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This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
[中文简述(自动翻译):]  这个基因编码的膜蛋白,其功能是作为对Epstein-Barr病毒的B和T淋巴细胞结合的受体(EBV)。在这种基因的遗传变异与易患系统性红斑狼疮9型(SLEB9)有关。另外剪接转录变体编码不同亚型也发现了这种基因。[由RefSeq的,2009年09月提供]
CR2基因(以及对应的蛋白质)的细胞分布位置:
CR2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Lupus Erythematosus, Systemic | 0.128815624 | 6 | 1 | BeFree_CTD_human_GAD_LHGDN |
Common Variable Immunodeficiency | 0.122171535 | 8 | 0 | BeFree_ORPHANET |
SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 9 | 0.12 | 0 | 0 | CLINVAR |
IMMUNODEFICIENCY, COMMON VARIABLE, 7 | 0.12 | 0 | 2 | CLINVAR |
Epstein-Barr Virus Infections | 0.005167327 | 10 | 0 | BeFree_LHGDN |
Lupus Erythematosus | 0.003181358 | 3 | 1 | BeFree_GAD |
Lymphoma | 0.002985861 | 11 | 0 | BeFree |
Cancer of Nasopharynx | 0.002638474 | 1 | 0 | BeFree_GAD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.002367032 | 1 | 1 | GAD |
Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
Parkinson Disease | 0.002367032 | 1 | 0 | GAD |
Age related macular degeneration | 0.002367032 | 1 | 0 | GAD |
HIV Infections | 0.001357209 | 5 | 0 | BeFree |
Rheumatoid Arthritis | 0.001085767 | 4 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.001085767 | 4 | 0 | BeFree |
Mixed cryoglobulinemia | 0.001085767 | 4 | 0 | BeFree |
Autoimmune Diseases | 0.000814326 | 3 | 0 | BeFree |
Lupus Vulgaris | 0.000814326 | 3 | 1 | BeFree |
Lupus Erythematosus, Discoid | 0.000814326 | 3 | 1 | BeFree |
Lymphoma, Follicular | 0.000814326 | 3 | 0 | BeFree |
Multiple Myeloma | 0.000814326 | 3 | 0 | BeFree |
Hypogammaglobulinemia | 0.000814326 | 3 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000814326 | 3 | 0 | BeFree |
Arthritis | 0.000542884 | 2 | 0 | BeFree |
Fibroid Tumor | 0.000542884 | 2 | 0 | BeFree |
leiomyosarcoma | 0.000542884 | 2 | 0 | BeFree |
Superinfection | 0.000542884 | 2 | 0 | BeFree |
Uterine Fibroids | 0.000542884 | 2 | 0 | BeFree |
B-Cell Lymphomas | 0.000542884 | 2 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Acquired Immunodeficiency Syndrome | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Hodgkin Disease | 0.000271442 | 1 | 0 | BeFree |
insulinoma | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Mitral Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Myasthenia Gravis | 0.000271442 | 1 | 0 | BeFree |
Mycoplasma Infections | 0.000271442 | 1 | 0 | BeFree |
Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
Wiskott-Aldrich Syndrome | 0.000271442 | 1 | 0 | BeFree |
Leukoplakia, Hairy | 0.000271442 | 1 | 0 | BeFree |
Chronic graft-versus-host disease | 0.000271442 | 1 | 0 | BeFree |
Astler-Coller B1 Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Direct Contact Transmission Infection | 0.000271442 | 1 | 0 | BeFree |
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