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CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
[中文简述(自动翻译):]  CCCTC结合因子(CTCF),参与基因调控的11锌指因子,利用不同的锌指结合不同的DNA靶位点。 CTCF形成甲基化敏感绝缘子调节X染色体失活。这种基因是CTCF的旁系并似乎在精母细胞的细胞质中主要表达,不像CTCF其在体细胞的细胞核主要表达。 CTCF和由该基因编码的蛋白质中,与雄性生殖细胞分化过程中甲基化标记的复位相关互斥图案通常表示。已发现该基因编码不同亚型多重选择性剪接转录变异体。 [由RefSeq的,2012年6月提供]
CTCFL基因(以及对应的蛋白质)的细胞分布位置:
CTCFL基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Malignant neoplasm of breast | 0.003452799 | 4 | 0 | BeFree_GAD |
| Lung Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| melanoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| ovarian neoplasm | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Uterine Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Malignant neoplasm of testis | 0.002714419 | 10 | 0 | BeFree |
| Malignant neoplasm of lung | 0.001357209 | 5 | 0 | BeFree |
| Carcinoma of lung | 0.001357209 | 5 | 0 | BeFree |
| Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
| Squamous cell carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Friedreich Ataxia | 0.000542884 | 2 | 0 | BeFree |
| Endometrial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
| Esophageal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Lymphocytic, Acute, L1 | 0.000271442 | 1 | 0 | BeFree |
| Embryonal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Esophageal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Uterine Cancer | 0.000271442 | 1 | 0 | BeFree |
| Russell-Silver syndrome | 0.000271442 | 1 | 0 | BeFree |
| Germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
| Angiofibroma | 0.000271442 | 1 | 0 | BeFree |
| Multiple malignancy | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
| Malignant Squamous Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
| Malignant Mixed Mesodermal (Mullerian) Tumor | 0.000271442 | 1 | 0 | BeFree |
| Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
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