CRYAA(crystallin, alpha A) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

21q22.3
基因染色体位置图

基因简述

基因简述

Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jan 2014]

[中文简述(自动翻译):]  哺乳动物镜头晶状体分为α，β和γ家庭。阿尔法晶状体组成的两种基因产物：字母A和字母B，分别用于酸性和碱性。阿尔法晶状体可以通过热休克诱导，并且是小的热休克蛋白（HSP20）家族的成员。他们作为分子伴侣，虽然他们不复性蛋白质和在一个真正的伴侣的方式释放他们。相反，他们拿着他们在大型可溶性聚集。翻译后修饰降低到伴侣的能力。这些异构聚集包括30-40亚基; α-A和阿尔法-B亚基具有一个3：1的比例，分别为。阿尔法晶状体的另外两个功能都在细胞内结构的autokinase活动和参与。所编码的蛋白质已被鉴定为是根据它来执行机制上不同功能能力的兼职蛋白。阿尔法-A和α-B基因产物差异表达;阿尔法-A优先限制在透镜和α-B在许多组织和器官中广泛表达。缺陷这个基因导致常染色体显性遗传先天性白内障（ADCC）。 [由RefSeq的，2014年1月提供]

OMIM数据库中对CRYAA基因的介绍     Wikipedia数据库中对CRYAA基因的介绍

基因序列

基因序列

CRYAA基因的碱基序列：[NCBI]

基因突变

基因突变

CRYAA基因的碱基突变：           显示全部snp
rs870137       rs870138       rs872331       rs3761381       rs3761382       rs3788057       rs3788059       rs3788061       rs3819160       rs4244357       rs5844151       rs7278468       rs9983145       rs11203176       rs11700709       rs11909366       rs11911164       rs11911275       rs13048089       rs13048590       rs13053109       rs17115947       rs34255326       rs56975193       rs61729442       rs61735855       rs61735856       rs61735857       rs66484621       rs71332392       rs72431917       rs73376206       rs73376211       rs73376213       rs73906469       rs73906471       rs73906472      
rs75543467       rs76740365       rs77693759       rs77809795       rs78862353       rs78898363       rs79100529       rs79545821       rs79614970       rs79868886       rs80280392       rs111727144       rs111923961       rs112211050       rs112360269       rs112493206       rs112855370       rs113104392       rs113498616       rs113802426       rs113894168       rs114323449       rs114376962       rs114592625       rs114611581       rs115311737       rs116032881       rs116059198       rs116507314       rs116590041       rs116821115       rs117331253       rs117396767       rs118166081       rs137889900       rs138508080       rs139487016       rs139794609       rs140011170       rs140042507       rs141987536       rs142180685       rs142926922       rs143349894       rs143992484       rs144722442       rs145337234       rs145489509       rs145514574       rs145774272       rs146039524       rs146057733       rs146497353       rs146914780       rs148370855       rs148704068       rs148972829       rs150106893       rs150629848       rs150684583       rs151103202       rs151213687       rs181524815       rs181741871       rs181877597       rs183125538       rs183226982       rs184542189       rs184724585       rs184911541       rs185368065       rs186003558       rs187771049       rs187866004       rs188609121       rs189034848       rs189176908       rs189494772       rs189826271       rs189888538       rs190671582       rs191516889       rs192868050       rs199640007       rs199675833       rs200183640       rs200543347       rs200576930       rs200594555       rs201043267       rs201415037       rs201572637       rs202112966       rs367826363       rs368391580       rs368462874       rs368616270       rs368746502       rs368931928       rs369466020       rs369609046       rs370015697       rs370051608       rs370282382       rs370765909       rs370849818       rs370972741       rs370974892       rs371043886       rs371850725       rs372202176       rs372727292       rs372739715       rs373108889       rs373635187       rs373652078       rs374208073       rs374245405       rs374349339       rs374457214       rs374487495       rs374495173       rs374585179       rs375346966       rs375621291       rs375948304       rs376164744       rs376490511       rs376676682       rs377009894       rs377222721       rs397515625       rs397515626       rs527653987       rs527765691       rs528147691       rs528273386       rs528354296       rs528861601       rs529586386       rs530432558       rs530500347       rs530710796       rs531020654       rs531094476       rs531743374       rs532140066       rs532922132       rs533142212       rs533351228       rs533668938       rs534186336       rs534321524       rs534785768       rs534786292       rs536503362       rs536787336       rs536872283       rs537125917       rs537385698       rs537579180       rs537868354       rs538575563       rs538680993       rs538745605       rs538782877       rs539106276       rs539733879       rs540097382       rs540844814       rs540844869       rs540953226       rs541193722       rs541606297       rs542025265       rs542736013       rs543297778       rs543336377       rs543854771       rs544134396       rs544662221       rs544842669       rs545025052       rs545083443       rs545258677       rs545642925       rs546044371       rs546282323       rs546374012       rs546535975       rs546661985       rs547223778       rs547553396       rs547561858       rs547809161       rs548700691       rs548865336       rs548881923       rs549207143       rs549215088       rs549300833       rs549651560       rs550131786       rs550485922       rs550491196       rs550630746       rs550642274       rs551242173       rs551377712       rs551394288       rs551624149       rs552752068       rs553025023       rs553059975       rs553062021       rs554082923       rs554121523       rs554660606       rs555429491       rs555644134       rs555796193       rs556147965       rs556915377       rs556985959       rs557074827       rs557926824       rs558009670       rs558055934       rs558240196       rs558250256       rs559229150       rs559251431       rs559348735       rs559509759       rs559640715       rs559693638       rs560386554       rs560719621       rs560832635       rs561425817       rs561529825       rs562032300       rs562102770       rs562715118       rs562779423       rs562801796       rs563262261       rs563322743       rs563605424       rs563644453       rs563898092       rs564576432       rs565724528       rs565977387       rs566710230       rs566991304       rs567171218       rs567203367       rs567470596       rs568007813       rs568155340       rs569539136       rs569694725       rs569782043       rs569866289       rs570183621       rs571178488       rs571284596       rs572226970       rs572311186       rs572460543       rs572586744       rs572788970       rs573356755       rs573484482       rs575769174       rs576458496       rs576686546       rs576760710       rs577551302       rs577569114       rs577571187       rs577733551       rs745631296       rs745922102       rs746159831       rs746161838       rs746475265       rs746803846       rs747067279       rs747297520       rs747581891       rs747639804       rs747872625       rs748181203       rs748206609       rs748438545       rs748552255       rs748700602       rs748924718       rs749068174       rs749084824       rs749564074       rs749673817       rs749838429       rs749922517       rs750150747       rs750325661       rs750766107       rs751092727       rs751282271       rs751576823       rs751903291       rs752455701       rs752790618       rs752920934       rs754607706       rs754701368       rs754701447       rs755150733       rs755276300       rs755756763       rs755769949       rs756103381       rs756261857       rs756453707       rs756625286       rs756635396       rs756882646       rs756903866       rs757357477       rs757584843       rs757786686       rs758146476       rs758292459       rs758615821       rs758705824       rs759008518       rs759492198       rs759943462       rs759996565       rs760115864       rs760134504       rs760170206       rs760190388       rs760734501       rs760958782       rs761060814       rs761324572       rs761477221       rs762079065       rs762504318       rs762710187       rs763214821       rs763595704       rs763634974       rs763738778       rs764642890       rs764877134       rs765790936       rs765848159       rs765952577       rs765962680       rs766395444       rs766581665       rs766604319       rs766860000       rs766996122       rs767091512       rs767125408       rs767753198       rs767833856       rs767991104       rs768361817       rs768389204       rs768546330       rs768603130       rs768779050       rs769019199       rs769072627       rs769466244       rs769509973       rs769749438       rs770111576       rs770164987       rs770432652       rs770930846       rs771092064       rs771814628       rs771990490       rs772130861       rs772214022       rs772424097       rs772562667       rs772796639       rs773132050       rs773417254       rs773621174       rs773657662       rs774227277       rs774502113       rs774854230       rs775028874       rs775142780       rs775573792       rs775716069       rs775994219       rs776011725       rs776377439       rs776849025       rs776884812       rs777410801       rs777526767       rs777728814       rs778151663       rs778575205       rs779374230       rs779457605       rs779557208       rs779706903       rs779756218       rs779814141       rs780381441       rs781041984       rs781119593       rs781411768       rs781462723       rs781501501       rs781515081      

基因表达

基因表达

CRYAA基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TTGAGTATGACCTGCTGCC
59
ATGGGTCATGAGCTCAGAG
58
TTGAGTATGACCTGCTGCC
59
ACATGGGTCATGAGCTCAG
59
CTTTGTGGAGATCCACGGA
59
AACTCACGGGAAATGTAGC
57
CATCTCTGAGCTCATGACC
57
AAGATGACGAACTTGTCCC
57
CTTTGTGGAGATCCACGGA
59
ACTCACGGGAAATGTAGCC
59
ACTTTGTGGAGATCCACGG
59
ACTCACGGGAAATGTAGCC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CRYAA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

CRYAA基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005212
E7EWH7(UniProtKB)
IEA
GO:0005212
E9PHE4(UniProtKB)
IEA
GO:0005212
P02489(UniProtKB)
IEA
GO:0005515
P02489(UniProtKB)
IPI
GO:0005515
P02489(UniProtKB)
IPI
GO:0005515
P02489(UniProtKB)
IPI
GO:0005515
P02489(UniProtKB)
IPI
GO:0005515
P02489(UniProtKB)
IPI
GO:0005515
P02489(UniProtKB)
IPI
GO:0005515
P02489(UniProtKB)
IPI
GO:0005515
P02489(UniProtKB)
IPI
GO:0005515
P02489(UniProtKB)
IPI
GO:0005515
P02489(UniProtKB)
IPI
GO:0005515
P02489(UniProtKB)
IPI
GO:0005515
P02489(UniProtKB)
IPI
GO:0005515
P02489(UniProtKB)
IPI
GO:0005634
P02489(UniProtKB)
IDA
GO:0005737
P02489(UniProtKB)
IDA
GO:0005737
P02489(UniProtKB)
IDA
GO:0007601
P02489(UniProtKB)
IMP
GO:0007601
P02489(UniProtKB)
IMP
GO:0007601
P02489(UniProtKB)
IMP
GO:0032387
P02489(UniProtKB)
IDA
GO:0042802
P02489(UniProtKB)
IPI
GO:0042802
P02489(UniProtKB)
IPI
GO:0042802
P02489(UniProtKB)
IPI
GO:0043066
P02489(UniProtKB)
IMP
GO:0043066
P02489(UniProtKB)
IDA
GO:0046872
P02489(UniProtKB)
IEA
GO:0050896
P02489(UniProtKB)
IEA
GO:0051082
P02489(UniProtKB)
IMP
GO:0051082
P02489(UniProtKB)
IPI
GO:0051260
P02489(UniProtKB)
IDA
GO:0070062
P02489(UniProtKB)
IDA
GO:0042026
P02489(UniProtKB)
ISS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控CRYAA基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
CATARACT, AUTOSOMAL DOMINANT 0.32 5 6 CLINVAR_MGD_UNIPROT
Cataract 0.217878945 23 4 BeFree_CTD_human_GAD_LHGDN_RGD
Nuclear cataract 0.120814326 3 2 BeFree_ORPHANET
Nuclear non-senile cataract 0.120814326 3 2 BeFree_ORPHANET
Age-related cataract 0.120271442 2 1 BeFree_GWASCAT
Autoimmune Diseases 0.12 1 0 CTD_human
Uveitis 0.12 2 0 CTD_human
Congenital total cataract 0.12 0 0 ORPHANET
CATARACT, ANTERIOR POLAR 0.12 0 0 ORPHANET
Cataract microcornea syndrome 0.12 0 0 ORPHANET
Galactosemias 0.08 1 0 RGD
Ocular Hypertension 0.08 1 0 RGD
Congenital ocular coloboma (disorder) 0.00272435 1 0 LHGDN
Corneal Opacity 0.00272435 1 0 LHGDN
Bilateral cataracts (disorder) 0.001900093 7 3 BeFree
Congenital cataract 0.001628651 6 2 BeFree
Microcornea 0.000542884 2 1 BeFree
AIDS related complex 0.000271442 1 0 BeFree
Coloboma of iris 0.000271442 1 1 BeFree
Congenital coloboma of iris 0.000271442 1 1 BeFree
Lens Opacities 0.000271442 1 0 BeFree
Cataract, Age-Related Nuclear 0.000271442 1 0 BeFree
CATARACT, MARNER TYPE 0.000271442 1 0 BeFree

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