitis | 0.002367032 | 1 | 0 | GAD |
Subacute Sclerosing Panencephalitis | 0.002367032 | 1 | 0 | GAD |
Sunburn | 0.002367032 | 1 | 0 | GAD |
Trachoma | 0.002367032 | 1 | 0 | GAD |
Anterior uveitis | 0.002367032 | 1 | 0 | GAD |
Diffuse Large B-Cell Lymphoma | 0.002367032 | 1 | 0 | GAD |
Polyendocrinopathies, Autoimmune | 0.002367032 | 1 | 0 | GAD |
Atopy | 0.002367032 | 1 | 0 | GAD |
Dermatitis and eczema | 0.002367032 | 1 | 0 | GAD |
Cardiomyopathies | 0.002367032 | 1 | 0 | GAD |
Cardiomyopathy, Familial Idiopathic | 0.002367032 | 1 | 0 | GAD |
Venous Thromboembolism | 0.002367032 | 1 | 0 | GAD |
Proteinuria Adverse Event | 0.002367032 | 1 | 0 | GAD |
Solar Erythema | 0.002367032 | 1 | 0 | GAD |
Thyroid associated orbitopathy | 0.002367032 | 1 | 0 | GAD |
Disorder of eye | 0.002171535 | 8 | 1 | BeFree |
Tumor Immunity | 0.002171535 | 8 | 0 | BeFree |
Diabetes, Autoimmune | 0.001900093 | 7 | 0 | BeFree |
Breast Carcinoma | 0.001900093 | 7 | 1 | BeFree |
Acute GVH disease | 0.001900093 | 7 | 1 | BeFree |
Eczema | 0.001628651 | 6 | 0 | BeFree |
Osteosarcoma | 0.001628651 | 6 | 4 | BeFree |
Allergic asthma | 0.001628651 | 6 | 0 | BeFree |
Colorectal Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Immune System Diseases | 0.001357209 | 5 | 0 | BeFree |
Influenza | 0.001357209 | 5 | 0 | BeFree |
Osteosarcoma of bone | 0.001357209 | 5 | 4 | BeFree |
Allergic disposition | 0.001357209 | 5 | 1 | BeFree |
Leukemia, Myelocytic, Acute | 0.001085767 | 4 | 0 | BeFree |
Tumor Progression | 0.001085767 | 4 | 0 | BeFree |
Granulomatosis | 0.001085767 | 4 | 0 | BeFree |
Sporadic Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
Atherosclerosis | 0.000814326 | 3 | 0 | BeFree |
Kidney Failure, Chronic | 0.000814326 | 3 | 0 | BeFree |
leukemia | 0.000814326 | 3 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000814326 | 3 | 0 | BeFree |
Lung Neoplasms | 0.000814326 | 3 | 0 | BeFree |
Wiskott-Aldrich Syndrome | 0.000814326 | 3 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000814326 | 3 | 0 | BeFree |
Polymyositis | 0.000814326 | 3 | 0 | BeFree |
Stable angina | 0.000814326 | 3 | 0 | BeFree |
Stomach Carcinoma | 0.000814326 | 3 | 0 | BeFree |
cancer regression | 0.000814326 | 3 | 0 | BeFree |
Generalized vitiligo | 0.000814326 | 3 | 7 | BeFree |
IMMUNE SUPPRESSION | 0.000814326 | 3 | 0 | BeFree |
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 0.000814326 | 3 | 0 | BeFree |
Juvenile rheumatoid arthritis | 0.000814326 | 3 | 0 | BeFree |
Colitis | 0.000542884 | 2 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Coronary heart disease | 0.000542884 | 2 | 0 | BeFree |
Cytomegalovirus Infections | 0.000542884 | 2 | 1 | BeFree |
Gingival Diseases | 0.000542884 | 2 | 0 | BeFree |
Hyperthyroidism | 0.000542884 | 2 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000542884 | 2 | 0 | BeFree |
Leprosy | 0.000542884 | 2 | 0 | BeFree |
Lupus Erythematosus, Subacute Cutaneous | 0.000542884 | 2 | 0 | BeFree |
Lymphopenia | 0.000542884 | 2 | 0 | BeFree |
Mitral Valve Stenosis | 0.000542884 | 2 | 0 | BeFree |
Monoclonal Gammopathy of Undetermined Significance | 0.000542884 | 2 | 0 | BeFree |
Paracoccidioidomycosis | 0.000542884 | 2 | 0 | BeFree |
Periodontal Diseases | 0.000542884 | 2 | 0 | BeFree |
Periodontitis, Juvenile | 0.000542884 | 2 | 2 | BeFree |
Post-kala-azar dermal leishmaniasis | 0.000542884 | 2 | 0 | BeFree |
Tetanus | 0.000542884 | 2 | 0 | BeFree |
Thalassemia | 0.000542884 | 2 | 0 | BeFree |
Wheezing | 0.000542884 | 2 | 6 | BeFree |
B-Cell Lymphomas | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, Large-Cell, Follicular | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
Neoplasm, Residual | 0.000542884 | 2 | 0 | BeFree |
Pemphigus Foliaceus | 0.000542884 | 2 | 0 | BeFree |
Psoriasis vulgaris | 0.000542884 | 2 | 0 | BeFree |
Chronic Periodontitis | 0.000542884 | 2 | 0 | BeFree |
Severe hereditary factor VIII deficiency disease | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Primary sclerosing cholangitis | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of bladder | 0.000542884 | 2 | 0 | BeFree |
Hyperlipoproteinemia Type IIa | 0.000542884 | 2 | 0 | BeFree |
Chronic graft-versus-host disease | 0.000542884 | 2 | 0 | BeFree |
Acute Coronary Syndrome | 0.000542884 | 2 | 0 | BeFree |
Arthritis, Collagen-Induced | 0.000542884 | 2 | 0 | BeFree |
Diffuse Scleroderma | 0.000542884 | 2 | 0 | BeFree |
Chronic kidney disease stage 5 | 0.000542884 | 2 | 0 | BeFree |
Affective Symptoms | 0.000271442 | 1 | 0 | BeFree |
Angina, Unstable | 0.000271442 | 1 | 0 | BeFree |
Antibody Deficiency Syndrome | 0.000271442 | 1 | 0 | BeFree |
Arthritis, Adjuvant-Induced | 0.000271442 | 1 | 0 | BeFree |
Melanoma, B16 | 0.000271442 | 1 | 0 | BeFree |
Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Bone neoplasms | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Chediak-Higashi Syndrome | 0.000271442 | 1 | 0 | BeFree |
Cholestasis | 0.000271442 | 1 | 0 | BeFree |
Common Cold | 0.000271442 | 1 | 0 | BeFree |
Exfoliative dermatitis | 0.000271442 | 1 | 0 | BeFree |
Dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Diabetic Ketoacidosis | 0.000271442 | 1 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
Endometriosis | 0.000271442 | 1 | 0 | BeFree |
Fuchs' heterochromic cyclitis | 0.000271442 | 1 | 0 | BeFree |
Membranous glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
Hematological Disease | 0.000271442 | 1 | 0 | BeFree |
Hepatitis | 0.000271442 | 1 | 0 | BeFree |
Hepatitis A | 0.000271442 | 1 | 0 | BeFree |
Histiocytosis, Langerhans-Cell | 0.000271442 | 1 | 0 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
Arthropathy | 0.000271442 | 1 | 0 | BeFree |
Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Leprosy, Lepromatous | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelomonocytic, Chronic | 0.000271442 | 1 | 0 | BeFree |
Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Lown-Ganong-Levine Syndrome | 0.000271442 | 1 | 0 | BeFree |
Lyme Disease | 0.000271442 | 1 | 0 | BeFree |
Lymphocytic Choriomeningitis | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
Mucocutaneous Lymph Node Syndrome | 0.000271442 | 1 | 1 | BeFree |
Mycoses | 0.000271442 | 1 | 0 | BeFree |
Nephritis | 0.000271442 | 1 | 0 | BeFree |
Lipoid nephrosis | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Papilloma | 0.000271442 | 1 | 0 | BeFree |
Pneumonia | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Kidney Failure | 0.000271442 | 1 | 0 | BeFree |
Sialadenitis | 0.000271442 | 1 | 0 | BeFree |
Urticaria | 0.000271442 | 1 | 0 | BeFree |
T-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Polyglandular Type I Autoimmune Syndrome | 0.000271442 | 1 | 0 | BeFree |
Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Primary Sj�gren's syndrome | 0.000271442 | 1 | 0 | BeFree |
Non-arthropod borne lymphocytic choriomeningitis | 0.000271442 | 1 | 0 | BeFree |
Acute myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
Acute intermittent porphyria | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm, Abdominal | 0.000271442 | 1 | 0 | BeFree |
Malignant ascites | 0.000271442 | 1 | 0 | BeFree |
Adult type dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
Lesion of brain | 0.000271442 | 1 | 0 | BeFree |
Rheumatoid Vasculitis | 0.000271442 | 1 | 0 | BeFree |
Erectile dysfunction | 0.000271442 | 1 | 0 | BeFree |
Lyme Arthritis | 0.000271442 | 1 | 0 | BeFree |
Age related macular degeneration | 0.000271442 | 1 | 0 | BeFree |
Chronic urticaria | 0.000271442 | 1 | 0 | BeFree |
Childhood asthma | 0.000271442 | 1 | 0 | BeFree |
Axonal neuropathy | 0.000271442 | 1 | 0 | BeFree |
Inflammatory neuropathy | 0.000271442 | 1 | 0 | BeFree |
Pulmonary paracoccidioidomycosis | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
Ulcerative jejunitis | 0.000271442 | 1 | 0 | BeFree |
Microscopic Polyangiitis | 0.000271442 | 1 | 0 | BeFree |
Asymptomatic human immunodeficiency virus infection | 0.000271442 | 1 | 0 | BeFree |
Chronic Chagas' disease | 0.000271442 | 1 | 0 | BeFree |
Hereditary hemochromatosis | 0.000271442 | 1 | 0 | BeFree |
Primary immune deficiency disorder | 0.000271442 | 1 | 0 | BeFree |
Idiopathic crescentic glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
Chronic rejection of renal transplant | 0.000271442 | 1 | 0 | BeFree |
Aortic valve calcification | 0.000271442 | 1 | 0 | BeFree |
Neuropathy | 0.000271442 | 1 | 0 | BeFree |
Nephrotic range proteinuria | 0.000271442 | 1 | 0 | BeFree |
Chlamydia trachomatis infection | 0.000271442 | 1 | 0 | BeFree |
Metabolic Syndrome X | 0.000271442 | 1 | 4 | BeFree |
Aqueous Humor Disorders | 0.000271442 | 1 | 0 | BeFree |
Inherited neuropathies | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
multiple pathologies | 0.000271442 | 1 | 0 | BeFree |
Skin carcinoma | 0.000271442 | 1 | 0 | BeFree |
early pregnancy | 0.000271442 | 1 | 0 | BeFree |
Blood autoimmune disorders | 0.000271442 | 1 | 0 | BeFree |
Progressive multiple sclerosis | 0.000271442 | 1 | 0 | BeFree |
Invasive Ductal Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Deficiency of vitamin D3 | 0.000271442 | 1 | 0 | BeFree |
Inflammatory disorder | 0.000271442 | 1 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Adenoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
Stage IV Skin Melanoma | 0.000271442 | 1 | 0 | BeFree |
Autoimmune Lymphoproliferative Syndrome | 0.000271442 | 1 | 0 | BeFree |
Gastric Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Human T-cell lymphotropic virus 1 infection | 0.000271442 | 1 | 0 | BeFree |
Salivary Gland Pleomorphic Adenoma | 0.000271442 | 1 | 0 | BeFree |
Glomerulonephritis, Minimal Change | 0.000271442 | 1 | 0 | BeFree |
Bone Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
MULTICYSTIC RENAL DYSPLASIA, BILATERAL | 0.000271442 | 1 | 0 | BeFree |
Latent autoimmune diabetes mellitus in adult | 0.000271442 | 1 | 0 | BeFree |
Vasculitic neuropathy | 0.000271442 | 1 | 0 | BeFree |
CD40 Ligand Deficiency | 0.000271442 | 1 | 0 | BeFree |
Allergic rhinitis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Autoimmune pancreatitis | 0.000271442 | 1 | 0 | BeFree |
Allergic sensitization | 0.000271442 | 1 | 0 | BeFree |
Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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