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This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
[中文简述(自动翻译):]  这个基因编码黄素腺嘌呤二核苷酸结合蛋白是这样的昼夜芯振荡器复杂,其调节生物钟的一个关键组成部分。该基因是由时钟/ ARNTL异上调但随后压制这种上调使用PER / CRY异与时钟/ ARNTL互动反馈环路。在这个基因多态性已与改变睡眠模式有关。所编码的蛋白质被跨越的植物和动物广泛保守的。在完全黑暗缩短昼夜周期中的鼠标结果相关基因的缺失。 [由RefSeq的,2014年1月提供]
CRY1基因(以及对应的蛋白质)的细胞分布位置:
CRY1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Myeloid Leukemia, Chronic | 0.12 | 1 | 0 | CTD_human |
Bipolar Disorder | 0.005276948 | 3 | 0 | BeFree_GAD |
Schizophrenia | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Mental Depression | 0.002909916 | 3 | 0 | BeFree_GAD |
Malignant neoplasm of prostate | 0.002638474 | 1 | 12 | BeFree_GAD |
Albuminuria | 0.002367032 | 1 | 1 | GAD |
Heroin Dependence | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Sleep Disorders | 0.002367032 | 1 | 0 | GAD |
Creatinine finding | 0.002367032 | 1 | 1 | GAD |
Depressive disorder | 0.000814326 | 3 | 9 | BeFree |
Hypertensive disease | 0.000814326 | 3 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of breast | 0.000542884 | 2 | 3 | BeFree |
Unipolar Depression | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 3 | BeFree |
Major Depressive Disorder | 0.000542884 | 2 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Nevus | 0.000271442 | 1 | 0 | BeFree |
Melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
Vertigo | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
stage, chronic lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
Opiate Addiction | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 12 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
winter depression | 0.000271442 | 1 | 9 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Benign melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 5 | BeFree |
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