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The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是一个克雷布斯三羧酸循环酶,从草酰乙酸和乙酰辅酶A.催化柠檬酸的合成的酶中发现的能够氧化代谢的几乎所有的细胞。这种蛋白是核编码和运输到线粒体基质,其中的成熟形式被发现。 [由RefSeq的,2008年7月提供]
CS基因(以及对应的蛋白质)的细胞分布位置:
CS基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Anoxia | 0.12 | 1 | 0 | CTD_human |
| Heart failure | 0.12 | 1 | 0 | CTD_human |
| Obesity | 0.12 | 1 | 0 | CTD_human |
| Cardiomyopathies | 0.12 | 1 | 0 | CTD_human |
| Inflammatory dermatosis | 0.12 | 1 | 1 | GWASCAT |
| Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| TYPHUS | 0.000814326 | 3 | 0 | BeFree |
| Amyotrophic Lateral Sclerosis | 0.000542884 | 2 | 0 | BeFree |
| Endocarditis | 0.000542884 | 2 | 0 | BeFree |
| Spotted fevers | 0.000542884 | 2 | 0 | BeFree |
| Flea Infestation | 0.000542884 | 2 | 0 | BeFree |
| Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Autistic Disorder | 0.000271442 | 1 | 0 | BeFree |
| Benign Ovarian Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Cardiomyopathy, Dilated | 0.000271442 | 1 | 0 | BeFree |
| Malaria | 0.000271442 | 1 | 0 | BeFree |
| Myopathy | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Sickle Cell Trait | 0.000271442 | 1 | 0 | BeFree |
| Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
| Typhoid Fever | 0.000271442 | 1 | 0 | BeFree |
| Mitochondrial Myopathies | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Depletion of mitochondrial DNA | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
| Post MI | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Peripheral Arterial Diseases | 0.000271442 | 1 | 0 | BeFree |
| Cataract and cardiomyopathy | 0.000271442 | 1 | 0 | BeFree |
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