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This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  这个基因编码的衔接蛋白家族结合几个酪氨酸磷酸化的蛋白质的成员。该基因的产物具有几个SH2和SH3结构域(SRC-同源结构域),并参与几个信号传导途径,在酪氨酸激酶通过SH2磷酸酪氨酸相互作用附近招募胞质蛋白。这种蛋白质的功能的N-末端SH2结构域作为变换而C末端SH3域函数作为变换的负调节的正调节。编码具有不同的生物活性的不同的同种型两种备选的转录已经描述。 [由RefSeq的,2008年7月提供]
CRK基因(以及对应的蛋白质)的细胞分布位置:
CRK基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
Breast Carcinoma | 0.007328931 | 27 | 0 | BeFree |
Malignant neoplasm of breast | 0.007057489 | 26 | 0 | BeFree |
Lung Neoplasms | 0.005991584 | 3 | 0 | BeFree_LHGDN |
Glioblastoma | 0.004624443 | 8 | 0 | BeFree_LHGDN |
Rheumatoid Arthritis | 0.003800186 | 14 | 0 | BeFree |
Malignant neoplasm of lung | 0.003800186 | 14 | 0 | BeFree |
Malignant neoplasm of prostate | 0.003800186 | 14 | 0 | BeFree |
Prostate carcinoma | 0.003800186 | 14 | 0 | BeFree |
Liver carcinoma | 0.003800186 | 14 | 0 | BeFree |
Carcinoma of lung | 0.003528744 | 13 | 0 | BeFree |
Colon Carcinoma | 0.003528744 | 13 | 0 | BeFree |
Malignant tumor of colon | 0.003257302 | 12 | 0 | BeFree |
synovial sarcoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Neoplasm Metastasis | 0.002985861 | 11 | 0 | BeFree |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
HIV Infections | 0.002442977 | 9 | 0 | BeFree |
Malignant neoplasm of stomach | 0.002442977 | 9 | 0 | BeFree |
Neuroblastoma | 0.002442977 | 9 | 0 | BeFree |
Pancreatic carcinoma | 0.002442977 | 9 | 0 | BeFree |
Carcinogenesis | 0.002442977 | 9 | 0 | BeFree |
Stomach Carcinoma | 0.002442977 | 9 | 0 | BeFree |
Central neuroblastoma | 0.002442977 | 9 | 0 | BeFree |
melanoma | 0.002171535 | 8 | 0 | BeFree |
Ovarian Carcinoma | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.002171535 | 8 | 0 | BeFree |
Hyperglycemia | 0.001900093 | 7 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Glioma | 0.001628651 | 6 | 0 | BeFree |
Heart failure | 0.001628651 | 6 | 0 | BeFree |
Congestive heart failure | 0.001628651 | 6 | 0 | BeFree |
Ischemia | 0.001628651 | 6 | 0 | BeFree |
Multiple Myeloma | 0.001628651 | 6 | 0 | BeFree |
Degenerative polyarthritis | 0.001628651 | 6 | 0 | BeFree |
Malignant neoplasm of ovary | 0.001628651 | 6 | 0 | BeFree |
Adenocarcinoma | 0.001357209 | 5 | 0 | BeFree |
Colorectal Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.001357209 | 5 | 0 | BeFree |
Liver neoplasms | 0.001357209 | 5 | 0 | BeFree |
Mammary Neoplasms | 0.001357209 | 5 | 0 | BeFree |
Squamous cell carcinoma | 0.001085767 | 4 | 0 | BeFree |
leukemia | 0.001085767 | 4 | 0 | BeFree |
Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Obesity | 0.001085767 | 4 | 0 | BeFree |
Tuberculosis | 0.001085767 | 4 | 0 | BeFree |
Virus Diseases | 0.001085767 | 4 | 0 | BeFree |
B-Cell Lymphomas | 0.001085767 | 4 | 0 | BeFree |
Cholangiocarcinoma | 0.001085767 | 4 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.001085767 | 4 | 0 | BeFree |
Colorectal Cancer | 0.001085767 | 4 | 0 | BeFree |
Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
Arthritis | 0.000814326 | 3 | 0 | BeFree |
Atherosclerosis | 0.000814326 | 3 | 0 | BeFree |
Malignant tumor of cervix | 0.000814326 | 3 | 0 | BeFree |
Chondrosarcoma | 0.000814326 | 3 | 0 | BeFree |
Diabetes Mellitus | 0.000814326 | 3 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma | 0.000814326 | 3 | 0 | BeFree |
bone destruction | 0.000814326 | 3 | 0 | BeFree |
Cervix carcinoma | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma of bone | 0.000814326 | 3 | 0 | BeFree |
Tauopathies | 0.000814326 | 3 | 0 | BeFree |
Autoimmune Diseases | 0.000542884 | 2 | 0 | BeFree |
Colitis | 0.000542884 | 2 | 0 | BeFree |
Crohn Disease | 0.000542884 | 2 | 0 | BeFree |
Depressive disorder | 0.000542884 | 2 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000542884 | 2 | 0 | BeFree |
Endometriosis | 0.000542884 | 2 | 0 | BeFree |
Hepatitis C | 0.000542884 | 2 | 0 | BeFree |
Influenza | 0.000542884 | 2 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
Malaria | 0.000542884 | 2 | 0 | BeFree |
Psoriasis | 0.000542884 | 2 | 0 | BeFree |
Rhabdomyosarcoma | 0.000542884 | 2 | 0 | BeFree |
Systemic Scleroderma | 0.000542884 | 2 | 0 | BeFree |
Werner Syndrome | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000542884 | 2 | 0 | BeFree |
Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
Lissencephaly | 0.000542884 | 2 | 0 | BeFree |
Disease due to Parvoviridae | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma of pancreas | 0.000542884 | 2 | 0 | BeFree |
Malignant Glioma | 0.000542884 | 2 | 0 | BeFree |
Endothelial dysfunction | 0.000542884 | 2 | 0 | BeFree |
Breast adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Sarcoma | 0.000542884 | 2 | 0 | BeFree |
Inflammatory disorder | 0.000542884 | 2 | 0 | BeFree |
Alcoholic Intoxication, Chronic | 0.000271442 | 1 | 0 | BeFree |
Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
Asbestosis | 0.000271442 | 1 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Autistic Disorder | 0.000271442 | 1 | 0 | BeFree |
Burkitt Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Cytomegalovirus Infections | 0.000271442 | 1 | 0 | BeFree |
Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Enteritis | 0.000271442 | 1 | 0 | BeFree |
Exanthema | 0.000271442 | 1 | 0 | BeFree |
Fibrodysplasia Ossificans Progressiva | 0.000271442 | 1 | 0 | BeFree |
Hypertensive disease | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Arthropathy | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Spinal Muscular Atrophy | 0.000271442 | 1 | 0 | BeFree |
Myasthenia Gravis | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Pemphigus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Pituitary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Respiratory Syncytial Virus Infections | 0.000271442 | 1 | 0 | BeFree |
Scrub Typhus | 0.000271442 | 1 | 0 | BeFree |
Dermatologic disorders | 0.000271442 | 1 | 0 | BeFree |
Varicocele | 0.000271442 | 1 | 0 | BeFree |
Dental White Spot | 0.000271442 | 1 | 0 | BeFree |
Polycystic Kidney, Autosomal Dominant | 0.000271442 | 1 | 0 | BeFree |
Depressive Symptoms | 0.000271442 | 1 | 0 | BeFree |
Epstein-Barr Virus Infections | 0.000271442 | 1 | 0 | BeFree |
Renal fibrosis | 0.000271442 | 1 | 0 | BeFree |
Intervertebral Disc Degeneration | 0.000271442 | 1 | 0 | BeFree |
Rhabdomyosarcoma, Embryonal | 0.000271442 | 1 | 0 | BeFree |
Anaplastic thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
Iron deficiency | 0.000271442 | 1 | 0 | BeFree |
Sepsis | 0.000271442 | 1 | 0 | BeFree |
Congenital anomaly of face | 0.000271442 | 1 | 0 | BeFree |
Muckle-Wells Syndrome | 0.000271442 | 1 | 0 | BeFree |
Rhinovirus infection | 0.000271442 | 1 | 0 | BeFree |
Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Chronic Infantile Neurological, Cutaneous, and Articular Syndrome | 0.000271442 | 1 | 0 | BeFree |
Peritoneal Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Periodic syndrome | 0.000271442 | 1 | 0 | BeFree |
Tumor Initiation | 0.000271442 | 1 | 0 | BeFree |
Malignant Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Spots on skin | 0.000271442 | 1 | 0 | BeFree |
Renal ischaemia | 0.000271442 | 1 | 0 | BeFree |
Primary infection NOS | 0.000271442 | 1 | 0 | BeFree |
Arthritis, Collagen-Induced | 0.000271442 | 1 | 0 | BeFree |
Anemia, Diamond-Blackfan | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Angiogenic Switch | 0.000271442 | 1 | 0 | BeFree |
androgen independent prostate cancer | 0.000271442 | 1 | 0 | BeFree |
Destructive Arthritis | 0.000271442 | 1 | 0 | BeFree |
Cavernous Hemangioma of Brain | 0.000271442 | 1 | 0 | BeFree |
Parkinson Disease, Familial, Type 1 | 0.000271442 | 1 | 0 | BeFree |
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