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This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
[中文简述(自动翻译):]  该基因编码的胞质聚腺苷酸化元件结合蛋白家族的一个成员。此高度保守的蛋白质结合特定RNA序列,称为胞质聚腺苷酸化元件,在3‘非翻译部分的mRNA的地区发现。在细胞质和细胞核中都所编码的蛋白质的功能。它参与mRNA翻译的调节,以及3‘非翻译区的处理,并且可以在细胞增殖和肿瘤发生的作用。选择性剪接结果在多个抄本变形。 [由RefSeq的,2014年1月提供]
CPEB1基因(以及对应的蛋白质)的细胞分布位置:
CPEB1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Chronic Lymphocytic Leukemia | 0.122367032 | 1 | 1 | CTD_human_GAD |
Glioblastoma | 0.080271442 | 1 | 0 | BeFree_RGD |
leukemia | 0.002367032 | 1 | 0 | GAD |
Glioma | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Fragile X Syndrome | 0.000271442 | 1 | 0 | BeFree |
Male infertility | 0.000271442 | 1 | 2 | BeFree |
nervous system disorder | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Memory impairment | 0.000271442 | 1 | 0 | BeFree |
Congenital diaphragmatic hernia | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Ovarian failure | 0.000271442 | 1 | 0 | BeFree |
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