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This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015]
[中文简述(自动翻译):]  该基因编码的羧成员锌金属蛋白酶家族。这种酶在胰腺产生和优先切割C-末端支链和从膳食蛋白质芳香族氨基酸。该基因和几个M组余烬存在于染色体上的7突变该基因可能与慢性胰腺炎的基因簇,而升高的蛋白水平可以与胰腺癌相关联。 [由RefSeq的,2015年1月提供]
CPA1基因(以及对应的蛋白质)的细胞分布位置:
CPA1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Pancreatitis, Chronic | 0.120542884 | 2 | 0 | BeFree_CTD_human |
| Adenoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
| Pancreatitis | 0.000542884 | 2 | 0 | BeFree |
| Non-Neoplastic Disorder | 0.000542884 | 2 | 0 | BeFree |
| Adrenal Gland Hyperfunction | 0.000271442 | 1 | 0 | BeFree |
| Cushing Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Mixed Salivary Gland Tumor | 0.000271442 | 1 | 0 | BeFree |
| Adrenocortical carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Conn Syndrome | 0.000271442 | 1 | 0 | BeFree |
| TROPICAL CALCIFIC PANCREATITIS | 0.000271442 | 1 | 0 | BeFree |
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