更多...
收起
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]
[中文简述(自动翻译):]  晶状体被分为两大类:分类单元专用,或酶,和无处不在。后者类构成脊椎动物眼透镜的主要的蛋白质,并保持透镜的透明性和折射率。前者类也被称为系统发育受限晶状体。该基因编码具有NADPH依赖性醌还原酶活性从其他已知的醌还原酶不同的特定分类单元晶状蛋白。它缺乏醇脱氢酶活性虽然通过相似它被认为是含锌醇脱氢酶家族的一个成员。不同于其他的哺乳动物的物种,在人类中,透镜表达是低的。已发现该基因编码不同亚型选择性剪接转录变异体。一个假基因已知存在。 [由RefSeq的,2008年9月提供]
CRYZ基因(以及对应的蛋白质)的细胞分布位置:
CRYZ基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Malignant neoplasm of lung | 0.003800186 | 14 | 1 | BeFree |
Carcinoma of lung | 0.003800186 | 14 | 1 | BeFree |
Parkinson Disease | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.002171535 | 8 | 1 | BeFree |
Colorectal Cancer | 0.002171535 | 8 | 1 | BeFree |
Colorectal Carcinoma | 0.001900093 | 7 | 1 | BeFree |
Acute lymphocytic leukemia | 0.001900093 | 7 | 0 | BeFree |
Colon Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Carcinoma of bladder | 0.001900093 | 7 | 1 | BeFree |
Liver carcinoma | 0.001900093 | 7 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.001628651 | 6 | 0 | BeFree |
Carcinogenesis | 0.001628651 | 6 | 0 | BeFree |
Malignant neoplasm of breast | 0.001357209 | 5 | 1 | BeFree |
Liver neoplasms | 0.001357209 | 5 | 0 | BeFree |
Breast Carcinoma | 0.001357209 | 5 | 1 | BeFree |
Malignant tumor of colon | 0.001085767 | 4 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.001085767 | 4 | 0 | BeFree |
leukemia | 0.001085767 | 4 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Schizophrenia | 0.000814326 | 3 | 0 | BeFree |
Small cell carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Asthma | 0.000542884 | 2 | 0 | BeFree |
Diabetes | 0.000542884 | 2 | 1 | BeFree |
Diabetes Mellitus | 0.000542884 | 2 | 1 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
Ischemia | 0.000542884 | 2 | 0 | BeFree |
Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 1 | BeFree |
Multiple Myeloma | 0.000542884 | 2 | 0 | BeFree |
Myeloproliferative disease | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cataract | 0.000542884 | 2 | 0 | BeFree |
Lingual-Facial-Buccal Dyskinesia | 0.000542884 | 2 | 0 | BeFree |
Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
Childhood asthma | 0.000542884 | 2 | 0 | BeFree |
Malignant Childhood Neoplasm | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000542884 | 2 | 2 | BeFree |
Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000542884 | 2 | 0 | BeFree |
Tardive Dyskinesia | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 1 | BeFree |
Carcinogenicity | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Anemia, Sickle Cell | 0.000271442 | 1 | 0 | BeFree |
Barrett Esophagus | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of prostate | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
Congenital cataract | 0.000271442 | 1 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000271442 | 1 | 2 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 2 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 1 | BeFree |
Esophageal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Hypertensive disease | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
Esophageal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma Of Esophagus | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
Restenosis | 0.000271442 | 1 | 0 | BeFree |
Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
Chromosome 8, trisomy | 0.000271442 | 1 | 0 | BeFree |
Bilateral cataracts (disorder) | 0.000271442 | 1 | 0 | BeFree |
Mood Disorders | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
Biliary Tract Cancer | 0.000271442 | 1 | 0 | BeFree |
Mitochondrial Diseases | 0.000271442 | 1 | 0 | BeFree |
Optic Atrophy, Hereditary, Leber | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。