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In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  在真核细胞中,内质网和高尔基体室之间蛋白质运输部分地由非网格蛋白包被小泡的外壳蛋白(的COP)介导的。七外壳蛋白已经确定,它们代表称为套体素复合物的亚基。亚基被指定的α-COP,β-COP,β-黄金COP,γ-COPΔ-COP,ε-缔约方会议和Zeta-COP。该α-缔约方会议COPA,与RET1P,在酵母中的套体素复合物的α亚基股高序列相似性的编码。也,α-COP的N-末端25个氨基酸进行编码的生物活性肽,xenin,刺激胰腺外分泌分泌,并且可以作为胃肠激素作用。选择性剪接结果编码不同亚型多重剪接形式。 [由RefSeq的,2008年7月提供]
COPA基因(以及对应的蛋白质)的细胞分布位置:
COPA基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Arthritis | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Autoimmune Diseases | 0.12 | 1 | 0 | CTD_human |
Lung Diseases, Interstitial | 0.12 | 1 | 0 | CTD_human |
Liver carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
Lung diseases | 0.000271442 | 1 | 0 | BeFree |
Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Spinal Muscular Atrophy | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
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